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Fusion gene ID: 40950 |
FusionGeneSummary for USO1_SECISBP2L |
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Fusion gene information | Fusion gene name: USO1_SECISBP2L | Fusion gene ID: 40950 | Hgene | Tgene | Gene symbol | USO1 | SECISBP2L | Gene ID | 8615 | 9728 |
Gene name | USO1 vesicle transport factor | SECIS binding protein 2 like | |
Synonyms | P115|TAP|VDP | SBP2L|SLAN | |
Cytomap | 4q21.1 | 15q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | general vesicular transport factor p115USO1 vesicle docking protein homologtranscytosis associated proteinvesicle docking protein p115 | selenocysteine insertion sequence-binding protein 2-like | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60763 | Q93073 | |
Ensembl transtripts involved in fusion gene | ENST00000538159, ENST00000514213, | ENST00000559471, ENST00000261847, ENST00000559122, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: USO1 [Title/Abstract] AND SECISBP2L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | H20018 | USO1 | chr4 | 76735304 | - | SECISBP2L | chr15 | 49308802 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000538159 | ENST00000559471 | USO1 | chr4 | 76735304 | - | SECISBP2L | chr15 | 49308802 | + |
intron-3CDS | ENST00000538159 | ENST00000261847 | USO1 | chr4 | 76735304 | - | SECISBP2L | chr15 | 49308802 | + |
intron-intron | ENST00000538159 | ENST00000559122 | USO1 | chr4 | 76735304 | - | SECISBP2L | chr15 | 49308802 | + |
intron-3CDS | ENST00000514213 | ENST00000559471 | USO1 | chr4 | 76735304 | - | SECISBP2L | chr15 | 49308802 | + |
intron-3CDS | ENST00000514213 | ENST00000261847 | USO1 | chr4 | 76735304 | - | SECISBP2L | chr15 | 49308802 | + |
intron-intron | ENST00000514213 | ENST00000559122 | USO1 | chr4 | 76735304 | - | SECISBP2L | chr15 | 49308802 | + |
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FusionProtFeatures for USO1_SECISBP2L |
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Hgene | Tgene |
USO1 | SECISBP2L |
General vesicular transport factor required forintercisternal transport in the Golgi stack; it is required fortranscytotic fusion and/or subsequent binding of the vesicles tothe target membrane. May well act as a vesicular anchor byinteracting with the target membrane and holding the vesicular andtarget membranes in proximity. {ECO:0000250|UniProtKB:P41542}. | Binds SECIS (Sec insertion sequence) elements present onselenocysteine (Sec) protein mRNAs, but does not promote Secincorporation into selenoproteins in vitro. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USO1_SECISBP2L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USO1_SECISBP2L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USO1_SECISBP2L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USO1_SECISBP2L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | USO1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | USO1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | USO1 | C0311375 | Arsenic Poisoning | 1 | CTD_human |