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Fusion gene ID: 40892 |
FusionGeneSummary for UQCRH_PIK3R3 |
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Fusion gene information | Fusion gene name: UQCRH_PIK3R3 | Fusion gene ID: 40892 | Hgene | Tgene | Gene symbol | UQCRH | PIK3R3 | Gene ID | 7388 | 8503 |
Gene name | ubiquinol-cytochrome c reductase hinge protein | phosphoinositide-3-kinase regulatory subunit 3 | |
Synonyms | QCR6|UQCR8 | p55|p55-GAMMA|p55PIK | |
Cytomap | 1p33 | 1p34.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome b-c1 complex subunit 6, mitochondrialcomplex III subunit 6cytochrome c1 non-heme 11 kDa proteinmitochondrial hinge proteinubiquinol-cytochrome c reductase complex 11 kDa proteinubiquinol-cytochrome c reductase, complex III subunit VIII | phosphatidylinositol 3-kinase regulatory subunit gammaPI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammaphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase, regulatory s | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P07919 | Q92569 | |
Ensembl transtripts involved in fusion gene | ENST00000311672, ENST00000486951, | ENST00000262741, ENST00000372006, ENST00000340332, ENST00000420542, ENST00000354242, ENST00000540385, ENST00000423209, ENST00000488808, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 4 X 3 X 4=48 |
# samples | 5 | 4 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UQCRH [Title/Abstract] AND PIK3R3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE515277 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000311672 | ENST00000262741 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
5CDS-intron | ENST00000311672 | ENST00000372006 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
5CDS-intron | ENST00000311672 | ENST00000340332 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
5CDS-intron | ENST00000311672 | ENST00000420542 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
5CDS-intron | ENST00000311672 | ENST00000354242 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
5CDS-intron | ENST00000311672 | ENST00000540385 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
5CDS-intron | ENST00000311672 | ENST00000423209 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
5CDS-intron | ENST00000311672 | ENST00000488808 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
intron-intron | ENST00000486951 | ENST00000262741 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
intron-intron | ENST00000486951 | ENST00000372006 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
intron-intron | ENST00000486951 | ENST00000340332 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
intron-intron | ENST00000486951 | ENST00000420542 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
intron-intron | ENST00000486951 | ENST00000354242 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
intron-intron | ENST00000486951 | ENST00000540385 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
intron-intron | ENST00000486951 | ENST00000423209 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
intron-intron | ENST00000486951 | ENST00000488808 | UQCRH | chr1 | 46775989 | + | PIK3R3 | chr1 | 46519492 | + |
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FusionProtFeatures for UQCRH_PIK3R3 |
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Hgene | Tgene |
UQCRH | PIK3R3 |
This is a component of the ubiquinol-cytochrome creductase complex (complex III or cytochrome b-c1 complex), whichis part of the mitochondrial respiratory chain. This protein maymediate formation of the complex between cytochromes c and c1. | Binds to activated (phosphorylated) protein-tyrosinekinases through its SH2 domain and regulates their kinaseactivity. During insulin stimulation, it also binds to IRS-1. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UQCRH_PIK3R3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UQCRH_PIK3R3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UQCRH_PIK3R3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PIK3R3 | Q92569 | DB01064 | Isoprenaline | Phosphatidylinositol 3-kinase regulatory subunit gamma | small molecule | approved|investigational |
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RelatedDiseases for UQCRH_PIK3R3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |