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Fusion gene ID: 41071 |
FusionGeneSummary for USP32_UPF2 |
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Fusion gene information | Fusion gene name: USP32_UPF2 | Fusion gene ID: 41071 | Hgene | Tgene | Gene symbol | USP32 | UPF2 | Gene ID | 84669 | 26019 |
Gene name | ubiquitin specific peptidase 32 | UPF2, regulator of nonsense mediated mRNA decay | |
Synonyms | NY-REN-60|USP10 | HUPF2|RENT2|smg-3 | |
Cytomap | 17q23.1-q23.2 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | regulator of nonsense transcripts 2FRS2/UPF2/LEMD3 fusionLEMD3/UPF2 fusionUPF2 regulator of nonsense transcripts homolognonsense mRNA reducing factor 2smg-3 homolog, nonsense mediated mRNA decay factorup-frameshift suppressor 2 homologyeast Upf2p h | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NFA0 | Q9HAU5 | |
Ensembl transtripts involved in fusion gene | ENST00000300896, ENST00000592339, ENST00000393003, ENST00000586881, | ENST00000356352, ENST00000357604, ENST00000397053, ENST00000460569, | |
Fusion gene scores | * DoF score | 28 X 15 X 9=3780 | 5 X 7 X 3=105 |
# samples | 27 | 10 | |
** MAII score | log2(27/3780*10)=-3.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/105*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: USP32 [Title/Abstract] AND UPF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CD639413 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000300896 | ENST00000356352 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000300896 | ENST00000357604 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000300896 | ENST00000397053 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-5UTR | ENST00000300896 | ENST00000460569 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000592339 | ENST00000356352 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000592339 | ENST00000357604 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000592339 | ENST00000397053 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-5UTR | ENST00000592339 | ENST00000460569 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000393003 | ENST00000356352 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000393003 | ENST00000357604 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000393003 | ENST00000397053 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-5UTR | ENST00000393003 | ENST00000460569 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000586881 | ENST00000356352 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000586881 | ENST00000357604 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-3CDS | ENST00000586881 | ENST00000397053 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
intron-5UTR | ENST00000586881 | ENST00000460569 | USP32 | chr17 | 58407704 | - | UPF2 | chr10 | 12077228 | - |
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FusionProtFeatures for USP32_UPF2 |
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Hgene | Tgene |
USP32 | UPF2 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP32_UPF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP32_UPF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP32_UPF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP32_UPF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |