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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40809

FusionGeneSummary for UNC50_UBA6

check button Fusion gene summary
Fusion gene informationFusion gene name: UNC50_UBA6
Fusion gene ID: 40809
HgeneTgene
Gene symbol

UNC50

UBA6

Gene ID

25972

55236

Gene nameunc-50 inner nuclear membrane RNA binding proteinubiquitin like modifier activating enzyme 6
SynonymsGMH1|HSD23|PDLs22|UNCL|URPE1-L2|MOP-4|UBE1L2
Cytomap

2q11.2

4q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein unc-50 homologgeal-6 membrane-associated high-copy suppressor 1periodontal ligament-specific protein 22protein GMH1 homologunc-50 relatedunc-50-like proteinuncoordinated-like proteinubiquitin-like modifier-activating enzyme 6UBA6, ubiquitin-activating enzyme E1monocyte protein 4ubiquitin-activating enzyme 6ubiquitin-activating enzyme E1-like 2ubiquitin-activating enzyme E1-like protein 2
Modification date2018052320180523
UniProtAcc

Q53HI1

A0AVT1

Ensembl transtripts involved in fusion geneENST00000409975, ENST00000357765, 
ENST00000409347, 
ENST00000322244, 
ENST00000420827, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 2=18
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UNC50 [Title/Abstract] AND UBA6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP365839UNC50chr2

99226393

+UBA6chr4

68543378

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000409975ENST00000322244UNC50chr2

99226393

+UBA6chr4

68543378

-
Frame-shiftENST00000409975ENST00000420827UNC50chr2

99226393

+UBA6chr4

68543378

-
Frame-shiftENST00000357765ENST00000322244UNC50chr2

99226393

+UBA6chr4

68543378

-
Frame-shiftENST00000357765ENST00000420827UNC50chr2

99226393

+UBA6chr4

68543378

-
Frame-shiftENST00000409347ENST00000322244UNC50chr2

99226393

+UBA6chr4

68543378

-
Frame-shiftENST00000409347ENST00000420827UNC50chr2

99226393

+UBA6chr4

68543378

-

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FusionProtFeatures for UNC50_UBA6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UNC50

Q53HI1

UBA6

A0AVT1

May be involved in cell surface expression of neuronalnicotinic receptors. Binds RNA (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UNC50_UBA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UNC50_UBA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UNC50_UBA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UNC50_UBA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource