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Fusion gene ID: 40817 |
FusionGeneSummary for UNC5C_RAP1GDS1 |
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Fusion gene information | Fusion gene name: UNC5C_RAP1GDS1 | Fusion gene ID: 40817 | Hgene | Tgene | Gene symbol | UNC5C | RAP1GDS1 | Gene ID | 8633 | 5910 |
Gene name | unc-5 netrin receptor C | Rap1 GTPase-GDP dissociation stimulator 1 | |
Synonyms | UNC5H3 | GDS1|SmgGDS | |
Cytomap | 4q22.3 | 4q23 | |
Type of gene | protein-coding | protein-coding | |
Description | netrin receptor UNC5Cprotein unc-5 homolog 3protein unc-5 homolog Cunc-5 homolog 3unc-5 homolog Cunc5 (C.elegans homolog) c | rap1 GTPase-GDP dissociation stimulator 1RAP1, GTP-GDP dissociation stimulator 1SMG GDS proteinSMG P21 stimulatory GDP/GTP exchange proteinexchange factor smgGDS | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O95185 | P52306 | |
Ensembl transtripts involved in fusion gene | ENST00000453304, ENST00000506749, ENST00000504962, | ENST00000380158, ENST00000264572, ENST00000408927, ENST00000512857, ENST00000453712, ENST00000339360, ENST00000408900, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 3 X 5 X 1=15 |
# samples | 3 | 5 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: UNC5C [Title/Abstract] AND RAP1GDS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA588240 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000453304 | ENST00000380158 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-intron | ENST00000453304 | ENST00000264572 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-intron | ENST00000453304 | ENST00000408927 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000453304 | ENST00000512857 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000453304 | ENST00000453712 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000453304 | ENST00000339360 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000453304 | ENST00000408900 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
Frame-shift | ENST00000506749 | ENST00000380158 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-intron | ENST00000506749 | ENST00000264572 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-intron | ENST00000506749 | ENST00000408927 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000506749 | ENST00000512857 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000506749 | ENST00000453712 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000506749 | ENST00000339360 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000506749 | ENST00000408900 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
Frame-shift | ENST00000504962 | ENST00000380158 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-intron | ENST00000504962 | ENST00000264572 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-intron | ENST00000504962 | ENST00000408927 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000504962 | ENST00000512857 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000504962 | ENST00000453712 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000504962 | ENST00000339360 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
5CDS-3UTR | ENST00000504962 | ENST00000408900 | UNC5C | chr4 | 96469885 | - | RAP1GDS1 | chr4 | 99313101 | + |
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FusionProtFeatures for UNC5C_RAP1GDS1 |
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Hgene | Tgene |
UNC5C | RAP1GDS1 |
Receptor for netrin required for axon guidance. Mediatesaxon repulsion of neuronal growth cones in the developing nervoussystem upon ligand binding. Axon repulsion in growth cones may becaused by its association with DCC that may trigger signaling forrepulsion. Also involved in corticospinal tract axon guidancesindependently of DCC. It also acts as a dependence receptorrequired for apoptosis induction when not associated with netrinligand. {ECO:0000250|UniProtKB:O08747}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UNC5C_RAP1GDS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UNC5C_RAP1GDS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UNC5C | NPM1, NTRK1, DAPK1, TMEM17 | RAP1GDS1 | NRAS, RHOA, RAP1A, HRAS, KRAS, RAC1, MBIP, ZNF451, KIFAP3, EGFR, CDC42, DCPS, GAPDH, GINS3, HSPA1L, NAE1, OLA1, PAFAH1B2, PPP1R2, PTMA, ABHD14A, ASNS, CAPN1, ECHS1, GMDS, GSS, HSPA5, HSPA9, MSN, PDIA4, PFAS, PPP5C, TATDN1, UBQLN1, USP14, VCL, YWHAE, DOC2A, PLEKHB1, MOV10, DIRAS3, RAB34, RASD2, HDAC7, APBB2, RAB1B, SNX24, GNAI1, GNAZ, SEPT12, TSC22D4, RAB31, RASL10A, SEPT6, BAIAP2, HSPB9, C2orf48, UNC45A, NTRK1, PUF60, CDK2, DUSP23, DIRAS1, UBTF, DIRAS2, RAC3, PRDM10, RAP2C, RAP1B, DNAL1, RHOF, RHOC, RAB15, RABL3, RBM42, IRGC, VASH1, NKIRAS2, IL13RA1, RAC2, ARL4C, NT5C, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UNC5C_RAP1GDS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UNC5C_RAP1GDS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | UNC5C | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | UNC5C | C0036341 | Schizophrenia | 1 | PSYGENET |