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Fusion gene ID: 4094 |
FusionGeneSummary for BCR_PPIL2 |
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Fusion gene information | Fusion gene name: BCR_PPIL2 | Fusion gene ID: 4094 | Hgene | Tgene | Gene symbol | BCR | PPIL2 | Gene ID | 613 | 23759 |
Gene name | BCR, RhoGEF and GTPase activating protein | peptidylprolyl isomerase like 2 | |
Synonyms | ALL|BCR1|CML|D22S11|D22S662|PHL | CYC4|CYP60|Cyp-60|UBOX7|hCyP-60 | |
Cytomap | 22q11.23 | 22q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | breakpoint cluster region proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26 | peptidyl-prolyl cis-trans isomerase-like 2PPIaseRING-type E3 ubiquitin transferase isomerase-like 2U-box domain containing 7cyclophilin, 60kDacyclophilin-60cyclophilin-like protein CyP-60peptidylprolyl cis-trans isomerasepeptidylprolyl isomerase ( | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P11274 | Q13356 | |
Ensembl transtripts involved in fusion gene | ENST00000305877, ENST00000359540, ENST00000398512, ENST00000436990, | ENST00000412327, ENST00000335025, ENST00000492445, ENST00000398831, ENST00000406385, ENST00000456792, ENST00000446951, | |
Fusion gene scores | * DoF score | 17 X 39 X 8=5304 | 4 X 4 X 3=48 |
# samples | 70 | 4 | |
** MAII score | log2(70/5304*10)=-2.92165394828026 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BCR [Title/Abstract] AND PPIL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPIL2 | GO:0000209 | protein polyubiquitination | 11435423 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-FD-A43N-01A | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000305877 | ENST00000412327 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000305877 | ENST00000335025 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000305877 | ENST00000492445 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000305877 | ENST00000398831 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000305877 | ENST00000406385 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000305877 | ENST00000456792 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
5CDS-3UTR | ENST00000305877 | ENST00000446951 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000359540 | ENST00000412327 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000359540 | ENST00000335025 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000359540 | ENST00000492445 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000359540 | ENST00000398831 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000359540 | ENST00000406385 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
Frame-shift | ENST00000359540 | ENST00000456792 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
5CDS-3UTR | ENST00000359540 | ENST00000446951 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000398512 | ENST00000412327 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000398512 | ENST00000335025 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000398512 | ENST00000492445 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000398512 | ENST00000398831 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000398512 | ENST00000406385 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000398512 | ENST00000456792 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3UTR | ENST00000398512 | ENST00000446951 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000436990 | ENST00000412327 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000436990 | ENST00000335025 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000436990 | ENST00000492445 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000436990 | ENST00000398831 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000436990 | ENST00000406385 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3CDS | ENST00000436990 | ENST00000456792 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
intron-3UTR | ENST00000436990 | ENST00000446951 | BCR | chr22 | 23615961 | + | PPIL2 | chr22 | 22048105 | + |
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FusionProtFeatures for BCR_PPIL2 |
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Hgene | Tgene |
BCR | PPIL2 |
GTPase-activating protein for RAC1 and CDC42. Promotesthe exchange of RAC or CDC42-bound GDP by GTP, thereby activatingthem. Displays serine/threonine kinase activity.{ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:1903516}. | Has a ubiquitin-protein ligase activity acting as an E3ubiquitin protein ligase or as an ubiquitin-ubiquitin ligasepromoting elongation of ubiquitin chains on substrates. Bymediating 'Lys-48'-linked polyubiquitination of proteins couldtarget them for proteasomal degradation (PubMed:11435423). Mayalso function as a chaperone, playing a role in transport to thecell membrane of BSG/Basigin for instance (PubMed:15946952).Probable inactive PPIase with no peptidyl-prolyl cis-transisomerase activity (PubMed:20676357).{ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:15946952,ECO:0000269|PubMed:20676357}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BCR_PPIL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BCR_PPIL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BCR | MLLT4, HCK, PTPN6, FES, RB1, ERCC3, GRB2, ABL1, GAB2, HOXA9, CRKL, KIT, PIK3CG, IGSF21, TP53, UNC119, SOS1, PXN, RAC1, CDC42, RHOA, IL3, WDR48, TSG101, VPS28, INPP5D, MYC, HSP90AA1, HSPA8, HIF1A, CRK, GABRR1, CBL, LNX1, LRRK1, GRK5, UBASH3B, PIK3R2, SHC1, AP2M1, CFTR, ERBB2IP, DOK1, PTGES3, HSPA4, HSPD1, UBC, CSNK2A2, STUB1, CCDC183, RSPH9, SEC13, NTRK1, CEP128, NINL, XPO1, PIK3R1, PDZK1, COMMD1, TULP3, JPH4, NAGK, USP15, SPAG9, MCM2, MCM4, WEE1, CSNK1A1, MCM6, TRIM25, RAD51 | PPIL2 | CALM1, HSP90AA1, PPIL2, BSG, APP, PRCC, ZNF830, TRIM23, FGL1, FKBP6, MAPK14, NTRK1, HIST1H2BG, PDGFRA, BAIAP2, PIM2, KLC2, VPS26B, KLC3, KANSL2, NAGK |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BCR_PPIL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | BCR | P11274 | DB06616 | Bosutinib | Breakpoint cluster region protein | small molecule | approved |
Hgene | BCR | P11274 | DB01254 | Dasatinib | Breakpoint cluster region protein | small molecule | approved|investigational |
Hgene | BCR | P11274 | DB08901 | Ponatinib | Breakpoint cluster region protein | small molecule | approved|investigational |
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RelatedDiseases for BCR_PPIL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BCR | C0005586 | Bipolar Disorder | 4 | PSYGENET |
Hgene | BCR | C0023473 | Myeloid Leukemia, Chronic | 3 | CTD_human;HPO;ORPHANET |
Hgene | BCR | C0005699 | Blast Phase | 1 | CTD_human |
Hgene | BCR | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | BCR | C0027022 | Myeloproliferative disease | 1 | CTD_human;HPO |
Hgene | BCR | C0027540 | Necrosis | 1 | CTD_human |
Hgene | BCR | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | BCR | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | BCR | C1269683 | Major Depressive Disorder | 1 | PSYGENET |