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Fusion gene ID: 40895 |
FusionGeneSummary for UQCRH_WASF1 |
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Fusion gene information | Fusion gene name: UQCRH_WASF1 | Fusion gene ID: 40895 | Hgene | Tgene | Gene symbol | UQCRH | WASF1 | Gene ID | 7388 | 8936 |
Gene name | ubiquinol-cytochrome c reductase hinge protein | WAS protein family member 1 | |
Synonyms | QCR6|UQCR8 | SCAR1|WAVE|WAVE1 | |
Cytomap | 1p33 | 6q21 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome b-c1 complex subunit 6, mitochondrialcomplex III subunit 6cytochrome c1 non-heme 11 kDa proteinmitochondrial hinge proteinubiquinol-cytochrome c reductase complex 11 kDa proteinubiquinol-cytochrome c reductase, complex III subunit VIII | wiskott-Aldrich syndrome protein family member 1WASP family protein member 1homology of dictyostelium scar 1protein WAVE-1verprolin homology domain-containing protein 1 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P07919 | Q92558 | |
Ensembl transtripts involved in fusion gene | ENST00000311672, ENST00000486951, | ENST00000392587, ENST00000392586, ENST00000392588, ENST00000392589, ENST00000359451, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 8 X 7 X 3=168 |
# samples | 5 | 8 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UQCRH [Title/Abstract] AND WASF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA168843 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000311672 | ENST00000392587 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
5CDS-5UTR | ENST00000311672 | ENST00000392586 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
5CDS-5UTR | ENST00000311672 | ENST00000392588 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
5CDS-5UTR | ENST00000311672 | ENST00000392589 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
5CDS-5UTR | ENST00000311672 | ENST00000359451 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
intron-intron | ENST00000486951 | ENST00000392587 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
intron-5UTR | ENST00000486951 | ENST00000392586 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
intron-5UTR | ENST00000486951 | ENST00000392588 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
intron-5UTR | ENST00000486951 | ENST00000392589 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
intron-5UTR | ENST00000486951 | ENST00000359451 | UQCRH | chr1 | 46775925 | + | WASF1 | chr6 | 110501082 | - |
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FusionProtFeatures for UQCRH_WASF1 |
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Hgene | Tgene |
UQCRH | WASF1 |
This is a component of the ubiquinol-cytochrome creductase complex (complex III or cytochrome b-c1 complex), whichis part of the mitochondrial respiratory chain. This protein maymediate formation of the complex between cytochromes c and c1. | Downstream effector molecule involved in thetransmission of signals from tyrosine kinase receptors and smallGTPases to the actin cytoskeleton. Promotes formation of actinfilaments. Part of the WAVE complex that regulates lamellipodiaformation. The WAVE complex regulates actin filamentreorganization via its interaction with the Arp2/3 complex (Bysimilarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (Bysimilarity). {ECO:0000250|UniProtKB:Q8R5H6,ECO:0000269|PubMed:9889097}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UQCRH_WASF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UQCRH_WASF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UQCRH_WASF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UQCRH_WASF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |