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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40753

FusionGeneSummary for UIMC1_LILRB1

check button Fusion gene summary
Fusion gene informationFusion gene name: UIMC1_LILRB1
Fusion gene ID: 40753
HgeneTgene
Gene symbol

UIMC1

LILRB1

Gene ID

51720

10859

Gene nameubiquitin interaction motif containing 1leukocyte immunoglobulin like receptor B1
SynonymsRAP80|X2HRIP110CD85J|ILT-2|ILT2|LIR-1|LIR1|MIR-7|MIR7|PIR-B|PIRB
Cytomap

5q35.2

19q13.42

Type of geneprotein-codingprotein-coding
DescriptionBRCA1-A complex subunit RAP80receptor-associated protein 80retinoid X receptor-interacting protein 110leukocyte immunoglobulin-like receptor subfamily B member 1CD85 antigen-like family member JIg-like transcript 2leucocyte Ig-like receptor B1leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoformleukocyte immunoglobulin-like rece
Modification date2018052320180527
UniProtAcc

Q96RL1

Q8NHL6

Ensembl transtripts involved in fusion geneENST00000377227, ENST00000377219, 
ENST00000506128, ENST00000511320, 
ENST00000503273, 		ENST00000418536, 
ENST00000448689, ENST00000396321, 
ENST00000396331, ENST00000396327, 
ENST00000434867, ENST00000324602, 
ENST00000396332, ENST00000427581, 
ENST00000396317, ENST00000396315, 
ENST00000462628, 
Fusion gene scores* DoF score7 X 5 X 6=2101 X 1 X 1=1
# samples 81
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: UIMC1 [Title/Abstract] AND LILRB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUIMC1

GO:0045892

negative regulation of transcription, DNA-templated

12080054

TgeneLILRB1

GO:0001915

negative regulation of T cell mediated cytotoxicity

21213105

TgeneLILRB1

GO:0002230

positive regulation of defense response to virus by host

18398485

TgeneLILRB1

GO:0002309

T cell proliferation involved in immune response

18094328

TgeneLILRB1

GO:0002740

negative regulation of cytokine secretion involved in immune response

18094328

TgeneLILRB1

GO:0002774

Fc receptor mediated inhibitory signaling pathway

9842885

TgeneLILRB1

GO:0007165

signal transduction

18802077

TgeneLILRB1

GO:0009615

response to virus

9285411|17869268|18094328

TgeneLILRB1

GO:0010628

positive regulation of gene expression

18094328

TgeneLILRB1

GO:0014063

negative regulation of serotonin secretion

11907092

TgeneLILRB1

GO:0032609

interferon-gamma production

11907092

TgeneLILRB1

GO:0032689

negative regulation of interferon-gamma production

17869268

TgeneLILRB1

GO:0032945

negative regulation of mononuclear cell proliferation

21551166

TgeneLILRB1

GO:0035548

negative regulation of interferon-beta secretion

21213105

TgeneLILRB1

GO:0042130

negative regulation of T cell proliferation

15585844

TgeneLILRB1

GO:0042536

negative regulation of tumor necrosis factor biosynthetic process

18684926

TgeneLILRB1

GO:0043065

positive regulation of apoptotic process

21551166

TgeneLILRB1

GO:0045077

negative regulation of interferon-gamma biosynthetic process

18684926

TgeneLILRB1

GO:0045786

negative regulation of cell cycle

21551166

TgeneLILRB1

GO:0045806

negative regulation of endocytosis

18094328

TgeneLILRB1

GO:0045919

positive regulation of cytolysis

18684926

TgeneLILRB1

GO:0045953

negative regulation of natural killer cell mediated cytotoxicity

18398485

TgeneLILRB1

GO:0046636

negative regulation of alpha-beta T cell activation

21213105

TgeneLILRB1

GO:0051607

defense response to virus

15585844

TgeneLILRB1

GO:0051926

negative regulation of calcium ion transport

9842885

TgeneLILRB1

GO:0072643

interferon-gamma secretion

15585844

TgeneLILRB1

GO:2000669

negative regulation of dendritic cell apoptotic process

18094328

TgeneLILRB1

GO:2001180

negative regulation of interleukin-10 secretion

18094328

TgeneLILRB1

GO:2001183

negative regulation of interleukin-12 secretion

18094328

TgeneLILRB1

GO:2001186

negative regulation of CD8-positive, alpha-beta T cell activation

21213105

TgeneLILRB1

GO:2001189

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

18094328

TgeneLILRB1

GO:2001193

positive regulation of gamma-delta T cell activation involved in immune response

21233315

TgeneLILRB1

GO:2001202

negative regulation of transforming growth factor-beta secretion

18094328

TgeneLILRB1

GO:2001205

negative regulation of osteoclast development

18802077


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0893-01BUIMC1chr5

176409470

-LILRB1chr19

55142477

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377227ENST00000418536UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377227ENST00000448689UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377227ENST00000396321UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377227ENST00000396331UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377227ENST00000396327UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377227ENST00000434867UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377227ENST00000324602UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377227ENST00000396332UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377227ENST00000427581UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377227ENST00000396317UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377227ENST00000396315UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377227ENST00000462628UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377219ENST00000418536UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377219ENST00000448689UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377219ENST00000396321UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377219ENST00000396331UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377219ENST00000396327UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377219ENST00000434867UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377219ENST00000324602UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377219ENST00000396332UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000377219ENST00000427581UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377219ENST00000396317UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377219ENST00000396315UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000377219ENST00000462628UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000506128ENST00000418536UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000506128ENST00000448689UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000506128ENST00000396321UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000506128ENST00000396331UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000506128ENST00000396327UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000506128ENST00000434867UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000506128ENST00000324602UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000506128ENST00000396332UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000506128ENST00000427581UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000506128ENST00000396317UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000506128ENST00000396315UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000506128ENST00000462628UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000511320ENST00000418536UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000511320ENST00000448689UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000511320ENST00000396321UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000511320ENST00000396331UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000511320ENST00000396327UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000511320ENST00000434867UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000511320ENST00000324602UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000511320ENST00000396332UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-5UTRENST00000511320ENST00000427581UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000511320ENST00000396317UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000511320ENST00000396315UIMC1chr5

176409470

-LILRB1chr19

55142477

+
5CDS-intronENST00000511320ENST00000462628UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-intronENST00000503273ENST00000418536UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-intronENST00000503273ENST00000448689UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-intronENST00000503273ENST00000396321UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-5UTRENST00000503273ENST00000396331UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-5UTRENST00000503273ENST00000396327UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-5UTRENST00000503273ENST00000434867UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-5UTRENST00000503273ENST00000324602UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-5UTRENST00000503273ENST00000396332UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-5UTRENST00000503273ENST00000427581UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-intronENST00000503273ENST00000396317UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-intronENST00000503273ENST00000396315UIMC1chr5

176409470

-LILRB1chr19

55142477

+
intron-intronENST00000503273ENST00000462628UIMC1chr5

176409470

-LILRB1chr19

55142477

+

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FusionProtFeatures for UIMC1_LILRB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UIMC1

Q96RL1

LILRB1

Q8NHL6

Receptor for class I MHC antigens. Recognizes a broadspectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor forH301/UL18, a human cytomegalovirus class I MHC homolog. Ligandbinding results in inhibitory signals and down-regulation of theimmune response. Engagement of LILRB1 present on natural killercells or T-cells by class I MHC molecules protects the targetcells from lysis. Interaction with HLA-B or HLA-E leads toinhibition of the signal triggered by FCER1A and inhibitsserotonin release. Inhibits FCGR1A-mediated phosphorylation ofcellular proteins and mobilization of intracellular calcium ions.{ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:9285411,ECO:0000269|PubMed:9842885}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UIMC1_LILRB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UIMC1_LILRB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UIMC1NR6A1, BRCA1, UBC, BARD1, BRE, BRCC3, ALB, CAPZA1, CAPZB, CCNA2, CDK1, DLST, F7, NRD1, PFAS, RFC4, CASK, NAE1, CPNE1, UBA3, COPS2, BAG5, ERP44, FAM175B, BABAM1, SSU72, GLTSCR2, AMOT, G3BP1, G3BP2, SPATA2, LIN7C, WDR48, PYCRL, THNSL1, FAM175A, DPY30, LOC344382, MDC1, TP53, MDM2, RAD23A, SUMO2, ATP8A2, RBBP8, ESR1, KIAA0368, HIST2H2AC, HIST2H2BE, PAXIP1, SUMO1, SKIL, BLM, C1QBP, HSPA4, RPS6, FANCG, SHMT2, MOV10, NXF1, HIST1H2BG, DVL2, PARP1, TRAIP, COMMD8, MINA, LDLRAD4, WBP2, TRIM25, USP13LILRB1HLA-A, HLA-B, HLA-C, HLA-G, HLA-F, PTPN6, LILRA3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UIMC1_LILRB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UIMC1_LILRB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLILRB1C0036341Schizophrenia1PSYGENET