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Fusion gene ID: 40832 |
FusionGeneSummary for UNKL_TJP1 |
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Fusion gene information | Fusion gene name: UNKL_TJP1 | Fusion gene ID: 40832 | Hgene | Tgene | Gene symbol | UNKL | TJP1 | Gene ID | 64718 | 7082 |
Gene name | unkempt family like zinc finger | tight junction protein 1 | |
Synonyms | C16orf28|ZC3H5L|ZC3HDC5L | ZO-1 | |
Cytomap | 16p13.3 | 15q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | putative E3 ubiquitin-protein ligase UNKLRING finger protein unkempt-likeunkempt family zinc finger-likeunkempt homolog-likezinc finger CCCH domain-containing protein 5-like | tight junction protein ZO-1zona occludens 1zonula occludens 1 protein | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9H9P5 | Q07157 | |
Ensembl transtripts involved in fusion gene | ENST00000389221, ENST00000508903, ENST00000397462, ENST00000391893, ENST00000403703, ENST00000248104, ENST00000397464, ENST00000402641, ENST00000301712, ENST00000503648, | ENST00000346128, ENST00000400011, ENST00000356107, ENST00000545208, ENST00000495972, | |
Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 5 X 6 X 3=90 |
# samples | 7 | 6 | |
** MAII score | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UNKL [Title/Abstract] AND TJP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | L14837 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000389221 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000389221 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000389221 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000389221 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000389221 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000508903 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000508903 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000508903 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000508903 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000508903 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000397462 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000397462 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000397462 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000397462 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000397462 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000391893 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000391893 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000391893 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000391893 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000391893 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000403703 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000403703 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000403703 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000403703 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000403703 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000248104 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000248104 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000248104 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000248104 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000248104 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000397464 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000397464 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000397464 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000397464 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000397464 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000402641 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000402641 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000402641 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000402641 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000402641 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000301712 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000301712 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000301712 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000301712 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000301712 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-3CDS | ENST00000503648 | ENST00000346128 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000503648 | ENST00000400011 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000503648 | ENST00000356107 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000503648 | ENST00000545208 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
intron-intron | ENST00000503648 | ENST00000495972 | UNKL | chr16 | 1421841 | + | TJP1 | chr15 | 30114706 | - |
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FusionProtFeatures for UNKL_TJP1 |
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Hgene | Tgene |
UNKL | TJP1 |
May participate in a protein complex showing an E3ligase activity regulated by RAC1. Ubiquitination is directedtowards itself and possibly other substrates, such asSMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.{ECO:0000269|PubMed:20148946}. | TJP1, TJP2, and TJP3 are closely related scaffoldingproteins that link tight junction (TJ) transmembrane proteins suchas claudins, junctional adhesion molecules, and occludin to theactin cytoskeleton (PubMed:7798316, PubMed:9792688). The tightjunction acts to limit movement of substances through theparacellular space and as a boundary between the compositionallydistinct apical and basolateral plasma membrane domains ofepithelial and endothelial cells. Necessary for lumenogenesis, andparticularly efficient epithelial polarization and barrierformation (By similarity). Plays a role in the regulation of cellmigration by targeting CDC42BPB to the leading edge of migratingcells (PubMed:21240187). Plays an important role in podosomeformation and associated function, thus regulating cell adhesionand matrix remodeling (PubMed:20930113). With TJP2 and TJP3,participates to the junctional retention and stability of thetranscription factor DBPA, but is not involved in its shuttling tothe nucleus (By similarity). {ECO:0000250|UniProtKB:O97758,ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UNKL_TJP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UNKL_TJP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UNKL_TJP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UNKL_TJP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |