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Fusion gene ID: 40762 |
FusionGeneSummary for ULK1_TCTN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ULK1_TCTN1 | Fusion gene ID: 40762 | Hgene | Tgene | Gene symbol | ULK1 | TCTN1 | Gene ID | 8408 | 79600 |
| Gene name | unc-51 like autophagy activating kinase 1 | tectonic family member 1 | |
| Synonyms | ATG1|ATG1A|UNC51|Unc51.1|hATG1 | JBTS13|TECT1 | |
| Cytomap | 12q24.33 | 12q24.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase ULK1ATG1 autophagy related 1 homologautophagy-related protein 1 homolog | tectonic-1 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | O75385 | Q2MV58 | |
| Ensembl transtripts involved in fusion gene | ENST00000321867, ENST00000540647, | ENST00000550703, ENST00000551590, ENST00000397655, ENST00000471804, ENST00000377654, ENST00000397659, ENST00000551555, | |
| Fusion gene scores | * DoF score | 5 X 7 X 5=175 | 3 X 3 X 2=18 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ULK1 [Title/Abstract] AND TCTN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ULK1 | GO:0006914 | autophagy | 18936157 |
| Hgene | ULK1 | GO:0018105 | peptidyl-serine phosphorylation | 25126726|27103069 |
| Hgene | ULK1 | GO:0018107 | peptidyl-threonine phosphorylation | 27103069 |
| Hgene | ULK1 | GO:0031333 | negative regulation of protein complex assembly | 25126726 |
| Hgene | ULK1 | GO:0046777 | protein autophosphorylation | 18936157 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-3B-A9HO-01A | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000321867 | ENST00000550703 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| In-frame | ENST00000321867 | ENST00000551590 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| In-frame | ENST00000321867 | ENST00000397655 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| 5CDS-intron | ENST00000321867 | ENST00000471804 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| 5CDS-5UTR | ENST00000321867 | ENST00000377654 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| 5CDS-5UTR | ENST00000321867 | ENST00000397659 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| 5CDS-3UTR | ENST00000321867 | ENST00000551555 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| intron-3CDS | ENST00000540647 | ENST00000550703 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| intron-3CDS | ENST00000540647 | ENST00000551590 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| intron-3CDS | ENST00000540647 | ENST00000397655 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| intron-intron | ENST00000540647 | ENST00000471804 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| intron-5UTR | ENST00000540647 | ENST00000377654 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| intron-5UTR | ENST00000540647 | ENST00000397659 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
| intron-3UTR | ENST00000540647 | ENST00000551555 | ULK1 | chr12 | 132399966 | + | TCTN1 | chr12 | 111066572 | + |
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FusionProtFeatures for ULK1_TCTN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ULK1 | TCTN1 |
| Serine/threonine-protein kinase involved in autophagy inresponse to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, theprecursors of autophagosomes. Part of regulatory feedback loops inautophagy: acts both as a downstream effector and negativeregulator of mammalian target of rapamycin complex 1 (mTORC1) viainteraction with RPTOR. Activated via phosphorylation by AMPK andalso acts as a regulator of AMPK by mediating phosphorylation ofAMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negativelyregulate AMPK activity. May phosphorylate ATG13/KIAA0652 andRPTOR; however such data need additional evidences. Plays a roleearly in neuronal differentiation and is required for granule cellaxon formation. May also phosphorylate SESN2 and SQSTM1 toregulate autophagy (PubMed:25040165).{ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634,ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:25040165}. | Component of the tectonic-like complex, a complexlocalized at the transition zone of primary cilia and acting as abarrier that prevents diffusion of transmembrane proteins betweenthe cilia and plasma membranes. Regulator of Hedgehog (Hh),required for both activation and inhibition of the Hh pathway inthe patterning of the neural tube. During neural tube development,it is required for formation of the most ventral cell types andfor full Hh pathway activation. Functions in Hh signaltransduction to fully activate the pathway in the presence of highHh levels and to repress the pathway in the absence of Hh signals.Modulates Hh signal transduction downstream of SMO and RAB23 (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ULK1_TCTN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ULK1_ENST00000321867_chr12_132399966_+_TCTN1_ENST00000551590_chr12_111066572_+_967aa MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYL VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFD EFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQS PTQFQTPRSSAIRRSGSTSPLGFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPDKPA LSFINPEVPDENNFDTLMKTSDGFTLNAESYVSFTTKLDIPTAAKYEYGVPLQTSDSFLRFPSSLTSSLCTDNNPAAFLVNQAVKCTRKI NLEQCEEIEALSMAFYSSPEILRVPDSRKKVPITVQSIVIQSLNKTLTRREDTDVLQPTLVNAGHFSLCVNVVLEVKYSLTYTDAGEVTK ADLSFVLGTVSSVVVPLQQKFEIHFLQENTQPVPLSGNPGYVVGLPLAAGFQPHKGSGIIQTTNRYGQLTILHSTTEQDCLALEGVRTPV LFGYTMQSGCKLRLTGALPCQLVAQKVKSLLWGQGFPDYVAPFGNSQAQDMLDWVPIHFITQSFNRKDSCQLPGALVIEVKWTKYGSLLN >In-frame_ULK1_ENST00000321867_chr12_132399966_+_TCTN1_ENST00000397655_chr12_111066572_+_953aa MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYL VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFD EFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQS PTQFQTPRSSAIRRSGSTSPLGFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPDKPA LSFINPEVPDENNFDTLMKTSDGFTLNAESYVSFTTKLDIPTAAKYEYGVPLQTSDSFLRFPSSLTSSLCTDNNPAGQAYWFTPVIPALW EAEARGSLEVPDSRKKVPITVQSIVIQSLNKTLTRREDTDVLQPTLVNAGHFSLCVNVVLEVKYSLTYTDAGEVTKADLSFVLGTVSSVV VPLQQKFEIHFLQENTQPVPLSGNPGYVVGLPLAAGFQPHKGSGIIQTTNRYGQLTILHSTTEQDCLALEGVRTPVLFGYTMQSGCKLRL TGALPCQLVAQKVKSLLWGQGFPDYVAPFGNSQAQDMLDWVPIHFITQSFNRKDSCQLPGALVIEVKWTKYGSLLNPQAKIVNVTANLIS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ULK1_ENST00000321867_chr12_132399966_+_TCTN1_ENST00000551590_chr12_111066572_+_2901nt ATGGAGCCCGGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTC TTCAAGGGCCGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTG GGGAAGGAAATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTG GTTATGGAGTACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAG CAGATCGCGGGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCC GGCCGCCGCGCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACA CTCTGCGGCTCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATC GTCTACCAGTGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTC CCCACCATCCCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGAT GAGTTTTTTCATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCC GGCAGCAGCTCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCC CCGGCTGACACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTC CCCGCGCAGTTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTG GCCTCTGCGGGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCG TTCTCCAGCAGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCA CCCACCCAGTTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCC CCTGCCCACGCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACC ATCCCTGAGCGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGATAAACCTGCA TTATCCTTTATTAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAAACATCTGATGGTTTTACATTGAATGCTGAATCA TATGTTTCCTTCACAACCAAACTGGATATTCCTACTGCTGCTAAATATGAGTATGGGGTTCCTCTGCAGACTTCAGATTCGTTTCTGAGA TTTCCTTCGTCCCTGACATCATCTCTGTGCACTGATAATAACCCTGCAGCGTTTCTGGTGAACCAGGCTGTTAAGTGCACCAGAAAAATA AATTTAGAACAGTGTGAAGAAATTGAAGCCCTCAGCATGGCTTTTTACAGCAGCCCGGAAATTCTGAGGGTACCTGATTCAAGAAAAAAG GTCCCTATCACTGTTCAGTCCATCGTCATTCAGTCTCTAAATAAAACGCTCACCCGACGGGAGGACACTGATGTGCTGCAGCCGACTCTC GTCAACGCTGGACACTTTAGCCTTTGCGTGAATGTTGTTCTTGAGGTAAAGTACAGCCTCACATACACAGATGCAGGTGAAGTCACCAAA GCTGATCTCTCATTCGTTCTGGGGACAGTTAGCAGCGTAGTGGTCCCACTGCAGCAAAAGTTTGAAATTCATTTTCTTCAGGAAAATACC CAGCCAGTCCCTCTCAGTGGAAACCCTGGTTATGTCGTGGGGCTCCCATTAGCTGCTGGATTCCAGCCTCATAAGGGGTCTGGGATTATT CAGACCACAAATAGATATGGACAGCTTACTATTCTTCATAGCACAACTGAGCAAGACTGCTTAGCACTGGAGGGGGTCCGGACCCCAGTA TTATTTGGTTACACTATGCAATCTGGCTGTAAACTAAGACTGACTGGAGCTCTCCCGTGTCAGCTCGTAGCACAGAAGGTGAAGAGCCTG CTGTGGGGCCAGGGCTTCCCAGATTACGTGGCCCCTTTTGGAAATTCCCAGGCCCAGGACATGCTGGACTGGGTGCCCATCCACTTCATC ACCCAGTCATTCAACAGGAAGGATTCCTGCCAGCTCCCAGGGGCTTTGGTTATAGAAGTGAAGTGGACTAAATACGGATCCCTGCTGAAT CCACAGGCCAAAATAGTCAATGTAACTGCAAATCTAATTTCATCCTCCTTTCCTGAGGCCAACTCAGGAAATGAAAGGACGATTCTTATT TCCACTGCGGTTACTTTTGTGGATGTGTCTGCACCTGCAGAGGCAGGCTTCAGAGCTCCACCAGCCATCAATGCCAGGCTGCCCTTTAAC >In-frame_ULK1_ENST00000321867_chr12_132399966_+_TCTN1_ENST00000397655_chr12_111066572_+_2859nt ATGGAGCCCGGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTC TTCAAGGGCCGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTG GGGAAGGAAATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTG GTTATGGAGTACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAG CAGATCGCGGGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCC GGCCGCCGCGCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACA CTCTGCGGCTCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATC GTCTACCAGTGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTC CCCACCATCCCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGAT GAGTTTTTTCATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCC GGCAGCAGCTCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCC CCGGCTGACACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTC CCCGCGCAGTTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTG GCCTCTGCGGGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCG TTCTCCAGCAGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCA CCCACCCAGTTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCC CCTGCCCACGCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACC ATCCCTGAGCGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGATAAACCTGCA TTATCCTTTATTAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAAACATCTGATGGTTTTACATTGAATGCTGAATCA TATGTTTCCTTCACAACCAAACTGGATATTCCTACTGCTGCTAAATATGAGTATGGGGTTCCTCTGCAGACTTCAGATTCGTTTCTGAGA TTTCCTTCGTCCCTGACATCATCTCTGTGCACTGATAATAACCCTGCAGGCCAGGCGTACTGGTTCACACCTGTAATCCCAGCACTCTGG GAGGCCGAGGCGAGAGGATCACTTGAGGTACCTGATTCAAGAAAAAAGGTCCCTATCACTGTTCAGTCCATCGTCATTCAGTCTCTAAAT AAAACGCTCACCCGACGGGAGGACACTGATGTGCTGCAGCCGACTCTCGTCAACGCTGGACACTTTAGCCTTTGCGTGAATGTTGTTCTT GAGGTAAAGTACAGCCTCACATACACAGATGCAGGTGAAGTCACCAAAGCTGATCTCTCATTCGTTCTGGGGACAGTTAGCAGCGTAGTG GTCCCACTGCAGCAAAAGTTTGAAATTCATTTTCTTCAGGAAAATACCCAGCCAGTCCCTCTCAGTGGAAACCCTGGTTATGTCGTGGGG CTCCCATTAGCTGCTGGATTCCAGCCTCATAAGGGGTCTGGGATTATTCAGACCACAAATAGATATGGACAGCTTACTATTCTTCATAGC ACAACTGAGCAAGACTGCTTAGCACTGGAGGGGGTCCGGACCCCAGTATTATTTGGTTACACTATGCAATCTGGCTGTAAACTAAGACTG ACTGGAGCTCTCCCGTGTCAGCTCGTAGCACAGAAGGTGAAGAGCCTGCTGTGGGGCCAGGGCTTCCCAGATTACGTGGCCCCTTTTGGA AATTCCCAGGCCCAGGACATGCTGGACTGGGTGCCCATCCACTTCATCACCCAGTCATTCAACAGGAAGGATTCCTGCCAGCTCCCAGGG GCTTTGGTTATAGAAGTGAAGTGGACTAAATACGGATCCCTGCTGAATCCACAGGCCAAAATAGTCAATGTAACTGCAAATCTAATTTCA TCCTCCTTTCCTGAGGCCAACTCAGGAAATGAAAGGACGATTCTTATTTCCACTGCGGTTACTTTTGTGGATGTGTCTGCACCTGCAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ULK1_ENST00000321867_chr12_132399966_+_TCTN1_ENST00000551590_chr12_111066572_+_3641nt GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG TTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCCCCTGCCCAC GCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACCATCCCTGAG CGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGATAAACCTGCATTATCCTTT ATTAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAAACATCTGATGGTTTTACATTGAATGCTGAATCATATGTTTCC TTCACAACCAAACTGGATATTCCTACTGCTGCTAAATATGAGTATGGGGTTCCTCTGCAGACTTCAGATTCGTTTCTGAGATTTCCTTCG TCCCTGACATCATCTCTGTGCACTGATAATAACCCTGCAGCGTTTCTGGTGAACCAGGCTGTTAAGTGCACCAGAAAAATAAATTTAGAA CAGTGTGAAGAAATTGAAGCCCTCAGCATGGCTTTTTACAGCAGCCCGGAAATTCTGAGGGTACCTGATTCAAGAAAAAAGGTCCCTATC ACTGTTCAGTCCATCGTCATTCAGTCTCTAAATAAAACGCTCACCCGACGGGAGGACACTGATGTGCTGCAGCCGACTCTCGTCAACGCT GGACACTTTAGCCTTTGCGTGAATGTTGTTCTTGAGGTAAAGTACAGCCTCACATACACAGATGCAGGTGAAGTCACCAAAGCTGATCTC TCATTCGTTCTGGGGACAGTTAGCAGCGTAGTGGTCCCACTGCAGCAAAAGTTTGAAATTCATTTTCTTCAGGAAAATACCCAGCCAGTC CCTCTCAGTGGAAACCCTGGTTATGTCGTGGGGCTCCCATTAGCTGCTGGATTCCAGCCTCATAAGGGGTCTGGGATTATTCAGACCACA AATAGATATGGACAGCTTACTATTCTTCATAGCACAACTGAGCAAGACTGCTTAGCACTGGAGGGGGTCCGGACCCCAGTATTATTTGGT TACACTATGCAATCTGGCTGTAAACTAAGACTGACTGGAGCTCTCCCGTGTCAGCTCGTAGCACAGAAGGTGAAGAGCCTGCTGTGGGGC CAGGGCTTCCCAGATTACGTGGCCCCTTTTGGAAATTCCCAGGCCCAGGACATGCTGGACTGGGTGCCCATCCACTTCATCACCCAGTCA TTCAACAGGAAGGATTCCTGCCAGCTCCCAGGGGCTTTGGTTATAGAAGTGAAGTGGACTAAATACGGATCCCTGCTGAATCCACAGGCC AAAATAGTCAATGTAACTGCAAATCTAATTTCATCCTCCTTTCCTGAGGCCAACTCAGGAAATGAAAGGACGATTCTTATTTCCACTGCG GTTACTTTTGTGGATGTGTCTGCACCTGCAGAGGCAGGCTTCAGAGCTCCACCAGCCATCAATGCCAGGCTGCCCTTTAACTTCTTCTTC CCGTTTGTTTGACAATGCTCAGATGCATCAGTTCCTTAATATACACGTGAAATTTGAAAACTGTACATTCGGTGAGATTAAATTTTATAT ACAACTAGCAATTGTCCAGCTTTGTTGCTCATTTTCAATTAAGGCTAAAGTGTTCAACATGAGAAAATGTGATACATTTGATACAGTGTG GGGTGGGAGTGGATGGGCAGCTCTTGGTGGTACTGGACCTTCCACAAGGCTGTGTCCACCCAGAATCCATGCTGGCAGGAGGGAGGCAGA GGTATCAAACCAAACCTCTCACCAAGCGGCCCAGGAGGGGCAGCTGTTCCTCTCGTGACAGCACAGGCCCATGAGACAGTGTCTTCTTTT >In-frame_ULK1_ENST00000321867_chr12_132399966_+_TCTN1_ENST00000397655_chr12_111066572_+_3297nt GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG TTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCCCCTGCCCAC GCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACCATCCCTGAG CGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGATAAACCTGCATTATCCTTT ATTAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAAACATCTGATGGTTTTACATTGAATGCTGAATCATATGTTTCC TTCACAACCAAACTGGATATTCCTACTGCTGCTAAATATGAGTATGGGGTTCCTCTGCAGACTTCAGATTCGTTTCTGAGATTTCCTTCG TCCCTGACATCATCTCTGTGCACTGATAATAACCCTGCAGGCCAGGCGTACTGGTTCACACCTGTAATCCCAGCACTCTGGGAGGCCGAG GCGAGAGGATCACTTGAGGTACCTGATTCAAGAAAAAAGGTCCCTATCACTGTTCAGTCCATCGTCATTCAGTCTCTAAATAAAACGCTC ACCCGACGGGAGGACACTGATGTGCTGCAGCCGACTCTCGTCAACGCTGGACACTTTAGCCTTTGCGTGAATGTTGTTCTTGAGGTAAAG TACAGCCTCACATACACAGATGCAGGTGAAGTCACCAAAGCTGATCTCTCATTCGTTCTGGGGACAGTTAGCAGCGTAGTGGTCCCACTG CAGCAAAAGTTTGAAATTCATTTTCTTCAGGAAAATACCCAGCCAGTCCCTCTCAGTGGAAACCCTGGTTATGTCGTGGGGCTCCCATTA GCTGCTGGATTCCAGCCTCATAAGGGGTCTGGGATTATTCAGACCACAAATAGATATGGACAGCTTACTATTCTTCATAGCACAACTGAG CAAGACTGCTTAGCACTGGAGGGGGTCCGGACCCCAGTATTATTTGGTTACACTATGCAATCTGGCTGTAAACTAAGACTGACTGGAGCT CTCCCGTGTCAGCTCGTAGCACAGAAGGTGAAGAGCCTGCTGTGGGGCCAGGGCTTCCCAGATTACGTGGCCCCTTTTGGAAATTCCCAG GCCCAGGACATGCTGGACTGGGTGCCCATCCACTTCATCACCCAGTCATTCAACAGGAAGGATTCCTGCCAGCTCCCAGGGGCTTTGGTT ATAGAAGTGAAGTGGACTAAATACGGATCCCTGCTGAATCCACAGGCCAAAATAGTCAATGTAACTGCAAATCTAATTTCATCCTCCTTT CCTGAGGCCAACTCAGGAAATGAAAGGACGATTCTTATTTCCACTGCGGTTACTTTTGTGGATGTGTCTGCACCTGCAGAGGCAGGCTTC AGAGCTCCACCAGCCATCAATGCCAGGCTGCCCTTTAACTTCTTCTTCCCGTTTGTTTGACAATGCTCAGATGCATCAGTTCCTTAATAT |
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FusionGenePPI for ULK1_TCTN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ULK1 | GABARAP, SYNGAP1, SDCBP, GABARAPL2, PRKAA2, RB1CC1, PRKAA1, ATG4B, G3BP1, CDC37, USP10, PRKAG1, PRKAB2, PPP1CA, AMBRA1, RPTOR, MTOR, MLST8, ATG13, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, ULK1, MBP, TRAF6, RALB, BECN1, EXOC8, EXOC2, ATG16L1, SESN2, SQSTM1, ATG101, OCLN, DAPK3, RAB1A, MUL1, HTT, MEFV, NLRP3, TRIM21, IRF3, IRGM, FLCN, PRKAB1, NEDD4L, BIRC2, CCDC53, TRIM16, TRIM25 | TCTN1 | IDS, TMEM25, DNASE2B, SIAE, KNG1, ASPH, BCAP31, BRI3BP, CALR, CALU, CANX, CCDC134, CKAP4, CNPY2, CNPY3, DDOST, DNAJB11, DNAJC10, DNAJC3, ERAP2, ERLEC1, ERLIN2, ERP29, GANAB, COLGALT1, GRAMD1A, HSP90B1, HSPA5, HYOU1, IKBIP, KDELC2, EMC1, P3H1, LMAN1, LRPAP1, MAGT1, MANF, MESDC2, MIA3, MINPP1, MLEC, MOGS, NENF, NUCB2, NUP210, OS9, P4HA1, P4HB, PDIA3, PDIA4, PDIA6, PPIB, PRDX4, PRKCSH, RCN1, RCN2, RPN1, RPN2, SDF2L1, SEC63, SEL1L, SEP15, SERPINH1, SLC39A7, STT3B, TMED2, TMTC3, TMX1, TOR1A, TTC13, TXNDC16, TXNDC5, UGGT1, UGGT2, AP3M1, APMAP, CHID1, CLCC1, EMC8, DDX47, DNM2, FKBP10, FKBP2, GARS, GFPT1, MAP2K1, MKL1, NCLN, NUP205, PLOD1, PLOD2, POFUT1, PRPS1, PRPS2, SEC11A, SIL1, SPCS3, SRSF2, TMED10, TMED9, EMC3, TOR1AIP1, ERO1L, ERO1LB, CC2D2A, TMEM231, B9D2, TUBB1, NPTX1, MKS1, SMOC1, MICA, GNB2, TCTN2, PSG8, SUSD4, NAAA, PSG1, TUBB8, SCGB2A2, PPOX, GML, FAM19A4, TCTN3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ULK1_TCTN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ULK1_TCTN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TCTN1 | C0431399 | Familial aplasia of the vermis | 1 | CTD_human;ORPHANET |
| Tgene | TCTN1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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