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Fusion gene ID: 40728 |
FusionGeneSummary for UHMK1_PPOX |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UHMK1_PPOX | Fusion gene ID: 40728 | Hgene | Tgene | Gene symbol | UHMK1 | PPOX | Gene ID | 127933 | 5498 |
| Gene name | U2AF homology motif kinase 1 | protoporphyrinogen oxidase | |
| Synonyms | KIS|KIST|P-CIP2 | PPO|V290M|VP | |
| Cytomap | 1q23.3 | 1q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase KistKIS protein kinasePAM COOH-terminal interactor protein 2U2AF homology motif (UHM) kinase 1kinase interacting with leukemia-associated gene (stathmin) | protoporphyrinogen oxidase | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8TAS1 | P50336 | |
| Ensembl transtripts involved in fusion gene | ENST00000545294, ENST00000538489, ENST00000489294, ENST00000282169, | ENST00000352210, ENST00000367999, ENST00000544598, ENST00000495483, ENST00000535223, ENST00000432542, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: UHMK1 [Title/Abstract] AND PPOX [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UHMK1 | GO:0018105 | peptidyl-serine phosphorylation | 12093740 |
| Hgene | UHMK1 | GO:0046777 | protein autophosphorylation | 12093740 |
| Hgene | UHMK1 | GO:0046825 | regulation of protein export from nucleus | 12093740 |
| Tgene | PPOX | GO:0006779 | porphyrin-containing compound biosynthetic process | 7713909 |
| Tgene | PPOX | GO:0006783 | heme biosynthetic process | 7713909 |
| Tgene | PPOX | GO:0055114 | oxidation-reduction process | 7713909 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A1NA-01A | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000545294 | ENST00000352210 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| In-frame | ENST00000545294 | ENST00000367999 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 5CDS-intron | ENST00000545294 | ENST00000544598 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 5CDS-3UTR | ENST00000545294 | ENST00000495483 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 5CDS-intron | ENST00000545294 | ENST00000535223 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 5CDS-intron | ENST00000545294 | ENST00000432542 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| intron-3CDS | ENST00000538489 | ENST00000352210 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| intron-3CDS | ENST00000538489 | ENST00000367999 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| intron-intron | ENST00000538489 | ENST00000544598 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| intron-3UTR | ENST00000538489 | ENST00000495483 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| intron-intron | ENST00000538489 | ENST00000535223 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| intron-intron | ENST00000538489 | ENST00000432542 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| In-frame | ENST00000489294 | ENST00000352210 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| In-frame | ENST00000489294 | ENST00000367999 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 5CDS-intron | ENST00000489294 | ENST00000544598 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 5CDS-3UTR | ENST00000489294 | ENST00000495483 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 5CDS-intron | ENST00000489294 | ENST00000535223 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 5CDS-intron | ENST00000489294 | ENST00000432542 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 3UTR-3CDS | ENST00000282169 | ENST00000352210 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 3UTR-3CDS | ENST00000282169 | ENST00000367999 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 3UTR-intron | ENST00000282169 | ENST00000544598 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 3UTR-3UTR | ENST00000282169 | ENST00000495483 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 3UTR-intron | ENST00000282169 | ENST00000535223 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
| 3UTR-intron | ENST00000282169 | ENST00000432542 | UHMK1 | chr1 | 162487980 | + | PPOX | chr1 | 161139450 | + |
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FusionProtFeatures for UHMK1_PPOX |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UHMK1 | PPOX |
| Upon serum stimulation, phosphorylates CDKN1B/p27Kip1,thus controlling CDKN1B subcellular location and cell cycleprogression in G1 phase. May be involved in trafficking and/orprocessing of RNA (By similarity). {ECO:0000250}. | Catalyzes the 6-electron oxidation ofprotoporphyrinogen-IX to form protoporphyrin-IX.{ECO:0000269|PubMed:21048046, ECO:0000269|PubMed:23467411,ECO:0000269|PubMed:7713909}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000489294 | + | 7 | 8 | 23_304 | 371 | 420 | Domain | Protein kinase |
| Hgene | UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000489294 | + | 7 | 8 | 29_37 | 371 | 420 | Nucleotide binding | ATP |
| Hgene | UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000545294 | + | 7 | 8 | 29_37 | 297 | 346 | Nucleotide binding | ATP |
| Tgene | >PPOX | chr1:162487980 | chr1:161139450 | ENST00000352210 | + | 6 | 13 | 454_456 | 269 | 478 | Nucleotide binding | FAD |
| Tgene | >PPOX | chr1:162487980 | chr1:161139450 | ENST00000367999 | + | 6 | 13 | 454_456 | 269 | 478 | Nucleotide binding | FAD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000489294 | + | 7 | 8 | 324_406 | 371 | 420 | Domain | RRM |
| Hgene | >UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000538489 | + | 1 | 7 | 23_304 | -66 | 345 | Domain | Protein kinase |
| Hgene | >UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000538489 | + | 1 | 7 | 324_406 | -66 | 345 | Domain | RRM |
| Hgene | >UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000545294 | + | 7 | 8 | 23_304 | 297 | 346 | Domain | Protein kinase |
| Hgene | >UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000545294 | + | 7 | 8 | 324_406 | 297 | 346 | Domain | RRM |
| Hgene | >UHMK1 | chr1:162487980 | chr1:161139450 | ENST00000538489 | + | 1 | 7 | 29_37 | -66 | 345 | Nucleotide binding | ATP |
| Tgene | PPOX | chr1:162487980 | chr1:161139450 | ENST00000352210 | + | 6 | 13 | 34_35 | 269 | 478 | Nucleotide binding | FAD |
| Tgene | PPOX | chr1:162487980 | chr1:161139450 | ENST00000352210 | + | 6 | 13 | 57_60 | 269 | 478 | Nucleotide binding | FAD |
| Tgene | PPOX | chr1:162487980 | chr1:161139450 | ENST00000352210 | + | 6 | 13 | 9_14 | 269 | 478 | Nucleotide binding | FAD |
| Tgene | PPOX | chr1:162487980 | chr1:161139450 | ENST00000367999 | + | 6 | 13 | 34_35 | 269 | 478 | Nucleotide binding | FAD |
| Tgene | PPOX | chr1:162487980 | chr1:161139450 | ENST00000367999 | + | 6 | 13 | 57_60 | 269 | 478 | Nucleotide binding | FAD |
| Tgene | PPOX | chr1:162487980 | chr1:161139450 | ENST00000367999 | + | 6 | 13 | 9_14 | 269 | 478 | Nucleotide binding | FAD |
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FusionGeneSequence for UHMK1_PPOX |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_506aa MFLTRPKVCVDLNRRVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNI LWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANS SAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVV EDVKEECQKYGPVVSLLVPKENPGRGQVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFG HLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQY >In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_506aa MFLTRPKVCVDLNRRVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNI LWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANS SAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVV EDVKEECQKYGPVVSLLVPKENPGRGQVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFG HLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQY >In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_580aa MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIV TLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL SFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNA AIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSL LVPKENPGRGQVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVY DSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLT >In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_580aa MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIV TLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL SFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNA AIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSL LVPKENPGRGQVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVY DSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_1518nt ATGTTTCTTACCAGACCGAAGGTCTGTGTTGACCTTAACCGGAGAGTGACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTG CCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATG ATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATA TTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACA GACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGAT CTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGT TCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATG CTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGAT CTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTA GAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTA AGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTG GCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGA CATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGC CTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGG GCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTAT ACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAG >In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_1518nt ATGTTTCTTACCAGACCGAAGGTCTGTGTTGACCTTAACCGGAGAGTGACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTG CCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATG ATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATA TTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACA GACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGAT CTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGT TCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATG CTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGAT CTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTA GAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTA AGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTG GCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGA CATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGC CTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGG GCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTAT ACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAG >In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_1740nt ATGGCGGGATCCGGCTGCGCCTGGGGCGCGGAGCCGCCGCGTTTTCTGGAGGCCTTCGGGCGGCTGTGGCAGGTACAGAGCCGTCTGGGT AGCGGCTCCTCCGCCTCGGTGTATCGGGTTCGCTGCTGCGGCAACCCTGGCTCGCCCCCCGGCGCCCTCAAGCAGTTCTTGCCGCCAGGA ACCACCGGGGCTGCGGCCTCTGCCGCCGAGTATGGTTTCCGCAAAGAGAGGGCGGCGCTGGAACAGTTGCAGGGTCACAGAAACATCGTG ACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTGCCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAA TTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATGATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCAT CATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATATTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTT AGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACAGACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAG GCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGATCTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAA CTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGTTCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCC GCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATGCTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGC AGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGATCTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGAT GATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTAGAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTA CTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTAAGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCT TCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTGGCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAAT CTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGACATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTAT GACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGCCTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAG GCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGGGCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGC CACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTATACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACT GCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAGGGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTC >In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_1740nt ATGGCGGGATCCGGCTGCGCCTGGGGCGCGGAGCCGCCGCGTTTTCTGGAGGCCTTCGGGCGGCTGTGGCAGGTACAGAGCCGTCTGGGT AGCGGCTCCTCCGCCTCGGTGTATCGGGTTCGCTGCTGCGGCAACCCTGGCTCGCCCCCCGGCGCCCTCAAGCAGTTCTTGCCGCCAGGA ACCACCGGGGCTGCGGCCTCTGCCGCCGAGTATGGTTTCCGCAAAGAGAGGGCGGCGCTGGAACAGTTGCAGGGTCACAGAAACATCGTG ACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTGCCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAA TTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATGATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCAT CATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATATTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTT AGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACAGACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAG GCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGATCTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAA CTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGTTCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCC GCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATGCTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGC AGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGATCTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGAT GATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTAGAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTA CTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTAAGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCT TCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTGGCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAAT CTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGACATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTAT GACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGCCTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAG GCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGGGCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGC CACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTATACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACT GCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAGGGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_1560nt ATGTTTCTTACCAGACCGAAGGTCTGTGTTGACCTTAACCGGAGAGTGACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTG CCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATG ATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATA TTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACA GACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGAT CTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGT TCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATG CTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGAT CTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTA GAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTA AGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTG GCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGA CATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGC CTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGG GCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTAT ACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAG GGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTCAGTGTCCTGGGCACAGAACCTAACAGCTGATCCCCAACTCTC >In-frame_UHMK1_ENST00000545294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_1558nt ATGTTTCTTACCAGACCGAAGGTCTGTGTTGACCTTAACCGGAGAGTGACTTTGTATGGAGTGTTTACAATCCACTTTTCTCCAAATGTG CCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACCAGGGTTGTTCCATGTGGATG ATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGGACCTCAAACCACGTAACATA TTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGGATGTAAAGTATATTCAGACA GACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAGAATGTACCTCAGCTGTTGAT CTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTCAGGAATGGAAGGCAAACAGT TCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAAGAGACCTTATCAAAAGCATG CTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTTTTGCCCCTCATATTGAAGAT CTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAGAGGAATATGAAGATGTTGTA GAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTGGCAGAGGACAAGTATCTCTA AGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCCCTGCTGAGGCTGCCCCTCTG GCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATCTGCCTGTCCAGGGATTTGGA CATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGCAGGACGGGAGCCCCCCTGGC CTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTCAGGAGCTGTTTCAACAGCGG GCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACAAGAACTGCATTCCCCAGTAT ACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTCTGGCTGGAGCCTCCTATGAG GGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTCAGTGTCCTGGGCACAGAACCTAACAGCTGATCCCCAACTCTC >In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000352210_chr1_161139450_+_1940nt GGTGTCATGGCTGCTTGAAGTCCCGGGAGTCGGTGAGGCGGCTGCAGGTCCCTCCCTGCGGAGCCGCTGGTCCGGCTGGCGGAGATGTGA CCGCGGGCCCGGCCGGCCTGCCTCAGGCGTCGCGTCAGCTCCCGTGTCCGTGCCCTTAACCCACACCGATGGCGGGATCCGGCTGCGCCT GGGGCGCGGAGCCGCCGCGTTTTCTGGAGGCCTTCGGGCGGCTGTGGCAGGTACAGAGCCGTCTGGGTAGCGGCTCCTCCGCCTCGGTGT ATCGGGTTCGCTGCTGCGGCAACCCTGGCTCGCCCCCCGGCGCCCTCAAGCAGTTCTTGCCGCCAGGAACCACCGGGGCTGCGGCCTCTG CCGCCGAGTATGGTTTCCGCAAAGAGAGGGCGGCGCTGGAACAGTTGCAGGGTCACAGAAACATCGTGACTTTGTATGGAGTGTTTACAA TCCACTTTTCTCCAAATGTGCCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACC AGGGTTGTTCCATGTGGATGATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGG ACCTCAAACCACGTAACATATTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGG ATGTAAAGTATATTCAGACAGACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAG AATGTACCTCAGCTGTTGATCTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTC AGGAATGGAAGGCAAACAGTTCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAA GAGACCTTATCAAAAGCATGCTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTT TTGCCCCTCATATTGAAGATCTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAG AGGAATATGAAGATGTTGTAGAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTG GCAGAGGACAAGTATCTCTAAGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCC CTGCTGAGGCTGCCCCTCTGGCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATC TGCCTGTCCAGGGATTTGGACATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGC AGGACGGGAGCCCCCCTGGCCTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTC AGGAGCTGTTTCAACAGCGGGCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACA AGAACTGCATTCCCCAGTATACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTC TGGCTGGAGCCTCCTATGAGGGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTCAGTGTCCTGGGCACAGAACCTA >In-frame_UHMK1_ENST00000489294_chr1_162487980_+_PPOX_ENST00000367999_chr1_161139450_+_1938nt GGTGTCATGGCTGCTTGAAGTCCCGGGAGTCGGTGAGGCGGCTGCAGGTCCCTCCCTGCGGAGCCGCTGGTCCGGCTGGCGGAGATGTGA CCGCGGGCCCGGCCGGCCTGCCTCAGGCGTCGCGTCAGCTCCCGTGTCCGTGCCCTTAACCCACACCGATGGCGGGATCCGGCTGCGCCT GGGGCGCGGAGCCGCCGCGTTTTCTGGAGGCCTTCGGGCGGCTGTGGCAGGTACAGAGCCGTCTGGGTAGCGGCTCCTCCGCCTCGGTGT ATCGGGTTCGCTGCTGCGGCAACCCTGGCTCGCCCCCCGGCGCCCTCAAGCAGTTCTTGCCGCCAGGAACCACCGGGGCTGCGGCCTCTG CCGCCGAGTATGGTTTCCGCAAAGAGAGGGCGGCGCTGGAACAGTTGCAGGGTCACAGAAACATCGTGACTTTGTATGGAGTGTTTACAA TCCACTTTTCTCCAAATGTGCCATCACGCTGTCTGTTGCTTGAACTCCTGGATGTCAGTGTTTCGGAATTGCTCTTATATTCCAGTCACC AGGGTTGTTCCATGTGGATGATACAGCATTGTGCCCGAGATGTTTTGGAGGCCCTTGCTTTTCTTCATCATGAGGGCTATGTCCATGCGG ACCTCAAACCACGTAACATATTGTGGAGTGCAGAGAATGAATGTTTTAAACTCATTGACTTTGGACTTAGCTTCAAAGAAGGCAATCAGG ATGTAAAGTATATTCAGACAGACGGGTATCGGGCTCCAGAAGCAGAATTGCAAAATTGCTTGGCCCAGGCTGGCCTGCAGAGTGATACAG AATGTACCTCAGCTGTTGATCTGTGGAGCCTAGGAATCATTTTACTGGAAATGTTCTCAGGAATGAAACTGAAACATACAGTCAGATCTC AGGAATGGAAGGCAAACAGTTCTGCTATTATTGATCACATATTTGCCAGTAAAGCAGTGGTGAATGCCGCAATTCCAGCCTATCACCTAA GAGACCTTATCAAAAGCATGCTTCATGATGATCCAAGCAGAAGAATTCCTGCTGAAATGGCATTGTGCAGCCCATTCTTTAGCATTCCTT TTGCCCCTCATATTGAAGATCTGGTCATGCTTCCCACTCCAGTGCTAAGACTGCTGAATGTGCTGGATGATGATTATCTTGAGAATGAAG AGGAATATGAAGATGTTGTAGAAGATGTAAAAGAGGAGTGTCAAAAATATGGACCAGTGGTATCTCTACTTGTTCCAAAGGAAAATCCTG GCAGAGGACAAGTATCTCTAAGGGACAGCAGTCTGGAGGCTGACCACGTTATTAGTGCCATTCCAGCTTCAGTGCTCAGTGAGCTGCTCC CTGCTGAGGCTGCCCCTCTGGCTCGTGCCCTGAGTGCCATCACTGCAGTGTCTGTAGCTGTGGTGAATCTGCAGTACCAAGGAGCCCATC TGCCTGTCCAGGGATTTGGACATTTGGTGCCATCTTCAGAAGATCCAGGAGTCCTGGGAATCGTGTATGACTCAGTTGCTTTCCCTGAGC AGGACGGGAGCCCCCCTGGCCTCAGAGTGACTGTGATGCTGGGAGGTTCCTGGTTACAGACACTGGAGGCTAGTGGCTGTGTCTTATCTC AGGAGCTGTTTCAACAGCGGGCCCAGGAAGCAGCTGCTACACAATTAGGACTGAAGGAGATGCCGAGCCACTGCTTGGTCCATCTACACA AGAACTGCATTCCCCAGTATACACTAGGTCACTGGCAAAAACTAGAGTCAGCTAGGCAATTCCTGACTGCTCACAGGTTGCCCCTGACTC TGGCTGGAGCCTCCTATGAGGGAGTTGCTGTTAATGACTGTATAGAGAGTGGGCGCCAGGCAGCAGTCAGTGTCCTGGGCACAGAACCTA |
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FusionGenePPI for UHMK1_PPOX |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UHMK1 | ELAVL1, EDEM2 | PPOX | HAP1, IMMT, COPS5, HNRNPD, PLAUR, NDUFA10, SDF4, CBWD1, ISLR, THBS3, ARSA, NANOG, POU5F1, COQ9, BPNT1, CRYBA4, ACSM5, PCDHA12, TCTN1, NDUFS7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UHMK1_PPOX |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UHMK1_PPOX |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | UHMK1 | C0036341 | Schizophrenia | 4 | PSYGENET |
| Hgene | UHMK1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | PPOX | C0162532 | Variegate Porphyria | 23 | ORPHANET;UNIPROT |
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