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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 40761

FusionGeneSummary for ULK1_SFSWAP

check button Fusion gene summary
Fusion gene informationFusion gene name: ULK1_SFSWAP
Fusion gene ID: 40761
HgeneTgene
Gene symbol

ULK1

SFSWAP

Gene ID

8408

6433

Gene nameunc-51 like autophagy activating kinase 1splicing factor SWAP
SynonymsATG1|ATG1A|UNC51|Unc51.1|hATG1SFRS8|SWAP
Cytomap

12q24.33

12q24.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase ULK1ATG1 autophagy related 1 homologautophagy-related protein 1 homologsplicing factor, suppressor of white-apricot homologsplicing factor SWAP homologsplicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila)splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot, Drosophila ho
Modification date2018052720180523
UniProtAcc

O75385

Q12872

Ensembl transtripts involved in fusion geneENST00000321867, ENST00000540647, 
ENST00000261674, ENST00000541286, 
ENST00000539506, 
Fusion gene scores* DoF score5 X 7 X 5=1758 X 8 X 8=512
# samples 810
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/512*10)=-2.35614381022528
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ULK1 [Title/Abstract] AND SFSWAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneULK1

GO:0006914

autophagy

18936157

HgeneULK1

GO:0018105

peptidyl-serine phosphorylation

25126726|27103069

HgeneULK1

GO:0018107

peptidyl-threonine phosphorylation

27103069

HgeneULK1

GO:0031333

negative regulation of protein complex assembly

25126726

HgeneULK1

GO:0046777

protein autophosphorylation

18936157


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-37-A5EN-01AULK1chr12

132399022

+SFSWAPchr12

132281723

+
TCGALDOVTCGA-25-1320-01AULK1chr12

132380369

+SFSWAPchr12

132262610

+
TCGALDSTADTCGA-BR-7704-01AULK1chr12

132380369

+SFSWAPchr12

132281723

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000321867ENST00000261674ULK1chr12

132399022

+SFSWAPchr12

132281723

+
In-frameENST00000321867ENST00000541286ULK1chr12

132399022

+SFSWAPchr12

132281723

+
5CDS-3UTRENST00000321867ENST00000539506ULK1chr12

132399022

+SFSWAPchr12

132281723

+
intron-3CDSENST00000540647ENST00000261674ULK1chr12

132399022

+SFSWAPchr12

132281723

+
intron-3CDSENST00000540647ENST00000541286ULK1chr12

132399022

+SFSWAPchr12

132281723

+
intron-3UTRENST00000540647ENST00000539506ULK1chr12

132399022

+SFSWAPchr12

132281723

+
In-frameENST00000321867ENST00000261674ULK1chr12

132380369

+SFSWAPchr12

132262610

+
In-frameENST00000321867ENST00000541286ULK1chr12

132380369

+SFSWAPchr12

132262610

+
5CDS-intronENST00000321867ENST00000539506ULK1chr12

132380369

+SFSWAPchr12

132262610

+
intron-3CDSENST00000540647ENST00000261674ULK1chr12

132380369

+SFSWAPchr12

132262610

+
intron-3CDSENST00000540647ENST00000541286ULK1chr12

132380369

+SFSWAPchr12

132262610

+
intron-intronENST00000540647ENST00000539506ULK1chr12

132380369

+SFSWAPchr12

132262610

+
Frame-shiftENST00000321867ENST00000261674ULK1chr12

132380369

+SFSWAPchr12

132281723

+
Frame-shiftENST00000321867ENST00000541286ULK1chr12

132380369

+SFSWAPchr12

132281723

+
5CDS-3UTRENST00000321867ENST00000539506ULK1chr12

132380369

+SFSWAPchr12

132281723

+
intron-3CDSENST00000540647ENST00000261674ULK1chr12

132380369

+SFSWAPchr12

132281723

+
intron-3CDSENST00000540647ENST00000541286ULK1chr12

132380369

+SFSWAPchr12

132281723

+
intron-3UTRENST00000540647ENST00000539506ULK1chr12

132380369

+SFSWAPchr12

132281723

+

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FusionProtFeatures for ULK1_SFSWAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ULK1

O75385

SFSWAP

Q12872

Serine/threonine-protein kinase involved in autophagy inresponse to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, theprecursors of autophagosomes. Part of regulatory feedback loops inautophagy: acts both as a downstream effector and negativeregulator of mammalian target of rapamycin complex 1 (mTORC1) viainteraction with RPTOR. Activated via phosphorylation by AMPK andalso acts as a regulator of AMPK by mediating phosphorylation ofAMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negativelyregulate AMPK activity. May phosphorylate ATG13/KIAA0652 andRPTOR; however such data need additional evidences. Plays a roleearly in neuronal differentiation and is required for granule cellaxon formation. May also phosphorylate SESN2 and SQSTM1 toregulate autophagy (PubMed:25040165).{ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634,ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:25040165}. Plays a role as an alternative splicing regulator.Regulate its own expression at the level of RNA processing. Alsoregulates the splicing of fibronectin and CD45 genes. May act, atleast in part, by interaction with other R/S-containing splicingfactors. Represses the splicing of MAPT/Tau exon 10.{ECO:0000269|PubMed:8940107}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneULK1chr12:132399022chr12:132281723ENST00000321867+1628297_3104571051Compositional biasNote=Poly-Ser
HgeneULK1chr12:132399022chr12:132281723ENST00000321867+162816_2784571051DomainProtein kinase
HgeneULK1chr12:132380369chr12:132262610ENST00000321867+32822_30821051Nucleotide bindingATP
HgeneULK1chr12:132399022chr12:132281723ENST00000321867+162822_304571051Nucleotide bindingATP
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218754_763714952Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218789_951714952Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218850_853714952Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219754_7637141004Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219789_9517141004Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219850_8537141004Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418850_853844952Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneULK1chr12:132380369chr12:132262610ENST00000321867+328297_310821051Compositional biasNote=Poly-Ser
HgeneULK1chr12:132380369chr12:132262610ENST00000321867+32816_278821051DomainProtein kinase
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218165_168714952Compositional biasNote=Poly-Glu
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218287_290714952Compositional biasNote=Poly-Asp
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218382_385714952Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218413_416714952Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218420_424714952Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218434_440714952Compositional biasNote=Poly-Thr
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218451_454714952Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218616_619714952Compositional biasNote=Poly-Ser
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218660_663714952Compositional biasNote=Poly-Ala
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219165_1687141004Compositional biasNote=Poly-Glu
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219287_2907141004Compositional biasNote=Poly-Asp
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219382_3857141004Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219413_4167141004Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219420_4247141004Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219434_4407141004Compositional biasNote=Poly-Thr
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219451_4547141004Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219616_6197141004Compositional biasNote=Poly-Ser
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219660_6637141004Compositional biasNote=Poly-Ala
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418165_168844952Compositional biasNote=Poly-Glu
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418287_290844952Compositional biasNote=Poly-Asp
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418382_385844952Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418413_416844952Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418420_424844952Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418434_440844952Compositional biasNote=Poly-Thr
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418451_454844952Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418616_619844952Compositional biasNote=Poly-Ser
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418660_663844952Compositional biasNote=Poly-Ala
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418754_763844952Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418789_951844952Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519165_1688961004Compositional biasNote=Poly-Glu
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519287_2908961004Compositional biasNote=Poly-Asp
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519382_3858961004Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519413_4168961004Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519420_4248961004Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519434_4408961004Compositional biasNote=Poly-Thr
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519451_4548961004Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519616_6198961004Compositional biasNote=Poly-Ser
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519660_6638961004Compositional biasNote=Poly-Ala
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519754_7638961004Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519789_9518961004Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519850_8538961004Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218211_253714952RepeatNote=SURP motif 1
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000261674+1218459_499714952RepeatNote=SURP motif 2
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219211_2537141004RepeatNote=SURP motif 1
TgeneSFSWAPchr12:132380369chr12:132262610ENST00000541286+1219459_4997141004RepeatNote=SURP motif 2
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418211_253844952RepeatNote=SURP motif 1
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000261674+1418459_499844952RepeatNote=SURP motif 2
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519211_2538961004RepeatNote=SURP motif 1
TgeneSFSWAPchr12:132399022chr12:132281723ENST00000541286+1519459_4998961004RepeatNote=SURP motif 2


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FusionGeneSequence for ULK1_SFSWAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ULK1_ENST00000321867_chr12_132399022_+_SFSWAP_ENST00000261674_chr12_132281723_+_565aa
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYL
VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFD
EFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQS
PTQFQTPRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSK

>In-frame_ULK1_ENST00000321867_chr12_132399022_+_SFSWAP_ENST00000541286_chr12_132281723_+_565aa
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYL
VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFD
EFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQS
PTQFQTPRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSK

>In-frame_ULK1_ENST00000321867_chr12_132380369_+_SFSWAP_ENST00000261674_chr12_132262610_+_320aa
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQESSTTPCP
LLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRSRSRSPRRR
AHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQ

>In-frame_ULK1_ENST00000321867_chr12_132380369_+_SFSWAP_ENST00000541286_chr12_132262610_+_372aa
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQESSTTPCP
LLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRVTASPGTLR
AEPCQSSASVTAAAEPGSYQAASTTTRFDSASSFEGKPGKTSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEK
KKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSKITQDLMAKVRAML


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ULK1_ENST00000321867_chr12_132399022_+_SFSWAP_ENST00000261674_chr12_132281723_+_1695nt
ATGGAGCCCGGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTC
TTCAAGGGCCGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTG
GGGAAGGAAATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTG
GTTATGGAGTACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAG
CAGATCGCGGGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCC
GGCCGCCGCGCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACA
CTCTGCGGCTCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATC
GTCTACCAGTGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTC
CCCACCATCCCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGAT
GAGTTTTTTCATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCC
GGCAGCAGCTCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCC
CCGGCTGACACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTC
CCCGCGCAGTTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTG
GCCTCTGCGGGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCG
TTCTCCAGCAGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCA
CCCACCCAGTTCCAAACACCTCGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAG
TCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGT
CGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAA

>In-frame_ULK1_ENST00000321867_chr12_132399022_+_SFSWAP_ENST00000541286_chr12_132281723_+_1695nt
ATGGAGCCCGGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTC
TTCAAGGGCCGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTG
GGGAAGGAAATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTG
GTTATGGAGTACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAG
CAGATCGCGGGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCC
GGCCGCCGCGCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACA
CTCTGCGGCTCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATC
GTCTACCAGTGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTC
CCCACCATCCCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGAT
GAGTTTTTTCATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCC
GGCAGCAGCTCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCC
CCGGCTGACACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTC
CCCGCGCAGTTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTG
GCCTCTGCGGGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCG
TTCTCCAGCAGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCA
CCCACCCAGTTCCAAACACCTCGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAG
TCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGT
CGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAA

>In-frame_ULK1_ENST00000321867_chr12_132380369_+_SFSWAP_ENST00000261674_chr12_132262610_+_960nt
ATGGAGCCCGGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTC
TTCAAGGGCCGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTG
GGGAAGGAAATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAATCCAGCACTACGCCCTGCCCT
CTACTGACTGGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAAGAA
GAGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGGTCT
AGATCACACTCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGGTCCCGCTCCCGGTCCCCTCGGAGGAGA
GCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACC
CGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGC
AAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAG
GAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTC

>In-frame_ULK1_ENST00000321867_chr12_132380369_+_SFSWAP_ENST00000541286_chr12_132262610_+_1116nt
ATGGAGCCCGGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTC
TTCAAGGGCCGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTG
GGGAAGGAAATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAATCCAGCACTACGCCCTGCCCT
CTACTGACTGGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAAGAA
GAGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGGTCT
AGATCACACTCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGAGTCACAGCCTCCCCAGGGACGCTGCGC
GCGGAGCCCTGTCAGAGCAGCGCGTCAGTGACAGCGGCAGCCGAGCCAGGAAGTTATCAGGCAGCCTCGACCACCACCAGATTTGACTCC
GCGAGCTCTTTTGAGGGAAAACCTGGTAAAACGTCAAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGG
GAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAG
AAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCG
GCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAG
GAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATGCTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ULK1_ENST00000321867_chr12_132399022_+_SFSWAP_ENST00000261674_chr12_132281723_+_2295nt
GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG
GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA
CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC
CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC
GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC
CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA
ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG
TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG
GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC
GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC
TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG
TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC
CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT
CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC
TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC
ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG
TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG
GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC
AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG
TTCCAAACACCTCGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCA
CCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCC
AGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAG
GATCTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCC
GGGAGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACGCCGGCCACACCATCCACCTGGCCGCCTCCATGGACCCTTGGTGGCTTTTGT
AAATTAATTTTTGATGACATTTTGAGTTTTAAGATTTCTGACCAGCAGTCTCTTACCTGTATATTTGTAAATATATCATGTTTCTGTGAA

>In-frame_ULK1_ENST00000321867_chr12_132399022_+_SFSWAP_ENST00000541286_chr12_132281723_+_2160nt
GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG
GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA
CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC
CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC
GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC
CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA
ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG
TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG
GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC
GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC
TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG
TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC
CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT
CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC
TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC
ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG
TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG
GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC
AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG
TTCCAAACACCTCGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCA
CCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCC
AGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAG
GATCTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCC
GGGAGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACGCCGGCCACACCATCCACCTGGCCGCCTCCATGGACCCTTGGTGGCTTTTGT

>In-frame_ULK1_ENST00000321867_chr12_132380369_+_SFSWAP_ENST00000261674_chr12_132262610_+_1560nt
GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG
GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA
CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC
CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC
GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC
CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA
ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAATCCAGCACTACGCCCTGCCCTCTACTGACT
GGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAAGAAGAGAAAGAA
AAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGGTCTAGATCACAC
TCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCC
CCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGA
AGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCA
GCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCC
AGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAA
GTCAGAGCGATGCTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGG
CTTCTGGGCAGGCTCACGCAGACGCCGGCCACACCATCCACCTGGCCGCCTCCATGGACCCTTGGTGGCTTTTGTAAATTAATTTTTGAT
GACATTTTGAGTTTTAAGATTTCTGACCAGCAGTCTCTTACCTGTATATTTGTAAATATATCATGTTTCTGTGAAAATGTATTATGAAAT

>In-frame_ULK1_ENST00000321867_chr12_132380369_+_SFSWAP_ENST00000541286_chr12_132262610_+_1581nt
GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG
GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA
CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC
CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC
GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC
CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA
ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAATCCAGCACTACGCCCTGCCCTCTACTGACT
GGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAAGAAGAGAAAGAA
AAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGGTCTAGATCACAC
TCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGAGTCACAGCCTCCCCAGGGACGCTGCGCGCGGAGCCC
TGTCAGAGCAGCGCGTCAGTGACAGCGGCAGCCGAGCCAGGAAGTTATCAGGCAGCCTCGACCACCACCAGATTTGACTCCGCGAGCTCT
TTTGAGGGAAAACCTGGTAAAACGTCAAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGG
AGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAG
AGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCG
GCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAA
GCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCC
AAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACG


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FusionGenePPI for ULK1_SFSWAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ULK1GABARAP, SYNGAP1, SDCBP, GABARAPL2, PRKAA2, RB1CC1, PRKAA1, ATG4B, G3BP1, CDC37, USP10, PRKAG1, PRKAB2, PPP1CA, AMBRA1, RPTOR, MTOR, MLST8, ATG13, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, ULK1, MBP, TRAF6, RALB, BECN1, EXOC8, EXOC2, ATG16L1, SESN2, SQSTM1, ATG101, OCLN, DAPK3, RAB1A, MUL1, HTT, MEFV, NLRP3, TRIM21, IRF3, IRGM, FLCN, PRKAB1, NEDD4L, BIRC2, CCDC53, TRIM16, TRIM25SFSWAPRNPS1, JMJD6, CAND1, EAF1, NTRK1, EWSR1, NEIL3, CFAP20, RBM17, CAPN13, TSEN2, DLST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneULK1chr12:132399022chr12:132281723ENST00000321867+1628287_4164571051GABARAP and GABARAPL2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneULK1chr12:132380369chr12:132262610ENST00000321867+328287_416821051GABARAP and GABARAPL2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ULK1_SFSWAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ULK1_SFSWAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSFSWAPC1510586Autism Spectrum Disorders1CTD_human