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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40720

FusionGeneSummary for UGT1A3_FGG

check button Fusion gene summary
Fusion gene informationFusion gene name: UGT1A3_FGG
Fusion gene ID: 40720
HgeneTgene
Gene symbol

UGT1A3

FGG

Gene ID

54659

2266

Gene nameUDP glucuronosyltransferase family 1 member A3fibrinogen gamma chain
SynonymsUDPGT|UDPGT 1-3|UGT-1C|UGT1-03|UGT1.3|UGT1A3S|UGT1C-
Cytomap

2q37.1

4q32.1

Type of geneprotein-codingprotein-coding
DescriptionUDP-glucuronosyltransferase 1-3UDP glucuronosyltransferase 1 family, polypeptide A3UDP glycosyltransferase 1 family, polypeptide A3UDP-glucuronosyltransferase 1 family polypeptide A3sUDP-glucuronosyltransferase 1-CUDP-glucuronosyltransferase 1A3UGT1fibrinogen gamma chainfibrinogen, gamma polypeptidetesticular tissue protein Li 70
Modification date2018052320180519
UniProtAcc

P35503

P02679

Ensembl transtripts involved in fusion geneENST00000482026, ENST00000404648, 
ENST00000405164, ENST00000336098, 
ENST00000407946, 
Fusion gene scores* DoF score2 X 1 X 2=48 X 9 X 3=216
# samples 214
** MAII scorelog2(2/4*10)=2.32192809488736log2(14/216*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UGT1A3 [Title/Abstract] AND FGG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUGT1A3

GO:0052695

cellular glucuronidation

17179145|22579593

HgeneUGT1A3

GO:0052696

flavonoid glucuronidation

20056724

HgeneUGT1A3

GO:0052697

xenobiotic glucuronidation

20056724

TgeneFGG

GO:0007160

cell-matrix adhesion

10903502

TgeneFGG

GO:0031639

plasminogen activation

16846481

TgeneFGG

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

TgeneFGG

GO:0034622

cellular protein-containing complex assembly

8910396

TgeneFGG

GO:0042730

fibrinolysis

16846481

TgeneFGG

GO:0045907

positive regulation of vasoconstriction

15739255

TgeneFGG

GO:0045921

positive regulation of exocytosis

19193866

TgeneFGG

GO:0050714

positive regulation of protein secretion

19193866

TgeneFGG

GO:0051592

response to calcium ion

6777381

TgeneFGG

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

TgeneFGG

GO:0070527

platelet aggregation

6281794

TgeneFGG

GO:0072378

blood coagulation, fibrin clot formation

16846481

TgeneFGG

GO:0090277

positive regulation of peptide hormone secretion

19193866

TgeneFGG

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

TgeneFGG

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A4NP-01AUGT1A3chr2

234681945

+FGGchr4

155534001

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000482026ENST00000404648UGT1A3chr2

234681945

+FGGchr4

155534001

-
5CDS-intronENST00000482026ENST00000405164UGT1A3chr2

234681945

+FGGchr4

155534001

-
5CDS-intronENST00000482026ENST00000336098UGT1A3chr2

234681945

+FGGchr4

155534001

-
5CDS-intronENST00000482026ENST00000407946UGT1A3chr2

234681945

+FGGchr4

155534001

-

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FusionProtFeatures for UGT1A3_FGG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UGT1A3

P35503

FGG

P02679

UDPGT is of major importance in the conjugation andsubsequent elimination of potentially toxic xenobiotics andendogenous compounds. Isoform 2 lacks transferase activity butacts as a negative regulator of isoform 1.{ECO:0000269|PubMed:18674515}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UGT1A3_FGG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UGT1A3_FGG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UGT1A3FGGFGA, FGB, F13B, FGG, KHDRBS2, VKORC1, FN1, ASB6, ASB7, ASB12, CA8, ASCC1, DDX19B, ALDH2, CHD9, NUP93, ICAM1, HIST1H2BJ, MAPK6, RING1, SNX27, CDK15, CCNYL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UGT1A3_FGG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGGP02679DB00364SucralfateFibrinogen gamma chainsmall moleculeapproved

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RelatedDiseases for UGT1A3_FGG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUGT1A3C0036341Schizophrenia1CTD_human
TgeneFGGC0272350Dysfibrinogenemia, Congenital7ORPHANET;UNIPROT
TgeneFGGC0022548Keloid1CTD_human
TgeneFGGC0038356Stomach Neoplasms1CTD_human
TgeneFGGC2584774Congenital hypofibrinogenemia1ORPHANET;UNIPROT