FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 40832

FusionGeneSummary for UNKL_TJP1

check button Fusion gene summary
Fusion gene informationFusion gene name: UNKL_TJP1
Fusion gene ID: 40832
HgeneTgene
Gene symbol

UNKL

TJP1

Gene ID

64718

7082

Gene nameunkempt family like zinc fingertight junction protein 1
SynonymsC16orf28|ZC3H5L|ZC3HDC5LZO-1
Cytomap

16p13.3

15q13.1

Type of geneprotein-codingprotein-coding
Descriptionputative E3 ubiquitin-protein ligase UNKLRING finger protein unkempt-likeunkempt family zinc finger-likeunkempt homolog-likezinc finger CCCH domain-containing protein 5-liketight junction protein ZO-1zona occludens 1zonula occludens 1 protein
Modification date2018051920180522
UniProtAcc

Q9H9P5

Q07157

Ensembl transtripts involved in fusion geneENST00000389221, ENST00000508903, 
ENST00000397462, ENST00000391893, 
ENST00000403703, ENST00000248104, 
ENST00000397464, ENST00000402641, 
ENST00000301712, ENST00000503648, 
ENST00000346128, ENST00000400011, 
ENST00000356107, ENST00000545208, 
ENST00000495972, 
Fusion gene scores* DoF score6 X 6 X 4=1445 X 6 X 3=90
# samples 76
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UNKL [Title/Abstract] AND TJP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1L14837UNKLchr16

1421841

+TJP1chr15

30114706

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000389221ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000389221ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000389221ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000389221ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000389221ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000508903ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000508903ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000508903ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000508903ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000508903ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000397462ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000397462ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000397462ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000397462ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000397462ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000391893ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000391893ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000391893ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000391893ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000391893ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000403703ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000403703ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000403703ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000403703ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000403703ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000248104ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000248104ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000248104ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000248104ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000248104ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000397464ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000397464ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000397464ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000397464ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000397464ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000402641ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000402641ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000402641ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000402641ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000402641ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000301712ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000301712ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000301712ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000301712ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000301712ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-3CDSENST00000503648ENST00000346128UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000503648ENST00000400011UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000503648ENST00000356107UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000503648ENST00000545208UNKLchr16

1421841

+TJP1chr15

30114706

-
intron-intronENST00000503648ENST00000495972UNKLchr16

1421841

+TJP1chr15

30114706

-

Top

FusionProtFeatures for UNKL_TJP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UNKL

Q9H9P5

TJP1

Q07157

May participate in a protein complex showing an E3ligase activity regulated by RAC1. Ubiquitination is directedtowards itself and possibly other substrates, such asSMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.{ECO:0000269|PubMed:20148946}. TJP1, TJP2, and TJP3 are closely related scaffoldingproteins that link tight junction (TJ) transmembrane proteins suchas claudins, junctional adhesion molecules, and occludin to theactin cytoskeleton (PubMed:7798316, PubMed:9792688). The tightjunction acts to limit movement of substances through theparacellular space and as a boundary between the compositionallydistinct apical and basolateral plasma membrane domains ofepithelial and endothelial cells. Necessary for lumenogenesis, andparticularly efficient epithelial polarization and barrierformation (By similarity). Plays a role in the regulation of cellmigration by targeting CDC42BPB to the leading edge of migratingcells (PubMed:21240187). Plays an important role in podosomeformation and associated function, thus regulating cell adhesionand matrix remodeling (PubMed:20930113). With TJP2 and TJP3,participates to the junctional retention and stability of thetranscription factor DBPA, but is not involved in its shuttling tothe nucleus (By similarity). {ECO:0000250|UniProtKB:O97758,ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for UNKL_TJP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for UNKL_TJP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UNKL_TJP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for UNKL_TJP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource