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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40750

FusionGeneSummary for UHRF2_PUM2

check button Fusion gene summary
Fusion gene informationFusion gene name: UHRF2_PUM2
Fusion gene ID: 40750
HgeneTgene
Gene symbol

UHRF2

PUM2

Gene ID

115426

23369

Gene nameubiquitin like with PHD and ring finger domains 2pumilio RNA binding family member 2
SynonymsNIRF|RNF107|TDRD23|URF2PUMH2|PUML2
Cytomap

9p24.1

2p24.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase UHRF2Np95-like ring finger proteinRING finger protein 107RING-type E3 ubiquitin transferase UHRF2np95/ICBP90-like RING finger proteinnuclear protein 97nuclear zinc finger protein NP97ubiquitin-like PHD and RING finger dopumilio homolog 2pumilio-2
Modification date2018052320180522
UniProtAcc

Q96PU4

Q8TB72

Ensembl transtripts involved in fusion geneENST00000276893, ENST00000381373, 
ENST00000485617, 
ENST00000338086, 
ENST00000319801, ENST00000361078, 
ENST00000536417, ENST00000403432, 
ENST00000420234, 
Fusion gene scores* DoF score5 X 4 X 4=808 X 7 X 5=280
# samples 510
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UHRF2 [Title/Abstract] AND PUM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUHRF2

GO:0016567

protein ubiquitination

14741369

HgeneUHRF2

GO:0051865

protein autoubiquitination

14741369

HgeneUHRF2

GO:0071158

positive regulation of cell cycle arrest

15178429

TgenePUM2

GO:0010608

posttranscriptional regulation of gene expression

25100735

TgenePUM2

GO:0043488

regulation of mRNA stability

26724866

TgenePUM2

GO:0051983

regulation of chromosome segregation

26724866

TgenePUM2

GO:1900246

positive regulation of RIG-I signaling pathway

25340845


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE697670UHRF2chr9

6506093

-PUM2chr2

20451426

-
ChiTaRS3.1BE697672UHRF2chr9

6506093

-PUM2chr2

20451426

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000276893ENST00000338086UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000319801UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000361078UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000536417UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000403432UHRF2chr9

6506093

-PUM2chr2

20451426

-
5CDS-intronENST00000276893ENST00000420234UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000338086UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000319801UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000361078UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000536417UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000403432UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-intronENST00000381373ENST00000420234UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000338086UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000319801UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000361078UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000536417UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000403432UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-intronENST00000485617ENST00000420234UHRF2chr9

6506093

-PUM2chr2

20451426

-

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FusionProtFeatures for UHRF2_PUM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UHRF2

Q96PU4

PUM2

Q8TB72

E3 ubiquitin-protein ligase that is an intermolecularhub protein in the cell cycle network. Through cooperative DNA andhistone binding, may contribute to a tighter epigenetic control ofgene expression in differentiated cells. Ubiquitinates cyclins,CCND1 and CCNE1, in an apparently phosphorylation-independentmanner and induces G1 arrest. Also ubiquitinates PCNP leading toits degradation by the proteasome. E3 SUMO-, but not ubiquitin-,protein ligase for ZNF131. {ECO:0000269|PubMed:12176013,ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429,ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639,ECO:0000269|PubMed:23404503}. Sequence-specific RNA-binding protein that acts as apost-transcriptional repressor by binding the 3'-UTR of mRNAtargets. Binds to an RNA consensus sequence, the Pumilio ResponseElement (PRE), 5'-UGUANAUA-3', that is related to the NanosResponse Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via differentmechanisms: acts via direct recruitment of the CCR4-POP2-NOTdeadenylase leading to translational inhibition and mRNAdegradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs(PubMed:18776931, PubMed:22345517). Acts as a post-transcriptionalrepressor of E2F3 mRNAs by binding to its 3'-UTR and facilitatingmiRNA regulation (PubMed:22345517). Plays a role in cytoplasmicsensing of viral infection (PubMed:25340845). Represses a programof genes necessary to maintain genomic stability such as keymitotic, DNA repair and DNA replication factors. Its ability torepress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its highabundance and multitude of PUMILIO binding sites, is able tosequester a significant fraction of PUM1 and PUM2 in the cytoplasm(PubMed:26724866). May regulate DCUN1D3 mRNA levels(PubMed:25349211). May support proliferation and self-renewal ofstem cells. Binds specifically to miRNA MIR199A precursor, withPUM1, regulates miRNA MIR199A expression at a postranscriptionallevel (PubMed:28431233). {ECO:0000269|PubMed:18776931,ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517,ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845,ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866,ECO:0000269|PubMed:28431233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UHRF2_PUM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0aa

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0nt

>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0nt


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FusionGenePPI for UHRF2_PUM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UHRF2_PUM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UHRF2_PUM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource