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Fusion gene ID: 40852 |
FusionGeneSummary for UPF2_MTAP |
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Fusion gene information | Fusion gene name: UPF2_MTAP | Fusion gene ID: 40852 | Hgene | Tgene | Gene symbol | UPF2 | MTAP | Gene ID | 26019 | 4507 |
Gene name | UPF2, regulator of nonsense mediated mRNA decay | methylthioadenosine phosphorylase | |
Synonyms | HUPF2|RENT2|smg-3 | BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus | |
Cytomap | 10p14 | 9p21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | regulator of nonsense transcripts 2FRS2/UPF2/LEMD3 fusionLEMD3/UPF2 fusionUPF2 regulator of nonsense transcripts homolognonsense mRNA reducing factor 2smg-3 homolog, nonsense mediated mRNA decay factorup-frameshift suppressor 2 homologyeast Upf2p h | S-methyl-5'-thioadenosine phosphorylase5'-methylthioadenosine phosphorylaseMTA phosphorylaseMTAPaseMeSAdo phosphorylaseepididymis luminal protein 249 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9HAU5 | Q13126 | |
Ensembl transtripts involved in fusion gene | ENST00000356352, ENST00000357604, ENST00000397053, ENST00000460569, | ENST00000580900, ENST00000380172, ENST00000460874, ENST00000427788, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 4 X 3 X 3=36 |
# samples | 5 | 4 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: UPF2 [Title/Abstract] AND MTAP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MTAP | GO:0006738 | nicotinamide riboside catabolic process | 19001417 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CR738223 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000356352 | ENST00000580900 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000356352 | ENST00000380172 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000356352 | ENST00000460874 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000356352 | ENST00000427788 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000357604 | ENST00000580900 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000357604 | ENST00000380172 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000357604 | ENST00000460874 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000357604 | ENST00000427788 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000397053 | ENST00000580900 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000397053 | ENST00000380172 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000397053 | ENST00000460874 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000397053 | ENST00000427788 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000460569 | ENST00000580900 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000460569 | ENST00000380172 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000460569 | ENST00000460874 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
intron-intron | ENST00000460569 | ENST00000427788 | UPF2 | chr10 | 12011461 | - | MTAP | chr9 | 21861026 | + |
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FusionProtFeatures for UPF2_MTAP |
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Hgene | Tgene |
UPF2 | MTAP |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UPF2_MTAP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UPF2_MTAP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UPF2_MTAP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UPF2_MTAP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MTAP | C0025202 | melanoma | 1 | CTD_human |
Tgene | MTAP | C0027960 | Nevus | 1 | CTD_human |
Tgene | MTAP | C0033578 | Prostatic Neoplasms | 1 | CTD_human |