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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40892

FusionGeneSummary for UQCRH_PIK3R3

check button Fusion gene summary
Fusion gene informationFusion gene name: UQCRH_PIK3R3
Fusion gene ID: 40892
HgeneTgene
Gene symbol

UQCRH

PIK3R3

Gene ID

7388

8503

Gene nameubiquinol-cytochrome c reductase hinge proteinphosphoinositide-3-kinase regulatory subunit 3
SynonymsQCR6|UQCR8p55|p55-GAMMA|p55PIK
Cytomap

1p33

1p34.1

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b-c1 complex subunit 6, mitochondrialcomplex III subunit 6cytochrome c1 non-heme 11 kDa proteinmitochondrial hinge proteinubiquinol-cytochrome c reductase complex 11 kDa proteinubiquinol-cytochrome c reductase, complex III subunit VIIIphosphatidylinositol 3-kinase regulatory subunit gammaPI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammaphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase, regulatory s
Modification date2018052320180523
UniProtAcc

P07919

Q92569

Ensembl transtripts involved in fusion geneENST00000311672, ENST00000486951, 
ENST00000262741, ENST00000372006, 
ENST00000340332, ENST00000420542, 
ENST00000354242, ENST00000540385, 
ENST00000423209, ENST00000488808, 
Fusion gene scores* DoF score5 X 5 X 3=754 X 3 X 4=48
# samples 54
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UQCRH [Title/Abstract] AND PIK3R3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE515277UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000311672ENST00000262741UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
5CDS-intronENST00000311672ENST00000372006UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
5CDS-intronENST00000311672ENST00000340332UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
5CDS-intronENST00000311672ENST00000420542UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
5CDS-intronENST00000311672ENST00000354242UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
5CDS-intronENST00000311672ENST00000540385UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
5CDS-intronENST00000311672ENST00000423209UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
5CDS-intronENST00000311672ENST00000488808UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
intron-intronENST00000486951ENST00000262741UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
intron-intronENST00000486951ENST00000372006UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
intron-intronENST00000486951ENST00000340332UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
intron-intronENST00000486951ENST00000420542UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
intron-intronENST00000486951ENST00000354242UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
intron-intronENST00000486951ENST00000540385UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
intron-intronENST00000486951ENST00000423209UQCRHchr1

46775989

+PIK3R3chr1

46519492

+
intron-intronENST00000486951ENST00000488808UQCRHchr1

46775989

+PIK3R3chr1

46519492

+

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FusionProtFeatures for UQCRH_PIK3R3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UQCRH

P07919

PIK3R3

Q92569

This is a component of the ubiquinol-cytochrome creductase complex (complex III or cytochrome b-c1 complex), whichis part of the mitochondrial respiratory chain. This protein maymediate formation of the complex between cytochromes c and c1. Binds to activated (phosphorylated) protein-tyrosinekinases through its SH2 domain and regulates their kinaseactivity. During insulin stimulation, it also binds to IRS-1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UQCRH_PIK3R3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UQCRH_PIK3R3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UQCRH_PIK3R3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePIK3R3Q92569DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit gammasmall moleculeapproved|investigational

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RelatedDiseases for UQCRH_PIK3R3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource