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Fusion gene ID: 40952 |
FusionGeneSummary for USP10_CDH13 |
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Fusion gene information | Fusion gene name: USP10_CDH13 | Fusion gene ID: 40952 | Hgene | Tgene | Gene symbol | USP10 | CDH13 | Gene ID | 84669 | 1012 |
Gene name | ubiquitin specific peptidase 32 | cadherin 13 | |
Synonyms | NY-REN-60|USP10 | CDHH|P105 | |
Cytomap | 17q23.1-q23.2 | 16q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | cadherin-13H-cadherin (heart)T-cadT-cadherincadherin 13, H-cadherin (heart)heart cadherin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q14694 | P55290 | |
Ensembl transtripts involved in fusion gene | ENST00000219473, ENST00000570191, ENST00000562743, | ENST00000566620, ENST00000268613, ENST00000565636, ENST00000431540, ENST00000428848, ENST00000567445, ENST00000446376, ENST00000569454, | |
Fusion gene scores | * DoF score | 9 X 6 X 5=270 | 5 X 5 X 5=125 |
# samples | 10 | 8 | |
** MAII score | log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/125*10)=-0.643856189774725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: USP10 [Title/Abstract] AND CDH13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CDH13 | GO:0002040 | sprouting angiogenesis | 16873731 |
Tgene | CDH13 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 10601632 |
Tgene | CDH13 | GO:0007162 | negative regulation of cell adhesion | 14729458 |
Tgene | CDH13 | GO:0008285 | negative regulation of cell proliferation | 10737605 |
Tgene | CDH13 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 10601632 |
Tgene | CDH13 | GO:0030032 | lamellipodium assembly | 15703273 |
Tgene | CDH13 | GO:0030335 | positive regulation of cell migration | 14729458 |
Tgene | CDH13 | GO:0043542 | endothelial cell migration | 14729458 |
Tgene | CDH13 | GO:0043616 | keratinocyte proliferation | 15816843 |
Tgene | CDH13 | GO:0050850 | positive regulation of calcium-mediated signaling | 16013438 |
Tgene | CDH13 | GO:0050927 | positive regulation of positive chemotaxis | 16013438 |
Tgene | CDH13 | GO:0055096 | low-density lipoprotein particle mediated signaling | 16013438 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-43-A56U-01A | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
TCGA | RV | STAD | TCGA-CG-4449-01A | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000219473 | ENST00000566620 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
Frame-shift | ENST00000219473 | ENST00000268613 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000565636 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000431540 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000428848 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000567445 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000446376 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000569454 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
Frame-shift | ENST00000570191 | ENST00000566620 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
Frame-shift | ENST00000570191 | ENST00000268613 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000570191 | ENST00000565636 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000570191 | ENST00000431540 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000570191 | ENST00000428848 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000570191 | ENST00000567445 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000570191 | ENST00000446376 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000570191 | ENST00000569454 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
3UTR-3CDS | ENST00000562743 | ENST00000566620 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
3UTR-3CDS | ENST00000562743 | ENST00000268613 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000565636 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000431540 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000428848 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000567445 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000446376 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000569454 | USP10 | chr16 | 84767109 | + | CDH13 | chr16 | 83781713 | + |
Frame-shift | ENST00000219473 | ENST00000566620 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
Frame-shift | ENST00000219473 | ENST00000268613 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000565636 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000431540 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000428848 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000567445 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000446376 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5CDS-intron | ENST00000219473 | ENST00000569454 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5UTR-3CDS | ENST00000570191 | ENST00000566620 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5UTR-3CDS | ENST00000570191 | ENST00000268613 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5UTR-intron | ENST00000570191 | ENST00000565636 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5UTR-intron | ENST00000570191 | ENST00000431540 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5UTR-intron | ENST00000570191 | ENST00000428848 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5UTR-intron | ENST00000570191 | ENST00000567445 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5UTR-intron | ENST00000570191 | ENST00000446376 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
5UTR-intron | ENST00000570191 | ENST00000569454 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
3UTR-3CDS | ENST00000562743 | ENST00000566620 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
3UTR-3CDS | ENST00000562743 | ENST00000268613 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000565636 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000431540 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000428848 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000567445 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000446376 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
3UTR-intron | ENST00000562743 | ENST00000569454 | USP10 | chr16 | 84733717 | + | CDH13 | chr16 | 83781713 | + |
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FusionProtFeatures for USP10_CDH13 |
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Hgene | Tgene |
USP10 | CDH13 |
Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}. | Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. May act as a negativeregulator of neural cell growth. {ECO:0000269|PubMed:10737605}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP10_CDH13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP10_CDH13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
USP10 | G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6 | CDH13 | MAPK6, HAX1, NUFIP1, DGUOK, DNAAF2, AURKA, CASP8, CCND1, CHEK2, HMMR, PTPN1, RAD51, SEC14L1, AGPAT5, INSIG1, DSTYK, RRAGB, ERMP1, VMP1, UQCC1, TUBB3, CHPT1, TUBB8, GHITM, ARF5, PIGU, TMX4, RPL23, MTNR1B |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP10_CDH13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP10_CDH13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CDH13 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
Tgene | CDH13 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Tgene | CDH13 | C2239176 | Liver carcinoma | 2 | CTD_human |
Tgene | CDH13 | C0004763 | Barrett Esophagus | 1 | CTD_human |
Tgene | CDH13 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | CDH13 | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | CDH13 | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | CDH13 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | CDH13 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | CDH13 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Tgene | CDH13 | C0236969 | Substance-Related Disorders | 1 | CTD_human |