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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41076

FusionGeneSummary for USP33_TARS

check button Fusion gene summary
Fusion gene informationFusion gene name: USP33_TARS
Fusion gene ID: 41076
HgeneTgene
Gene symbol

USP33

TARS

Gene ID

23032

6897

Gene nameubiquitin specific peptidase 33threonyl-tRNA synthetase
SynonymsVDU1ThrRS
Cytomap

1p31.1

5p13.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 33VHL-interacting deubiquitinating enzyme 1deubiquitinating enzyme 33pVHL-interacting deubiquitinating enzyme 1ubiquitin thioesterase 33ubiquitin thiolesterase 33ubiquitin-specific-processing protease 33threonine--tRNA ligase, cytoplasmicthreonine tRNA ligase 1, cytoplasmicthreonyl-tRNA synthetase, cytoplasmic
Modification date2018052320180523
UniProtAcc

Q8TEY7

P26639

Ensembl transtripts involved in fusion geneENST00000370794, ENST00000357428, 
ENST00000370793, ENST00000370792, 
ENST00000528150, 		ENST00000502553, 
ENST00000265112, ENST00000541634, 
ENST00000455217, ENST00000414361, 
ENST00000509410, 
Fusion gene scores* DoF score5 X 3 X 5=752 X 2 X 1=4
# samples 52
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: USP33 [Title/Abstract] AND TARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP33

GO:0009267

cellular response to starvation

24056301

HgeneUSP33

GO:0016579

protein deubiquitination

11739384|19363159|19424180|23486064

HgeneUSP33

GO:0070536

protein K63-linked deubiquitination

19363159

HgeneUSP33

GO:0071108

protein K48-linked deubiquitination

19363159


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A0DA-01AUSP33chr1

78225328

-TARSchr5

33445430

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000370794ENST00000502553USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-3CDSENST00000370794ENST00000265112USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370794ENST00000541634USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370794ENST00000455217USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370794ENST00000414361USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-intronENST00000370794ENST00000509410USP33chr1

78225328

-TARSchr5

33445430

+
intron-3CDSENST00000357428ENST00000502553USP33chr1

78225328

-TARSchr5

33445430

+
intron-3CDSENST00000357428ENST00000265112USP33chr1

78225328

-TARSchr5

33445430

+
intron-5UTRENST00000357428ENST00000541634USP33chr1

78225328

-TARSchr5

33445430

+
intron-5UTRENST00000357428ENST00000455217USP33chr1

78225328

-TARSchr5

33445430

+
intron-5UTRENST00000357428ENST00000414361USP33chr1

78225328

-TARSchr5

33445430

+
intron-intronENST00000357428ENST00000509410USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-3CDSENST00000370793ENST00000502553USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-3CDSENST00000370793ENST00000265112USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370793ENST00000541634USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370793ENST00000455217USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370793ENST00000414361USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-intronENST00000370793ENST00000509410USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-3CDSENST00000370792ENST00000502553USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-3CDSENST00000370792ENST00000265112USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370792ENST00000541634USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370792ENST00000455217USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000370792ENST00000414361USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-intronENST00000370792ENST00000509410USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-3CDSENST00000528150ENST00000502553USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-3CDSENST00000528150ENST00000265112USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000528150ENST00000541634USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000528150ENST00000455217USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-5UTRENST00000528150ENST00000414361USP33chr1

78225328

-TARSchr5

33445430

+
5UTR-intronENST00000528150ENST00000509410USP33chr1

78225328

-TARSchr5

33445430

+

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FusionProtFeatures for USP33_TARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP33

Q8TEY7

TARS

P26639

Deubiquitinating enzyme involved in various processessuch as centrosome duplication, cellular migration and beta-2adrenergic receptor/ADRB2 recycling. Involved in regulation ofcentrosome duplication by mediating deubiquitination of CCP110 inS and G2/M phase, leading to stabilize CCP110 during the periodwhich centrioles duplicate and elongate. Involved in cellmigration via its interaction with intracellular domain of ROBO1,leading to regulate the Slit signaling. Plays a role incommissural axon guidance cross the ventral midline of the neuraltube in a Slit-dependent manner, possibly by mediating thedeubiquitination of ROBO1. Acts as a regulator of G-proteincoupled receptor (GPCR) signaling by mediating thedeubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2adrenergic receptor (ADRB2). Plays a central role in ADRB2recycling and resensitization after prolonged agonist stimulationby constitutively binding ADRB2, mediating deubiquitination ofADRB2 and inhibiting lysosomal trafficking of ADRB2. Upondissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination anddisengagement from ADRB2. This suggests the existence of a dynamicexchange between the ADRB2 and beta-arrestins. DeubiquitinatesDIO2, thereby regulating thyroid hormone regulation. Mediatesdeubiquitination of both 'Lys-48'- and 'Lys-63'-linkedpolyubiquitin chains. {ECO:0000269|PubMed:12865408,ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180,ECO:0000269|PubMed:23486064}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP33_TARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP33_TARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP33DIO2, DDX56, EIF6, VHL, TCEB1, SELENBP1, KRR1, IFIT5, ZFR, PRPF38B, ROBO1, ARRB2, ARRB1, ELAVL1, TRIM63, TRIM54, USP21, USP15, USP28, TCEB2, ADRB2, USP20, CCP110, NEURL4, RALA, RALB, BECN1, EXOC2, UBC, SPINT2, SPA17, MPPED1, CGRRF1, OBFC1, GNAI3, VSX2, VAPB, LDLRAD4, MYC, TRAF6, PCGF6, VAPA, ZNRF4, APBA2, TKTL2, TLR2, LPCAT4TARSHLA-B, BCAR3, MCC, ELF3, TRAF6, VHL, ATG101, DDA1, GBAS, PIK3C2A, PRKAG1, PRKAG2, UBA5, HDAC5, NDRG1, ISG15, CUL3, CDK2, CUL1, EEF2, RPLP0P6, CCT5, RPS27A, PREP, SARS, AURKA, RPL4, BRCA1, VCAM1, FN1, ITGA4, APEH, CORO1B, FAM129B, NUDC, PAPOLA, PUF60, SET, CORO1C, DVL2, FAM114A1, UGP2, VPS26A, ZYX, DCP2, HUWE1, C7orf25, TARSL2, CUL7, RNF2, EGFR, HSPB1, PTGES3L-AARSD1, AARSD1, AHNAK, CHEK1, EIF2AK4, FARSA, FARSB, GARS, GFPT1, HNRNPD, NAA50, NHP2L1, SARS2, SFPQ, TARBP1, FHOD1, FUS, TOMM34, TPD52L2, UBLCP1, NTRK1, MCM2, SENP3, EIF4E2, CCDC102B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP33_TARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP33_TARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTARSC0027121Myositis1CTD_human