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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41061

FusionGeneSummary for USP32_RAD51C

check button Fusion gene summary
Fusion gene informationFusion gene name: USP32_RAD51C
Fusion gene ID: 41061
HgeneTgene
Gene symbol

USP32

RAD51C

Gene ID

84669

5889

Gene nameubiquitin specific peptidase 32RAD51 paralog C
SynonymsNY-REN-60|USP10BROVCA3|FANCO|R51H3|RAD51L2
Cytomap

17q23.1-q23.2

17q22

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32DNA repair protein RAD51 homolog 3RAD51-like protein 2yeast RAD51 homolog 3
Modification date2018052320180523
UniProtAcc

Q8NFA0

O43502

Ensembl transtripts involved in fusion geneENST00000300896, ENST00000592339, 
ENST00000393003, ENST00000586881, 
ENST00000583539, ENST00000337432, 
ENST00000487921, ENST00000421782, 
Fusion gene scores* DoF score28 X 15 X 9=37807 X 4 X 2=56
# samples 278
** MAII scorelog2(27/3780*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: USP32 [Title/Abstract] AND RAD51C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAD51C

GO:0006281

DNA repair

19451272

TgeneRAD51C

GO:0006310

DNA recombination

19451272


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A0J5-01AUSP32chr17

58469243

-RAD51Cchr17

56772292

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000300896ENST00000583539USP32chr17

58469243

-RAD51Cchr17

56772292

+
Frame-shiftENST00000300896ENST00000337432USP32chr17

58469243

-RAD51Cchr17

56772292

+
5CDS-3UTRENST00000300896ENST00000487921USP32chr17

58469243

-RAD51Cchr17

56772292

+
5CDS-3UTRENST00000300896ENST00000421782USP32chr17

58469243

-RAD51Cchr17

56772292

+
intron-3CDSENST00000592339ENST00000583539USP32chr17

58469243

-RAD51Cchr17

56772292

+
intron-3CDSENST00000592339ENST00000337432USP32chr17

58469243

-RAD51Cchr17

56772292

+
intron-3UTRENST00000592339ENST00000487921USP32chr17

58469243

-RAD51Cchr17

56772292

+
intron-3UTRENST00000592339ENST00000421782USP32chr17

58469243

-RAD51Cchr17

56772292

+
Frame-shiftENST00000393003ENST00000583539USP32chr17

58469243

-RAD51Cchr17

56772292

+
Frame-shiftENST00000393003ENST00000337432USP32chr17

58469243

-RAD51Cchr17

56772292

+
5CDS-3UTRENST00000393003ENST00000487921USP32chr17

58469243

-RAD51Cchr17

56772292

+
5CDS-3UTRENST00000393003ENST00000421782USP32chr17

58469243

-RAD51Cchr17

56772292

+
intron-3CDSENST00000586881ENST00000583539USP32chr17

58469243

-RAD51Cchr17

56772292

+
intron-3CDSENST00000586881ENST00000337432USP32chr17

58469243

-RAD51Cchr17

56772292

+
intron-3UTRENST00000586881ENST00000487921USP32chr17

58469243

-RAD51Cchr17

56772292

+
intron-3UTRENST00000586881ENST00000421782USP32chr17

58469243

-RAD51Cchr17

56772292

+

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FusionProtFeatures for USP32_RAD51C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP32

Q8NFA0

RAD51C

O43502

Essential for the homologous recombination (HR) pathwayof DNA repair. Involved in the homologous recombination repair(HRR) pathway of double-stranded DNA breaks arising during DNAreplication or induced by DNA-damaging agents. Part of the RAD21paralog protein complexes BCDX2 and CX3 which act at differentstages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage,BCDX2 seems to act downstream of BRCA2 recruitment and upstream ofRAD51 recruitment; CX3 seems to act downstream of RAD51recruitment; both complexes bind predominantly to the intersectionof the four duplex arms of the Holliday junction (HJ) and tojunction of replication forks. The BCDX2 complex was originallyreported to bind single-stranded DNA, single-stranded gaps induplex DNA and specifically to nicks in duplex DNA. The BCDX2subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependentATPase activity suggesting an involvement in early stages of theHR pathway. Involved in RAD51 foci formation in response to DNAdamage suggesting an involvement in early stages of HR probably inthe invasion step. Has an early function in DNA repair infacilitating phosphorylation of the checkpoint kinase CHEK2 andthereby transduction of the damage signal, leading to cell cyclearrest and HR activation. Participates in branch migration and HJresolution and thus is important for processing HR intermediateslate in the DNA repair process; the function may be linked to theCX3 complex. Part of a PALB2-scaffolded HR complex containingBRCA2 and which is thought to play a role in DNA repair by HR.Protects RAD51 from ubiquitin-mediated degradation that isenhanced following DNA damage. Plays a role in regulatingmitochondrial DNA copy number under conditions of oxidative stressin the presence of RAD51 and XRCC3. Contributes to DNA cross-linkresistance, sister chromatid cohesion and genomic stability.Involved in maintaining centrosome number in mitosis.{ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:16215984,ECO:0000269|PubMed:16395335, ECO:0000269|PubMed:19451272,ECO:0000269|PubMed:19783859, ECO:0000269|PubMed:20413593,ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP32_RAD51C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP32_RAD51C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP32CDK1, FARSA, KRT8, KRT18, KRT19, ABCD3, YWHAB, TUBA1A, SMC1A, USP6, TRIP13, ERP44, UBXN1, MRPL39, VPS35, LRRC47, USP32P2, USP4, CUL3, CAND1, RBCK1, TRIM46, RNF144A, TRIM74, ZDHHC17, RAP1B, SORT1, SYNCRIP, BAG6, FDFT1, RAB6B, TPCN2, MANSC1, ENTPD7, ALDH3B1, CD83, NME4, HSPA12A, UBC, MTNR1A, TRIM25RAD51CRAD51, RAD51B, XRCC3, XRCC2, RAD51D, APP, SWSAP1, BSG, SPACA1, IL12RB1, CBWD1, TGOLN2, WNT4, THBS3, KLHL10, PTPN9, CCDC140, EFNB3, DKKL1, FAM174A, ADAMTS4, HENMT1, HELQ, PALB2, BRCA2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP32_RAD51C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP32_RAD51C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAD51CC3150659BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 33CTD_human;UNIPROT
TgeneRAD51CC3150653FANCONI ANEMIA, COMPLEMENTATION GROUP O2CTD_human;UNIPROT
TgeneRAD51CC0015625Fanconi Anemia1CTD_human;ORPHANET
TgeneRAD51CC0919267ovarian neoplasm1CTD_human
TgeneRAD51CC1458155Mammary Neoplasms1CTD_human