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Fusion gene ID: 40750 |
FusionGeneSummary for UHRF2_PUM2 |
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Fusion gene information | Fusion gene name: UHRF2_PUM2 | Fusion gene ID: 40750 | Hgene | Tgene | Gene symbol | UHRF2 | PUM2 | Gene ID | 115426 | 23369 |
Gene name | ubiquitin like with PHD and ring finger domains 2 | pumilio RNA binding family member 2 | |
Synonyms | NIRF|RNF107|TDRD23|URF2 | PUMH2|PUML2 | |
Cytomap | 9p24.1 | 2p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase UHRF2Np95-like ring finger proteinRING finger protein 107RING-type E3 ubiquitin transferase UHRF2np95/ICBP90-like RING finger proteinnuclear protein 97nuclear zinc finger protein NP97ubiquitin-like PHD and RING finger do | pumilio homolog 2pumilio-2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q96PU4 | Q8TB72 | |
Ensembl transtripts involved in fusion gene | ENST00000276893, ENST00000381373, ENST00000485617, | ENST00000338086, ENST00000319801, ENST00000361078, ENST00000536417, ENST00000403432, ENST00000420234, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 8 X 7 X 5=280 |
# samples | 5 | 10 | |
** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UHRF2 [Title/Abstract] AND PUM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | UHRF2 | GO:0016567 | protein ubiquitination | 14741369 |
Hgene | UHRF2 | GO:0051865 | protein autoubiquitination | 14741369 |
Hgene | UHRF2 | GO:0071158 | positive regulation of cell cycle arrest | 15178429 |
Tgene | PUM2 | GO:0010608 | posttranscriptional regulation of gene expression | 25100735 |
Tgene | PUM2 | GO:0043488 | regulation of mRNA stability | 26724866 |
Tgene | PUM2 | GO:0051983 | regulation of chromosome segregation | 26724866 |
Tgene | PUM2 | GO:1900246 | positive regulation of RIG-I signaling pathway | 25340845 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE697670 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - | ||
ChiTaRS3.1 | BE697672 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000276893 | ENST00000338086 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
In-frame | ENST00000276893 | ENST00000319801 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
In-frame | ENST00000276893 | ENST00000361078 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
In-frame | ENST00000276893 | ENST00000536417 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
In-frame | ENST00000276893 | ENST00000403432 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
5CDS-intron | ENST00000276893 | ENST00000420234 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
intron-3CDS | ENST00000381373 | ENST00000338086 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
intron-3CDS | ENST00000381373 | ENST00000319801 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
intron-3CDS | ENST00000381373 | ENST00000361078 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
intron-3CDS | ENST00000381373 | ENST00000536417 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
intron-3CDS | ENST00000381373 | ENST00000403432 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
intron-intron | ENST00000381373 | ENST00000420234 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
3UTR-3CDS | ENST00000485617 | ENST00000338086 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
3UTR-3CDS | ENST00000485617 | ENST00000319801 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
3UTR-3CDS | ENST00000485617 | ENST00000361078 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
3UTR-3CDS | ENST00000485617 | ENST00000536417 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
3UTR-3CDS | ENST00000485617 | ENST00000403432 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
3UTR-intron | ENST00000485617 | ENST00000420234 | UHRF2 | chr9 | 6506093 | - | PUM2 | chr2 | 20451426 | - |
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FusionProtFeatures for UHRF2_PUM2 |
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Hgene | Tgene |
UHRF2 | PUM2 |
E3 ubiquitin-protein ligase that is an intermolecularhub protein in the cell cycle network. Through cooperative DNA andhistone binding, may contribute to a tighter epigenetic control ofgene expression in differentiated cells. Ubiquitinates cyclins,CCND1 and CCNE1, in an apparently phosphorylation-independentmanner and induces G1 arrest. Also ubiquitinates PCNP leading toits degradation by the proteasome. E3 SUMO-, but not ubiquitin-,protein ligase for ZNF131. {ECO:0000269|PubMed:12176013,ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429,ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639,ECO:0000269|PubMed:23404503}. | Sequence-specific RNA-binding protein that acts as apost-transcriptional repressor by binding the 3'-UTR of mRNAtargets. Binds to an RNA consensus sequence, the Pumilio ResponseElement (PRE), 5'-UGUANAUA-3', that is related to the NanosResponse Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via differentmechanisms: acts via direct recruitment of the CCR4-POP2-NOTdeadenylase leading to translational inhibition and mRNAdegradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs(PubMed:18776931, PubMed:22345517). Acts as a post-transcriptionalrepressor of E2F3 mRNAs by binding to its 3'-UTR and facilitatingmiRNA regulation (PubMed:22345517). Plays a role in cytoplasmicsensing of viral infection (PubMed:25340845). Represses a programof genes necessary to maintain genomic stability such as keymitotic, DNA repair and DNA replication factors. Its ability torepress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its highabundance and multitude of PUMILIO binding sites, is able tosequester a significant fraction of PUM1 and PUM2 in the cytoplasm(PubMed:26724866). May regulate DCUN1D3 mRNA levels(PubMed:25349211). May support proliferation and self-renewal ofstem cells. Binds specifically to miRNA MIR199A precursor, withPUM1, regulates miRNA MIR199A expression at a postranscriptionallevel (PubMed:28431233). {ECO:0000269|PubMed:18776931,ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517,ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845,ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866,ECO:0000269|PubMed:28431233}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UHRF2_PUM2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0aa >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000338086_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000319801_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000361078_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000536417_chr2_20451426_-_0nt >In-frame_UHRF2_ENST00000276893_chr9_6506093_-_PUM2_ENST00000403432_chr2_20451426_-_0nt |
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FusionGenePPI for UHRF2_PUM2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UHRF2_PUM2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UHRF2_PUM2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |