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Fusion gene ID: 40820 |
FusionGeneSummary for UNC5D_PRKAR2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UNC5D_PRKAR2B | Fusion gene ID: 40820 | Hgene | Tgene | Gene symbol | UNC5D | PRKAR2B | Gene ID | 137970 | 5577 |
| Gene name | unc-5 netrin receptor D | protein kinase cAMP-dependent type II regulatory subunit beta | |
| Synonyms | PRO34692|Unc5h4 | PRKAR2|RII-BETA | |
| Cytomap | 8p12 | 7q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | netrin receptor UNC5Dnetrin receptor Unc5h4protein unc-5 homolog 4protein unc-5 homolog Dunc-5 homolog 4unc-5 homolog D | cAMP-dependent protein kinase type II-beta regulatory subunitH_RG363E19.2WUGSC:H_RG363E19.2cAMP-dependent protein kinase type II-beta regulatory chainprotein kinase, cAMP-dependent, regulatory subunit type II betaprotein kinase, cAMP-dependent, regul | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | Q6UXZ4 | P31323 | |
| Ensembl transtripts involved in fusion gene | ENST00000287272, ENST00000453357, ENST00000404895, ENST00000420357, ENST00000416672, ENST00000449677, | ENST00000265717, ENST00000393613, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 5 X 3 X 5=75 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UNC5D [Title/Abstract] AND PRKAR2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UNC5D | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 26235030 |
| Tgene | PRKAR2B | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 21812984 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | T06404 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000287272 | ENST00000265717 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000287272 | ENST00000393613 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000453357 | ENST00000265717 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000453357 | ENST00000393613 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000404895 | ENST00000265717 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000404895 | ENST00000393613 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000420357 | ENST00000265717 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000420357 | ENST00000393613 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000416672 | ENST00000265717 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000416672 | ENST00000393613 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000449677 | ENST00000265717 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
| intron-intron | ENST00000449677 | ENST00000393613 | UNC5D | chr8 | 35317123 | - | PRKAR2B | chr7 | 106689677 | + |
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FusionProtFeatures for UNC5D_PRKAR2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UNC5D | PRKAR2B |
| Receptor for the netrin NTN4 that promotes neuronal cellsurvival (By similarity). Plays a role in cell-cell adhesion andcell guidance. Receptor for netrin involved in cell migration.Plays a role in axon guidance by mediating axon repulsion ofneuronal growth cones in the developing nervous system upon ligandbinding (By similarity). May play a role in apoptosis in responseto DNA damage (PubMed:24691657). It also acts as a dependencereceptor required for apoptosis induction when not associated withnetrin ligand (PubMed:24519068). Mediates cell-cell adhesion viaits interaction with FLRT3 on an adjacent cell (By similarity).{ECO:0000250|UniProtKB:Q8K1S2, ECO:0000305|PubMed:24519068,ECO:0000305|PubMed:24691657}. | Regulatory subunit of the cAMP-dependent protein kinasesinvolved in cAMP signaling in cells. Type II regulatory chainsmediate membrane association by binding to anchoring proteins,including the MAP2 kinase. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UNC5D_PRKAR2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UNC5D_PRKAR2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UNC5D_PRKAR2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UNC5D_PRKAR2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PRKAR2B | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | PRKAR2B | C0028754 | Obesity | 1 | CTD_human |
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