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Fusion gene ID: 40891 |
FusionGeneSummary for UQCRH_CLTA |
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Fusion gene information | Fusion gene name: UQCRH_CLTA | Fusion gene ID: 40891 | Hgene | Tgene | Gene symbol | UQCRH | CLTA | Gene ID | 7388 | 1211 |
Gene name | ubiquinol-cytochrome c reductase hinge protein | clathrin light chain A | |
Synonyms | QCR6|UQCR8 | LCA | |
Cytomap | 1p33 | 9p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome b-c1 complex subunit 6, mitochondrialcomplex III subunit 6cytochrome c1 non-heme 11 kDa proteinmitochondrial hinge proteinubiquinol-cytochrome c reductase complex 11 kDa proteinubiquinol-cytochrome c reductase, complex III subunit VIII | clathrin light chain Aclathrin, light polypeptide (Lca) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P07919 | P09496 | |
Ensembl transtripts involved in fusion gene | ENST00000311672, ENST00000486951, | ENST00000540080, ENST00000433436, ENST00000538225, ENST00000345519, ENST00000470744, ENST00000242285, ENST00000466396, ENST00000396603, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 3 X 1=9 |
# samples | 5 | 3 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: UQCRH [Title/Abstract] AND CLTA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU960348 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000311672 | ENST00000540080 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
5CDS-3UTR | ENST00000311672 | ENST00000433436 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
5CDS-3UTR | ENST00000311672 | ENST00000538225 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
5CDS-3UTR | ENST00000311672 | ENST00000345519 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
5CDS-3UTR | ENST00000311672 | ENST00000470744 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
5CDS-3UTR | ENST00000311672 | ENST00000242285 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
5CDS-intron | ENST00000311672 | ENST00000466396 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
5CDS-3UTR | ENST00000311672 | ENST00000396603 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
3UTR-3UTR | ENST00000486951 | ENST00000540080 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
3UTR-3UTR | ENST00000486951 | ENST00000433436 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
3UTR-3UTR | ENST00000486951 | ENST00000538225 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
3UTR-3UTR | ENST00000486951 | ENST00000345519 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
3UTR-3UTR | ENST00000486951 | ENST00000470744 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
3UTR-3UTR | ENST00000486951 | ENST00000242285 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
3UTR-intron | ENST00000486951 | ENST00000466396 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
3UTR-3UTR | ENST00000486951 | ENST00000396603 | UQCRH | chr1 | 46769493 | + | CLTA | chr9 | 36211952 | + |
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FusionProtFeatures for UQCRH_CLTA |
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Hgene | Tgene |
UQCRH | CLTA |
This is a component of the ubiquinol-cytochrome creductase complex (complex III or cytochrome b-c1 complex), whichis part of the mitochondrial respiratory chain. This protein maymediate formation of the complex between cytochromes c and c1. | Clathrin is the major protein of the polyhedral coat ofcoated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization ofkinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).{ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UQCRH_CLTA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UQCRH_CLTA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UQCRH_CLTA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UQCRH_CLTA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |