	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 40941

FusionGeneSummary for USF2_ZNF30

Fusion gene summary

Fusion gene information	Fusion gene name: USF2_ZNF30
	Fusion gene ID: 40941
		Hgene	Tgene
	Gene symbol	USF2	ZNF30
	Gene ID	7392	90075
	Gene name	upstream transcription factor 2, c-fos interacting	zinc finger protein 30
	Synonyms	FIP\|bHLHb12	KOX28
	Cytomap	19q13.12	19q13.11
	Type of gene	protein-coding	protein-coding
	Description	upstream stimulatory factor 2c-fos interacting proteinclass B basic helix-loop-helix protein 12major late transcription factor 2	zinc finger protein 30zinc finger protein 30 (KOX 28)zinc finger protein KOX28
	Modification date	20180522	20180522
	UniProtAcc	Q15853	P17039
	Ensembl transtripts involved in fusion gene	ENST00000343550, ENST00000222305, ENST00000595068, ENST00000379134, ENST00000594064, ENST00000600341,	ENST00000303586, ENST00000439785, ENST00000601957, ENST00000601142, ENST00000426813, ENST00000595818,
Fusion gene scores	* DoF score	3 X 4 X 3=36	1 X 1 X 1=1
	# samples	3	1
	** MAII score	log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: USF2 [Title/Abstract] AND ZNF30 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	ESCA	TCGA-L5-A8NI-01A	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
TCGA	LD	ESCA	TCGA-L5-A8NI-01A	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000343550	ENST00000303586	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000343550	ENST00000439785	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000343550	ENST00000601957	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000343550	ENST00000601142	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-5UTR	ENST00000343550	ENST00000426813	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000343550	ENST00000595818	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000303586	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000439785	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000601957	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000601142	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-5UTR	ENST00000222305	ENST00000426813	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000595818	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000303586	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000439785	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000601957	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000601142	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-5UTR	ENST00000595068	ENST00000426813	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000595818	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000379134	ENST00000303586	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000379134	ENST00000439785	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000379134	ENST00000601957	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000379134	ENST00000601142	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-5UTR	ENST00000379134	ENST00000426813	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000379134	ENST00000595818	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000303586	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000439785	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000601957	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000601142	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-5UTR	ENST00000594064	ENST00000426813	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000595818	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000303586	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000439785	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000601957	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000601142	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
intron-5UTR	ENST00000600341	ENST00000426813	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000595818	USF2	chr19	35760602	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000343550	ENST00000303586	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000343550	ENST00000439785	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000343550	ENST00000601957	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000343550	ENST00000601142	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-5UTR	ENST00000343550	ENST00000426813	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000343550	ENST00000595818	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000303586	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000439785	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000601957	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000601142	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-5UTR	ENST00000222305	ENST00000426813	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000222305	ENST00000595818	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000303586	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000439785	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000601957	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000601142	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-5UTR	ENST00000595068	ENST00000426813	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000595068	ENST00000595818	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000379134	ENST00000303586	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000379134	ENST00000439785	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000379134	ENST00000601957	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000379134	ENST00000601142	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-5UTR	ENST00000379134	ENST00000426813	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000379134	ENST00000595818	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000303586	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000439785	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000601957	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000601142	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-5UTR	ENST00000594064	ENST00000426813	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
5CDS-intron	ENST00000594064	ENST00000595818	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000303586	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000439785	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000601957	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000601142	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-5UTR	ENST00000600341	ENST00000426813	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+
intron-intron	ENST00000600341	ENST00000595818	USF2	chr19	35760906	+	ZNF30	chr19	35433498	+

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FusionProtFeatures for USF2_ZNF30

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
USF2 Q15853	ZNF30 P17039
	May be involved in transcriptional regulation.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for USF2_ZNF30

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USF2_ZNF30

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
USF2	USF2, USF1, BIRC5, SERPINB3, S100A9, SERPINB4, HSPA4L, PTP4A2, S100A8, NPM1, FUS, BRCA1, EP300, MAF, RELA, TFAP4, FOS, TEAD2, LZTS2, ADAMTS12, PSG1, PPARGC1A, FOXJ2, CCDC102B, FOSL2	ZNF30	CLK2, TRIM28

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for USF2_ZNF30

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for USF2_ZNF30

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 40941

FusionGeneSummary for USF2_ZNF30

FusionProtFeatures for USF2_ZNF30

FusionGeneSequence for USF2_ZNF30

FusionGenePPI for USF2_ZNF30

RelatedDrugs for USF2_ZNF30

RelatedDiseases for USF2_ZNF30