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Fusion gene ID: 40956 |
FusionGeneSummary for USP10_NUP93 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP10_NUP93 | Fusion gene ID: 40956 | Hgene | Tgene | Gene symbol | USP10 | NUP93 | Gene ID | 84669 | 9688 |
| Gene name | ubiquitin specific peptidase 32 | nucleoporin 93 | |
| Synonyms | NY-REN-60|USP10 | NIC96 | |
| Cytomap | 17q23.1-q23.2 | 16q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | nuclear pore complex protein Nup9393 kDa nucleoporinnucleoporin 93kDanucleoporin Nup93 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14694 | Q8N1F7 | |
| Ensembl transtripts involved in fusion gene | ENST00000219473, ENST00000570191, ENST00000562743, | ENST00000308159, ENST00000569842, ENST00000564887, ENST00000569595, ENST00000542526, | |
| Fusion gene scores | * DoF score | 9 X 6 X 5=270 | 8 X 8 X 5=320 |
| # samples | 10 | 7 | |
| ** MAII score | log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/320*10)=-2.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP10 [Title/Abstract] AND NUP93 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NUP93 | GO:0006998 | nuclear envelope organization | 26878725 |
| Tgene | NUP93 | GO:0051292 | nuclear pore complex assembly | 26878725 |
| Tgene | NUP93 | GO:0060391 | positive regulation of SMAD protein signal transduction | 26878725 |
| Tgene | NUP93 | GO:0060395 | SMAD protein signal transduction | 26878725 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CN307206 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000219473 | ENST00000308159 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| In-frame | ENST00000219473 | ENST00000569842 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 5CDS-5UTR | ENST00000219473 | ENST00000564887 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 5CDS-3UTR | ENST00000219473 | ENST00000569595 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 5CDS-5UTR | ENST00000219473 | ENST00000542526 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 5UTR-3CDS | ENST00000570191 | ENST00000308159 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 5UTR-3CDS | ENST00000570191 | ENST00000569842 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 5UTR-5UTR | ENST00000570191 | ENST00000564887 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 5UTR-3UTR | ENST00000570191 | ENST00000569595 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 5UTR-5UTR | ENST00000570191 | ENST00000542526 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 3UTR-3CDS | ENST00000562743 | ENST00000308159 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 3UTR-3CDS | ENST00000562743 | ENST00000569842 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 3UTR-5UTR | ENST00000562743 | ENST00000564887 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 3UTR-3UTR | ENST00000562743 | ENST00000569595 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
| 3UTR-5UTR | ENST00000562743 | ENST00000542526 | USP10 | chr16 | 84733718 | + | NUP93 | chr16 | 56832386 | + |
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FusionProtFeatures for USP10_NUP93 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP10 | NUP93 |
| Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}. | Plays a role in the nuclear pore complex (NPC) assemblyand/or maintenance (PubMed:9348540). May anchor nucleoporins, butnot NUP153 and TPR, to the NPC. During renal development,regulates podocyte migration and proliferation through SMAD4signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283,ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725,ECO:0000269|PubMed:9348540}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >USP10 | chr16:84733718 | chr16:56832386 | ENST00000219473 | + | 1 | 14 | 415_795 | 7 | 799 | Domain | Note=USP |
| Hgene | >USP10 | chr16:84733718 | chr16:56832386 | ENST00000570191 | + | 1 | 15 | 415_795 | -30 | 803 | Domain | Note=USP |
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FusionGeneSequence for USP10_NUP93 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_USP10_ENST00000219473_chr16_84733718_+_NUP93_ENST00000308159_chr16_56832386_+_728aa MALHSPQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQESEPSYISDVGPPGRSSLDNIE MAYARQIYIYNEKIVNGHLQPNLVDLCASVAELDDKSISDMWTMVKQMTDVLLTPATDALKNRSSVEVRMEFVRQALAYLEQSYKNYTLV TVFGNLHQAQLGGVPGTYQLVRSFLNIKLPAPLPGLQDGEVEGHPVWALIYYCMRCGDLLAASQVVNRAQHQLGEFKTWFQEYMNSKDRR LSPATENKLRLHYRRALRNNTDPYKRAVYCIIGRCDVTDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESH FTVNQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFEST DPREALQYFYFLRDEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEEAAKLYDLA KNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPL NQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSSSRPQRVIEDRDSQLRSQARTLITFAGMIPYRTSGDTNARLV >In-frame_USP10_ENST00000219473_chr16_84733718_+_NUP93_ENST00000569842_chr16_56832386_+_789aa MALHSPQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQESEPSYISDVGPPGRSSLDNIE MAYARQIYIYNEKIVNGHLQPNLVDLCASVAELDDKSISDMWTMVKQMTDVLLTPATDALKNRSSVEVRMEFVRQALAYLEQSYKNYTLV TVFGNLHQAQLGGVPGTYQLVRSFLNIKLPAPLPGLQDGEVEGHPVWALIYYCMRCGDLLAASQVVNRAQHQLGEFKTWFQEYMNSKDRR LSPATENKLRLHYRRALRNNTDPYKRAVYCIIGRCDVTDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESH FTVNQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFEST DPREALQYFYFLRDEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEEAAKLYDLA KNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPL NQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSSSRPQRVIEDRDSGLALLPRLECNDTISAHCNLYLLGSSHPP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_USP10_ENST00000219473_chr16_84733718_+_NUP93_ENST00000308159_chr16_56832386_+_2184nt ATGGCCCTCCACAGCCCGCAGGGCTTCCTGAAGAATGAGAAGGACAATGCCCTGCTGTCTGCCATCGAAGAGTCCCGGAAGAGGACCTTC GGCATGGCTGAGGAGTACCATCGGGAGTCAATGTTGGTTGAGTGGGAGCAAGTGAAACAGCGAATTCTGCACACACTGCTGGCATCAGGA GAAGACGCCCTTGACTTTACTCAAGAAAGCGAGCCAAGCTACATCAGTGATGTGGGACCCCCTGGTCGAAGCTCTCTGGATAACATCGAG ATGGCCTATGCGCGGCAAATTTATATCTATAATGAGAAAATTGTAAATGGACACCTGCAGCCTAACCTGGTGGACCTTTGTGCTTCCGTC GCAGAGCTCGATGATAAGAGCATTTCCGACATGTGGACCATGGTAAAACAAATGACAGACGTGTTGTTGACACCGGCAACGGATGCCCTG AAGAACCGCAGCAGCGTGGAAGTGCGCATGGAGTTTGTCAGGCAGGCCTTGGCGTACCTTGAGCAGAGTTATAAGAATTACACCCTTGTG ACTGTCTTTGGAAATTTGCATCAGGCCCAGCTGGGCGGGGTGCCTGGGACTTACCAATTGGTTCGAAGTTTCCTGAACATTAAACTGCCA GCTCCCTTGCCTGGACTACAGGATGGAGAGGTGGAAGGCCATCCTGTGTGGGCGCTAATTTACTACTGCATGCGCTGTGGAGACCTGCTT GCCGCTTCACAGGTAGTTAATCGAGCCCAGCACCAGCTGGGAGAGTTTAAAACCTGGTTCCAGGAGTACATGAACAGCAAGGACAGAAGA TTGTCCCCAGCTACGGAAAACAAGCTCCGGCTGCATTACCGTAGGGCCCTCAGGAACAATACAGATCCCTACAAGCGGGCCGTGTACTGT ATCATTGGCAGATGTGACGTCACCGACAACCAGAGTGAAGTGGCGGACAAAACTGAGGATTACCTGTGGCTGAAGTTGAACCAAGTGTGT TTTGACGACGATGGCACCAGCTCCCCACAAGACAGGCTCACTCTCTCACAGTTCCAGAAGCAGTTGTTGGAAGACTATGGCGAGTCCCAC TTTACGGTGAACCAGCAACCCTTCCTCTACTTCCAAGTCCTGTTCCTGACAGCGCAGTTTGAAGCAGCAGTTGCCTTTCTTTTCCGCATG GAGCGGCTGCGCTGCCATGCTGTCCATGTAGCACTGGTGCTGTTTGAGCTGAAGCTGCTTTTAAAGTCCTCTGGACAGAGTGCTCAGCTC CTCAGCCACGAGCCTGGTGACCCTCCTTGCTTGCGGCGGCTGAACTTCGTGCGGCTCCTCATGCTGTACACCCGGAAGTTTGAGTCCACG GACCCAAGGGAGGCCCTCCAGTACTTCTATTTCCTCAGGGATGAGAAAGATAGTCAAGGAGAAAACATGTTTCTGCGCTGTGTGAGTGAG CTTGTGATTGAAAGCCGAGAGTTCGATATGATTCTTGGGAAACTAGAGAATGACGGAAGTAGAAAGCCTGGAGTCATAGATAAGTTTACT AGTGACACAAAGCCTATTATCAACAAAGTTGCTTCTGTGGCAGAAAATAAAGGACTGTTTGAAGAGGCAGCAAAGCTGTATGACCTTGCC AAGAATGCTGACAAGGTACTGGAGCTGATGAACAAACTGCTGAGCCCTGTCGTCCCCCAGATCAGTGCCCCGCAATCCAACAAGGAGAGG CTGAAGAACATGGCACTCTCCATTGCCGAACGGTATAGGGCTCAAGGAATAAGCGCAAATAAATTTGTGGACTCCACGTTCTATCTTCTT TTGGACTTGATCACCTTTTTTGACGAGTATCATAGTGGTCATATTGATAGAGCTTTTGATATCATTGAGCGCTTGAAGCTGGTGCCCCTG AATCAGGAAAGTGTGGAAGAGAGAGTGGCTGCCTTCAGAAATTTCAGTGATGAAATCAGGCACAACCTCTCAGAAGTGCTTCTTGCCACC ATGAACATCTTGTTCACACAGTTTAAGAGGCTCAAGGGGACAAGTCCATCCTCGTCATCCAGGCCCCAGCGAGTCATCGAGGACCGCGAC TCTCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACCATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTG >In-frame_USP10_ENST00000219473_chr16_84733718_+_NUP93_ENST00000569842_chr16_56832386_+_2367nt ATGGCCCTCCACAGCCCGCAGGGCTTCCTGAAGAATGAGAAGGACAATGCCCTGCTGTCTGCCATCGAAGAGTCCCGGAAGAGGACCTTC GGCATGGCTGAGGAGTACCATCGGGAGTCAATGTTGGTTGAGTGGGAGCAAGTGAAACAGCGAATTCTGCACACACTGCTGGCATCAGGA GAAGACGCCCTTGACTTTACTCAAGAAAGCGAGCCAAGCTACATCAGTGATGTGGGACCCCCTGGTCGAAGCTCTCTGGATAACATCGAG ATGGCCTATGCGCGGCAAATTTATATCTATAATGAGAAAATTGTAAATGGACACCTGCAGCCTAACCTGGTGGACCTTTGTGCTTCCGTC GCAGAGCTCGATGATAAGAGCATTTCCGACATGTGGACCATGGTAAAACAAATGACAGACGTGTTGTTGACACCGGCAACGGATGCCCTG AAGAACCGCAGCAGCGTGGAAGTGCGCATGGAGTTTGTCAGGCAGGCCTTGGCGTACCTTGAGCAGAGTTATAAGAATTACACCCTTGTG ACTGTCTTTGGAAATTTGCATCAGGCCCAGCTGGGCGGGGTGCCTGGGACTTACCAATTGGTTCGAAGTTTCCTGAACATTAAACTGCCA GCTCCCTTGCCTGGACTACAGGATGGAGAGGTGGAAGGCCATCCTGTGTGGGCGCTAATTTACTACTGCATGCGCTGTGGAGACCTGCTT GCCGCTTCACAGGTAGTTAATCGAGCCCAGCACCAGCTGGGAGAGTTTAAAACCTGGTTCCAGGAGTACATGAACAGCAAGGACAGAAGA TTGTCCCCAGCTACGGAAAACAAGCTCCGGCTGCATTACCGTAGGGCCCTCAGGAACAATACAGATCCCTACAAGCGGGCCGTGTACTGT ATCATTGGCAGATGTGACGTCACCGACAACCAGAGTGAAGTGGCGGACAAAACTGAGGATTACCTGTGGCTGAAGTTGAACCAAGTGTGT TTTGACGACGATGGCACCAGCTCCCCACAAGACAGGCTCACTCTCTCACAGTTCCAGAAGCAGTTGTTGGAAGACTATGGCGAGTCCCAC TTTACGGTGAACCAGCAACCCTTCCTCTACTTCCAAGTCCTGTTCCTGACAGCGCAGTTTGAAGCAGCAGTTGCCTTTCTTTTCCGCATG GAGCGGCTGCGCTGCCATGCTGTCCATGTAGCACTGGTGCTGTTTGAGCTGAAGCTGCTTTTAAAGTCCTCTGGACAGAGTGCTCAGCTC CTCAGCCACGAGCCTGGTGACCCTCCTTGCTTGCGGCGGCTGAACTTCGTGCGGCTCCTCATGCTGTACACCCGGAAGTTTGAGTCCACG GACCCAAGGGAGGCCCTCCAGTACTTCTATTTCCTCAGGGATGAGAAAGATAGTCAAGGAGAAAACATGTTTCTGCGCTGTGTGAGTGAG CTTGTGATTGAAAGCCGAGAGTTCGATATGATTCTTGGGAAACTAGAGAATGACGGAAGTAGAAAGCCTGGAGTCATAGATAAGTTTACT AGTGACACAAAGCCTATTATCAACAAAGTTGCTTCTGTGGCAGAAAATAAAGGACTGTTTGAAGAGGCAGCAAAGCTGTATGACCTTGCC AAGAATGCTGACAAGGTACTGGAGCTGATGAACAAACTGCTGAGCCCTGTCGTCCCCCAGATCAGTGCCCCGCAATCCAACAAGGAGAGG CTGAAGAACATGGCACTCTCCATTGCCGAACGGTATAGGGCTCAAGGAATAAGCGCAAATAAATTTGTGGACTCCACGTTCTATCTTCTT TTGGACTTGATCACCTTTTTTGACGAGTATCATAGTGGTCATATTGATAGAGCTTTTGATATCATTGAGCGCTTGAAGCTGGTGCCCCTG AATCAGGAAAGTGTGGAAGAGAGAGTGGCTGCCTTCAGAAATTTCAGTGATGAAATCAGGCACAACCTCTCAGAAGTGCTTCTTGCCACC ATGAACATCTTGTTCACACAGTTTAAGAGGCTCAAGGGGACAAGTCCATCCTCGTCATCCAGGCCCCAGCGAGTCATCGAGGACCGCGAC TCTGGCCTGGCTCTGTTGCCCAGGCTGGAATGCAATGACACGATCTCAGCTCACTGCAACCTCTACCTCTTGGGCTCAAGCCACCCTCCC ACCTCACCCTCCCAAGTAGCTGGGACTACAGCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACCATACCGAAC GTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGGCACACTGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_USP10_ENST00000219473_chr16_84733718_+_NUP93_ENST00000308159_chr16_56832386_+_2457nt GCGCAGGCGCGGCGGCCGATGCGAGTGTGTATGTGCGGGCGAGAAGATGGCGGCGGCGGGGGAAGCAGCGTGAGCAGCCGGAGGATCGCG GAGTCCCAATGAAACGGGCAGCCATGGCCCTCCACAGCCCGCAGGGCTTCCTGAAGAATGAGAAGGACAATGCCCTGCTGTCTGCCATCG AAGAGTCCCGGAAGAGGACCTTCGGCATGGCTGAGGAGTACCATCGGGAGTCAATGTTGGTTGAGTGGGAGCAAGTGAAACAGCGAATTC TGCACACACTGCTGGCATCAGGAGAAGACGCCCTTGACTTTACTCAAGAAAGCGAGCCAAGCTACATCAGTGATGTGGGACCCCCTGGTC GAAGCTCTCTGGATAACATCGAGATGGCCTATGCGCGGCAAATTTATATCTATAATGAGAAAATTGTAAATGGACACCTGCAGCCTAACC TGGTGGACCTTTGTGCTTCCGTCGCAGAGCTCGATGATAAGAGCATTTCCGACATGTGGACCATGGTAAAACAAATGACAGACGTGTTGT TGACACCGGCAACGGATGCCCTGAAGAACCGCAGCAGCGTGGAAGTGCGCATGGAGTTTGTCAGGCAGGCCTTGGCGTACCTTGAGCAGA GTTATAAGAATTACACCCTTGTGACTGTCTTTGGAAATTTGCATCAGGCCCAGCTGGGCGGGGTGCCTGGGACTTACCAATTGGTTCGAA GTTTCCTGAACATTAAACTGCCAGCTCCCTTGCCTGGACTACAGGATGGAGAGGTGGAAGGCCATCCTGTGTGGGCGCTAATTTACTACT GCATGCGCTGTGGAGACCTGCTTGCCGCTTCACAGGTAGTTAATCGAGCCCAGCACCAGCTGGGAGAGTTTAAAACCTGGTTCCAGGAGT ACATGAACAGCAAGGACAGAAGATTGTCCCCAGCTACGGAAAACAAGCTCCGGCTGCATTACCGTAGGGCCCTCAGGAACAATACAGATC CCTACAAGCGGGCCGTGTACTGTATCATTGGCAGATGTGACGTCACCGACAACCAGAGTGAAGTGGCGGACAAAACTGAGGATTACCTGT GGCTGAAGTTGAACCAAGTGTGTTTTGACGACGATGGCACCAGCTCCCCACAAGACAGGCTCACTCTCTCACAGTTCCAGAAGCAGTTGT TGGAAGACTATGGCGAGTCCCACTTTACGGTGAACCAGCAACCCTTCCTCTACTTCCAAGTCCTGTTCCTGACAGCGCAGTTTGAAGCAG CAGTTGCCTTTCTTTTCCGCATGGAGCGGCTGCGCTGCCATGCTGTCCATGTAGCACTGGTGCTGTTTGAGCTGAAGCTGCTTTTAAAGT CCTCTGGACAGAGTGCTCAGCTCCTCAGCCACGAGCCTGGTGACCCTCCTTGCTTGCGGCGGCTGAACTTCGTGCGGCTCCTCATGCTGT ACACCCGGAAGTTTGAGTCCACGGACCCAAGGGAGGCCCTCCAGTACTTCTATTTCCTCAGGGATGAGAAAGATAGTCAAGGAGAAAACA TGTTTCTGCGCTGTGTGAGTGAGCTTGTGATTGAAAGCCGAGAGTTCGATATGATTCTTGGGAAACTAGAGAATGACGGAAGTAGAAAGC CTGGAGTCATAGATAAGTTTACTAGTGACACAAAGCCTATTATCAACAAAGTTGCTTCTGTGGCAGAAAATAAAGGACTGTTTGAAGAGG CAGCAAAGCTGTATGACCTTGCCAAGAATGCTGACAAGGTACTGGAGCTGATGAACAAACTGCTGAGCCCTGTCGTCCCCCAGATCAGTG CCCCGCAATCCAACAAGGAGAGGCTGAAGAACATGGCACTCTCCATTGCCGAACGGTATAGGGCTCAAGGAATAAGCGCAAATAAATTTG TGGACTCCACGTTCTATCTTCTTTTGGACTTGATCACCTTTTTTGACGAGTATCATAGTGGTCATATTGATAGAGCTTTTGATATCATTG AGCGCTTGAAGCTGGTGCCCCTGAATCAGGAAAGTGTGGAAGAGAGAGTGGCTGCCTTCAGAAATTTCAGTGATGAAATCAGGCACAACC TCTCAGAAGTGCTTCTTGCCACCATGAACATCTTGTTCACACAGTTTAAGAGGCTCAAGGGGACAAGTCCATCCTCGTCATCCAGGCCCC AGCGAGTCATCGAGGACCGCGACTCTCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACCATACCGAACGTCTG GGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGGCACACTGTCAGTAC ATCAGGCACATGGGCCCACTAGGCTGGGGTTTCTGGTTTTGTTTCTGTTGTGTTTTGTTTTGGTTTCTGTATTATGTATTTTTGTCAACG >In-frame_USP10_ENST00000219473_chr16_84733718_+_NUP93_ENST00000569842_chr16_56832386_+_2575nt GCGCAGGCGCGGCGGCCGATGCGAGTGTGTATGTGCGGGCGAGAAGATGGCGGCGGCGGGGGAAGCAGCGTGAGCAGCCGGAGGATCGCG GAGTCCCAATGAAACGGGCAGCCATGGCCCTCCACAGCCCGCAGGGCTTCCTGAAGAATGAGAAGGACAATGCCCTGCTGTCTGCCATCG AAGAGTCCCGGAAGAGGACCTTCGGCATGGCTGAGGAGTACCATCGGGAGTCAATGTTGGTTGAGTGGGAGCAAGTGAAACAGCGAATTC TGCACACACTGCTGGCATCAGGAGAAGACGCCCTTGACTTTACTCAAGAAAGCGAGCCAAGCTACATCAGTGATGTGGGACCCCCTGGTC GAAGCTCTCTGGATAACATCGAGATGGCCTATGCGCGGCAAATTTATATCTATAATGAGAAAATTGTAAATGGACACCTGCAGCCTAACC TGGTGGACCTTTGTGCTTCCGTCGCAGAGCTCGATGATAAGAGCATTTCCGACATGTGGACCATGGTAAAACAAATGACAGACGTGTTGT TGACACCGGCAACGGATGCCCTGAAGAACCGCAGCAGCGTGGAAGTGCGCATGGAGTTTGTCAGGCAGGCCTTGGCGTACCTTGAGCAGA GTTATAAGAATTACACCCTTGTGACTGTCTTTGGAAATTTGCATCAGGCCCAGCTGGGCGGGGTGCCTGGGACTTACCAATTGGTTCGAA GTTTCCTGAACATTAAACTGCCAGCTCCCTTGCCTGGACTACAGGATGGAGAGGTGGAAGGCCATCCTGTGTGGGCGCTAATTTACTACT GCATGCGCTGTGGAGACCTGCTTGCCGCTTCACAGGTAGTTAATCGAGCCCAGCACCAGCTGGGAGAGTTTAAAACCTGGTTCCAGGAGT ACATGAACAGCAAGGACAGAAGATTGTCCCCAGCTACGGAAAACAAGCTCCGGCTGCATTACCGTAGGGCCCTCAGGAACAATACAGATC CCTACAAGCGGGCCGTGTACTGTATCATTGGCAGATGTGACGTCACCGACAACCAGAGTGAAGTGGCGGACAAAACTGAGGATTACCTGT GGCTGAAGTTGAACCAAGTGTGTTTTGACGACGATGGCACCAGCTCCCCACAAGACAGGCTCACTCTCTCACAGTTCCAGAAGCAGTTGT TGGAAGACTATGGCGAGTCCCACTTTACGGTGAACCAGCAACCCTTCCTCTACTTCCAAGTCCTGTTCCTGACAGCGCAGTTTGAAGCAG CAGTTGCCTTTCTTTTCCGCATGGAGCGGCTGCGCTGCCATGCTGTCCATGTAGCACTGGTGCTGTTTGAGCTGAAGCTGCTTTTAAAGT CCTCTGGACAGAGTGCTCAGCTCCTCAGCCACGAGCCTGGTGACCCTCCTTGCTTGCGGCGGCTGAACTTCGTGCGGCTCCTCATGCTGT ACACCCGGAAGTTTGAGTCCACGGACCCAAGGGAGGCCCTCCAGTACTTCTATTTCCTCAGGGATGAGAAAGATAGTCAAGGAGAAAACA TGTTTCTGCGCTGTGTGAGTGAGCTTGTGATTGAAAGCCGAGAGTTCGATATGATTCTTGGGAAACTAGAGAATGACGGAAGTAGAAAGC CTGGAGTCATAGATAAGTTTACTAGTGACACAAAGCCTATTATCAACAAAGTTGCTTCTGTGGCAGAAAATAAAGGACTGTTTGAAGAGG CAGCAAAGCTGTATGACCTTGCCAAGAATGCTGACAAGGTACTGGAGCTGATGAACAAACTGCTGAGCCCTGTCGTCCCCCAGATCAGTG CCCCGCAATCCAACAAGGAGAGGCTGAAGAACATGGCACTCTCCATTGCCGAACGGTATAGGGCTCAAGGAATAAGCGCAAATAAATTTG TGGACTCCACGTTCTATCTTCTTTTGGACTTGATCACCTTTTTTGACGAGTATCATAGTGGTCATATTGATAGAGCTTTTGATATCATTG AGCGCTTGAAGCTGGTGCCCCTGAATCAGGAAAGTGTGGAAGAGAGAGTGGCTGCCTTCAGAAATTTCAGTGATGAAATCAGGCACAACC TCTCAGAAGTGCTTCTTGCCACCATGAACATCTTGTTCACACAGTTTAAGAGGCTCAAGGGGACAAGTCCATCCTCGTCATCCAGGCCCC AGCGAGTCATCGAGGACCGCGACTCTGGCCTGGCTCTGTTGCCCAGGCTGGAATGCAATGACACGATCTCAGCTCACTGCAACCTCTACC TCTTGGGCTCAAGCCACCCTCCCACCTCACCCTCCCAAGTAGCTGGGACTACAGCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTT GCTGGAATGATACCATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTG GGAGTCTGGGTCGGCACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTTTCTGGTTTTGTTTCTGTTGTGTTTTGTTTTG |
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FusionGenePPI for USP10_NUP93 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| USP10 | G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6 | NUP93 | PHLDA3, GIPC1, CASP4, PNKP, NEK6, TSC22D1, PHB2, BRF2, MYC, TPR, PAN2, RAE1, AIRE, CLN3, RYK, HDAC5, PIDD1, ELAVL1, SIRT7, CUL3, NXF1, TLN2, ECT2, VCAM1, ITGA4, AICDA, SOX2, HDAC9, HDAC11, ADRB2, BAG3, NUP62, EGFR, FBXO6, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, KCMF1, FGG, MTPN, NUP205, NUP188, UBA1, UBA6, UCHL3, NTRK1, SCARNA22, KRAS, IFI16, NUP35, KPNB1, UBE2I, XRCC3, NUPL1, NUP153, NUP107, SEH1L, CDC5L, SENP3, RNF126, OTUB1, BMI1, CTDSPL2, DLST, PDHA1, SOD1, BRCA1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | USP10 | chr16:84733718 | chr16:56832386 | ENST00000219473 | + | 1 | 14 | 2_100 | 7 | 799 | p53/TP53 |
| Hgene | USP10 | chr16:84733718 | chr16:56832386 | ENST00000570191 | + | 1 | 15 | 2_100 | -30 | 803 | p53/TP53 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP10_NUP93 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP10_NUP93 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NUP93 | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | CTD_human |
| Tgene | NUP93 | C4225166 | NEPHROTIC SYNDROME, TYPE 12 | 1 | UNIPROT |
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