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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41065

FusionGeneSummary for USP32_SPANXN4

check button Fusion gene summary
Fusion gene informationFusion gene name: USP32_SPANXN4
Fusion gene ID: 41065
HgeneTgene
Gene symbol

USP32

SPANXN4

Gene ID

84669

441525

Gene nameubiquitin specific peptidase 32SPANX family member N4
SynonymsNY-REN-60|USP10CT11.9
Cytomap

17q23.1-q23.2

Xq27.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32sperm protein associated with the nucleus on the X chromosome N4cancer/testis antigen family 11, member 9nuclear-associated protein SPAN-Xn4
Modification date2018052320180519
UniProtAcc

Q8NFA0

Q5MJ08

Ensembl transtripts involved in fusion geneENST00000300896, ENST00000592339, 
ENST00000393003, ENST00000586881, 
ENST00000446864, ENST00000370504, 
Fusion gene scores* DoF score28 X 15 X 9=37801 X 1 X 1=1
# samples 271
** MAII scorelog2(27/3780*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: USP32 [Title/Abstract] AND SPANXN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-S9-A6WG-01AUSP32chr17

58422842

-SPANXN4chrX

142121811

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000300896ENST00000446864USP32chr17

58422842

-SPANXN4chrX

142121811

+
In-frameENST00000300896ENST00000370504USP32chr17

58422842

-SPANXN4chrX

142121811

+
intron-3CDSENST00000592339ENST00000446864USP32chr17

58422842

-SPANXN4chrX

142121811

+
intron-3CDSENST00000592339ENST00000370504USP32chr17

58422842

-SPANXN4chrX

142121811

+
Frame-shiftENST00000393003ENST00000446864USP32chr17

58422842

-SPANXN4chrX

142121811

+
In-frameENST00000393003ENST00000370504USP32chr17

58422842

-SPANXN4chrX

142121811

+
intron-3CDSENST00000586881ENST00000446864USP32chr17

58422842

-SPANXN4chrX

142121811

+
intron-3CDSENST00000586881ENST00000370504USP32chr17

58422842

-SPANXN4chrX

142121811

+

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FusionProtFeatures for USP32_SPANXN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP32

Q8NFA0

SPANXN4

Q5MJ08


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP32_SPANXN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_USP32_ENST00000300896_chr17_58422842_-_SPANXN4_ENST00000370504_chrX_142121811_+_193aa
MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEKKNLHRASAPEQSLKETEKAKYPTLVFY
CRKNKKRNSNQLENNQPTESSTDPIKEKGDLDISAGSPQDGEEEKDLVFLGARACLEEHIRRSVLYVGDSDTLSKMKTSESPPSGHIPQS

>In-frame_USP32_ENST00000393003_chr17_58422842_-_SPANXN4_ENST00000370504_chrX_142121811_+_193aa
MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEKKNLHRASAPEQSLKETEKAKYPTLVFY
CRKNKKRNSNQLENNQPTESSTDPIKEKGDLDISAGSPQDGEEEKDLVFLGARACLEEHIRRSVLYVGDSDTLSKMKTSESPPSGHIPQS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_USP32_ENST00000300896_chr17_58422842_-_SPANXN4_ENST00000370504_chrX_142121811_+_579nt
ATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTAAAACGACTGAAGGAT
GCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTT
GCTGAGAAGAAGAATCTGCACAGAGCCTCAGCCCCTGAACAGAGTTTGAAAGAGACAGAAAAAGCAAAATATCCAACATTAGTGTTTTAC
TGCAGGAAGAATAAGAAAAGAAATTCAAATCAACTGGAGAATAACCAGCCTACAGAGAGCTCCACTGATCCAATCAAAGAGAAAGGAGAC
CTAGACATATCTGCAGGATCTCCACAGGATGGAGAGGAAGAAAAGGATTTGGTGTTCCTTGGAGCACGTGCATGTTTAGAAGAGCACATA
AGAAGATCTGTATTGTATGTAGGTGACAGTGACACTCTTTCCAAAATGAAGACATCAGAATCACCACCTTCAGGCCACATACCTCAGAGT

>In-frame_USP32_ENST00000393003_chr17_58422842_-_SPANXN4_ENST00000370504_chrX_142121811_+_579nt
ATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTAAAACGACTGAAGGAT
GCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTT
GCTGAGAAGAAGAATCTGCACAGAGCCTCAGCCCCTGAACAGAGTTTGAAAGAGACAGAAAAAGCAAAATATCCAACATTAGTGTTTTAC
TGCAGGAAGAATAAGAAAAGAAATTCAAATCAACTGGAGAATAACCAGCCTACAGAGAGCTCCACTGATCCAATCAAAGAGAAAGGAGAC
CTAGACATATCTGCAGGATCTCCACAGGATGGAGAGGAAGAAAAGGATTTGGTGTTCCTTGGAGCACGTGCATGTTTAGAAGAGCACATA
AGAAGATCTGTATTGTATGTAGGTGACAGTGACACTCTTTCCAAAATGAAGACATCAGAATCACCACCTTCAGGCCACATACCTCAGAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_USP32_ENST00000300896_chr17_58422842_-_SPANXN4_ENST00000370504_chrX_142121811_+_780nt
ACGTGATCCGGCATGGAGGCGGTGGCGGCGACCGGGAGGAGCCGCCGGGGCAGAAGCCGCACTTGTTAGTGTGGGGGGAGGTGGGGGCGG
GGGACGCCGACACCGTCACCGTCACCCAGGGACGCCGAGGAGAAGGCGGGAGGGGGGTGGGGGCGAGATCAGGCTCCGACCCCCCGCCGA
GGGGATGAGGGGAGCATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTA
AAACGACTGAAGGATGCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGA
GTGCCTCCAAAGGTTGCTGAGAAGAAGAATCTGCACAGAGCCTCAGCCCCTGAACAGAGTTTGAAAGAGACAGAAAAAGCAAAATATCCA
ACATTAGTGTTTTACTGCAGGAAGAATAAGAAAAGAAATTCAAATCAACTGGAGAATAACCAGCCTACAGAGAGCTCCACTGATCCAATC
AAAGAGAAAGGAGACCTAGACATATCTGCAGGATCTCCACAGGATGGAGAGGAAGAAAAGGATTTGGTGTTCCTTGGAGCACGTGCATGT
TTAGAAGAGCACATAAGAAGATCTGTATTGTATGTAGGTGACAGTGACACTCTTTCCAAAATGAAGACATCAGAATCACCACCTTCAGGC

>In-frame_USP32_ENST00000393003_chr17_58422842_-_SPANXN4_ENST00000370504_chrX_142121811_+_621nt
CAGGCTCCGACCCCCCGCCGAGGGGATGAGGGGAGCATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGG
AGAGTTACAGATGTAGAGCTAAAACGACTGAAGGATGCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATC
CGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTTGCTGAGAAGAAGAATCTGCACAGAGCCTCAGCCCCTGAACAGAGTTTGAAAGAG
ACAGAAAAAGCAAAATATCCAACATTAGTGTTTTACTGCAGGAAGAATAAGAAAAGAAATTCAAATCAACTGGAGAATAACCAGCCTACA
GAGAGCTCCACTGATCCAATCAAAGAGAAAGGAGACCTAGACATATCTGCAGGATCTCCACAGGATGGAGAGGAAGAAAAGGATTTGGTG
TTCCTTGGAGCACGTGCATGTTTAGAAGAGCACATAAGAAGATCTGTATTGTATGTAGGTGACAGTGACACTCTTTCCAAAATGAAGACA


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FusionGenePPI for USP32_SPANXN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP32CDK1, FARSA, KRT8, KRT18, KRT19, ABCD3, YWHAB, TUBA1A, SMC1A, USP6, TRIP13, ERP44, UBXN1, MRPL39, VPS35, LRRC47, USP32P2, USP4, CUL3, CAND1, RBCK1, TRIM46, RNF144A, TRIM74, ZDHHC17, RAP1B, SORT1, SYNCRIP, BAG6, FDFT1, RAB6B, TPCN2, MANSC1, ENTPD7, ALDH3B1, CD83, NME4, HSPA12A, UBC, MTNR1A, TRIM25SPANXN4SRPK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP32_SPANXN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP32_SPANXN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource