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Fusion gene ID: 40813 |
FusionGeneSummary for UNC5B_ADAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UNC5B_ADAP2 | Fusion gene ID: 40813 | Hgene | Tgene | Gene symbol | UNC5B | ADAP2 | Gene ID | 219699 | 55803 |
| Gene name | unc-5 netrin receptor B | ArfGAP with dual PH domains 2 | |
| Synonyms | UNC5H2|p53RDL1 | CENTA2|HSA272195|cent-b | |
| Cytomap | 10q22.1 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | netrin receptor UNC5Bp53-regulated receptor for death and life protein 1protein unc-5 homolog 2protein unc-5 homolog Btransmembrane receptor Unc5H2unc-5 homolog 2unc-5 homolog B | arf-GAP with dual PH domain-containing protein 2centaurin betacentaurin-alpha 2 protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IZJ1 | Q9NPF8 | |
| Ensembl transtripts involved in fusion gene | ENST00000335350, ENST00000373192, | ENST00000583688, ENST00000330889, ENST00000580525, | |
| Fusion gene scores | * DoF score | 3 X 6 X 3=54 | 5 X 3 X 5=75 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/54*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UNC5B [Title/Abstract] AND ADAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-TS-A7OZ-01A | UNC5B | chr10 | 73047522 | + | ADAP2 | chr17 | 29271925 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000335350 | ENST00000583688 | UNC5B | chr10 | 73047522 | + | ADAP2 | chr17 | 29271925 | + |
| 5CDS-intron | ENST00000335350 | ENST00000330889 | UNC5B | chr10 | 73047522 | + | ADAP2 | chr17 | 29271925 | + |
| 5CDS-intron | ENST00000335350 | ENST00000580525 | UNC5B | chr10 | 73047522 | + | ADAP2 | chr17 | 29271925 | + |
| 5CDS-intron | ENST00000373192 | ENST00000583688 | UNC5B | chr10 | 73047522 | + | ADAP2 | chr17 | 29271925 | + |
| 5CDS-intron | ENST00000373192 | ENST00000330889 | UNC5B | chr10 | 73047522 | + | ADAP2 | chr17 | 29271925 | + |
| 5CDS-intron | ENST00000373192 | ENST00000580525 | UNC5B | chr10 | 73047522 | + | ADAP2 | chr17 | 29271925 | + |
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FusionProtFeatures for UNC5B_ADAP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UNC5B | ADAP2 |
| Receptor for netrin required for axon guidance. Mediatesaxon repulsion of neuronal growth cones in the developing nervoussystem upon ligand binding. Axon repulsion in growth cones may becaused by its association with DCC that may trigger signaling forrepulsion (By similarity). Functions as netrin receptor thatnegatively regulates vascular branching during angiogenesis.Mediates retraction of tip cell filopodia on endothelial growthcones in response to netrin (By similarity). It also acts as adependence receptor required for apoptosis induction when notassociated with netrin ligand (PubMed:12598906). Mediatesapoptosis by activating DAPK1. In the absence of NTN1, activatesDAPK1 by reducing its autoinhibitory phosphorylation at Ser-308thereby increasing its catalytic activity (By similarity).{ECO:0000250|UniProtKB:O08722, ECO:0000250|UniProtKB:Q8K1S3,ECO:0000269|PubMed:12598906}. | GTPase-activating protein for the ADP ribosylationfactor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate(InsP4). Possesses a stoichiometry of two binding sites for InsP4with identical affinity. {ECO:0000269|PubMed:14690521,ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UNC5B_ADAP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UNC5B_ADAP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UNC5B | TUBG1, PPP2R1B, DAPK1, PPP2CA, KIAA1524, NTRK1, TMEM17, TMEM216, LRRIQ1 | ADAP2 | EEF1G, IKBKG, SNCA, NEDD4L, PRNP, APP, RANBP9, NCL, KCTD10, MICA, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UNC5B_ADAP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UNC5B_ADAP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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