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Fusion gene ID: 40772 |
FusionGeneSummary for ULK4_PAQR3 |
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Fusion gene information | Fusion gene name: ULK4_PAQR3 | Fusion gene ID: 40772 | Hgene | Tgene | Gene symbol | ULK4 | PAQR3 | Gene ID | 54986 | 152559 |
Gene name | unc-51 like kinase 4 | progestin and adipoQ receptor family member 3 | |
Synonyms | FAM7C1|REC01035 | RKTG | |
Cytomap | 3p22.1 | 4q21.21 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase ULK4 | progestin and adipoQ receptor family member 3Raf kinase trapping to Golgiprogestin and adipoQ receptor family member III | |
Modification date | 20180519 | 20180520 | |
UniProtAcc | Q96C45 | Q6TCH7 | |
Ensembl transtripts involved in fusion gene | ENST00000301831, ENST00000420927, ENST00000489118, ENST00000414606, | ENST00000295462, ENST00000512733, ENST00000515541, ENST00000380645, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 3=27 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ULK4 [Title/Abstract] AND PAQR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PAQR3 | GO:0001933 | negative regulation of protein phosphorylation | 17724343 |
Tgene | PAQR3 | GO:0010977 | negative regulation of neuron projection development | 17724343 |
Tgene | PAQR3 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 17724343 |
Tgene | PAQR3 | GO:0043407 | negative regulation of MAP kinase activity | 17724343 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW812700 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000301831 | ENST00000295462 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000301831 | ENST00000512733 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000301831 | ENST00000515541 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000301831 | ENST00000380645 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000420927 | ENST00000295462 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000420927 | ENST00000512733 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000420927 | ENST00000515541 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000420927 | ENST00000380645 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000489118 | ENST00000295462 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000489118 | ENST00000512733 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000489118 | ENST00000515541 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000489118 | ENST00000380645 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000414606 | ENST00000295462 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000414606 | ENST00000512733 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000414606 | ENST00000515541 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
intron-intron | ENST00000414606 | ENST00000380645 | ULK4 | chr3 | 41977686 | - | PAQR3 | chr4 | 79851809 | + |
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FusionProtFeatures for ULK4_PAQR3 |
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Hgene | Tgene |
ULK4 | PAQR3 |
May be involved in the remodeling of cytoskeletalcomponents, such as alpha-tubulin, and in this way regulatesneurite branching and elongation, as well as cell motility.{ECO:0000269|PubMed:24284070}. | Functions as a spatial regulator of RAF1 kinase bysequestrating it to the Golgi. {ECO:0000269|PubMed:18547165}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ULK4_PAQR3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ULK4_PAQR3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ULK4_PAQR3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ULK4_PAQR3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ULK4 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | ULK4 | C0026764 | Multiple Myeloma | 1 | CTD_human |
Hgene | ULK4 | C0036341 | Schizophrenia | 1 | PSYGENET |