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Fusion gene ID: 41029 |
FusionGeneSummary for USP28_DRD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP28_DRD2 | Fusion gene ID: 41029 | Hgene | Tgene | Gene symbol | USP28 | DRD2 | Gene ID | 57646 | 1813 |
| Gene name | ubiquitin specific peptidase 28 | dopamine receptor D2 | |
| Synonyms | - | D2DR|D2R | |
| Cytomap | 11q23.2 | 11q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 28deubiquitinating enzyme 28ubiquitin carboxyl-terminal hydrolase 28 variant 1ubiquitin thioesterase 28ubiquitin thiolesterase 28ubiquitin-specific-processing protease 28 | D(2) dopamine receptordopamine D2 receptordopamine receptor D2 isoformseven transmembrane helix receptor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96RU2 | P14416 | |
| Ensembl transtripts involved in fusion gene | ENST00000003302, ENST00000260188, ENST00000544967, ENST00000545540, ENST00000537706, ENST00000542033, | ENST00000355319, ENST00000346454, ENST00000362072, ENST00000544518, ENST00000542968, ENST00000538967, ENST00000535984, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: USP28 [Title/Abstract] AND DRD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP28 | GO:0006974 | cellular response to DNA damage stimulus | 17873522 |
| Hgene | USP28 | GO:0010212 | response to ionizing radiation | 16901786 |
| Hgene | USP28 | GO:0016579 | protein deubiquitination | 16901786|17558397|18662541 |
| Hgene | USP28 | GO:0034644 | cellular response to UV | 17873522 |
| Hgene | USP28 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 16901786 |
| Tgene | DRD2 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway | 8666994|26554819 |
| Tgene | DRD2 | GO:0034776 | response to histamine | 16839358 |
| Tgene | DRD2 | GO:0050482 | arachidonic acid secretion | 8301582 |
| Tgene | DRD2 | GO:0050709 | negative regulation of protein secretion | 16839358 |
| Tgene | DRD2 | GO:1900168 | positive regulation of glial cell-derived neurotrophic factor secretion | 23373701 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-GN-A26D-06A | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000003302 | ENST00000355319 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000003302 | ENST00000346454 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000003302 | ENST00000362072 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000003302 | ENST00000544518 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000003302 | ENST00000542968 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-intron | ENST00000003302 | ENST00000538967 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-intron | ENST00000003302 | ENST00000535984 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000260188 | ENST00000355319 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000260188 | ENST00000346454 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000260188 | ENST00000362072 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000260188 | ENST00000544518 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000260188 | ENST00000542968 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-intron | ENST00000260188 | ENST00000538967 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-intron | ENST00000260188 | ENST00000535984 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| intron-5UTR | ENST00000544967 | ENST00000355319 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| intron-5UTR | ENST00000544967 | ENST00000346454 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| intron-5UTR | ENST00000544967 | ENST00000362072 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| intron-5UTR | ENST00000544967 | ENST00000544518 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| intron-5UTR | ENST00000544967 | ENST00000542968 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| intron-intron | ENST00000544967 | ENST00000538967 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| intron-intron | ENST00000544967 | ENST00000535984 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000545540 | ENST00000355319 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000545540 | ENST00000346454 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000545540 | ENST00000362072 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000545540 | ENST00000544518 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000545540 | ENST00000542968 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-intron | ENST00000545540 | ENST00000538967 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-intron | ENST00000545540 | ENST00000535984 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000537706 | ENST00000355319 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000537706 | ENST00000346454 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000537706 | ENST00000362072 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000537706 | ENST00000544518 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-5UTR | ENST00000537706 | ENST00000542968 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-intron | ENST00000537706 | ENST00000538967 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5CDS-intron | ENST00000537706 | ENST00000535984 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000542033 | ENST00000355319 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000542033 | ENST00000346454 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000542033 | ENST00000362072 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000542033 | ENST00000544518 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-5UTR | ENST00000542033 | ENST00000542968 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-intron | ENST00000542033 | ENST00000538967 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
| 5UTR-intron | ENST00000542033 | ENST00000535984 | USP28 | chr11 | 113712385 | - | DRD2 | chr11 | 113295404 | - |
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FusionProtFeatures for USP28_DRD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP28 | DRD2 |
| Deubiquitinase involved in DNA damage responsecheckpoint and MYC proto-oncogene stability. Involved in DNAdamage induced apoptosis by specifically deubiquitinating proteinsof the DNA damage pathway such as CLSPN. Also involved in G2 DNAdamage checkpoint, by deubiquitinating CLSPN, and preventing itsdegradation by the anaphase promoting complex/cyclosome (APC/C).In contrast, it does not deubiquitinate PLK1. Specificallydeubiquitinates MYC in the nucleoplasm, leading to prevent MYCdegradation by the proteasome: acts by specifically interactingwith isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm andcounteracting ubiquitination of MYC by the SCF(FBW7) complex. Incontrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma)in the nucleolus, allowing MYC degradation and explaining theselective MYC degradation in the nucleolus. DeubiquitinatesZNF304, hence preventing ZNF304 degradation by the proteasome andleading to the activated KRAS-mediated promoter hypermethylationand transcriptional silencing of tumor suppressor genes (TSGs) ina subset of colorectal cancers (CRC) cells (PubMed:24623306).{ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397,ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541,ECO:0000269|PubMed:24623306}. | Dopamine receptor whose activity is mediated by Gproteins which inhibit adenylyl cyclase.{ECO:0000269|PubMed:21645528}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP28_DRD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP28_DRD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| USP28 | SUMO2, TP53BP1, AQR, USP25, CLSPN, MDC1, ELAVL1, MYC, FBXW7, RFFL, PJA1, TRIM63, TRIM55, USP21, USP20, USP51, USP5, USP7, STAMBP, OTUB1, JOSD1, UCHL3, USP8, UCHL5, OTUB2, ATXN3L, USP33, USP15, USP28, ESPL1, SENP8, USP14, STAM, BAP1, UCHL1, UBC, USP4, ZC3H4, TWF1, USO1, ZCCHC8, CIT, PFAS, RCHY1, PLA2G2A, NSMCE2, KDM1A, MAP3K1, COMTD1, FOXK1, ZNF304, PRKD1, MRPS7, KLHL2, SPPL2B, SENP2, ST6GAL1, MTNR1A | DRD2 | CLIC6, ADORA2A, PPP1R9B, NCS1, EPB41L1, FLNA, KCNJ3, KCNJ6, KCNJ5, PAWR, CALM1, ARRB2, GNB5, EGFR, MSRA, COLEC12, WDR45, NDFIP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP28_DRD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | DRD2 | P14416 | DB00246 | Ziprasidone | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00248 | Cabergoline | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00363 | Clozapine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00370 | Mirtazapine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00408 | Loxapine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00458 | Imipramine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00502 | Haloperidol | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00540 | Nortriptyline | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00543 | Amoxapine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00623 | Fluphenazine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00696 | Ergotamine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00726 | Trimipramine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00777 | Propiomazine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00805 | Minaprine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00850 | Perphenazine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00915 | Amantadine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00988 | Dopamine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01063 | Acetophenazine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01100 | Pimozide | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01224 | Quetiapine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01235 | Levodopa | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01267 | Paliperidone | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01425 | Alizapride | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01618 | Molindone | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01622 | Thioproperazine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB01623 | Thiothixene | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB04946 | Iloperidone | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB05271 | Rotigotine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB06216 | Asenapine | D(2) dopamine receptor | small molecule | approved |
| Tgene | DRD2 | P14416 | DB00182 | Amphetamine | D(2) dopamine receptor | small molecule | approved|illicit|investigational |
| Tgene | DRD2 | P14416 | DB00268 | Ropinirole | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00334 | Olanzapine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00391 | Sulpiride | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00413 | Pramipexole | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00490 | Buspirone | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00555 | Lamotrigine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00568 | Cinnarizine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00589 | Lisuride | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00714 | Apomorphine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00734 | Risperidone | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00831 | Trifluoperazine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00933 | Mesoridazine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00934 | Maprotiline | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01043 | Memantine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01069 | Promethazine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01142 | Doxepin | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01151 | Desipramine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01200 | Bromocriptine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01233 | Metoclopramide | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01238 | Aripiprazole | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01403 | Methotrimeprazine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01621 | Pipotiazine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB01624 | Zuclopenthixol | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB04842 | Fluspirilene | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB04844 | Tetrabenazine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB06016 | Cariprazine | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB06148 | Mianserin | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB06288 | Amisulpride | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB08815 | Lurasidone | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB09018 | Bromopride | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB09097 | Quinagolide | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB09128 | Brexpiprazole | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB09224 | Melperone | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB09286 | Pipamperone | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB13025 | Tiapride | D(2) dopamine receptor | small molecule | approved|investigational |
| Tgene | DRD2 | P14416 | DB00477 | Chlorpromazine | D(2) dopamine receptor | small molecule | approved|investigational|vet_approved |
| Tgene | DRD2 | P14416 | DB01184 | Domperidone | D(2) dopamine receptor | small molecule | approved|investigational|vet_approved |
| Tgene | DRD2 | P14416 | DB01392 | Yohimbine | D(2) dopamine receptor | small molecule | approved|investigational|vet_approved |
| Tgene | DRD2 | P14416 | DB01186 | Pergolide | D(2) dopamine receptor | small molecule | approved|investigational|vet_approved|withdrawn |
| Tgene | DRD2 | P14416 | DB00875 | Flupentixol | D(2) dopamine receptor | small molecule | approved|investigational|withdrawn |
| Tgene | DRD2 | P14416 | DB01239 | Chlorprothixene | D(2) dopamine receptor | small molecule | approved|investigational|withdrawn |
| Tgene | DRD2 | P14416 | DB06144 | Sertindole | D(2) dopamine receptor | small molecule | approved|investigational|withdrawn |
| Tgene | DRD2 | P14416 | DB09225 | Zotepine | D(2) dopamine receptor | small molecule | approved|investigational|withdrawn |
| Tgene | DRD2 | P14416 | DB00420 | Promazine | D(2) dopamine receptor | small molecule | approved|vet_approved |
| Tgene | DRD2 | P14416 | DB00433 | Prochlorperazine | D(2) dopamine receptor | small molecule | approved|vet_approved |
| Tgene | DRD2 | P14416 | DB00450 | Droperidol | D(2) dopamine receptor | small molecule | approved|vet_approved |
| Tgene | DRD2 | P14416 | DB00508 | Triflupromazine | D(2) dopamine receptor | small molecule | approved|vet_approved |
| Tgene | DRD2 | P14416 | DB01221 | Ketamine | D(2) dopamine receptor | small molecule | approved|vet_approved |
| Tgene | DRD2 | P14416 | DB01614 | Acepromazine | D(2) dopamine receptor | small molecule | approved|vet_approved |
| Tgene | DRD2 | P14416 | DB00409 | Remoxipride | D(2) dopamine receptor | small molecule | approved|withdrawn |
| Tgene | DRD2 | P14416 | DB00679 | Thioridazine | D(2) dopamine receptor | small molecule | approved|withdrawn |
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RelatedDiseases for USP28_DRD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DRD2 | C0236736 | Cocaine-Related Disorders | 10 | CTD_human |
| Tgene | DRD2 | C0001973 | Alcoholic Intoxication, Chronic | 5 | PSYGENET |
| Tgene | DRD2 | C0004782 | Basal Ganglia Diseases | 5 | CTD_human |
| Tgene | DRD2 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Tgene | DRD2 | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | DRD2 | C0011581 | Depressive disorder | 5 | HPO;PSYGENET |
| Tgene | DRD2 | C0041696 | Unipolar Depression | 5 | PSYGENET |
| Tgene | DRD2 | C0085762 | Alcohol abuse | 5 | PSYGENET |
| Tgene | DRD2 | C0525045 | Mood Disorders | 5 | PSYGENET |
| Tgene | DRD2 | C0600427 | Cocaine Dependence | 5 | PSYGENET |
| Tgene | DRD2 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| Tgene | DRD2 | C0007370 | Catalepsy | 4 | CTD_human |
| Tgene | DRD2 | C0009171 | Cocaine Abuse | 4 | PSYGENET |
| Tgene | DRD2 | C0020649 | Hypotension | 4 | CTD_human |
| Tgene | DRD2 | C0036341 | Schizophrenia | 4 | CTD_human |
| Tgene | DRD2 | C0013386 | Dyskinesia, Drug-Induced | 3 | CTD_human |
| Tgene | DRD2 | C0021122 | Disruptive, Impulse Control, and Conduct Disorders | 3 | CTD_human |
| Tgene | DRD2 | C0036572 | Seizures | 3 | CTD_human |
| Tgene | DRD2 | C0236733 | Amphetamine-Related Disorders | 3 | CTD_human |
| Tgene | DRD2 | C0242422 | Parkinsonian Disorders | 3 | CTD_human |
| Tgene | DRD2 | C0003469 | Anxiety Disorders | 2 | CTD_human |
| Tgene | DRD2 | C0006870 | Cannabis Dependence | 2 | PSYGENET |
| Tgene | DRD2 | C0011206 | Delirium | 2 | PSYGENET |
| Tgene | DRD2 | C0020514 | Hyperprolactinemia | 2 | CTD_human |
| Tgene | DRD2 | C0024809 | Marijuana Abuse | 2 | PSYGENET |
| Tgene | DRD2 | C0039231 | Tachycardia | 2 | CTD_human |
| Tgene | DRD2 | C0424295 | Hyperactive behavior | 2 | CTD_human |
| Tgene | DRD2 | C0428977 | Bradycardia | 2 | CTD_human |
| Tgene | DRD2 | C0008073 | Developmental Disabilities | 1 | CTD_human |
| Tgene | DRD2 | C0009241 | Cognition Disorders | 1 | CTD_human |
| Tgene | DRD2 | C0013384 | Dyskinetic syndrome | 1 | CTD_human |
| Tgene | DRD2 | C0019337 | Heroin Dependence | 1 | CTD_human |
| Tgene | DRD2 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | DRD2 | C0023015 | Language Disorders | 1 | CTD_human |
| Tgene | DRD2 | C0024517 | Single major depressive episode | 1 | PSYGENET |
| Tgene | DRD2 | C0025261 | Memory Disorders | 1 | CTD_human |
| Tgene | DRD2 | C0026650 | Movement Disorders | 1 | CTD_human |
| Tgene | DRD2 | C0030193 | Pain | 1 | CTD_human |
| Tgene | DRD2 | C0030567 | Parkinson Disease | 1 | CTD_human |
| Tgene | DRD2 | C0032019 | Pituitary Neoplasms | 1 | CTD_human |
| Tgene | DRD2 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| Tgene | DRD2 | C0040336 | Tobacco Use Disorder | 1 | CTD_human |
| Tgene | DRD2 | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | DRD2 | C0178417 | Anhedonia | 1 | PSYGENET |
| Tgene | DRD2 | C0221480 | Recurrent depression | 1 | PSYGENET |
| Tgene | DRD2 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | DRD2 | C0588008 | Severe depression | 1 | PSYGENET |
| Tgene | DRD2 | C1263846 | Attention deficit hyperactivity disorder | 1 | CTD_human |
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