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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40950

FusionGeneSummary for USO1_SECISBP2L

check button Fusion gene summary
Fusion gene informationFusion gene name: USO1_SECISBP2L
Fusion gene ID: 40950
HgeneTgene
Gene symbol

USO1

SECISBP2L

Gene ID

8615

9728

Gene nameUSO1 vesicle transport factorSECIS binding protein 2 like
SynonymsP115|TAP|VDPSBP2L|SLAN
Cytomap

4q21.1

15q21.1

Type of geneprotein-codingprotein-coding
Descriptiongeneral vesicular transport factor p115USO1 vesicle docking protein homologtranscytosis associated proteinvesicle docking protein p115selenocysteine insertion sequence-binding protein 2-like
Modification date2018052320180523
UniProtAcc

O60763

Q93073

Ensembl transtripts involved in fusion geneENST00000538159, ENST00000514213, 
ENST00000559471, ENST00000261847, 
ENST00000559122, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: USO1 [Title/Abstract] AND SECISBP2L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1H20018USO1chr4

76735304

-SECISBP2Lchr15

49308802

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000538159ENST00000559471USO1chr4

76735304

-SECISBP2Lchr15

49308802

+
intron-3CDSENST00000538159ENST00000261847USO1chr4

76735304

-SECISBP2Lchr15

49308802

+
intron-intronENST00000538159ENST00000559122USO1chr4

76735304

-SECISBP2Lchr15

49308802

+
intron-3CDSENST00000514213ENST00000559471USO1chr4

76735304

-SECISBP2Lchr15

49308802

+
intron-3CDSENST00000514213ENST00000261847USO1chr4

76735304

-SECISBP2Lchr15

49308802

+
intron-intronENST00000514213ENST00000559122USO1chr4

76735304

-SECISBP2Lchr15

49308802

+

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FusionProtFeatures for USO1_SECISBP2L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USO1

O60763

SECISBP2L

Q93073

General vesicular transport factor required forintercisternal transport in the Golgi stack; it is required fortranscytotic fusion and/or subsequent binding of the vesicles tothe target membrane. May well act as a vesicular anchor byinteracting with the target membrane and holding the vesicular andtarget membranes in proximity. {ECO:0000250|UniProtKB:P41542}. Binds SECIS (Sec insertion sequence) elements present onselenocysteine (Sec) protein mRNAs, but does not promote Secincorporation into selenoproteins in vitro.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USO1_SECISBP2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USO1_SECISBP2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USO1_SECISBP2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USO1_SECISBP2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSO1C0033578Prostatic Neoplasms1CTD_human
HgeneUSO1C0037274Dermatologic disorders1CTD_human
HgeneUSO1C0311375Arsenic Poisoning1CTD_human