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Fusion gene ID: 40958 |
FusionGeneSummary for USP10_USP10 |
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Fusion gene information | Fusion gene name: USP10_USP10 | Fusion gene ID: 40958 | Hgene | Tgene | Gene symbol | USP10 | USP10 | Gene ID | 84669 | 84669 |
Gene name | ubiquitin specific peptidase 32 | ubiquitin specific peptidase 32 | |
Synonyms | NY-REN-60|USP10 | NY-REN-60|USP10 | |
Cytomap | 17q23.1-q23.2 | 17q23.1-q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q14694 | Q14694 | |
Ensembl transtripts involved in fusion gene | ENST00000219473, ENST00000570191, ENST00000562743, | ENST00000219473, ENST00000570191, ENST00000562743, | |
Fusion gene scores | * DoF score | 9 X 6 X 5=270 | 6 X 5 X 5=150 |
# samples | 10 | 6 | |
** MAII score | log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: USP10 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE091809 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000219473 | ENST00000219473 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
In-frame | ENST00000219473 | ENST00000570191 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
5CDS-intron | ENST00000219473 | ENST00000562743 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
In-frame | ENST00000570191 | ENST00000219473 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
In-frame | ENST00000570191 | ENST00000570191 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
5CDS-intron | ENST00000570191 | ENST00000562743 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
intron-3CDS | ENST00000562743 | ENST00000219473 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
intron-3CDS | ENST00000562743 | ENST00000570191 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
intron-intron | ENST00000562743 | ENST00000562743 | USP10 | chr16 | 84779098 | + | USP10 | chr16 | 84779062 | - |
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FusionProtFeatures for USP10_USP10 |
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Hgene | Tgene |
USP10 | USP10 |
Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}. | Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >USP10 | chr16:84779098 | chr16:84779062 | ENST00000219473 | + | 1 | 14 | 415_795 | -38 | 799 | Domain | Note=USP |
Hgene | >USP10 | chr16:84779098 | chr16:84779062 | ENST00000570191 | + | 1 | 15 | 415_795 | -66 | 803 | Domain | Note=USP |
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FusionGeneSequence for USP10_USP10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP10_USP10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | USP10 | chr16:84779098 | chr16:84779062 | ENST00000219473 | + | 1 | 14 | 2_100 | -38 | 799 | p53/TP53 |
Hgene | USP10 | chr16:84779098 | chr16:84779062 | ENST00000570191 | + | 1 | 15 | 2_100 | -66 | 803 | p53/TP53 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP10_USP10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP10_USP10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |