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Fusion gene ID: 40725 |
FusionGeneSummary for UGT2B7_FTO |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UGT2B7_FTO | Fusion gene ID: 40725 | Hgene | Tgene | Gene symbol | UGT2B7 | FTO | Gene ID | 7364 | 79068 |
| Gene name | UDP glucuronosyltransferase family 2 member B7 | FTO, alpha-ketoglutarate dependent dioxygenase | |
| Synonyms | UDPGT 2B7|UDPGT 2B9|UDPGT2B7|UDPGTH2|UDPGTh-2|UGT2B9 | ALKBH9|BMIQ14|GDFD | |
| Cytomap | 4q13.2 | 16q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UDP-glucuronosyltransferase 2B73,4-catechol estrogen specific3,4-catechol estrogen-specific UDPGTUDP glucuronosyltransferase 2 family, polypeptide B7UDP-glucuronosyltransferase 2B9UDP-glucuronyltransferase, family 2, beta-7 | alpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9fat mass and obesity associatedfat mass and obesity-associated protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P16662 | Q9C0B1 | |
| Ensembl transtripts involved in fusion gene | ENST00000509763, ENST00000305231, ENST00000508661, | ENST00000471389, ENST00000394647, ENST00000431610, ENST00000460382, ENST00000463855, ENST00000472835, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 4 X 6=192 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/192*10)=-1.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UGT2B7 [Title/Abstract] AND FTO [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UGT2B7 | GO:0008209 | androgen metabolic process | 17442341 |
| Hgene | UGT2B7 | GO:0052695 | cellular glucuronidation | 17442341|20056724|22579593 |
| Tgene | FTO | GO:0006307 | DNA dealkylation involved in DNA repair | 18775698|20376003 |
| Tgene | FTO | GO:0035552 | oxidative single-stranded DNA demethylation | 18775698|20376003 |
| Tgene | FTO | GO:0035553 | oxidative single-stranded RNA demethylation | 18775698|22002720 |
| Tgene | FTO | GO:0042245 | RNA repair | 18775698 |
| Tgene | FTO | GO:0070989 | oxidative demethylation | 18775698 |
| Tgene | FTO | GO:0080111 | DNA demethylation | 18775698 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | T05729 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000509763 | ENST00000471389 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000509763 | ENST00000394647 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000509763 | ENST00000431610 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-3UTR | ENST00000509763 | ENST00000460382 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-3UTR | ENST00000509763 | ENST00000463855 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000509763 | ENST00000472835 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-3UTR | ENST00000305231 | ENST00000471389 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000305231 | ENST00000394647 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000305231 | ENST00000431610 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-3UTR | ENST00000305231 | ENST00000460382 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-3UTR | ENST00000305231 | ENST00000463855 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000305231 | ENST00000472835 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-3UTR | ENST00000508661 | ENST00000471389 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000508661 | ENST00000394647 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000508661 | ENST00000431610 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-3UTR | ENST00000508661 | ENST00000460382 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-3UTR | ENST00000508661 | ENST00000463855 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
| intron-intron | ENST00000508661 | ENST00000472835 | UGT2B7 | chr4 | 69969008 | - | FTO | chr16 | 54146782 | + |
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FusionProtFeatures for UGT2B7_FTO |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UGT2B7 | FTO |
| UDPGT is of major importance in the conjugation andsubsequent elimination of potentially toxic xenobiotics andendogenous compounds. {ECO:0000269|PubMed:17442341}. Its unique specificity for 3,4-catechol estrogens andestriol suggests it may play an important role in regulating thelevel and activity of these potent and active estrogenmetabolites. Is also active with androsterone, hyodeoxycholic acidand tetrachlorocatechol (in vitro). {ECO:0000269|PubMed:17442341}. | Dioxygenase that repairs alkylated DNA and RNA byoxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylaseactivity towards single-stranded DNA containing 1-methyladenine or3-methylcytosine (PubMed:18775698, PubMed:20376003). Specificallydemethylates N(6)-methyladenosine (m6A) RNA, the most prevalentinternal modification of messenger RNA (mRNA) in higher eukaryotes(PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-strandedDNA. Requires molecular oxygen, alpha-ketoglutarate and iron.Contributes to the regulation of the global metabolic rate, energyexpenditure and energy homeostasis. Contributes to the regulationof body size and body fat accumulation (PubMed:18775698,PubMed:20376003). In particular, it is involved in the regulationof thermogenesis and the control of adipocyte differentiation intobrown or white fat cells (PubMed:26287746).{ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003,ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:26287746,ECO:0000269|PubMed:26458103}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UGT2B7_FTO |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UGT2B7_FTO |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UGT2B7_FTO |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | FTO | Q9C0B1 | DB11638 | Artenimol | Alpha-ketoglutarate-dependent dioxygenase FTO | small molecule | approved|investigational |
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RelatedDiseases for UGT2B7_FTO |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | UGT2B7 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | FTO | C0028754 | Obesity | 6 | CTD_human |
| Tgene | FTO | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
| Tgene | FTO | C0011581 | Depressive disorder | 3 | PSYGENET |
| Tgene | FTO | C2752001 | Growth Retardation, Developmental Delay, Coarse Facies, And Early Death | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | FTO | C0005910 | Body Weight | 2 | CTD_human |
| Tgene | FTO | C0011570 | Mental Depression | 2 | PSYGENET |
| Tgene | FTO | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Tgene | FTO | C0025202 | melanoma | 1 | CTD_human |
| Tgene | FTO | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | FTO | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | FTO | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | FTO | C2362324 | Pediatric Obesity | 1 | CTD_human |
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