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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40854

FusionGeneSummary for UPF2_PPP2R5C

check button Fusion gene summary
Fusion gene informationFusion gene name: UPF2_PPP2R5C
Fusion gene ID: 40854
HgeneTgene
Gene symbol

UPF2

PPP2R5C

Gene ID

26019

5527

Gene nameUPF2, regulator of nonsense mediated mRNA decayprotein phosphatase 2 regulatory subunit B'gamma
SynonymsHUPF2|RENT2|smg-3B56G|B56gamma|PR61G
Cytomap

10p14

14q32.31

Type of geneprotein-codingprotein-coding
Descriptionregulator of nonsense transcripts 2FRS2/UPF2/LEMD3 fusionLEMD3/UPF2 fusionUPF2 regulator of nonsense transcripts homolognonsense mRNA reducing factor 2smg-3 homolog, nonsense mediated mRNA decay factorup-frameshift suppressor 2 homologyeast Upf2p hserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphat
Modification date2018052320180523
UniProtAcc

Q9HAU5

Q13362

Ensembl transtripts involved in fusion geneENST00000356352, ENST00000357604, 
ENST00000397053, ENST00000460569, 
ENST00000422945, ENST00000556068, 
ENST00000554442, ENST00000328724, 
ENST00000350249, ENST00000445439, 
ENST00000334743, ENST00000557095, 
ENST00000556260, ENST00000556946, 
ENST00000557714, 
Fusion gene scores* DoF score5 X 5 X 3=7510 X 9 X 8=720
# samples 513
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UPF2 [Title/Abstract] AND PPP2R5C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP2R5C

GO:0008285

negative regulation of cell proliferation

17245430


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0RS-01AUPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356352ENST00000422945UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000356352ENST00000556068UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000356352ENST00000554442UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000356352ENST00000328724UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000356352ENST00000350249UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000356352ENST00000445439UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000356352ENST00000334743UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000356352ENST00000557095UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000356352ENST00000556260UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000356352ENST00000556946UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000356352ENST00000557714UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000357604ENST00000422945UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000357604ENST00000556068UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000357604ENST00000554442UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000357604ENST00000328724UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000357604ENST00000350249UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000357604ENST00000445439UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000357604ENST00000334743UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000357604ENST00000557095UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000357604ENST00000556260UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000357604ENST00000556946UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000357604ENST00000557714UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000397053ENST00000422945UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000397053ENST00000556068UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000397053ENST00000554442UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-3UTRENST00000397053ENST00000328724UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000397053ENST00000350249UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000397053ENST00000445439UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000397053ENST00000334743UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000397053ENST00000557095UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000397053ENST00000556260UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000397053ENST00000556946UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
5CDS-intronENST00000397053ENST00000557714UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-intronENST00000460569ENST00000422945UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-3UTRENST00000460569ENST00000556068UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-3UTRENST00000460569ENST00000554442UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-3UTRENST00000460569ENST00000328724UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-intronENST00000460569ENST00000350249UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-intronENST00000460569ENST00000445439UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-intronENST00000460569ENST00000334743UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-intronENST00000460569ENST00000557095UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-intronENST00000460569ENST00000556260UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-intronENST00000460569ENST00000556946UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+
intron-intronENST00000460569ENST00000557714UPF2chr10

11984664

-PPP2R5Cchr14

102252355

+

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FusionProtFeatures for UPF2_PPP2R5C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UPF2

Q9HAU5

PPP2R5C

Q13362

The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. The PP2A-PPP2R5C holoenzyme may specificallydephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may alsoregulate the ERK signaling pathway through ERK dephosphorylation.{ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UPF2_PPP2R5C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UPF2_PPP2R5C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UPF2RPS25, UPF3B, EIF4A1, XRN2, UPF1, UPF2, DCP2, XRN1, EXOSC10, EXOSC2, EXOSC4, PARN, UPF3A, SMG1, POLD1, ELAVL1, RNPS1, PAIP1, PRPF31, MMS22L, RBM8A, HBB, TP63, RPS15, RPL5, RPS7, PHB2, MAP1LC3B, NOB1, RPL13, SERBP1, BLM, KRT18, TUBB2A, ENO1, ATP1B3, ITGB1, MRPL40, TOP3B, CALR, E4F1, HBZ, ZBTB48, HS3ST3A1, HSF2BP, CIZ1, NOMO1, RRP7A, WNK1, ZGPAT, SUMO3, TYMS, MIF, RPS6, COMTD1, NDUFA7, LDHA, RPL8, CYBA, TK1, SERF2, CENPU, GADD45GIP1, HMGA1, AGPAT1, GLTSCR2, MTERF3, ZNF44, RSRC2, TNNI2, ABCF2, PITX1, DPF2, EXOSC8, EXOSC6, ZNF408, ZFP36, DCP1B, EXOSC1, LSM1, SKIV2L2, MYB, MAP1A, ART4, LGR4, PUF60, FUS, SMARCD1, SMARCD2, SMARCD3, TRIP10, NTRK1, XPO1, KIF15PPP2R5CCCNG2, PPP2CA, PPP2R5A, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, MBP, TBC1D3, APP, BRCA1, PAXIP1, IER3, MAPK1, SOX2, COL4A3BP, FAF1, JMJD6, PACSIN2, UGP2, PSMG3, SWAP70, EGFR, EP300, FAM43A, CCNG1, API5, LSM6, LSM7, PPP2R2A, POLD1, PPP2R5E, RQCD1, TP53, PRR14, PPP1CA, PPP1CB, PPP1CC, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UPF2_PPP2R5C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UPF2_PPP2R5C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPP2R5CC0023434Chronic Lymphocytic Leukemia1CTD_human
TgenePPP2R5CC1257806Chromosomal Instability1CTD_human
TgenePPP2R5CC1449861Micronuclei, Chromosome-Defective1CTD_human