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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40952

FusionGeneSummary for USP10_CDH13

check button Fusion gene summary
Fusion gene informationFusion gene name: USP10_CDH13
Fusion gene ID: 40952
HgeneTgene
Gene symbol

USP10

CDH13

Gene ID

84669

1012

Gene nameubiquitin specific peptidase 32cadherin 13
SynonymsNY-REN-60|USP10CDHH|P105
Cytomap

17q23.1-q23.2

16q23.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32cadherin-13H-cadherin (heart)T-cadT-cadherincadherin 13, H-cadherin (heart)heart cadherin
Modification date2018052320180523
UniProtAcc

Q14694

P55290

Ensembl transtripts involved in fusion geneENST00000219473, ENST00000570191, 
ENST00000562743, 
ENST00000566620, 
ENST00000268613, ENST00000565636, 
ENST00000431540, ENST00000428848, 
ENST00000567445, ENST00000446376, 
ENST00000569454, 
Fusion gene scores* DoF score9 X 6 X 5=2705 X 5 X 5=125
# samples 108
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/125*10)=-0.643856189774725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP10 [Title/Abstract] AND CDH13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDH13

GO:0002040

sprouting angiogenesis

16873731

TgeneCDH13

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

10601632

TgeneCDH13

GO:0007162

negative regulation of cell adhesion

14729458

TgeneCDH13

GO:0008285

negative regulation of cell proliferation

10737605

TgeneCDH13

GO:0016339

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

10601632

TgeneCDH13

GO:0030032

lamellipodium assembly

15703273

TgeneCDH13

GO:0030335

positive regulation of cell migration

14729458

TgeneCDH13

GO:0043542

endothelial cell migration

14729458

TgeneCDH13

GO:0043616

keratinocyte proliferation

15816843

TgeneCDH13

GO:0050850

positive regulation of calcium-mediated signaling

16013438

TgeneCDH13

GO:0050927

positive regulation of positive chemotaxis

16013438

TgeneCDH13

GO:0055096

low-density lipoprotein particle mediated signaling

16013438


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-A56U-01AUSP10chr16

84767109

+CDH13chr16

83781713

+
TCGARVSTADTCGA-CG-4449-01AUSP10chr16

84733717

+CDH13chr16

83781713

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000219473ENST00000566620USP10chr16

84767109

+CDH13chr16

83781713

+
Frame-shitENST00000219473ENST00000268613USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000565636USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000431540USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000428848USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000567445USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000446376USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000569454USP10chr16

84767109

+CDH13chr16

83781713

+
Frame-shitENST00000570191ENST00000566620USP10chr16

84767109

+CDH13chr16

83781713

+
Frame-shitENST00000570191ENST00000268613USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000570191ENST00000565636USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000570191ENST00000431540USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000570191ENST00000428848USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000570191ENST00000567445USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000570191ENST00000446376USP10chr16

84767109

+CDH13chr16

83781713

+
5CDS-intronENST00000570191ENST00000569454USP10chr16

84767109

+CDH13chr16

83781713

+
3UTR-3CDSENST00000562743ENST00000566620USP10chr16

84767109

+CDH13chr16

83781713

+
3UTR-3CDSENST00000562743ENST00000268613USP10chr16

84767109

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000565636USP10chr16

84767109

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000431540USP10chr16

84767109

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000428848USP10chr16

84767109

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000567445USP10chr16

84767109

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000446376USP10chr16

84767109

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000569454USP10chr16

84767109

+CDH13chr16

83781713

+
Frame-shitENST00000219473ENST00000566620USP10chr16

84733717

+CDH13chr16

83781713

+
Frame-shitENST00000219473ENST00000268613USP10chr16

84733717

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000565636USP10chr16

84733717

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000431540USP10chr16

84733717

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000428848USP10chr16

84733717

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000567445USP10chr16

84733717

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000446376USP10chr16

84733717

+CDH13chr16

83781713

+
5CDS-intronENST00000219473ENST00000569454USP10chr16

84733717

+CDH13chr16

83781713

+
5UTR-3CDSENST00000570191ENST00000566620USP10chr16

84733717

+CDH13chr16

83781713

+
5UTR-3CDSENST00000570191ENST00000268613USP10chr16

84733717

+CDH13chr16

83781713

+
5UTR-intronENST00000570191ENST00000565636USP10chr16

84733717

+CDH13chr16

83781713

+
5UTR-intronENST00000570191ENST00000431540USP10chr16

84733717

+CDH13chr16

83781713

+
5UTR-intronENST00000570191ENST00000428848USP10chr16

84733717

+CDH13chr16

83781713

+
5UTR-intronENST00000570191ENST00000567445USP10chr16

84733717

+CDH13chr16

83781713

+
5UTR-intronENST00000570191ENST00000446376USP10chr16

84733717

+CDH13chr16

83781713

+
5UTR-intronENST00000570191ENST00000569454USP10chr16

84733717

+CDH13chr16

83781713

+
3UTR-3CDSENST00000562743ENST00000566620USP10chr16

84733717

+CDH13chr16

83781713

+
3UTR-3CDSENST00000562743ENST00000268613USP10chr16

84733717

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000565636USP10chr16

84733717

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000431540USP10chr16

84733717

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000428848USP10chr16

84733717

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000567445USP10chr16

84733717

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000446376USP10chr16

84733717

+CDH13chr16

83781713

+
3UTR-intronENST00000562743ENST00000569454USP10chr16

84733717

+CDH13chr16

83781713

+

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FusionProtFeatures for USP10_CDH13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP10

Q14694

CDH13

P55290

Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}. Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. May act as a negativeregulator of neural cell growth. {ECO:0000269|PubMed:10737605}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP10_CDH13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP10_CDH13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP10G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6CDH13MAPK6, HAX1, NUFIP1, DGUOK, DNAAF2, AURKA, CASP8, CCND1, CHEK2, HMMR, PTPN1, RAD51, SEC14L1, AGPAT5, INSIG1, DSTYK, RRAGB, ERMP1, VMP1, UQCC1, TUBB3, CHPT1, TUBB8, GHITM, ARF5, PIGU, TMX4, RPL23, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP10_CDH13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP10_CDH13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCDH13C0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneCDH13C0033578Prostatic Neoplasms2CTD_human
TgeneCDH13C2239176Liver carcinoma2CTD_human
TgeneCDH13C0004763Barrett Esophagus1CTD_human
TgeneCDH13C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneCDH13C0011570Mental Depression1PSYGENET
TgeneCDH13C0011581Depressive disorder1PSYGENET
TgeneCDH13C0014859Esophageal Neoplasms1CTD_human
TgeneCDH13C0024121Lung Neoplasms1CTD_human
TgeneCDH13C0236733Amphetamine-Related Disorders1CTD_human
TgeneCDH13C0236969Substance-Related Disorders1CTD_human