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Fusion gene ID: 40759 |
FusionGeneSummary for ULK1_FBXW8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ULK1_FBXW8 | Fusion gene ID: 40759 | Hgene | Tgene | Gene symbol | ULK1 | FBXW8 | Gene ID | 8408 | 26259 |
| Gene name | unc-51 like autophagy activating kinase 1 | F-box and WD repeat domain containing 8 | |
| Synonyms | ATG1|ATG1A|UNC51|Unc51.1|hATG1 | FBW6|FBW8|FBX29|FBXO29|FBXW6 | |
| Cytomap | 12q24.33 | 12q24.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase ULK1ATG1 autophagy related 1 homologautophagy-related protein 1 homolog | F-box/WD repeat-containing protein 8F-box and WD-40 domain protein 8F-box and WD-40 domain-containing protein 8F-box only protein 29 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | O75385 | Q8N3Y1 | |
| Ensembl transtripts involved in fusion gene | ENST00000321867, ENST00000540647, | ENST00000309909, ENST00000455858, ENST00000551773, | |
| Fusion gene scores | * DoF score | 5 X 7 X 5=175 | 3 X 4 X 3=36 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ULK1 [Title/Abstract] AND FBXW8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ULK1 | GO:0006914 | autophagy | 18936157 |
| Hgene | ULK1 | GO:0018105 | peptidyl-serine phosphorylation | 25126726|27103069 |
| Hgene | ULK1 | GO:0018107 | peptidyl-threonine phosphorylation | 27103069 |
| Hgene | ULK1 | GO:0031333 | negative regulation of protein complex assembly | 25126726 |
| Hgene | ULK1 | GO:0046777 | protein autophosphorylation | 18936157 |
| Tgene | FBXW8 | GO:0008283 | cell proliferation | 24362026 |
| Tgene | FBXW8 | GO:0016567 | protein ubiquitination | 18498745|24362026 |
| Tgene | FBXW8 | GO:0050775 | positive regulation of dendrite morphogenesis | 21572988 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-34-5232-01A | ULK1 | chr12 | 132403929 | + | FBXW8 | chr12 | 117461952 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000321867 | ENST00000309909 | ULK1 | chr12 | 132403929 | + | FBXW8 | chr12 | 117461952 | + |
| In-frame | ENST00000321867 | ENST00000455858 | ULK1 | chr12 | 132403929 | + | FBXW8 | chr12 | 117461952 | + |
| 5CDS-intron | ENST00000321867 | ENST00000551773 | ULK1 | chr12 | 132403929 | + | FBXW8 | chr12 | 117461952 | + |
| In-frame | ENST00000540647 | ENST00000309909 | ULK1 | chr12 | 132403929 | + | FBXW8 | chr12 | 117461952 | + |
| In-frame | ENST00000540647 | ENST00000455858 | ULK1 | chr12 | 132403929 | + | FBXW8 | chr12 | 117461952 | + |
| 5CDS-intron | ENST00000540647 | ENST00000551773 | ULK1 | chr12 | 132403929 | + | FBXW8 | chr12 | 117461952 | + |
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FusionProtFeatures for ULK1_FBXW8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ULK1 | FBXW8 |
| Serine/threonine-protein kinase involved in autophagy inresponse to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, theprecursors of autophagosomes. Part of regulatory feedback loops inautophagy: acts both as a downstream effector and negativeregulator of mammalian target of rapamycin complex 1 (mTORC1) viainteraction with RPTOR. Activated via phosphorylation by AMPK andalso acts as a regulator of AMPK by mediating phosphorylation ofAMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negativelyregulate AMPK activity. May phosphorylate ATG13/KIAA0652 andRPTOR; however such data need additional evidences. Plays a roleearly in neuronal differentiation and is required for granule cellaxon formation. May also phosphorylate SESN2 and SQSTM1 toregulate autophagy (PubMed:25040165).{ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634,ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:25040165}. | Substrate-recognition component of a Cul7-RINGubiquitin-protein ligase complex, which mediates theubiquitination and subsequent proteasomal degradation of targetproteins. The Cul7-RING(FBXW8) complex mediates ubiquitination andconsequent degradation of GORASP1, acting as a component of theubiquitin ligase pathway that regulates Golgi morphogenesis anddendrite patterning in brain (PubMed:21572988). Mediatesubiquitination and degradation of IRS1 in a mTOR-dependent manner:the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previouslyphosphorylated by S6 kinase (RPS6KB1 or RPS6KB2)(PubMed:18498745). The Cul7-RING(FBXW8) complex also mediatesubiquitination of MAP4K1/HPK1: recognizes and bindsautophosphorylated MAP4K1/HPK1, leading to its degradation,thereby affecting cell proliferation and differentiation(PubMed:24362026). Associated component of the 3M complex,suggesting that it mediates some of 3M complex functions(PubMed:24793695). {ECO:0000269|PubMed:18498745,ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026,ECO:0000269|PubMed:24793695}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ULK1 | chr12:132403929 | chr12:117461952 | ENST00000321867 | + | 24 | 28 | 297_310 | 894 | 1051 | Compositional bias | Note=Poly-Ser |
| Hgene | ULK1 | chr12:132403929 | chr12:117461952 | ENST00000321867 | + | 24 | 28 | 16_278 | 894 | 1051 | Domain | Protein kinase |
| Hgene | ULK1 | chr12:132403929 | chr12:117461952 | ENST00000321867 | + | 24 | 28 | 22_30 | 894 | 1051 | Nucleotide binding | ATP |
| Tgene | >FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000309909 | + | 7 | 11 | 473_510 | 455 | 599 | Repeat | Note=WD 5 |
| Tgene | >FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000455858 | + | 7 | 11 | 430_470 | 389 | 533 | Repeat | Note=WD 4 |
| Tgene | >FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000455858 | + | 7 | 11 | 473_510 | 389 | 533 | Repeat | Note=WD 5 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000309909 | + | 7 | 11 | 113_159 | 455 | 599 | Domain | F-box |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000455858 | + | 7 | 11 | 113_159 | 389 | 533 | Domain | F-box |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000309909 | + | 7 | 11 | 197_245 | 455 | 599 | Repeat | Note=WD 1 |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000309909 | + | 7 | 11 | 254_294 | 455 | 599 | Repeat | Note=WD 2 |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000309909 | + | 7 | 11 | 297_336 | 455 | 599 | Repeat | Note=WD 3 |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000309909 | + | 7 | 11 | 430_470 | 455 | 599 | Repeat | Note=WD 4 |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000455858 | + | 7 | 11 | 197_245 | 389 | 533 | Repeat | Note=WD 1 |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000455858 | + | 7 | 11 | 254_294 | 389 | 533 | Repeat | Note=WD 2 |
| Tgene | FBXW8 | chr12:132403929 | chr12:117461952 | ENST00000455858 | + | 7 | 11 | 297_336 | 389 | 533 | Repeat | Note=WD 3 |
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FusionGeneSequence for ULK1_FBXW8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ULK1_ENST00000321867_chr12_132403929_+_FBXW8_ENST00000309909_chr12_117461952_+_1038aa MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYL VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFD EFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQS PTQFQTPRSSAIRRSGSTSPLGFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPS FDFPKTPSSQNLLALLARQGVVMTPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCS FADPITANLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHD LRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRR >In-frame_ULK1_ENST00000321867_chr12_132403929_+_FBXW8_ENST00000455858_chr12_117461952_+_1038aa MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYL VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFD EFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQS PTQFQTPRSSAIRRSGSTSPLGFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPS FDFPKTPSSQNLLALLARQGVVMTPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCS FADPITANLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHD LRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRR >In-frame_ULK1_ENST00000540647_chr12_132403929_+_FBXW8_ENST00000309909_chr12_117461952_+_283aa MDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHTEILR GLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGL VSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHY >In-frame_ULK1_ENST00000540647_chr12_132403929_+_FBXW8_ENST00000455858_chr12_117461952_+_283aa MDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHTEILR GLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGL VSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ULK1_ENST00000321867_chr12_132403929_+_FBXW8_ENST00000309909_chr12_117461952_+_3114nt ATGGAGCCCGGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTC TTCAAGGGCCGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTG GGGAAGGAAATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTG GTTATGGAGTACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAG CAGATCGCGGGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCC GGCCGCCGCGCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACA CTCTGCGGCTCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATC GTCTACCAGTGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTC CCCACCATCCCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGAT GAGTTTTTTCATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCC GGCAGCAGCTCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCC CCGGCTGACACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTC CCCGCGCAGTTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTG GCCTCTGCGGGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCG TTCTCCAGCAGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCA CCCACCCAGTTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCC CCTGCCCACGCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACC ATCCCTGAGCGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGGCTCCTCTGCA CCCGAGCACTCTCCCCGCACTTCCGGGCTGGGCTGCCGCCTGCACAGCGCCCCCAACCTGTCTGACTTGCACGTCGTCCGCCCCAAGCTG CCCAAACCCCCCACGGACCCCCTGGGAGCTGTGTTCAGCCCACCACAGGCCAGCCCTCCCCAGCCGTCCCACGGCCTGCAGTCCTGCCGG AACCTGCGGGGCTCACCCAAGCTGCCCGACTTCCTGCAGCGAAACCCCCTGCCCCCCATCCTGGGCTCCCCCACCAAGGCTGTGCCCTCC TTTGACTTCCCGAAGACCCCCAGCTCCCAGAACCTGCTGGCCCTCCTAGCCCGGCAGGGCGTGGTGATGACGCCCCCTCGAAACCGGACG CTGCCCGACCTCTCGGAGGTGGGACCCTTCCATGGTCAGCCGTTGGGCCCTGGCCTGCGGCCAGGCGAGGACCCCAAGGGCCCCTTTGGC CGGTCTTTCAGCACCAGCCGCCTCACTGACCTGCTCCTTAAGGCGGCGTTTGGGACACAAGCCCCGGACCCGGGCAGCACGGAGAGCCTG CAGGAGAAGCCCATGGAGATCGCACCCTCAGCTGGCTTTGGAGGGAGCCTGCACCCAGGAGCCCGTGCTGGGGGCACCAGCAGCCCTTCC CCGGTGGTCTTCACCGTGGGCTCTCCCCCGAGCGGGAGCACGCCCCCCCAGGGCCCCCGCACCAGGATGTTCTCAGCGGGCCCCACTGGC TCTGCCAGCTCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGC TTTGCCGACCCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCAC ACGGAGATCCTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCG GCGGGGGGCCCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGAC CTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGA GGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCA TTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGA CACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCC >In-frame_ULK1_ENST00000321867_chr12_132403929_+_FBXW8_ENST00000455858_chr12_117461952_+_3114nt ATGGAGCCCGGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTC TTCAAGGGCCGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTG GGGAAGGAAATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTG GTTATGGAGTACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAG CAGATCGCGGGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCC GGCCGCCGCGCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACA CTCTGCGGCTCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATC GTCTACCAGTGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTC CCCACCATCCCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGAT GAGTTTTTTCATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCC GGCAGCAGCTCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCC CCGGCTGACACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTC CCCGCGCAGTTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTG GCCTCTGCGGGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCG TTCTCCAGCAGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCA CCCACCCAGTTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCC CCTGCCCACGCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACC ATCCCTGAGCGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGGCTCCTCTGCA CCCGAGCACTCTCCCCGCACTTCCGGGCTGGGCTGCCGCCTGCACAGCGCCCCCAACCTGTCTGACTTGCACGTCGTCCGCCCCAAGCTG CCCAAACCCCCCACGGACCCCCTGGGAGCTGTGTTCAGCCCACCACAGGCCAGCCCTCCCCAGCCGTCCCACGGCCTGCAGTCCTGCCGG AACCTGCGGGGCTCACCCAAGCTGCCCGACTTCCTGCAGCGAAACCCCCTGCCCCCCATCCTGGGCTCCCCCACCAAGGCTGTGCCCTCC TTTGACTTCCCGAAGACCCCCAGCTCCCAGAACCTGCTGGCCCTCCTAGCCCGGCAGGGCGTGGTGATGACGCCCCCTCGAAACCGGACG CTGCCCGACCTCTCGGAGGTGGGACCCTTCCATGGTCAGCCGTTGGGCCCTGGCCTGCGGCCAGGCGAGGACCCCAAGGGCCCCTTTGGC CGGTCTTTCAGCACCAGCCGCCTCACTGACCTGCTCCTTAAGGCGGCGTTTGGGACACAAGCCCCGGACCCGGGCAGCACGGAGAGCCTG CAGGAGAAGCCCATGGAGATCGCACCCTCAGCTGGCTTTGGAGGGAGCCTGCACCCAGGAGCCCGTGCTGGGGGCACCAGCAGCCCTTCC CCGGTGGTCTTCACCGTGGGCTCTCCCCCGAGCGGGAGCACGCCCCCCCAGGGCCCCCGCACCAGGATGTTCTCAGCGGGCCCCACTGGC TCTGCCAGCTCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGC TTTGCCGACCCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCAC ACGGAGATCCTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCG GCGGGGGGCCCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGAC CTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGA GGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCA TTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGA CACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCC >In-frame_ULK1_ENST00000540647_chr12_132403929_+_FBXW8_ENST00000309909_chr12_117461952_+_849nt ATGGATGGGGGCCACGGTGTCTGCTGGTCCTGGTGTGCCCCTCATCGCCCTCTCCCTGCAGCGGGCCCCACTGGCTCTGCCAGCTCTTCT GCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGACCCCATT ACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATCCTGCGT GGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGCCCTGAG TACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGTGGTAAC ATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTG GTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGC CTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATC CGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTAC >In-frame_ULK1_ENST00000540647_chr12_132403929_+_FBXW8_ENST00000455858_chr12_117461952_+_849nt ATGGATGGGGGCCACGGTGTCTGCTGGTCCTGGTGTGCCCCTCATCGCCCTCTCCCTGCAGCGGGCCCCACTGGCTCTGCCAGCTCTTCT GCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGACCCCATT ACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATCCTGCGT GGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGCCCTGAG TACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGTGGTAAC ATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTG GTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGC CTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATC CGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ULK1_ENST00000321867_chr12_132403929_+_FBXW8_ENST00000309909_chr12_117461952_+_3929nt GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG TTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCCCCTGCCCAC GCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACCATCCCTGAG CGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGGCTCCTCTGCACCCGAGCAC TCTCCCCGCACTTCCGGGCTGGGCTGCCGCCTGCACAGCGCCCCCAACCTGTCTGACTTGCACGTCGTCCGCCCCAAGCTGCCCAAACCC CCCACGGACCCCCTGGGAGCTGTGTTCAGCCCACCACAGGCCAGCCCTCCCCAGCCGTCCCACGGCCTGCAGTCCTGCCGGAACCTGCGG GGCTCACCCAAGCTGCCCGACTTCCTGCAGCGAAACCCCCTGCCCCCCATCCTGGGCTCCCCCACCAAGGCTGTGCCCTCCTTTGACTTC CCGAAGACCCCCAGCTCCCAGAACCTGCTGGCCCTCCTAGCCCGGCAGGGCGTGGTGATGACGCCCCCTCGAAACCGGACGCTGCCCGAC CTCTCGGAGGTGGGACCCTTCCATGGTCAGCCGTTGGGCCCTGGCCTGCGGCCAGGCGAGGACCCCAAGGGCCCCTTTGGCCGGTCTTTC AGCACCAGCCGCCTCACTGACCTGCTCCTTAAGGCGGCGTTTGGGACACAAGCCCCGGACCCGGGCAGCACGGAGAGCCTGCAGGAGAAG CCCATGGAGATCGCACCCTCAGCTGGCTTTGGAGGGAGCCTGCACCCAGGAGCCCGTGCTGGGGGCACCAGCAGCCCTTCCCCGGTGGTC TTCACCGTGGGCTCTCCCCCGAGCGGGAGCACGCCCCCCCAGGGCCCCCGCACCAGGATGTTCTCAGCGGGCCCCACTGGCTCTGCCAGC TCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGAC CCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATC CTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGC CCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGT GGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAA GGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGC CACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGG CTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACT CACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTGCCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAG TTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAGGGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCAC GCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGTGCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACAT AGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGCCTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGC TTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCTTTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGG >In-frame_ULK1_ENST00000321867_chr12_132403929_+_FBXW8_ENST00000455858_chr12_117461952_+_6441nt GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG TTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCCCCTGCCCAC GCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACCATCCCTGAG CGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGGCTCCTCTGCACCCGAGCAC TCTCCCCGCACTTCCGGGCTGGGCTGCCGCCTGCACAGCGCCCCCAACCTGTCTGACTTGCACGTCGTCCGCCCCAAGCTGCCCAAACCC CCCACGGACCCCCTGGGAGCTGTGTTCAGCCCACCACAGGCCAGCCCTCCCCAGCCGTCCCACGGCCTGCAGTCCTGCCGGAACCTGCGG GGCTCACCCAAGCTGCCCGACTTCCTGCAGCGAAACCCCCTGCCCCCCATCCTGGGCTCCCCCACCAAGGCTGTGCCCTCCTTTGACTTC CCGAAGACCCCCAGCTCCCAGAACCTGCTGGCCCTCCTAGCCCGGCAGGGCGTGGTGATGACGCCCCCTCGAAACCGGACGCTGCCCGAC CTCTCGGAGGTGGGACCCTTCCATGGTCAGCCGTTGGGCCCTGGCCTGCGGCCAGGCGAGGACCCCAAGGGCCCCTTTGGCCGGTCTTTC AGCACCAGCCGCCTCACTGACCTGCTCCTTAAGGCGGCGTTTGGGACACAAGCCCCGGACCCGGGCAGCACGGAGAGCCTGCAGGAGAAG CCCATGGAGATCGCACCCTCAGCTGGCTTTGGAGGGAGCCTGCACCCAGGAGCCCGTGCTGGGGGCACCAGCAGCCCTTCCCCGGTGGTC TTCACCGTGGGCTCTCCCCCGAGCGGGAGCACGCCCCCCCAGGGCCCCCGCACCAGGATGTTCTCAGCGGGCCCCACTGGCTCTGCCAGC TCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGAC CCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATC CTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGC CCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGT GGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAA GGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGC CACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGG CTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACT CACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTGCCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAG TTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAGGGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCAC GCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGTGCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACAT AGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGCCTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGC TTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCTTTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGG CCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTTTCCCTGTATTTACTTGGGGTGCTCTTCTGTGACACTTG CCACCACCACCTTCCAGTAGCAAGCTGGTAGAGCTGTACTTTTTCTTCACAGCTTTTACCATGGTTTATAATTATATACTTATACAGTTT AGTCATCAATGACTATTTTGCTTACTATTGTGTCTATGATATGTGATACAAAGCAAATATTTTCTAAATATTCATTGACTAAACAGCCAT CAAGATGAAACAGGACAGGAGAGAACTGTTCAGTGTGATACAGAGCTGCCATTTCCAAAGTATTCTGGAAGCAAGCCATTGCCTTACTCT TGATTTTCAACAGTTCTAAACAGCAACAGCATCCACCTAATATACCTTCAGAATATCAAAGCGAAAACTGATAGAACTACAAAGAGAAAT AAAATCCATTCTCACGGCAGGCAAATCAGTGAGAAAAATGTAAAGATCTGGAGGATTTACTTAGTATCGCTAACAAGCTGGATCCAGTAG ATGCGTATGGAATTTCAAATACACATAGACGATGCACAAAAAACCACCCTGTACGAAGGCCACAAAGAACAGCTCAGATGCACAAAGATT CACACCATACAGGCCAAATTATAGAATCCCCCAACCCCAAGACACTGCACCCTATGGGCTATACCCTCAGGCAGGGCCCTGCTTTTCTAG GAATTGACTCCAATGCAGAATAGTGAGAAATCAACAAAAAGCAAAATAAGACAATTCCAGACACTCCTGAATTTACTTGGATTTAAAGAG GTTAATAAAAACAAACTATAAACTCTCTAGACTGGGCTGACAGTAAAAGCACAGAATACAAAACCCAGGGGATGGGGCTGGGAGGGGCTG TGAGGGGCTGGCACCTCAGCTCAGAAAAGGTAGCAGCAATCCCAAAGCAGCAGAAGGCAGGGGTTAAATCAGGATAAAAACAGACATCAG TGGAATCGAAAACCAATAGTTAGTTAATATAAAGCCAGAAGGTTTTGTTTTTTTTCAGGTGGGGTCTCGCTCTGTCACCTAGACTAGACT GGAGTGCAATGGCCTGATCTCGGCTCACTGCAACCTCTGCCTCCCGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAT TACAGGCGTCCGCTACCACAACTGGCTAATTTTTACATTTTTAGTAGAGACGGGGGATATTGCTATGTTGGCCAGGCTGGTCTCAAACTT CTGACCTCAAATGATTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGTCACTGTACCCAGCCCAAAAGCAGTTTAAAAA AAAAAAAGACAAAATATACAACTCTTGATAAAACATAAAGGTACAGTGGTCTATGAGGAAGAGAAAAGGTACCTGAGGATGCAGAAGTAC CTACCACATGGGAACCGTTTGTCCACACTCATTCCAGAGAAAACCGAGTCCTCTCAGTTGCACACGTGTACGTATCAGTGGGAAGTGCTT GCCATTACTCCAAAGCCTAGAACCTTCACGTCATGAAGGTTCTGGAAGGTTTTTCAGATTGCTTAAGATACGCAGCCATTCCATATTCAT CTCCAACTACACAGGGGAACGGAGCAGATAGAGCTGCGACTGGGAAGCGTCACCTTCCCGTCCAGAGCGCTTTCTTTCAGACCCTGCCTA CCTGCAGGCAGATGGACCGGAGGGTTTTCTGCTTCCTTTCAACCAGATAACTTCCTAAGTGGAGATGGCCTGTAGGTAGCAAATGCAGGA TTTTGTTTACTTTCATCATGTCATGTGGTGGTCAGACTGCTCGCTGGTGGCCTCGCTTTAGAAGGTTTTCATCAAGCCCCGCCCTTTCTC TCTCATAGTCTTAATGCGTCTGGACCACTGGGGAAAATATTTTTCTTTTCAAAAAGCAGCCCCTTCAGTCTGCGTTCCCAGTTCATTTTG CAGGCGCATTCGCCCTTCCTAGTTTGCAGCAATTAAAGATAACGGAGTGTAAAGTCATTAGACCCAGAATTAGAGCAGCCAGCAGCTGGC CCAGTGTAAAAATGTCCCAAGTGTAGCCCCTCCCACCGCAGAGCCTGTTTCTAACGTACCTGCCATTCGTGGAAGTCGCCTGGGTTTTGT AAAGGAGAATTTTTTGGACTCAAGCTGTCATCTTCAAGCACGCCAACTTCAGGCAGTGTTTTCTACTGCAAACCTCCACATCCTGGAATC AATCACACTGACAGGGAAAGGATAAATGCTCCTTTATAAGCCAACATGTATCCAAATTAAGCCCCCTTACCTTTATCCAGACCCTTTCAC AAACAAGTTCTGAGTTTTTAGCCAATTGATCCTCTACTTTCCTTCTTTAGTCCCTCTCAGGGACGCCTCCATCCCCGGCTCCCCTAAAGG TAGAAGATACTCGAGCATGCTGCCAGGGGAGCTGGATGGTGAAACACCTGAAGATCTCATATCGCCTCTCAAAACACTGTCGGACTTGCT >In-frame_ULK1_ENST00000540647_chr12_132403929_+_FBXW8_ENST00000309909_chr12_117461952_+_1447nt TGTGGTGAGTGGCAAGAGGTTGAGGAGTGGCTCTAGGGGCCTGCTGTGCTTCTCCTGTTGGAGCATTGGGATATAACAGGTGTAAACCGA GGCAGAGGCACATTGGGCCCTGGAGGTGTGGGAGTCTGTGGGGGATGGATGGGGGCCACGGTGTCTGCTGGTCCTGGTGTGCCCCTCATC GCCCTCTCCCTGCAGCGGGCCCCACTGGCTCTGCCAGCTCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTG AGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGACCCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCC CTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATCCTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCG CAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGCCCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGA GCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGC AGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGT ATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCG ACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTC TCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTG CCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAGTTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAG GGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCACGCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGT GCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACATAGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGC CTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGCTTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCT TTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGGCCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTT >In-frame_ULK1_ENST00000540647_chr12_132403929_+_FBXW8_ENST00000455858_chr12_117461952_+_3959nt TGTGGTGAGTGGCAAGAGGTTGAGGAGTGGCTCTAGGGGCCTGCTGTGCTTCTCCTGTTGGAGCATTGGGATATAACAGGTGTAAACCGA GGCAGAGGCACATTGGGCCCTGGAGGTGTGGGAGTCTGTGGGGGATGGATGGGGGCCACGGTGTCTGCTGGTCCTGGTGTGCCCCTCATC GCCCTCTCCCTGCAGCGGGCCCCACTGGCTCTGCCAGCTCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTG AGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGACCCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCC CTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATCCTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCG CAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGCCCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGA GCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGC AGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGT ATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCG ACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTC TCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTG CCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAGTTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAG GGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCACGCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGT GCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACATAGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGC CTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGCTTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCT TTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGGCCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTT TCCCTGTATTTACTTGGGGTGCTCTTCTGTGACACTTGCCACCACCACCTTCCAGTAGCAAGCTGGTAGAGCTGTACTTTTTCTTCACAG CTTTTACCATGGTTTATAATTATATACTTATACAGTTTAGTCATCAATGACTATTTTGCTTACTATTGTGTCTATGATATGTGATACAAA GCAAATATTTTCTAAATATTCATTGACTAAACAGCCATCAAGATGAAACAGGACAGGAGAGAACTGTTCAGTGTGATACAGAGCTGCCAT TTCCAAAGTATTCTGGAAGCAAGCCATTGCCTTACTCTTGATTTTCAACAGTTCTAAACAGCAACAGCATCCACCTAATATACCTTCAGA ATATCAAAGCGAAAACTGATAGAACTACAAAGAGAAATAAAATCCATTCTCACGGCAGGCAAATCAGTGAGAAAAATGTAAAGATCTGGA GGATTTACTTAGTATCGCTAACAAGCTGGATCCAGTAGATGCGTATGGAATTTCAAATACACATAGACGATGCACAAAAAACCACCCTGT ACGAAGGCCACAAAGAACAGCTCAGATGCACAAAGATTCACACCATACAGGCCAAATTATAGAATCCCCCAACCCCAAGACACTGCACCC TATGGGCTATACCCTCAGGCAGGGCCCTGCTTTTCTAGGAATTGACTCCAATGCAGAATAGTGAGAAATCAACAAAAAGCAAAATAAGAC AATTCCAGACACTCCTGAATTTACTTGGATTTAAAGAGGTTAATAAAAACAAACTATAAACTCTCTAGACTGGGCTGACAGTAAAAGCAC AGAATACAAAACCCAGGGGATGGGGCTGGGAGGGGCTGTGAGGGGCTGGCACCTCAGCTCAGAAAAGGTAGCAGCAATCCCAAAGCAGCA GAAGGCAGGGGTTAAATCAGGATAAAAACAGACATCAGTGGAATCGAAAACCAATAGTTAGTTAATATAAAGCCAGAAGGTTTTGTTTTT TTTCAGGTGGGGTCTCGCTCTGTCACCTAGACTAGACTGGAGTGCAATGGCCTGATCTCGGCTCACTGCAACCTCTGCCTCCCGAGTTCA AGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTCCGCTACCACAACTGGCTAATTTTTACATTTTTAGTAGAGACG GGGGATATTGCTATGTTGGCCAGGCTGGTCTCAAACTTCTGACCTCAAATGATTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGG TGTAAGTCACTGTACCCAGCCCAAAAGCAGTTTAAAAAAAAAAAAGACAAAATATACAACTCTTGATAAAACATAAAGGTACAGTGGTCT ATGAGGAAGAGAAAAGGTACCTGAGGATGCAGAAGTACCTACCACATGGGAACCGTTTGTCCACACTCATTCCAGAGAAAACCGAGTCCT CTCAGTTGCACACGTGTACGTATCAGTGGGAAGTGCTTGCCATTACTCCAAAGCCTAGAACCTTCACGTCATGAAGGTTCTGGAAGGTTT TTCAGATTGCTTAAGATACGCAGCCATTCCATATTCATCTCCAACTACACAGGGGAACGGAGCAGATAGAGCTGCGACTGGGAAGCGTCA CCTTCCCGTCCAGAGCGCTTTCTTTCAGACCCTGCCTACCTGCAGGCAGATGGACCGGAGGGTTTTCTGCTTCCTTTCAACCAGATAACT TCCTAAGTGGAGATGGCCTGTAGGTAGCAAATGCAGGATTTTGTTTACTTTCATCATGTCATGTGGTGGTCAGACTGCTCGCTGGTGGCC TCGCTTTAGAAGGTTTTCATCAAGCCCCGCCCTTTCTCTCTCATAGTCTTAATGCGTCTGGACCACTGGGGAAAATATTTTTCTTTTCAA AAAGCAGCCCCTTCAGTCTGCGTTCCCAGTTCATTTTGCAGGCGCATTCGCCCTTCCTAGTTTGCAGCAATTAAAGATAACGGAGTGTAA AGTCATTAGACCCAGAATTAGAGCAGCCAGCAGCTGGCCCAGTGTAAAAATGTCCCAAGTGTAGCCCCTCCCACCGCAGAGCCTGTTTCT AACGTACCTGCCATTCGTGGAAGTCGCCTGGGTTTTGTAAAGGAGAATTTTTTGGACTCAAGCTGTCATCTTCAAGCACGCCAACTTCAG GCAGTGTTTTCTACTGCAAACCTCCACATCCTGGAATCAATCACACTGACAGGGAAAGGATAAATGCTCCTTTATAAGCCAACATGTATC CAAATTAAGCCCCCTTACCTTTATCCAGACCCTTTCACAAACAAGTTCTGAGTTTTTAGCCAATTGATCCTCTACTTTCCTTCTTTAGTC CCTCTCAGGGACGCCTCCATCCCCGGCTCCCCTAAAGGTAGAAGATACTCGAGCATGCTGCCAGGGGAGCTGGATGGTGAAACACCTGAA |
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FusionGenePPI for ULK1_FBXW8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ULK1 | GABARAP, SYNGAP1, SDCBP, GABARAPL2, PRKAA2, RB1CC1, PRKAA1, ATG4B, G3BP1, CDC37, USP10, PRKAG1, PRKAB2, PPP1CA, AMBRA1, RPTOR, MTOR, MLST8, ATG13, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, ULK1, MBP, TRAF6, RALB, BECN1, EXOC8, EXOC2, ATG16L1, SESN2, SQSTM1, ATG101, OCLN, DAPK3, RAB1A, MUL1, HTT, MEFV, NLRP3, TRIM21, IRF3, IRGM, FLCN, PRKAB1, NEDD4L, BIRC2, CCDC53, TRIM16, TRIM25 | FBXW8 | CUL7, SKP1, RBX1, CCND1, CUL1, MYC, HSPA4, HSP90AA1, BTRC, FBXW2, SKP2, FBXO4, CUL2, CCT6B, CCT7, CCT3, CCT2, PFDN5, CCT6A, VBP1, CCDC8, TRIP13, OBSL1, PDCD5, GORASP1, NFKBIA, BCL3, CUL4A, DDB1, REST, TBC1D3, IRS1, UBE2D3, MAP4K1, EP300, TCP1, TTC29, MAPK14, CASQ2, XPO1, TP53, ZNF669, KLHL2, ZNF263, ZNF408, ZFC3H1, CETN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | ULK1 | chr12:132403929 | chr12:117461952 | ENST00000321867 | + | 24 | 28 | 287_416 | 894 | 1051 | GABARAP and GABARAPL2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ULK1_FBXW8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ULK1_FBXW8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FBXW8 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
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