![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 40841 |
FusionGeneSummary for UNK_NAF1 |
![]() |
Fusion gene information | Fusion gene name: UNK_NAF1 | Fusion gene ID: 40841 | Hgene | Tgene | Gene symbol | UNK | NAF1 | Gene ID | 85451 | 92345 |
Gene name | unkempt family zinc finger | nuclear assembly factor 1 ribonucleoprotein | |
Synonyms | UNKEMPT|ZC3H5|ZC3HDC5 | - | |
Cytomap | 17q25.1 | 4q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | RING finger protein unkempt homologunkempt homologzinc finger CCCH domain-containing protein 5zinc finger CCCH-type containing 5zinc finger CCCH-type domain containing 5 | H/ACA ribonucleoprotein complex non-core subunit NAF1nuclear assembly factor 1 homolog | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9C0B0 | Q96HR8 | |
Ensembl transtripts involved in fusion gene | ENST00000293218, ENST00000589666, | ENST00000509434, ENST00000422287, ENST00000274054, | |
Fusion gene scores | * DoF score | 12 X 1 X 7=84 | 1 X 1 X 1=1 |
# samples | 15 | 1 | |
** MAII score | log2(15/84*10)=0.836501267717121 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: UNK [Title/Abstract] AND NAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NAF1 | GO:0042254 | ribosome biogenesis | 16618814 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-86-7955-01A | UNK | chr17 | 73781065 | + | NAF1 | chr4 | 164085543 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000293218 | ENST00000509434 | UNK | chr17 | 73781065 | + | NAF1 | chr4 | 164085543 | - |
5CDS-intron | ENST00000293218 | ENST00000422287 | UNK | chr17 | 73781065 | + | NAF1 | chr4 | 164085543 | - |
5CDS-intron | ENST00000293218 | ENST00000274054 | UNK | chr17 | 73781065 | + | NAF1 | chr4 | 164085543 | - |
5CDS-intron | ENST00000589666 | ENST00000509434 | UNK | chr17 | 73781065 | + | NAF1 | chr4 | 164085543 | - |
5CDS-intron | ENST00000589666 | ENST00000422287 | UNK | chr17 | 73781065 | + | NAF1 | chr4 | 164085543 | - |
5CDS-intron | ENST00000589666 | ENST00000274054 | UNK | chr17 | 73781065 | + | NAF1 | chr4 | 164085543 | - |
Top |
FusionProtFeatures for UNK_NAF1 |
![]() |
Hgene | Tgene |
UNK | NAF1 |
Sequence-specific RNA-binding protein which plays animportant role in the establishment and maintenance of the earlymorphology of cortical neurons during embryonic development. Actsas a translation repressor and controls a translationallyregulated cell morphology program to ensure proper structuring ofthe nervous system. Translational control depends on recognitionof its binding element within target mRNAs which consists of amandatory UAG trimer upstream of a U/A-rich motif. Associated withpolysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. | RNA-binding protein required for the maturation of boxH/ACA snoRNPs complex and ribosome biogenesis. During assembly ofthe H/ACA snoRNPs complex, it associates with the complex anddisappears during maturation of the complex and is replaced byNOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probablycompetes with NOLA1/GAR1 for binding with DKC1/NOLA4.{ECO:0000269|PubMed:16618814}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for UNK_NAF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for UNK_NAF1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UNK | ATXN1, ATP6V1B2, ZFYVE19, UBA2, UBA52, YAP1, UBXN1, UFC1, UBE2A, UBE2B, TTLL12, PAICS, ATP6V1F, USP9X, TYMS, TRIP6, KIAA1598, UBE2D1, UCHL3, ZRANB2, SEC24A, VPS26A, UBE2C, S100A4, S100A9, DSTN, USP34, UBQLN1, SRXN1, STAM, IGBP1, SAV1, DPY30, HINT1, CALM2, CLTC, USMG5, ARF4, GDI2, MGST3, TUBB, HSPA4, CSDE1, PPP2CA, CDC42, EEF1A1, CSE1L, SERINC1, MATR3, MINOS1, ACTR3, RAB1A, KPNB1, VPS35, MTA2, TRA2B, RTN4, COPS3, C16orf72, CCT5, COX7B, TCP1, CALM1, LEPROTL1, COPA, RPL30, SPCS1, TMEM30A, RER1, COPB2, PDIA3, RPA3, RPS27L, HNRNPH1, HSPE1, ARF5, RAB5A, GNB2L1, COMMD6, PHB2, PDIA6, PCBP1, HNRNPU, CCT8, NUP155, PICALM, RAB14, CUL2, UGP2, ATP6V1H, YME1L1, YWHAG, KDM1A, GARS, PRRC2B, PTGES3, ITM2B, CBX3, RBFOX2, DDX5, SDCBP, HSP90AB1, ARF1, VCL, LAPTM4A, ANP32E, COX7A2, ACTR2, PLK2, CKAP5, MKLN1, PNRC1, IPO7, PRDX3, FAM49B, LDHA, LIMCH1, CCT4, CBX5, YBX1, TNPO3, C14orf2, PSMB1, PARK7, KRAS, GGPS1, SRRM2, CAND1, TROVE2, ARPC2, CTNNB1, YWHAE, GHITM, ATP2A2, ACTB, HAT1, EIF4H, ACAT1, SPTBN1, COX5A, HDAC2, HSP90AA1, YWHAB, GDI1, ITGB1, UBA1, ATP6AP2, KPNA4, DHX15, FBXO11, EIF2S3, RRN3, PPP1CB, EIF4A1, MYEOV2, TXNL1, SLC38A2, LRRC58, SFPQ, HNRNPAB, NDFIP1, MSH6, ABCD3, YIPF4, RANBP9, UBE2G1, OCIAD1, H2AFY, TMPO, SAR1A, MCMBP, EIF4A2, PJA2, DNM1L, HUWE1, HERC1, OPA1, NCL, TFG, DYNC1H1, SUB1, YWHAZ, HSPD1, EEF2, ID3, CUL4A, RPL22L1, PLS3, DPYSL2, RAD21, IPO9, ARPC4, EIF3A, HN1, USP14, RPS3, EIF3E, BFAR, IP6K2, EMC6, H3F3B, EIF4G1, TOMM70A, ATP2B1, CTNNA1, NCBP1, TXN, SIN3A, MAPRE1, GLS, POLR2H, SF3B1, BIRC6, SKIV2L2, PDCD10, ATP5A1, CTSB, PPID, SNRPE, RAP1A, PSEN1, CHMP5, ATP5EP2, GFPT1, MTMR2, PDCD4, SDHC, MGA, WAC, OGDH, PKN2, RLIM, NUFIP2, TOP2A, SLC25A3, TXNL4A, NAP1L4, HNRNPL, EIF4G2, OGT, CSTF3, GPR85, SAFB, CNOT8, HSPA9, BCLAF1, HNRNPDL, EIF3H, RTCB, MARCH5, AP1G1, SF3B3, PPP6R3, XPO1, SLC38A1, PLAA, ARID1A, DHX36, BRD3, SLC4A7, ARL6IP1, PTP4A2, MCL1, CSNK2B, PPP1R15B, FOXP1, NFIB, DST, ATP5O, GLUD1, NUP98, ARHGAP5, SLC16A1, PTPRF, LUC7L3, CNIH4, STT3B, FAM13B, HIATL1, TOP2B, MED14, NPAT, KPNA6, TRAPPC8, ATPIF1, TSC22D1, HMGCR, GTF2H5, ABCB7, CALM3, POLR2A, MLLT6, YIPF6 | NAF1 | WDR48, DKC1, NHP2, NOP10, FBL, SCARNA13, SCARNA8, SNORA74A, GRK5, HTATSF1, CSNK2A1, SHQ1, NCS1, DAB1, FAM168A, RBFOX2, FAM9A, EDA, EPB41L3, XPO1, FKBP1A, MTOR, HADHA, HADHB, RAD51, DPF2, RPL10, TAF13, TBP, ICAM5, TAF1C, TAF1B, TAF1A, DDX23, ATP5J2, NOS1AP, KEAP1, RANBP9, DHRS2, MRPL3, JMJD6, SF3B1, KPNA6, ABT1, PHF21A, SNX9, OTUD4, RABL6, CAMSAP3, TAF1D, VANGL1, MPP1, MIB2, SNX33, C1orf226, DAXX, YWHAE, C9orf114, BCHE, PIP4K2A, PES1, MDK, EPB41L5, SMOC1, CAMKV, PTPN21, EAF1, DDX20, EIF2AK1, AP3B1, ATRX, POLD1, RBM14, MFAP1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for UNK_NAF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for UNK_NAF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |