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Fusion gene ID: 41082 |
FusionGeneSummary for USP34_CCT4 |
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Fusion gene information | Fusion gene name: USP34_CCT4 | Fusion gene ID: 41082 | Hgene | Tgene | Gene symbol | USP34 | CCT4 | Gene ID | 9736 | 10575 |
Gene name | ubiquitin specific peptidase 34 | chaperonin containing TCP1 subunit 4 | |
Synonyms | - | CCT-DELTA|Cctd|SRB | |
Cytomap | 2p15 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34 | T-complex protein 1 subunit deltaTCP-1-deltachaperonin containing TCP1, subunit 4 (delta)chaperonin containing t-complex polypeptide 1, delta subunitstimulator of TAR RNA-binding | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q70CQ2 | P50991 | |
Ensembl transtripts involved in fusion gene | ENST00000398571, ENST00000472689, | ENST00000394440, ENST00000461540, ENST00000544079, ENST00000544185, ENST00000538252, | |
Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 5 X 6 X 4=120 |
# samples | 20 | 6 | |
** MAII score | log2(20/2520*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: USP34 [Title/Abstract] AND CCT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | USP34 | GO:0016579 | protein deubiquitination | 14715245 |
Hgene | USP34 | GO:0071108 | protein K48-linked deubiquitination | 21383061 |
Hgene | USP34 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21383061 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-8060-01A | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000398571 | ENST00000394440 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
5CDS-intron | ENST00000398571 | ENST00000461540 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
5CDS-intron | ENST00000398571 | ENST00000544079 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
5CDS-5UTR | ENST00000398571 | ENST00000544185 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
5CDS-5UTR | ENST00000398571 | ENST00000538252 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
intron-3CDS | ENST00000472689 | ENST00000394440 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
intron-intron | ENST00000472689 | ENST00000461540 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
intron-intron | ENST00000472689 | ENST00000544079 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
intron-5UTR | ENST00000472689 | ENST00000544185 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
intron-5UTR | ENST00000472689 | ENST00000538252 | USP34 | chr2 | 61697785 | - | CCT4 | chr2 | 62112207 | - |
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FusionProtFeatures for USP34_CCT4 |
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Hgene | Tgene |
USP34 | CCT4 |
Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP34_CCT4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP34_CCT4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
USP34 | ATM, SIRT7, UBE2C, UFC1, UFM1, ZRANB2, UBE2V2, SRXN1, STAM, AHCYL1, UBE4B, UBQLN1, UBXN7, UBA2, UBE2L3, UBE2V1, TTLL12, UCHL3, UBQLN2, UBXN1, ZFYVE19, SULT1A1, UBE2D1, UBQLN4, ATP6V1B2, LAGE3, SSSCA1, UBL7, USP9X, SEC24A, UNK, VPS4B, SOX2, CD2AP, ELP2, KIAA1033, SNRNP200, CSNK1A1, ZNF707, EIF3M, PCGF1, DPPA4, NANOG, POU5F1, EGFR, EPHA1, ZNF214, ZNF785, ZNF764, SUV39H1, ZNF669, ERMAP, ZNF550, LYPD4, TSPYL6, ZNF354C, ZNF211, RBM3, MTNR1A, MTNR1B, TRIM25 | CCT4 | PPP4C, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, ACTA2, ACTA1, MEPCE, HNRNPH1, GPN1, CDK9, RFWD2, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, HDAC5, PSMA3, RPS6KA1, PCK1, VHL, ISG15, FBXO25, CUL3, CUL5, CDK2, CUL1, COPS5, GRB2, PACRG, CCT2, CCT6A, CCT3, CCT7, CCT5, CCT8, CCT6B, RPSA, P4HB, PSMA6, SSR1, G6PD, XPO1, TXNL1, SMURF1, VCP, CFAP52, FN1, VCAM1, ATF2, PEX14, PPP5C, NOS2, FAM86B2, METTL18, METTL21B, ITGA4, CFTR, PAN2, CD81, IGSF8, ICAM1, HDAC3, HDAC11, FBXW4, FBXO6, PRPF40A, USP9X, VARS, VRK2, CDK5, ILK, UBC, STAU1, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, CUL7, IKBKE, IRAK1, JAK3, MAPK8, PTK6, SGK2, TSSK6, TYK2, WDR76, POC1A, TXNDC9, WDR83, PEX7, ACTR1B, SEC31B, ACTL6A, TTLL3, CDK15, RPS6KB2, DCAF7, AMBRA1, UNK, CANX, CAD, DNAJA2, EHD2, MCM7, SLC25A3, DNAJA4, HSPE1, KIAA0368, PDCL3, PSMC2, NTRK1, BTRC, B9D1, MKS1, CETN2, AHSA1, CDK1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, BUB3, ACTR2, FGFR1OP2, WRAP53, RFWD3, KIF21A, MYO19, SEH1L, TUBA1C, ARMC6, GAN, CRY1, CRY2, ALKBH3, MCM2, SNW1, CDC5L, TTC27, NLE1, CDC73, ZNF746, FLCN, PPM1J, KLHL33, KLHDC8A, KDM4B, ACTR3B, RAP2C, WDR86, THOC3, DCAF11, DCAF10, DCAF8, WDR77, TUBG2, WDTC1, WDR5B, HCFC2, TBL1Y, PDDC1, WDR34, DNAI2, PNPLA5, WDR37, POC1B, GNB2, TUBA1B, ODF1, ACTBL2, CDK11A, ACTR3, ASTN2, GANAB, RBM3, CYLD, WDR92, TRIM25, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP34_CCT4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP34_CCT4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |