FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 40728

FusionGeneSummary for UHMK1_PPOX

check button Fusion gene summary
Fusion gene informationFusion gene name: UHMK1_PPOX
Fusion gene ID: 40728
HgeneTgene
Gene symbol

UHMK1

PPOX

Gene ID

127933

5498

Gene nameU2AF homology motif kinase 1protoporphyrinogen oxidase
SynonymsKIS|KIST|P-CIP2PPO|V290M|VP
Cytomap

1q23.3

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase KistKIS protein kinasePAM COOH-terminal interactor protein 2U2AF homology motif (UHM) kinase 1kinase interacting with leukemia-associated gene (stathmin)protoporphyrinogen oxidase
Modification date2018052320180519
UniProtAcc

Q8TAS1

P50336

Ensembl transtripts involved in fusion geneENST00000545294, ENST00000538489, 
ENST00000489294, ENST00000282169, 
ENST00000352210, ENST00000367999, 
ENST00000544598, ENST00000495483, 
ENST00000535223, ENST00000432542, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: UHMK1 [Title/Abstract] AND PPOX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUHMK1

GO:0018105

peptidyl-serine phosphorylation

12093740

HgeneUHMK1

GO:0046777

protein autophosphorylation

12093740

HgeneUHMK1

GO:0046825

regulation of protein export from nucleus

12093740

TgenePPOX

GO:0006779

porphyrin-containing compound biosynthetic process

7713909

TgenePPOX

GO:0006783

heme biosynthetic process

7713909

TgenePPOX

GO:0055114

oxidation-reduction process

7713909


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1NA-01AUHMK1chr1

162487980

+PPOXchr1

161139450

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000545294ENST00000352210UHMK1chr1

162487980

+PPOXchr1

161139450

+
In-frameENST00000545294ENST00000367999UHMK1chr1

162487980

+PPOXchr1

161139450

+
5CDS-intronENST00000545294ENST00000544598UHMK1chr1

162487980

+PPOXchr1

161139450

+
5CDS-3UTRENST00000545294ENST00000495483UHMK1chr1

162487980

+PPOXchr1

161139450

+
5CDS-intronENST00000545294ENST00000535223UHMK1chr1

162487980

+PPOXchr1

161139450

+
5CDS-intronENST00000545294ENST00000432542UHMK1chr1

162487980

+PPOXchr1

161139450

+
intron-3CDSENST00000538489ENST00000352210UHMK1chr1

162487980

+PPOXchr1

161139450

+
intron-3CDSENST00000538489ENST00000367999UHMK1chr1

162487980

+PPOXchr1

161139450

+
intron-intronENST00000538489ENST00000544598UHMK1chr1

162487980

+PPOXchr1

161139450

+
intron-3UTRENST00000538489ENST00000495483UHMK1chr1

162487980

+PPOXchr1

161139450

+
intron-intronENST00000538489ENST00000535223UHMK1chr1

162487980

+PPOXchr1

161139450

+
intron-intronENST00000538489ENST00000432542UHMK1chr1

162487980

+PPOXchr1

161139450

+
In-frameENST00000489294ENST00000352210UHMK1chr1

162487980

+PPOXchr1

161139450

+
In-frameENST00000489294ENST00000367999UHMK1chr1

162487980

+PPOXchr1

161139450

+
5CDS-intronENST00000489294ENST00000544598UHMK1chr1

162487980

+PPOXchr1

161139450

+
5CDS-3UTRENST00000489294ENST00000495483UHMK1chr1

162487980

+PPOXchr1

161139450

+
5CDS-intronENST00000489294ENST00000535223UHMK1chr1

162487980

+PPOXchr1

161139450

+
5CDS-intronENST00000489294ENST00000432542UHMK1chr1

162487980

+PPOXchr1

161139450

+
3UTR-3CDSENST00000282169ENST00000352210UHMK1chr1

162487980

+PPOXchr1

161139450

+
3UTR-3CDSENST00000282169ENST00000367999UHMK1chr1

162487980

+PPOXchr1

161139450

+
3UTR-intronENST00000282169ENST00000544598UHMK1chr1

162487980

+PPOXchr1

161139450

+
3UTR-3UTRENST00000282169ENST00000495483UHMK1chr1

162487980

+PPOXchr1

161139450

+
3UTR-intronENST00000282169ENST00000535223UHMK1chr1

162487980

+PPOXchr1

161139450

+
3UTR-intronENST00000282169ENST00000432542UHMK1chr1

162487980

+PPOXchr1

161139450

+

Top

FusionProtFeatures for UHMK1_PPOX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UHMK1

Q8TAS1

PPOX

P50336

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1,thus controlling CDKN1B subcellular location and cell cycleprogression in G1 phase. May be involved in trafficking and/orprocessing of RNA (By similarity). {ECO:0000250}. Catalyzes the 6-electron oxidation ofprotoporphyrinogen-IX to form protoporphyrin-IX.{ECO:0000269|PubMed:21048046, ECO:0000269|PubMed:23467411,ECO:0000269|PubMed:7713909}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUHMK1chr1:162487980chr1:161139450ENST00000489294+7823_304371420DomainProtein kinase
HgeneUHMK1chr1:162487980chr1:161139450ENST00000489294+7829_37371420Nucleotide bindingATP
HgeneUHMK1chr1:162487980chr1:161139450ENST00000545294+7829_37297346Nucleotide bindingATP
TgenePPOXchr1:162487980chr1:161139450ENST00000352210+613454_456269478Nucleotide bindingFAD
TgenePPOXchr1:162487980chr1:161139450ENST00000367999+613454_456269478Nucleotide bindingFAD

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUHMK1chr1:162487980chr1:161139450ENST00000489294+78324_406371420DomainRRM
HgeneUHMK1chr1:162487980chr1:161139450ENST00000538489+1723_304-66345DomainProtein kinase
HgeneUHMK1chr1:162487980chr1:161139450ENST00000538489+17324_406-66345DomainRRM
HgeneUHMK1chr1:162487980chr1:161139450ENST00000545294+7823_304297346DomainProtein kinase
HgeneUHMK1chr1:162487980chr1:161139450ENST00000545294+78324_406297346DomainRRM
HgeneUHMK1chr1:162487980chr1:161139450ENST00000538489+1729_37-66345Nucleotide bindingATP
TgenePPOXchr1:162487980chr1:161139450ENST00000352210+61334_35269478Nucleotide bindingFAD
TgenePPOXchr1:162487980chr1:161139450ENST00000352210+61357_60269478Nucleotide bindingFAD
TgenePPOXchr1:162487980chr1:161139450ENST00000352210+6139_14269478Nucleotide bindingFAD
TgenePPOXchr1:162487980chr1:161139450ENST00000367999+61334_35269478Nucleotide bindingFAD
TgenePPOXchr1:162487980chr1:161139450ENST00000367999+61357_60269478Nucleotide bindingFAD
TgenePPOXchr1:162487980chr1:161139450ENST00000367999+6139_14269478Nucleotide bindingFAD


Top

FusionGeneSequence for UHMK1_PPOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_506aa
MFLTRPKVCVDLNRRVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNI
LWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANS
SAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVV
EDVKEECQKYGPVVSLLVPKENPGRGQVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFG
HLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQY

>In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_506aa
MFLTRPKVCVDLNRRVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNI
LWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANS
SAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVV
EDVKEECQKYGPVVSLLVPKENPGRGQVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFG
HLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQY

>In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_580aa
MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIV
TLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL
SFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNA
AIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSL
LVPKENPGRGQVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVY
DSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLT

>In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_580aa
MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIV
TLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL
SFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNA
AIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSL
LVPKENPGRGQVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVY
DSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_1518nt
ATGTTTCTTACCAGACCGAAGGTCTGTGTTGACCTTAACCGGAGAGTGACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTG
CCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATG
ATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATA
TTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACA
GACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGAT
CTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGT
TCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATG
CTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGAT
CTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTA
GAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTA
AGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTG
GCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGA
CATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGC
CTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGG
GCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTAT
ACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAG

>In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_1518nt
ATGTTTCTTACCAGACCGAAGGTCTGTGTTGACCTTAACCGGAGAGTGACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTG
CCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATG
ATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATA
TTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACA
GACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGAT
CTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGT
TCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATG
CTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGAT
CTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTA
GAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTA
AGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTG
GCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGA
CATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGC
CTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGG
GCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTAT
ACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAG

>In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_1740nt
ATGGCGGGATCCGGCTGCGCCTGGGGCGCGGAGCCGCCGCGTTTTCTGGAGGCCTTCGGGCGGCTGTGGCAGGTACAGAGCCGTCTGGGT
AGCGGCTCCTCCGCCTCGGTGTATCGGGTTCGCTGCTGCGGCAACCCTGGCTCGCCCCCCGGCGCCCTCAAGCAGTTCTTGCCGCCAGGA
ACCACCGGGGCTGCGGCCTCTGCCGCCGAGTATGGTTTCCGCAAAGAGAGGGCGGCGCTGGAACAGTTGCAGGGTCACAGAAACATCGTG
ACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTGCCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAA
TTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATGATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCAT
CATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATATTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTT
AGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACAGACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAG
GCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGATCTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAA
CTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGTTCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCC
GCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATGCTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGC
AGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGATCTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGAT
GATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTAGAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTA
CTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTAAGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCT
TCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTGGCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAAT
CTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGACATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTAT
GACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGCCTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAG
GCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGGGCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGC
CACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTATACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACT
GCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAGGGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTC

>In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_1740nt
ATGGCGGGATCCGGCTGCGCCTGGGGCGCGGAGCCGCCGCGTTTTCTGGAGGCCTTCGGGCGGCTGTGGCAGGTACAGAGCCGTCTGGGT
AGCGGCTCCTCCGCCTCGGTGTATCGGGTTCGCTGCTGCGGCAACCCTGGCTCGCCCCCCGGCGCCCTCAAGCAGTTCTTGCCGCCAGGA
ACCACCGGGGCTGCGGCCTCTGCCGCCGAGTATGGTTTCCGCAAAGAGAGGGCGGCGCTGGAACAGTTGCAGGGTCACAGAAACATCGTG
ACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTGCCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAA
TTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATGATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCAT
CATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATATTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTT
AGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACAGACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAG
GCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGATCTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAA
CTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGTTCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCC
GCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATGCTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGC
AGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGATCTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGAT
GATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTAGAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTA
CTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTAAGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCT
TCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTGGCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAAT
CTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGACATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTAT
GACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGCCTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAG
GCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGGGCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGC
CACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTATACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACT
GCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAGGGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_1560nt
ATGTTTCTTACCAGACCGAAGGTCTGTGTTGACCTTAACCGGAGAGTGACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTG
CCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATG
ATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATA
TTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACA
GACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGAT
CTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGT
TCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATG
CTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGAT
CTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTA
GAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTA
AGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTG
GCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGA
CATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGC
CTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGG
GCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTAT
ACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAG
GGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTCAGTGTCCTGGGCACAGAACCTAACAGCTGATCCCCAACTCTC

>In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_1558nt
ATGTTTCTTACCAGACCGAAGGTCTGTGTTGACCTTAACCGGAGAGTGACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTG
CCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATG
ATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATA
TTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACA
GACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGAT
CTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGT
TCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATG
CTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGAT
CTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTA
GAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTA
AGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTG
GCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGA
CATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGC
CTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGG
GCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTAT
ACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAG
GGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTCAGTGTCCTGGGCACAGAACCTAACAGCTGATCCCCAACTCTC

>In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_1940nt
GGTGTCATGGCTGCTTGAAGTCCCGGGAGTCGGTGAGGCGGCTGCAGGTCCCTCCCTGCGGAGCCGCTGGTCCGGCTGGCGGAGATGTGA
CCGCGGGCCCGGCCGGCCTGCCTCAGGCGTCGCGTCAGCTCCCGTGTCCGTGCCCTTAACCCACACCGATGGCGGGATCCGGCTGCGCCT
GGGGCGCGGAGCCGCCGCGTTTTCTGGAGGCCTTCGGGCGGCTGTGGCAGGTACAGAGCCGTCTGGGTAGCGGCTCCTCCGCCTCGGTGT
ATCGGGTTCGCTGCTGCGGCAACCCTGGCTCGCCCCCCGGCGCCCTCAAGCAGTTCTTGCCGCCAGGAACCACCGGGGCTGCGGCCTCTG
CCGCCGAGTATGGTTTCCGCAAAGAGAGGGCGGCGCTGGAACAGTTGCAGGGTCACAGAAACATCGTGACTTTGTATGGAGTGTTTACAA
TCCACTTTTCTCCAAATGTGCCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACC
AGGGTTGTTCCATGTGGATGATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGG
ACCTCAAACCACGTAACATATTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGG
ATGTAAAGTATATTCAGACAGACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAG
AATGTACCTCAGCTGTTGATCTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTC
AGGAATGGAAGGCAAACAGTTCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAA
GAGACCTTATCAAAAGCATGCTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTT
TTGCCCCTCATATTGAAGATCTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAG
AGGAATATGAAGATGTTGTAGAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTG
GCAGAGGACAAGTATCTCTAAGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCC
CTGCTGAGGCTGCCCCTCTGGCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATC
TGCCTGTCCAGGGATTTGGACATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGC
AGGACGGGAGCCCCCCTGGCCTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTC
AGGAGCTGTTTCAACAGCGGGCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACA
AGAACTGCATTCCCCAGTATACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTC
TGGCTGGAGCCTCCTATGAGGGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTCAGTGTCCTGGGCACAGAACCTA

>In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_1938nt
GGTGTCATGGCTGCTTGAAGTCCCGGGAGTCGGTGAGGCGGCTGCAGGTCCCTCCCTGCGGAGCCGCTGGTCCGGCTGGCGGAGATGTGA
CCGCGGGCCCGGCCGGCCTGCCTCAGGCGTCGCGTCAGCTCCCGTGTCCGTGCCCTTAACCCACACCGATGGCGGGATCCGGCTGCGCCT
GGGGCGCGGAGCCGCCGCGTTTTCTGGAGGCCTTCGGGCGGCTGTGGCAGGTACAGAGCCGTCTGGGTAGCGGCTCCTCCGCCTCGGTGT
ATCGGGTTCGCTGCTGCGGCAACCCTGGCTCGCCCCCCGGCGCCCTCAAGCAGTTCTTGCCGCCAGGAACCACCGGGGCTGCGGCCTCTG
CCGCCGAGTATGGTTTCCGCAAAGAGAGGGCGGCGCTGGAACAGTTGCAGGGTCACAGAAACATCGTGACTTTGTATGGAGTGTTTACAA
TCCACTTTTCTCCAAATGTGCCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACC
AGGGTTGTTCCATGTGGATGATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGG
ACCTCAAACCACGTAACATATTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGG
ATGTAAAGTATATTCAGACAGACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAG
AATGTACCTCAGCTGTTGATCTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTC
AGGAATGGAAGGCAAACAGTTCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAA
GAGACCTTATCAAAAGCATGCTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTT
TTGCCCCTCATATTGAAGATCTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAG
AGGAATATGAAGATGTTGTAGAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTG
GCAGAGGACAAGTATCTCTAAGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCC
CTGCTGAGGCTGCCCCTCTGGCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATC
TGCCTGTCCAGGGATTTGGACATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGC
AGGACGGGAGCCCCCCTGGCCTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTC
AGGAGCTGTTTCAACAGCGGGCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACA
AGAACTGCATTCCCCAGTATACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTC
TGGCTGGAGCCTCCTATGAGGGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTCAGTGTCCTGGGCACAGAACCTA


Top

FusionGenePPI for UHMK1_PPOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UHMK1ELAVL1, EDEM2PPOXHAP1, IMMT, COPS5, HNRNPD, PLAUR, NDUFA10, SDF4, CBWD1, ISLR, THBS3, ARSA, NANOG, POU5F1, COQ9, BPNT1, CRYBA4, ACSM5, PCDHA12, TCTN1, NDUFS7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UHMK1_PPOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for UHMK1_PPOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUHMK1C0036341Schizophrenia4PSYGENET
HgeneUHMK1C0005586Bipolar Disorder1PSYGENET
TgenePPOXC0162532Variegate Porphyria23ORPHANET;UNIPROT