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Fusion gene ID: 40724 |
FusionGeneSummary for UGT2B4_MTHFD2L |
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Fusion gene information | Fusion gene name: UGT2B4_MTHFD2L | Fusion gene ID: 40724 | Hgene | Tgene | Gene symbol | UGT2B4 | MTHFD2L | Gene ID | 7363 | 441024 |
Gene name | UDP glucuronosyltransferase family 2 member B4 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like | |
Synonyms | HLUG25|UDPGT2B4|UDPGTH1|UDPGTh-1|UGT2B11 | - | |
Cytomap | 4q13.3 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | UDP-glucuronosyltransferase 2B4UDP glucuronosyltransferase 2 family, polypeptide B4UDP-glucuronyltransferase, family 2, beta-4UDPGT 2B4hyodeoxycholic acidhyodeoxycholic acid-specific UDPGT | probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2MTHFD2-likeNADP-dependent methylenetetrahydrofolate dehydrogenase 2-like proteintetrahydrofolate dehydrogenase/cyclohydrolase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P06133 | Q9H903 | |
Ensembl transtripts involved in fusion gene | ENST00000381096, ENST00000512583, ENST00000305107, ENST00000506580, | ENST00000433372, ENST00000331145, ENST00000395759, ENST00000325278, ENST00000461101, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 4=80 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UGT2B4 [Title/Abstract] AND MTHFD2L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | UGT2B4 | GO:0052695 | cellular glucuronidation | 20056724 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-BC-A217-01A | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000381096 | ENST00000433372 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000381096 | ENST00000331145 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000381096 | ENST00000395759 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000381096 | ENST00000325278 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-3UTR | ENST00000381096 | ENST00000461101 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-5UTR | ENST00000512583 | ENST00000433372 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000512583 | ENST00000331145 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000512583 | ENST00000395759 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000512583 | ENST00000325278 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-3UTR | ENST00000512583 | ENST00000461101 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-5UTR | ENST00000305107 | ENST00000433372 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000305107 | ENST00000331145 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000305107 | ENST00000395759 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-intron | ENST00000305107 | ENST00000325278 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5CDS-3UTR | ENST00000305107 | ENST00000461101 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5UTR-5UTR | ENST00000506580 | ENST00000433372 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5UTR-intron | ENST00000506580 | ENST00000331145 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5UTR-intron | ENST00000506580 | ENST00000395759 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5UTR-intron | ENST00000506580 | ENST00000325278 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
5UTR-3UTR | ENST00000506580 | ENST00000461101 | UGT2B4 | chr4 | 70355157 | - | MTHFD2L | chr4 | 75025772 | + |
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FusionProtFeatures for UGT2B4_MTHFD2L |
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Hgene | Tgene |
UGT2B4 | MTHFD2L |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UGT2B4_MTHFD2L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UGT2B4_MTHFD2L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UGT2B4 | STAT5A | MTHFD2L | MTHFD2, HENMT1, PROSER2, SRP9, HDHD3, CST4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UGT2B4_MTHFD2L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UGT2B4_MTHFD2L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |