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Fusion gene ID: 40818 |
FusionGeneSummary for UNC5C_UNC5C |
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Fusion gene information | Fusion gene name: UNC5C_UNC5C | Fusion gene ID: 40818 | Hgene | Tgene | Gene symbol | UNC5C | UNC5C | Gene ID | 8633 | 8633 |
Gene name | unc-5 netrin receptor C | unc-5 netrin receptor C | |
Synonyms | UNC5H3 | UNC5H3 | |
Cytomap | 4q22.3 | 4q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | netrin receptor UNC5Cprotein unc-5 homolog 3protein unc-5 homolog Cunc-5 homolog 3unc-5 homolog Cunc5 (C.elegans homolog) c | netrin receptor UNC5Cprotein unc-5 homolog 3protein unc-5 homolog Cunc-5 homolog 3unc-5 homolog Cunc5 (C.elegans homolog) c | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O95185 | O95185 | |
Ensembl transtripts involved in fusion gene | ENST00000453304, ENST00000506749, ENST00000504962, | ENST00000453304, ENST00000506749, ENST00000504962, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: UNC5C [Title/Abstract] AND UNC5C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA319525 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000453304 | ENST00000453304 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
intron-intron | ENST00000453304 | ENST00000506749 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
intron-intron | ENST00000453304 | ENST00000504962 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
intron-intron | ENST00000506749 | ENST00000453304 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
intron-intron | ENST00000506749 | ENST00000506749 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
intron-intron | ENST00000506749 | ENST00000504962 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
intron-intron | ENST00000504962 | ENST00000453304 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
intron-intron | ENST00000504962 | ENST00000506749 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
intron-intron | ENST00000504962 | ENST00000504962 | UNC5C | chr4 | 96366346 | - | UNC5C | chr4 | 96368571 | - |
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FusionProtFeatures for UNC5C_UNC5C |
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Hgene | Tgene |
UNC5C | UNC5C |
Receptor for netrin required for axon guidance. Mediatesaxon repulsion of neuronal growth cones in the developing nervoussystem upon ligand binding. Axon repulsion in growth cones may becaused by its association with DCC that may trigger signaling forrepulsion. Also involved in corticospinal tract axon guidancesindependently of DCC. It also acts as a dependence receptorrequired for apoptosis induction when not associated with netrinligand. {ECO:0000250|UniProtKB:O08747}. | Receptor for netrin required for axon guidance. Mediatesaxon repulsion of neuronal growth cones in the developing nervoussystem upon ligand binding. Axon repulsion in growth cones may becaused by its association with DCC that may trigger signaling forrepulsion. Also involved in corticospinal tract axon guidancesindependently of DCC. It also acts as a dependence receptorrequired for apoptosis induction when not associated with netrinligand. {ECO:0000250|UniProtKB:O08747}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UNC5C_UNC5C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UNC5C_UNC5C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UNC5C_UNC5C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UNC5C_UNC5C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | UNC5C | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | UNC5C | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | UNC5C | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | UNC5C | C0036341 | Schizophrenia | 1 | PSYGENET |