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Fusion gene ID: 40819 |
FusionGeneSummary for UNC5D_EIF4EBP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UNC5D_EIF4EBP1 | Fusion gene ID: 40819 | Hgene | Tgene | Gene symbol | UNC5D | EIF4EBP1 | Gene ID | 137970 | 1978 |
| Gene name | unc-5 netrin receptor D | eukaryotic translation initiation factor 4E binding protein 1 | |
| Synonyms | PRO34692|Unc5h4 | 4E-BP1|4EBP1|BP-1|PHAS-I | |
| Cytomap | 8p12 | 8p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | netrin receptor UNC5Dnetrin receptor Unc5h4protein unc-5 homolog 4protein unc-5 homolog Dunc-5 homolog 4unc-5 homolog D | eukaryotic translation initiation factor 4E-binding protein 1eIF4E-binding protein 1phosphorylated heat- and acid-stable protein regulated by insulin 1 | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | Q6UXZ4 | Q13541 | |
| Ensembl transtripts involved in fusion gene | ENST00000287272, ENST00000453357, ENST00000404895, ENST00000420357, ENST00000416672, ENST00000449677, | ENST00000338825, ENST00000520657, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 9 X 1 X 5=45 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/45*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UNC5D [Title/Abstract] AND EIF4EBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UNC5D | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 26235030 |
| Tgene | EIF4EBP1 | GO:0031929 | TOR signaling | 12150926|22578813 |
| Tgene | EIF4EBP1 | GO:0045947 | negative regulation of translational initiation | 22578813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-J9-A8CP-01A | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000287272 | ENST00000338825 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 5CDS-3UTR | ENST00000287272 | ENST00000520657 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3CDS | ENST00000453357 | ENST00000338825 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3UTR | ENST00000453357 | ENST00000520657 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| In-frame | ENST00000404895 | ENST00000338825 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 5CDS-3UTR | ENST00000404895 | ENST00000520657 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| In-frame | ENST00000420357 | ENST00000338825 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 5CDS-3UTR | ENST00000420357 | ENST00000520657 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| In-frame | ENST00000416672 | ENST00000338825 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 5CDS-3UTR | ENST00000416672 | ENST00000520657 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3CDS | ENST00000449677 | ENST00000338825 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3UTR | ENST00000449677 | ENST00000520657 | UNC5D | chr8 | 35093405 | + | EIF4EBP1 | chr8 | 37914599 | + |
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FusionProtFeatures for UNC5D_EIF4EBP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UNC5D | EIF4EBP1 |
| Receptor for the netrin NTN4 that promotes neuronal cellsurvival (By similarity). Plays a role in cell-cell adhesion andcell guidance. Receptor for netrin involved in cell migration.Plays a role in axon guidance by mediating axon repulsion ofneuronal growth cones in the developing nervous system upon ligandbinding (By similarity). May play a role in apoptosis in responseto DNA damage (PubMed:24691657). It also acts as a dependencereceptor required for apoptosis induction when not associated withnetrin ligand (PubMed:24519068). Mediates cell-cell adhesion viaits interaction with FLRT3 on an adjacent cell (By similarity).{ECO:0000250|UniProtKB:Q8K1S2, ECO:0000305|PubMed:24519068,ECO:0000305|PubMed:24691657}. | Repressor of translation initiation that regulates EIF4Eactivity by preventing its assembly into the eIF4F complex:hypophosphorylated form competes with EIF4G1/EIF4G3 and stronglybinds to EIF4E, leading to repress translation. In contrast,hyperphosphorylated form dissociates from EIF4E, allowinginteraction between EIF4G1/EIF4G3 and EIF4E, leading to initiationof translation. Mediates the regulation of protein translation byhormones, growth factors and other stimuli that signal through theMAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813,ECO:0000269|PubMed:7935836}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >EIF4EBP1 | chr8:35093405 | chr8:37914599 | ENST00000338825 | + | 0 | 3 | 114_118 | 48 | 119 | Motif | TOS motif |
| Tgene | >EIF4EBP1 | chr8:35093405 | chr8:37914599 | ENST00000338825 | + | 0 | 3 | 54_60 | 48 | 119 | Motif | YXXXXLphi motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 153_244 | 34 | 954 | Domain | Note=Ig-like C2-type |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 252_306 | 34 | 954 | Domain | TSP type-1 1 |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 308_360 | 34 | 954 | Domain | TSP type-1 2 |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 542_682 | 34 | 954 | Domain | ZU5 |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 54_151 | 34 | 954 | Domain | Note=Ig-like |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 859_936 | 34 | 954 | Domain | Note=Death |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 153_244 | -19 | 949 | Domain | Note=Ig-like C2-type |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 252_306 | -19 | 949 | Domain | TSP type-1 1 |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 308_360 | -19 | 949 | Domain | TSP type-1 2 |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 542_682 | -19 | 949 | Domain | ZU5 |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 54_151 | -19 | 949 | Domain | Note=Ig-like |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 859_936 | -19 | 949 | Domain | Note=Death |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 33_379 | 34 | 954 | Topological domain | Extracellular |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 401_953 | 34 | 954 | Topological domain | Cytoplasmic |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 33_379 | -19 | 949 | Topological domain | Extracellular |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 401_953 | -19 | 949 | Topological domain | Cytoplasmic |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000404895 | + | 1 | 17 | 380_400 | 34 | 954 | Transmembrane | Helical |
| Hgene | >UNC5D | chr8:35093405 | chr8:37914599 | ENST00000453357 | + | 1 | 17 | 380_400 | -19 | 949 | Transmembrane | Helical |
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FusionGeneSequence for UNC5D_EIF4EBP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UNC5D_ENST00000287272_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_105aa MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPED >In-frame_UNC5D_ENST00000404895_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_105aa MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPED >In-frame_UNC5D_ENST00000420357_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_105aa MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPED >In-frame_UNC5D_ENST00000416672_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_105aa MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPED |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UNC5D_ENST00000287272_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_315nt ATGGGGAGAGCGGCGGCCACCGCAGGCGGCGGCGGAGGGGCGCGCCGCTGGCTCCCGTGGCTGGGGCTGTGCTTCTGGGCGGCAGGGACC GCGGCTGCCCGAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGAT CTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGAT >In-frame_UNC5D_ENST00000404895_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_315nt ATGGGGAGAGCGGCGGCCACCGCAGGCGGCGGCGGAGGGGCGCGCCGCTGGCTCCCGTGGCTGGGGCTGTGCTTCTGGGCGGCAGGGACC GCGGCTGCCCGAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGAT CTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGAT >In-frame_UNC5D_ENST00000420357_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_315nt ATGGGGAGAGCGGCGGCCACCGCAGGCGGCGGCGGAGGGGCGCGCCGCTGGCTCCCGTGGCTGGGGCTGTGCTTCTGGGCGGCAGGGACC GCGGCTGCCCGAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGAT CTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGAT >In-frame_UNC5D_ENST00000416672_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_315nt ATGGGGAGAGCGGCGGCCACCGCAGGCGGCGGCGGAGGGGCGCGCCGCTGGCTCCCGTGGCTGGGGCTGTGCTTCTGGGCGGCAGGGACC GCGGCTGCCCGAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGAT CTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UNC5D_ENST00000287272_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_765nt TCCGGAACGCGGCGAGGAGCATGGGGAGAGCGGCGGCCACCGCAGGCGGCGGCGGAGGGGCGCGCCGCTGGCTCCCGTGGCTGGGGCTGT GCTTCTGGGCGGCAGGGACCGCGGCTGCCCGAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGA CCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACC TGCGCAATAGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGATGGACATTTAAAGCACCAGCCATCGTGTGGAGCACT ACCAAGGGGCCCCTCAGGGCCTTCCTGGGAGGAGTCCCACCAGCCAGGCCTTATGAAAGTGATCATACTGGGCAGGCGTTGGCGTGGGGT CGGACACCCCAGCCCTTTCTCCCTCACTCAGGGCACCTGCCCCCTCCTCTTCGTGAACACCAGCAGATACCTCCTTGTGCCTCCACTGAT GCAGGAGCTGCCACCCCAAGGGGAGTGACCCCTGCCAGCACACCCTGCAGCCAAGGGCCAGGAAGTGGACAAGAACGAACCCTTCCTTCC GAATGATCAGCAGTTCCAGCCCCTCGCTGCTGGGGGCGCAACCACCCCTTCCTTAGGTTGATGTGCTTGGGAAAGCTCCCTCCCCCTCCT >In-frame_UNC5D_ENST00000404895_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_1073nt CGGACTCTCGCCTCCGCTCCGTAGTTCGGGGCCCGGCAGCGGCGCGAGGGCTGGGAACTGCGCGGCGGGGACTGCGGGCGACTCCGGCAT CCGCGCTGGCGGCAGCGGTCGCCGCGCCGTGGGAAGCTATGGGGACGCGCCCTTTCTCGGGGTGCCCATTCAGCGGCGGCTCGGAGCTCC CTGCCCCGCTGCTTTAGGAAGCGATCGTGGAGCAGAGTCACTCTCTGAAGACTCCCGAGACCCATTCGACTCGGGACCCTCATCGCCGAC CCTTTCCCGGGCTCCCGGAGCGTGAAGAAGAGCCGCCCTCCGGAACGCGGCGAGGAGCATGGGGAGAGCGGCGGCCACCGCAGGCGGCGG CGGAGGGGCGCGCCGCTGGCTCCCGTGGCTGGGGCTGTGCTTCTGGGCGGCAGGGACCGCGGCTGCCCGAGGTACCAGGATCATCTATGA CCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTC CAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGA GATGGACATTTAAAGCACCAGCCATCGTGTGGAGCACTACCAAGGGGCCCCTCAGGGCCTTCCTGGGAGGAGTCCCACCAGCCAGGCCTT ATGAAAGTGATCATACTGGGCAGGCGTTGGCGTGGGGTCGGACACCCCAGCCCTTTCTCCCTCACTCAGGGCACCTGCCCCCTCCTCTTC GTGAACACCAGCAGATACCTCCTTGTGCCTCCACTGATGCAGGAGCTGCCACCCCAAGGGGAGTGACCCCTGCCAGCACACCCTGCAGCC AAGGGCCAGGAAGTGGACAAGAACGAACCCTTCCTTCCGAATGATCAGCAGTTCCAGCCCCTCGCTGCTGGGGGCGCAACCACCCCTTCC >In-frame_UNC5D_ENST00000420357_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_765nt TCCGGAACGCGGCGAGGAGCATGGGGAGAGCGGCGGCCACCGCAGGCGGCGGCGGAGGGGCGCGCCGCTGGCTCCCGTGGCTGGGGCTGT GCTTCTGGGCGGCAGGGACCGCGGCTGCCCGAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGA CCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACC TGCGCAATAGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGATGGACATTTAAAGCACCAGCCATCGTGTGGAGCACT ACCAAGGGGCCCCTCAGGGCCTTCCTGGGAGGAGTCCCACCAGCCAGGCCTTATGAAAGTGATCATACTGGGCAGGCGTTGGCGTGGGGT CGGACACCCCAGCCCTTTCTCCCTCACTCAGGGCACCTGCCCCCTCCTCTTCGTGAACACCAGCAGATACCTCCTTGTGCCTCCACTGAT GCAGGAGCTGCCACCCCAAGGGGAGTGACCCCTGCCAGCACACCCTGCAGCCAAGGGCCAGGAAGTGGACAAGAACGAACCCTTCCTTCC GAATGATCAGCAGTTCCAGCCCCTCGCTGCTGGGGGCGCAACCACCCCTTCCTTAGGTTGATGTGCTTGGGAAAGCTCCCTCCCCCTCCT >In-frame_UNC5D_ENST00000416672_chr8_35093405_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_755nt GGCGAGGAGCATGGGGAGAGCGGCGGCCACCGCAGGCGGCGGCGGAGGGGCGCGCCGCTGGCTCCCGTGGCTGGGGCTGTGCTTCTGGGC GGCAGGGACCGCGGCTGCCCGAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACC CCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAG CCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGATGGACATTTAAAGCACCAGCCATCGTGTGGAGCACTACCAAGGGGC CCCTCAGGGCCTTCCTGGGAGGAGTCCCACCAGCCAGGCCTTATGAAAGTGATCATACTGGGCAGGCGTTGGCGTGGGGTCGGACACCCC AGCCCTTTCTCCCTCACTCAGGGCACCTGCCCCCTCCTCTTCGTGAACACCAGCAGATACCTCCTTGTGCCTCCACTGATGCAGGAGCTG CCACCCCAAGGGGAGTGACCCCTGCCAGCACACCCTGCAGCCAAGGGCCAGGAAGTGGACAAGAACGAACCCTTCCTTCCGAATGATCAG CAGTTCCAGCCCCTCGCTGCTGGGGGCGCAACCACCCCTTCCTTAGGTTGATGTGCTTGGGAAAGCTCCCTCCCCCTCCTTCCCCAAGAG |
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FusionGenePPI for UNC5D_EIF4EBP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UNC5D | EIF4EBP1 | CHTF8, EIF4E, UBAC1, ATM, MTOR, LRPAP1, PPP2R2A, RPTOR, GSK3B, IRAK4, PRKCA, KLHL25, MAPK1, AGO2, LRRK2, MAPK14, STK3, PPP2R4, PRKDC, LATS1, SLMAP, MLST8, REL, TCF4, AKT2, AKT3, CCDC94, CHMP2A, DDX1, FLNB, GGA1, HNRNPA1, SHMT2, HNRNPAB, AKT1, BUB1, MAPKAPK5, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UNC5D_EIF4EBP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UNC5D_EIF4EBP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | EIF4EBP1 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | EIF4EBP1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | EIF4EBP1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | EIF4EBP1 | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |
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