![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 40854 |
FusionGeneSummary for UPF2_PPP2R5C |
![]() |
Fusion gene information | Fusion gene name: UPF2_PPP2R5C | Fusion gene ID: 40854 | Hgene | Tgene | Gene symbol | UPF2 | PPP2R5C | Gene ID | 26019 | 5527 |
Gene name | UPF2, regulator of nonsense mediated mRNA decay | protein phosphatase 2 regulatory subunit B'gamma | |
Synonyms | HUPF2|RENT2|smg-3 | B56G|B56gamma|PR61G | |
Cytomap | 10p14 | 14q32.31 | |
Type of gene | protein-coding | protein-coding | |
Description | regulator of nonsense transcripts 2FRS2/UPF2/LEMD3 fusionLEMD3/UPF2 fusionUPF2 regulator of nonsense transcripts homolognonsense mRNA reducing factor 2smg-3 homolog, nonsense mediated mRNA decay factorup-frameshift suppressor 2 homologyeast Upf2p h | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphat | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9HAU5 | Q13362 | |
Ensembl transtripts involved in fusion gene | ENST00000356352, ENST00000357604, ENST00000397053, ENST00000460569, | ENST00000422945, ENST00000556068, ENST00000554442, ENST00000328724, ENST00000350249, ENST00000445439, ENST00000334743, ENST00000557095, ENST00000556260, ENST00000556946, ENST00000557714, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 10 X 9 X 8=720 |
# samples | 5 | 13 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UPF2 [Title/Abstract] AND PPP2R5C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPP2R5C | GO:0008285 | negative regulation of cell proliferation | 17245430 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A0RS-01A | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000356352 | ENST00000422945 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000356352 | ENST00000556068 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000356352 | ENST00000554442 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000356352 | ENST00000328724 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000356352 | ENST00000350249 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000356352 | ENST00000445439 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000356352 | ENST00000334743 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000356352 | ENST00000557095 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000356352 | ENST00000556260 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000356352 | ENST00000556946 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000356352 | ENST00000557714 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000357604 | ENST00000422945 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000357604 | ENST00000556068 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000357604 | ENST00000554442 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000357604 | ENST00000328724 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000357604 | ENST00000350249 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000357604 | ENST00000445439 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000357604 | ENST00000334743 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000357604 | ENST00000557095 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000357604 | ENST00000556260 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000357604 | ENST00000556946 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000357604 | ENST00000557714 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000397053 | ENST00000422945 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000397053 | ENST00000556068 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000397053 | ENST00000554442 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-3UTR | ENST00000397053 | ENST00000328724 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000397053 | ENST00000350249 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000397053 | ENST00000445439 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000397053 | ENST00000334743 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000397053 | ENST00000557095 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000397053 | ENST00000556260 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000397053 | ENST00000556946 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
5CDS-intron | ENST00000397053 | ENST00000557714 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-intron | ENST00000460569 | ENST00000422945 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-3UTR | ENST00000460569 | ENST00000556068 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-3UTR | ENST00000460569 | ENST00000554442 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-3UTR | ENST00000460569 | ENST00000328724 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-intron | ENST00000460569 | ENST00000350249 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-intron | ENST00000460569 | ENST00000445439 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-intron | ENST00000460569 | ENST00000334743 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-intron | ENST00000460569 | ENST00000557095 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-intron | ENST00000460569 | ENST00000556260 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-intron | ENST00000460569 | ENST00000556946 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
intron-intron | ENST00000460569 | ENST00000557714 | UPF2 | chr10 | 11984664 | - | PPP2R5C | chr14 | 102252355 | + |
Top |
FusionProtFeatures for UPF2_PPP2R5C |
![]() |
Hgene | Tgene |
UPF2 | PPP2R5C |
The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. The PP2A-PPP2R5C holoenzyme may specificallydephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may alsoregulate the ERK signaling pathway through ERK dephosphorylation.{ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for UPF2_PPP2R5C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for UPF2_PPP2R5C |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UPF2 | RPS25, UPF3B, EIF4A1, XRN2, UPF1, UPF2, DCP2, XRN1, EXOSC10, EXOSC2, EXOSC4, PARN, UPF3A, SMG1, POLD1, ELAVL1, RNPS1, PAIP1, PRPF31, MMS22L, RBM8A, HBB, TP63, RPS15, RPL5, RPS7, PHB2, MAP1LC3B, NOB1, RPL13, SERBP1, BLM, KRT18, TUBB2A, ENO1, ATP1B3, ITGB1, MRPL40, TOP3B, CALR, E4F1, HBZ, ZBTB48, HS3ST3A1, HSF2BP, CIZ1, NOMO1, RRP7A, WNK1, ZGPAT, SUMO3, TYMS, MIF, RPS6, COMTD1, NDUFA7, LDHA, RPL8, CYBA, TK1, SERF2, CENPU, GADD45GIP1, HMGA1, AGPAT1, GLTSCR2, MTERF3, ZNF44, RSRC2, TNNI2, ABCF2, PITX1, DPF2, EXOSC8, EXOSC6, ZNF408, ZFP36, DCP1B, EXOSC1, LSM1, SKIV2L2, MYB, MAP1A, ART4, LGR4, PUF60, FUS, SMARCD1, SMARCD2, SMARCD3, TRIP10, NTRK1, XPO1, KIF15 | PPP2R5C | CCNG2, PPP2CA, PPP2R5A, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, MBP, TBC1D3, APP, BRCA1, PAXIP1, IER3, MAPK1, SOX2, COL4A3BP, FAF1, JMJD6, PACSIN2, UGP2, PSMG3, SWAP70, EGFR, EP300, FAM43A, CCNG1, API5, LSM6, LSM7, PPP2R2A, POLD1, PPP2R5E, RQCD1, TP53, PRR14, PPP1CA, PPP1CB, PPP1CC, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for UPF2_PPP2R5C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for UPF2_PPP2R5C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PPP2R5C | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
Tgene | PPP2R5C | C1257806 | Chromosomal Instability | 1 | CTD_human |
Tgene | PPP2R5C | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |