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Fusion gene ID: 40967 |
FusionGeneSummary for USP12_LNX2 |
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Fusion gene information | Fusion gene name: USP12_LNX2 | Fusion gene ID: 40967 | Hgene | Tgene | Gene symbol | USP12 | LNX2 | Gene ID | 219333 | 222484 |
Gene name | ubiquitin specific peptidase 12 | ligand of numb-protein X 2 | |
Synonyms | UBH1|USP12L1 | PDZRN1 | |
Cytomap | 13q12.13 | 13q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 12deubiquitinating enzyme 12ubiquitin specific protease 12 like 1ubiquitin thioesterase 12ubiquitin thiolesterase 12ubiquitin-hydrolyzing enzyme 1ubiquitin-specific-processing protease 12 | ligand of Numb protein X 2PDZ domain containing ring finger 1PDZ domain-containing RING finger protein 1numb-binding protein 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O75317 | Q8N448 | |
Ensembl transtripts involved in fusion gene | ENST00000282344, | ENST00000316334, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: USP12 [Title/Abstract] AND LNX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | USP12 | GO:0016579 | protein deubiquitination | 19075014|24145035 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-4357-01A | USP12 | chr13 | 27669738 | - | LNX2 | chr13 | 28134122 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000282344 | ENST00000316334 | USP12 | chr13 | 27669738 | - | LNX2 | chr13 | 28134122 | - |
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FusionProtFeatures for USP12_LNX2 |
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Hgene | Tgene |
USP12 | LNX2 |
Deubiquitinating enzyme. Has almost no deubiquitinatingactivity by itself and requires the interaction with WDR20 andWDR48 to have a high activity (PubMed:19075014, PubMed:27373336).Not involved in deubiquitination of monoubiquitinated FANCD2(PubMed:19075014). In complex with WDR48, acts as a potentialtumor suppressor by positively regulating PHLPP1 stability(PubMed:24145035). {ECO:0000269|PubMed:19075014,ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:27373336}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >LNX2 | chr13:27669738 | chr13:28134122 | ENST00000316334 | - | 4 | 10 | 468_554 | 408 | 691 | Domain | PDZ 3 |
Tgene | >LNX2 | chr13:27669738 | chr13:28134122 | ENST00000316334 | - | 4 | 10 | 600_688 | 408 | 691 | Domain | PDZ 4 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >USP12 | chr13:27669738 | chr13:28134122 | ENST00000282344 | - | 4 | 9 | 39_369 | 191 | 371 | Domain | Note=USP |
Tgene | LNX2 | chr13:27669738 | chr13:28134122 | ENST00000316334 | - | 4 | 10 | 233_318 | 408 | 691 | Domain | PDZ 1 |
Tgene | LNX2 | chr13:27669738 | chr13:28134122 | ENST00000316334 | - | 4 | 10 | 339_422 | 408 | 691 | Domain | PDZ 2 |
Tgene | LNX2 | chr13:27669738 | chr13:28134122 | ENST00000316334 | - | 4 | 10 | 208_211 | 408 | 691 | Motif | Note=NPXY motif |
Tgene | LNX2 | chr13:27669738 | chr13:28134122 | ENST00000316334 | - | 4 | 10 | 50_88 | 408 | 691 | Zinc finger | RING-type |
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FusionGeneSequence for USP12_LNX2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_USP12_ENST00000282344_chr13_27669738_-_LNX2_ENST00000316334_chr13_28134122_-_474aa MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHS IATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTL TNETRCLTCETASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGR GSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEY DASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSAL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_USP12_ENST00000282344_chr13_27669738_-_LNX2_ENST00000316334_chr13_28134122_-_1422nt ATGGAAATCCTAATGACAGTCTCCAAATTCGCCTCCATCTGTACCATGGGCGCCAATGCTTCGGCATTAGAGAAAGAGATTGGTCCAGAA CAGTTTCCGGTCAATGAGCACTATTTTGGATTAGTCAATTTTGGGAATACCTGCTACTGCAATTCAGTTCTTCAAGCACTTTATTTTTGT CGTCCATTTCGGGAAAAAGTTCTTGCGTATAAGAGTCAACCTAGGAAAAAGGAGAGCCTTCTTACATGCTTAGCAGATCTCTTCCATAGC ATAGCCACTCAGAAGAAAAAGGTTGGAGTAATACCCCCTAAGAAGTTCATCACAAGATTACGGAAAGAAAATGAGCTTTTTGACAACTAC ATGCAACAAGATGCCCATGAATTCTTAAATTACCTACTAAATACAATTGCTGATATTTTACAAGAAGAGAGAAAGCAGGAAAAACAAAAT GGTCGTTTACCTAATGGTAATATTGATAATGAAAATAATAACAGCACACCAGACCCAACGTGGGTTCATGAGATTTTTCAGGGAACATTA ACTAATGAAACCAGATGTCTTACTTGTGAAACTGCCAGTGGAGAGAGAGTGAATTTAACAATTGCTAGACCAGGGAAACCCCAGCCTGGT AACACCATTAGAGAAGCAGGAAATCATAGCAGCAGCAGCCAGCACCACACACCACCACCGTATTATAGCAGACCAAGCTCACATAAGGAT CTTACTCAGTGTGTTACATGCCAAGAAAAACACATTACTGTAAAGAAGGAACCACATGAATCCCTTGGCATGACCGTTGCTGGGGGCAGG GGAAGTAAGAGTGGTGAGCTGCCCATCTTTGTGACCAGTGTGCCACCCCATGGCTGCCTTGCACGAGATGGCAGAATAAAGAGAGGTGAT GTGTTGCTAAATATCAACGGCATTGATTTGACCAATTTAAGTCACAGTGAGGCAGTTGCAATGCTGAAAGCCAGTGCCGCGTCCCCTGCT GTTGCCCTTAAAGCACTTGAGGTCCAGATTGTTGAGGAGGCGACTCAGAACGCGGAGGAGCAGCCGAGTACTTTCAGCGAAAATGAGTAT GATGCCAGTTGGTCCCCATCATGGGTCATGTGGCTTGGGCTTCCCAGCACACTTCATAGCTGCCACGATATAGTTTTACGAAGAAGTTAC TTGGGAAGTTGGGGCTTTAGTATCGTTGGTGGATATGAAGAGAACCACACCAATCAGCCTTTTTTCATTAAAACTATTGTCTTGGGAACT CCTGCTTATTATGATGGAAGATTAAAGTGTGGTGACATGATTGTGGCCGTAAATGGGCTGTCAACCGTGGGCATGAGCCACTCTGCACTA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_USP12_ENST00000282344_chr13_27669738_-_LNX2_ENST00000316334_chr13_28134122_-_4101nt CGGAGGCAGCGGCTGCGCCCTGCGCCGGGGCGGAGCCGGGGGCGGGCCGGCGGCCGGCAGGCGGGGGCTGGGGCCCGAGGCCGGGAGTGC CTGAGCGCCGGCGGCGACGACGGCAGCGGCGGCCCAGCGGGCTCGGTGGTTGGGTCCGCGGCGGCTCGGGGTCCGCCCGCGGGCTGCGGT GCGAGCGGGCGGCCCGGCTCCCCTCCTCCCCCGCCCGCCGCCGCCGCTGTGATTGGGTGGAAGATGGCGCTGGCCGGATGGAAATCCTAA TGACAGTCTCCAAATTCGCCTCCATCTGTACCATGGGCGCCAATGCTTCGGCATTAGAGAAAGAGATTGGTCCAGAACAGTTTCCGGTCA ATGAGCACTATTTTGGATTAGTCAATTTTGGGAATACCTGCTACTGCAATTCAGTTCTTCAAGCACTTTATTTTTGTCGTCCATTTCGGG AAAAAGTTCTTGCGTATAAGAGTCAACCTAGGAAAAAGGAGAGCCTTCTTACATGCTTAGCAGATCTCTTCCATAGCATAGCCACTCAGA AGAAAAAGGTTGGAGTAATACCCCCTAAGAAGTTCATCACAAGATTACGGAAAGAAAATGAGCTTTTTGACAACTACATGCAACAAGATG CCCATGAATTCTTAAATTACCTACTAAATACAATTGCTGATATTTTACAAGAAGAGAGAAAGCAGGAAAAACAAAATGGTCGTTTACCTA ATGGTAATATTGATAATGAAAATAATAACAGCACACCAGACCCAACGTGGGTTCATGAGATTTTTCAGGGAACATTAACTAATGAAACCA GATGTCTTACTTGTGAAACTGCCAGTGGAGAGAGAGTGAATTTAACAATTGCTAGACCAGGGAAACCCCAGCCTGGTAACACCATTAGAG AAGCAGGAAATCATAGCAGCAGCAGCCAGCACCACACACCACCACCGTATTATAGCAGACCAAGCTCACATAAGGATCTTACTCAGTGTG TTACATGCCAAGAAAAACACATTACTGTAAAGAAGGAACCACATGAATCCCTTGGCATGACCGTTGCTGGGGGCAGGGGAAGTAAGAGTG GTGAGCTGCCCATCTTTGTGACCAGTGTGCCACCCCATGGCTGCCTTGCACGAGATGGCAGAATAAAGAGAGGTGATGTGTTGCTAAATA TCAACGGCATTGATTTGACCAATTTAAGTCACAGTGAGGCAGTTGCAATGCTGAAAGCCAGTGCCGCGTCCCCTGCTGTTGCCCTTAAAG CACTTGAGGTCCAGATTGTTGAGGAGGCGACTCAGAACGCGGAGGAGCAGCCGAGTACTTTCAGCGAAAATGAGTATGATGCCAGTTGGT CCCCATCATGGGTCATGTGGCTTGGGCTTCCCAGCACACTTCATAGCTGCCACGATATAGTTTTACGAAGAAGTTACTTGGGAAGTTGGG GCTTTAGTATCGTTGGTGGATATGAAGAGAACCACACCAATCAGCCTTTTTTCATTAAAACTATTGTCTTGGGAACTCCTGCTTATTATG ATGGAAGATTAAAGTGTGGTGACATGATTGTGGCCGTAAATGGGCTGTCAACCGTGGGCATGAGCCACTCTGCACTAGTTCCCATGTTGA AGGAGCAGAGGAACAAAGTCACTCTGACCGTTATTTGTTGGCCTGGCAGCCTTGTATAGATTTTGGAAATTGGTTTCAAATCTTGCATCT TCCTTTTTTAGATTTTTGAAAGAAAACCCTTTGGTTTCATTGTGTTTGTGGTTTAGGAGCTGCTGACACTGCTGGTATACACAGGGCCAA AACCCACTAAGATTGTCCGTTTATGTTTATTTAAATGGTTTCCTAAGTTAGTTACATTTCTTTTAGCTTGGAAACAGTCTTCCACTAACC TTTGTGAGTTTATATTTTCAGAATTCAGACTTAGTTGTTAAAATGTTACCTATGGTAATGAGCAAAGCTCACCCAAACTGTGCCCCAGAT GGAGTAAAGACCTTCTGGTGGGTCTTTGTTTTCAGTAACTGAATCATAGAACGAGTTCTGTATCCCTCAGGCCTGATGTCAGCAAAGCCA GTAACAACAGCGTGTACTGCCACTGTCATAACCAATACCATGAATGAATATACTTTAAATTTTGGTGATAACTGTTCCCCATTTTTTTTT GAACCACAGTCTCACTCTCACCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTC CCACCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGTGTGCCACCATGCCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCAC CGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCG CACCCGGCCGTTCCCATTTTTTATTGGTGCCAACATTTCAAAACTTCATACTGTTTATAAACTGATTTTCTGGTTTATTTCTACTGTAAT CTCTCAATATTCATAGAAGATGAAGAAATAAGTCTGACAACACTAAAGAAATTTCTTAATATACTATTATTAGAATAGTAGAGGATAAAA GATAATGTTATCCAGTTACAAAGGAATTTGGATGATAATTATAACTTAATGTTAGAGATGGTAAAGCTGCACTTACTTGAACAGCCCAAA AGCATTAAAAATCTATTTCCAGAGGAATGTTTTGCTATGTAGGGAAATTTTGAAGTAGTTTTTGCTAAAAAATTATTTCTAGAGTTGTGT TATTCTTAGCAGTAATCTTGGCTAGAAATGTTTTTGTGATTTATGCGATTAAACGAAATGATAAAGATAAAACCATATTATTAAATACCT ATATATCACAGCTAAGTAGGAGAAAGGGAGACCTTTTTATTTTGTTCAGGTAGGAGTATTTCTTGTGTATTTTAGAAACAATTATTTTTC CCATTATTTCTTATGAGATTAGTTGTTTCAAGTAGGAGACAGAAAAGTTCTGTTTTGTTGGAAATGTAGGTTTTAGATGTATCTTTCAGT CAGCTCTCAGTCACTAGACTATTTCATATTTTTTGAAATGTTTTTGAAAATTATGACTAGCCCATTTTTTGTCCTTTATTCAACATACTT ATCCTCTGAACACATAAATAAGTGAATAAGATAAAAATATCTTTACCTTATTAATATTATACATACTTGAAAAAAATTTCATTTAGAAAC CTAGTTCAGAATCTGAGCAAATTTACAAGTGACCTCTGTAATAAATGGTATTGATAATCAGAGAATGTATTTCAGAATACTACAGTACAA TATATTATGAAGCATGACCACTTTATTTTGAAACTTAGCAATTGTATTGCTGGGGTTTATTGTATCTGTAGCATGTCACTGATTATTTCA GTTAGTTTTATAATGATTTTTAAAAAACATATCTATTTGGAATAAGATACAGCAACAATCATTGCTACTGACTTGTTCAACCCCTTAGTT ACACTGTATGATCAACATATAACAAGATACAGTGGAATGGCCCATACAGTATATTACTGTTGTGTGATGATTGGCTTTGGAAGCAGTTTG ATTTTGAAATGCTTTGATATTCTAATTGACATGGAACAAGTTTTTTCCCTGCTCCCCAAATAGAATTTTGTAACCAACTTTGCTATTTTT TTAAAGTTTGTAAGAATGTGTCATTTCTTGGGGAGTAGCCATCCATCAACAAATATCCTGACTGCTACTTTGTTATATACAAAATACTTA CATTGAACCTGGTGGCATAATGAGTATTTTGAAAGAAGAAATTTCTTCACTCTCATTTTTATAGAAATCTTGGAATCAGCTTAAGCTGTA GCTTTTATGACAAAAGACAGTCATTTTTGGTCAGAGTGATATTTGGTGACGGAAACTTGTTCATAATTTATTGTTACTATAGAACTATTT GGATTTTCTCATTTTTAGTTCTGATAGTTAAATATTTTGGTTTGTTCTGTGCCTTCAGTTTAAATTATTTCAGGATTTTTCAGATGTTTA |
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FusionGenePPI for USP12_LNX2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
USP12 | DHX8, DMWD, MMP2, PAIP1, RAD51AP1, USP39, PHLPP2, PHLPP1, NUP160, SDF4, UCHL5, WDR48, WDR20, USP46, HIST2H2AC, WDR26, WDR77, HIST2H2BE, ITCH, APP, AR, UBC, NOTCH1, VSX2, CBLB, ZAP70, LAT, GRB2, TRAT1, TSPYL6, GORASP1, RNF19B, GPR161, VSX1, HSPB9 | LNX2 | UBE2Z, UBE2I, UBE2T, CD8A, PRKCA, PLEKHG5, LNX1, CXADR, PKDREJ, PDZRN3, PDZRN4, MDGA1, CBX4, SHISA2, USP2, RLIM, RNF138, LATS2, IGSF5, LNX2, NXF1, NUMB, OPTN, TUBB, PEG10, MSRB3, MYLIP, IL16, ATP5B, NMD3, IP6K2, SCLY, PTCD3, MAPK9, MAP2K5, TRAF2, VTN, DDA1, C10orf88, LRRC8E, RBM17, PHYKPL, PIK3R3, SRSF11, UBE2D2, TRIM25, NOTCH1, SMARCB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP12_LNX2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP12_LNX2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |