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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4084

FusionGeneSummary for BCR_FGFR1

check button Fusion gene summary
Fusion gene informationFusion gene name: BCR_FGFR1
Fusion gene ID: 4084
HgeneTgene
Gene symbol

BCR

FGFR1

Gene ID

613

2260

Gene nameBCR, RhoGEF and GTPase activating proteinfibroblast growth factor receptor 1
SynonymsALL|BCR1|CML|D22S11|D22S662|PHLBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1
Cytomap

22q11.23

8p11.23

Type of geneprotein-codingprotein-coding
Descriptionbreakpoint cluster region proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr
Modification date2018052720180527
UniProtAcc

P11274

P11362

Ensembl transtripts involved in fusion geneENST00000305877, ENST00000359540, 
ENST00000398512, ENST00000436990, 
ENST00000425967, ENST00000397091, 
ENST00000447712, ENST00000341462, 
ENST00000532791, ENST00000397113, 
ENST00000356207, ENST00000335922, 
ENST00000326324, ENST00000397103, 
ENST00000397108, ENST00000496629, 
Fusion gene scores* DoF score17 X 39 X 8=53049 X 8 X 4=288
# samples 7012
** MAII scorelog2(70/5304*10)=-2.92165394828026
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/288*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCR [Title/Abstract] AND FGFR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

TgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

TgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

TgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

TgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

TgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

TgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ298916BCRchr22

23603730

+FGFR1chr8

38275904

-
ChiTaRS3.1AB742170BCRchr22

23603730

+FGFR1chr8

38275904

-
ChiTaRS3.1AJ298918BCRchr22

23606792

+FGFR1chr8

38277025

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000305877ENST00000425967BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000397091BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000447712BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000341462BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000532791BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000397113BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000356207BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000335922BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000326324BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000397103BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000397108BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000305877ENST00000496629BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000425967BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000397091BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000447712BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000341462BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000532791BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000397113BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000356207BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000335922BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000326324BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000397103BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000397108BCRchr22

23603730

+FGFR1chr8

38275904

-
5CDS-intronENST00000359540ENST00000496629BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000425967BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000397091BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000447712BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000341462BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000532791BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000397113BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000356207BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000335922BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000326324BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000397103BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000397108BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000398512ENST00000496629BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000425967BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000397091BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000447712BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000341462BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000532791BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000397113BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000356207BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000335922BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000326324BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000397103BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000397108BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000436990ENST00000496629BCRchr22

23603730

+FGFR1chr8

38275904

-
intron-intronENST00000305877ENST00000425967BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000397091BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000447712BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000341462BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000532791BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000397113BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000356207BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000335922BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000326324BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000397103BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000397108BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000305877ENST00000496629BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000425967BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000397091BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000447712BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000341462BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000532791BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000397113BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000356207BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000335922BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000326324BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000397103BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000397108BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000359540ENST00000496629BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000425967BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000397091BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000447712BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000341462BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000532791BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000397113BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000356207BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000335922BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000326324BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000397103BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000397108BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000398512ENST00000496629BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000425967BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000397091BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000447712BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000341462BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000532791BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000397113BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000356207BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000335922BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000326324BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000397103BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000397108BCRchr22

23606792

+FGFR1chr8

38277025

-
intron-intronENST00000436990ENST00000496629BCRchr22

23606792

+FGFR1chr8

38277025

-

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FusionProtFeatures for BCR_FGFR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCR

P11274

FGFR1

P11362

GTPase-activating protein for RAC1 and CDC42. Promotesthe exchange of RAC or CDC42-bound GDP by GTP, thereby activatingthem. Displays serine/threonine kinase activity.{ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:1903516}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BCR_FGFR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BCR_FGFR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BCR_FGFR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneBCRP11274DB06616BosutinibBreakpoint cluster region proteinsmall moleculeapproved
HgeneBCRP11274DB01254DasatinibBreakpoint cluster region proteinsmall moleculeapproved|investigational
HgeneBCRP11274DB08901PonatinibBreakpoint cluster region proteinsmall moleculeapproved|investigational
TgeneFGFR1P11362DB00039PaliferminFibroblast growth factor receptor 1biotechapproved
TgeneFGFR1P11362DB08896RegorafenibFibroblast growth factor receptor 1small moleculeapproved
TgeneFGFR1P11362DB09079NintedanibFibroblast growth factor receptor 1small moleculeapproved
TgeneFGFR1P11362DB00398SorafenibFibroblast growth factor receptor 1small moleculeapproved|investigational
TgeneFGFR1P11362DB01109HeparinFibroblast growth factor receptor 1small moleculeapproved|investigational
TgeneFGFR1P11362DB08901PonatinibFibroblast growth factor receptor 1small moleculeapproved|investigational
TgeneFGFR1P11362DB09078LenvatinibFibroblast growth factor receptor 1small moleculeapproved|investigational

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RelatedDiseases for BCR_FGFR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCRC0005586Bipolar Disorder4PSYGENET
HgeneBCRC0023473Myeloid Leukemia, Chronic3CTD_human;HPO;ORPHANET
HgeneBCRC0005699Blast Phase1CTD_human
HgeneBCRC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneBCRC0027022Myeloproliferative disease1CTD_human;HPO
HgeneBCRC0027540Necrosis1CTD_human
HgeneBCRC0027659Neoplasms, Experimental1CTD_human
HgeneBCRC0041696Unipolar Depression1PSYGENET
HgeneBCRC1269683Major Depressive Disorder1PSYGENET
TgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)14ORPHANET;UNIPROT
TgeneFGFR1C0011570Mental Depression5PSYGENET
TgeneFGFR1C0011581Depressive disorder5CTD_human;HPO;PSYGENET
TgeneFGFR1C0005586Bipolar Disorder3PSYGENET
TgeneFGFR1C0041696Unipolar Depression3PSYGENET
TgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
TgeneFGFR1C0027022Myeloproliferative disease2CTD_human
TgeneFGFR1C0220658Pfeiffer Syndrome2UNIPROT
TgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis2ORPHANET;UNIPROT
TgeneFGFR1C0432283Osteoglophonic dwarfism2CTD_human;ORPHANET;UNIPROT
TgeneFGFR1C1458155Mammary Neoplasms2CTD_human
TgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate2ORPHANET;UNIPROT
TgeneFGFR1C0004114Astrocytoma1CTD_human
TgeneFGFR1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneFGFR1C0007137Squamous cell carcinoma1CTD_human
TgeneFGFR1C0008924Cleft Lip1CTD_human;HPO
TgeneFGFR1C0008925Cleft Palate1CTD_human;HPO
TgeneFGFR1C0017638Glioma1CTD_human
TgeneFGFR1C0024121Lung Neoplasms1CTD_human
TgeneFGFR1C0036341Schizophrenia1CTD_human
TgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
TgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
TgeneFGFR1C0432122Interfrontal craniofaciosynostosis1CTD_human;UNIPROT