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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40841

FusionGeneSummary for UNK_NAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: UNK_NAF1
Fusion gene ID: 40841
HgeneTgene
Gene symbol

UNK

NAF1

Gene ID

85451

92345

Gene nameunkempt family zinc fingernuclear assembly factor 1 ribonucleoprotein
SynonymsUNKEMPT|ZC3H5|ZC3HDC5-
Cytomap

17q25.1

4q32.2

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein unkempt homologunkempt homologzinc finger CCCH domain-containing protein 5zinc finger CCCH-type containing 5zinc finger CCCH-type domain containing 5H/ACA ribonucleoprotein complex non-core subunit NAF1nuclear assembly factor 1 homolog
Modification date2018051920180519
UniProtAcc

Q9C0B0

Q96HR8

Ensembl transtripts involved in fusion geneENST00000293218, ENST00000589666, 
ENST00000509434, ENST00000422287, 
ENST00000274054, 
Fusion gene scores* DoF score12 X 1 X 7=841 X 1 X 1=1
# samples 151
** MAII scorelog2(15/84*10)=0.836501267717121
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: UNK [Title/Abstract] AND NAF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNAF1

GO:0042254

ribosome biogenesis

16618814


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-86-7955-01AUNKchr17

73781065

+NAF1chr4

164085543

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000293218ENST00000509434UNKchr17

73781065

+NAF1chr4

164085543

-
5CDS-intronENST00000293218ENST00000422287UNKchr17

73781065

+NAF1chr4

164085543

-
5CDS-intronENST00000293218ENST00000274054UNKchr17

73781065

+NAF1chr4

164085543

-
5CDS-intronENST00000589666ENST00000509434UNKchr17

73781065

+NAF1chr4

164085543

-
5CDS-intronENST00000589666ENST00000422287UNKchr17

73781065

+NAF1chr4

164085543

-
5CDS-intronENST00000589666ENST00000274054UNKchr17

73781065

+NAF1chr4

164085543

-

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FusionProtFeatures for UNK_NAF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UNK

Q9C0B0

NAF1

Q96HR8

Sequence-specific RNA-binding protein which plays animportant role in the establishment and maintenance of the earlymorphology of cortical neurons during embryonic development. Actsas a translation repressor and controls a translationallyregulated cell morphology program to ensure proper structuring ofthe nervous system. Translational control depends on recognitionof its binding element within target mRNAs which consists of amandatory UAG trimer upstream of a U/A-rich motif. Associated withpolysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. RNA-binding protein required for the maturation of boxH/ACA snoRNPs complex and ribosome biogenesis. During assembly ofthe H/ACA snoRNPs complex, it associates with the complex anddisappears during maturation of the complex and is replaced byNOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probablycompetes with NOLA1/GAR1 for binding with DKC1/NOLA4.{ECO:0000269|PubMed:16618814}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UNK_NAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UNK_NAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UNKATXN1, ATP6V1B2, ZFYVE19, UBA2, UBA52, YAP1, UBXN1, UFC1, UBE2A, UBE2B, TTLL12, PAICS, ATP6V1F, USP9X, TYMS, TRIP6, KIAA1598, UBE2D1, UCHL3, ZRANB2, SEC24A, VPS26A, UBE2C, S100A4, S100A9, DSTN, USP34, UBQLN1, SRXN1, STAM, IGBP1, SAV1, DPY30, HINT1, CALM2, CLTC, USMG5, ARF4, GDI2, MGST3, TUBB, HSPA4, CSDE1, PPP2CA, CDC42, EEF1A1, CSE1L, SERINC1, MATR3, MINOS1, ACTR3, RAB1A, KPNB1, VPS35, MTA2, TRA2B, RTN4, COPS3, C16orf72, CCT5, COX7B, TCP1, CALM1, LEPROTL1, COPA, RPL30, SPCS1, TMEM30A, RER1, COPB2, PDIA3, RPA3, RPS27L, HNRNPH1, HSPE1, ARF5, RAB5A, GNB2L1, COMMD6, PHB2, PDIA6, PCBP1, HNRNPU, CCT8, NUP155, PICALM, RAB14, CUL2, UGP2, ATP6V1H, YME1L1, YWHAG, KDM1A, GARS, PRRC2B, PTGES3, ITM2B, CBX3, RBFOX2, DDX5, SDCBP, HSP90AB1, ARF1, VCL, LAPTM4A, ANP32E, COX7A2, ACTR2, PLK2, CKAP5, MKLN1, PNRC1, IPO7, PRDX3, FAM49B, LDHA, LIMCH1, CCT4, CBX5, YBX1, TNPO3, C14orf2, PSMB1, PARK7, KRAS, GGPS1, SRRM2, CAND1, TROVE2, ARPC2, CTNNB1, YWHAE, GHITM, ATP2A2, ACTB, HAT1, EIF4H, ACAT1, SPTBN1, COX5A, HDAC2, HSP90AA1, YWHAB, GDI1, ITGB1, UBA1, ATP6AP2, KPNA4, DHX15, FBXO11, EIF2S3, RRN3, PPP1CB, EIF4A1, MYEOV2, TXNL1, SLC38A2, LRRC58, SFPQ, HNRNPAB, NDFIP1, MSH6, ABCD3, YIPF4, RANBP9, UBE2G1, OCIAD1, H2AFY, TMPO, SAR1A, MCMBP, EIF4A2, PJA2, DNM1L, HUWE1, HERC1, OPA1, NCL, TFG, DYNC1H1, SUB1, YWHAZ, HSPD1, EEF2, ID3, CUL4A, RPL22L1, PLS3, DPYSL2, RAD21, IPO9, ARPC4, EIF3A, HN1, USP14, RPS3, EIF3E, BFAR, IP6K2, EMC6, H3F3B, EIF4G1, TOMM70A, ATP2B1, CTNNA1, NCBP1, TXN, SIN3A, MAPRE1, GLS, POLR2H, SF3B1, BIRC6, SKIV2L2, PDCD10, ATP5A1, CTSB, PPID, SNRPE, RAP1A, PSEN1, CHMP5, ATP5EP2, GFPT1, MTMR2, PDCD4, SDHC, MGA, WAC, OGDH, PKN2, RLIM, NUFIP2, TOP2A, SLC25A3, TXNL4A, NAP1L4, HNRNPL, EIF4G2, OGT, CSTF3, GPR85, SAFB, CNOT8, HSPA9, BCLAF1, HNRNPDL, EIF3H, RTCB, MARCH5, AP1G1, SF3B3, PPP6R3, XPO1, SLC38A1, PLAA, ARID1A, DHX36, BRD3, SLC4A7, ARL6IP1, PTP4A2, MCL1, CSNK2B, PPP1R15B, FOXP1, NFIB, DST, ATP5O, GLUD1, NUP98, ARHGAP5, SLC16A1, PTPRF, LUC7L3, CNIH4, STT3B, FAM13B, HIATL1, TOP2B, MED14, NPAT, KPNA6, TRAPPC8, ATPIF1, TSC22D1, HMGCR, GTF2H5, ABCB7, CALM3, POLR2A, MLLT6, YIPF6NAF1WDR48, DKC1, NHP2, NOP10, FBL, SCARNA13, SCARNA8, SNORA74A, GRK5, HTATSF1, CSNK2A1, SHQ1, NCS1, DAB1, FAM168A, RBFOX2, FAM9A, EDA, EPB41L3, XPO1, FKBP1A, MTOR, HADHA, HADHB, RAD51, DPF2, RPL10, TAF13, TBP, ICAM5, TAF1C, TAF1B, TAF1A, DDX23, ATP5J2, NOS1AP, KEAP1, RANBP9, DHRS2, MRPL3, JMJD6, SF3B1, KPNA6, ABT1, PHF21A, SNX9, OTUD4, RABL6, CAMSAP3, TAF1D, VANGL1, MPP1, MIB2, SNX33, C1orf226, DAXX, YWHAE, C9orf114, BCHE, PIP4K2A, PES1, MDK, EPB41L5, SMOC1, CAMKV, PTPN21, EAF1, DDX20, EIF2AK1, AP3B1, ATRX, POLD1, RBM14, MFAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UNK_NAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UNK_NAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource