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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 40716

FusionGeneSummary for UGP2_MDH1

check button Fusion gene summary
Fusion gene informationFusion gene name: UGP2_MDH1
Fusion gene ID: 40716
HgeneTgene
Gene symbol

UGP2

MDH1

Gene ID

7360

4190

Gene nameUDP-glucose pyrophosphorylase 2malate dehydrogenase 1
SynonymsUDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379HEL-S-32|MDH-s|MDHA|MGC:1375|MOR2
Cytomap

2p15

2p15

Type of geneprotein-codingprotein-coding
DescriptionUTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testimalate dehydrogenase, cytoplasmicmalate dehydrogenase, peroxisomalcytosolic malate dehydrogenasediiodophenylpyruvate reductaseepididymis secretory protein Li 32malate dehydrogenase 1, NAD (soluble)soluble malate dehydrogenase
Modification date2018052320180523
UniProtAcc

Q16851

P40925

Ensembl transtripts involved in fusion geneENST00000394417, ENST00000467648, 
ENST00000487469, ENST00000337130, 
ENST00000445915, 		ENST00000233114, 
ENST00000409908, ENST00000409476, 
ENST00000539945, ENST00000544381, 
ENST00000394423, ENST00000462944, 
Fusion gene scores* DoF score5 X 4 X 3=606 X 6 X 4=144
# samples 614
** MAII scorelog2(6/60*10)=0log2(14/144*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UGP2 [Title/Abstract] AND MDH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-BC-A10T-01AUGP2chr2

64085070

+MDH1chr2

63821622

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394417ENST00000233114UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000394417ENST00000409908UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000394417ENST00000409476UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000394417ENST00000539945UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-5UTRENST00000394417ENST00000544381UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-5UTRENST00000394417ENST00000394423UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000394417ENST00000462944UGP2chr2

64085070

+MDH1chr2

63821622

+
In-frameENST00000467648ENST00000233114UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000467648ENST00000409908UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000467648ENST00000409476UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000467648ENST00000539945UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-5UTRENST00000467648ENST00000544381UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-5UTRENST00000467648ENST00000394423UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000467648ENST00000462944UGP2chr2

64085070

+MDH1chr2

63821622

+
intron-3CDSENST00000487469ENST00000233114UGP2chr2

64085070

+MDH1chr2

63821622

+
intron-intronENST00000487469ENST00000409908UGP2chr2

64085070

+MDH1chr2

63821622

+
intron-intronENST00000487469ENST00000409476UGP2chr2

64085070

+MDH1chr2

63821622

+
intron-intronENST00000487469ENST00000539945UGP2chr2

64085070

+MDH1chr2

63821622

+
intron-5UTRENST00000487469ENST00000544381UGP2chr2

64085070

+MDH1chr2

63821622

+
intron-5UTRENST00000487469ENST00000394423UGP2chr2

64085070

+MDH1chr2

63821622

+
intron-intronENST00000487469ENST00000462944UGP2chr2

64085070

+MDH1chr2

63821622

+
In-frameENST00000337130ENST00000233114UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000337130ENST00000409908UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000337130ENST00000409476UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000337130ENST00000539945UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-5UTRENST00000337130ENST00000544381UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-5UTRENST00000337130ENST00000394423UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000337130ENST00000462944UGP2chr2

64085070

+MDH1chr2

63821622

+
In-frameENST00000445915ENST00000233114UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000445915ENST00000409908UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000445915ENST00000409476UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000445915ENST00000539945UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-5UTRENST00000445915ENST00000544381UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-5UTRENST00000445915ENST00000394423UGP2chr2

64085070

+MDH1chr2

63821622

+
5CDS-intronENST00000445915ENST00000462944UGP2chr2

64085070

+MDH1chr2

63821622

+

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FusionProtFeatures for UGP2_MDH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UGP2

Q16851

MDH1

P40925

Plays a central role as a glucosyl donor in cellularmetabolic pathways.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMDH1chr2:64085070chr2:63821622ENST00000233114+0911_171335Nucleotide bindingNAD
TgeneMDH1chr2:64085070chr2:63821622ENST00000233114+09129_1311335Nucleotide bindingNAD
TgeneMDH1chr2:64085070chr2:63821622ENST00000394423+0911_171335Nucleotide bindingNAD
TgeneMDH1chr2:64085070chr2:63821622ENST00000394423+09129_1311335Nucleotide bindingNAD
TgeneMDH1chr2:64085070chr2:63821622ENST00000539945+09129_13119353Nucleotide bindingNAD
TgeneMDH1chr2:64085070chr2:63821622ENST00000544381+0811_17-56246Nucleotide bindingNAD
TgeneMDH1chr2:64085070chr2:63821622ENST00000544381+08129_131-56246Nucleotide bindingNAD

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUGP2chr2:64085070chr2:63821622ENST00000337130+310113_11685509RegionUTP binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000337130+310115_11685509RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000337130+310251_25385509RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000337130+310457_50885509RegionNote=Oligomerization
HgeneUGP2chr2:64085070chr2:63821622ENST00000394417+310113_11674498RegionUTP binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000394417+310115_11674498RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000394417+310251_25374498RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000394417+310457_50874498RegionNote=Oligomerization
HgeneUGP2chr2:64085070chr2:63821622ENST00000467648+411113_11674498RegionUTP binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000467648+411115_11674498RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000467648+411251_25374498RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:63821622ENST00000467648+411457_50874498RegionNote=Oligomerization
TgeneMDH1chr2:64085070chr2:63821622ENST00000539945+0911_1719353Nucleotide bindingNAD


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FusionGeneSequence for UGP2_MDH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UGP2_ENST00000394417_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_408aa
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSSEPIRVLVTGAAGQIA
YSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVK
IFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNH
AKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYS

>In-frame_UGP2_ENST00000467648_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_408aa
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSSEPIRVLVTGAAGQIA
YSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVK
IFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNH
AKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYS

>In-frame_UGP2_ENST00000337130_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_419aa
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSSEPIR
VLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGM
ERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGN
HSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGN

>In-frame_UGP2_ENST00000445915_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_428aa
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILV
GSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTAND
VKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UGP2_ENST00000394417_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_1224nt
ATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACC
ACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCT
TCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCA
TATTCACTGCTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTGTTGGATATCACCCCCATGATG
GGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGTGCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCC
TTCAAAGACCTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGATTTACTGAAAGCAAATGTGAAA
ATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCCAAGAAGTCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGC
CTGACTGCTTCCAAGTCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCACAACCGAGCTAAAGCTCAAATT
GCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAATGTCATTATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCAT
GCCAAGGTGAAATTGCAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAGGGAGAATTTGTCACGACTGTG
CAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTATCCAGTGCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATC
TGGTTTGGAACCCCAGAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTTCCTGATGATCTGCTCTACTCA
TTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTTGAAGGTCTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCA

>In-frame_UGP2_ENST00000467648_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_1224nt
ATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACC
ACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCT
TCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCA
TATTCACTGCTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTGTTGGATATCACCCCCATGATG
GGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGTGCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCC
TTCAAAGACCTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGATTTACTGAAAGCAAATGTGAAA
ATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCCAAGAAGTCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGC
CTGACTGCTTCCAAGTCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCACAACCGAGCTAAAGCTCAAATT
GCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAATGTCATTATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCAT
GCCAAGGTGAAATTGCAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAGGGAGAATTTGTCACGACTGTG
CAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTATCCAGTGCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATC
TGGTTTGGAACCCCAGAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTTCCTGATGATCTGCTCTACTCA
TTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTTGAAGGTCTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCA

>In-frame_UGP2_ENST00000337130_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_1257nt
ATGTCGAGATTTGTACAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTA
TCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCGGAAG
CTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGTCTGAACCAATCAGA
GTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGCTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATA
ATTCTTGTGCTGTTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGTGCCCTTCCCCTCCTGAAA
GATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGACCTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATG
GAGAGAAAAGATTTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCCAAGAAGTCAGTTAAGGTT
ATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCTTCCAAGTCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACT
CGTTTGGATCACAACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAATGTCATTATCTGGGGAAAC
CATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTGAAATTGCAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGAC
AGCTGGCTCAAGGGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTATCCAGTGCCATGTCTGCT
GCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGAACCCCAGAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAAC
TCCTATGGTGTTCCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTTGAAGGTCTCCCTATTAAT

>In-frame_UGP2_ENST00000445915_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_1284nt
ATGCTCCTGTACCCTGCTGGGTTTAGTTTTGCCTCCCTGAAATCAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAA
GAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACC
AAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCC
CCTGAAGATTCGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGCTGTACAGTATTGGAAATGGA
TCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTGTTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTG
CAAGACTGTGCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGACCTGGATGTGGCCATTCTTGTG
GGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGATTTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGAT
AAATACGCCAAGAAGTCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCTTCCAAGTCAGCTCCATCCATC
CCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCACAACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGAT
GTAAAGAATGTCATTATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTGAAATTGCAAGGAAAGGAAGTT
GGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAGGGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCT
CGAAAACTATCCAGTGCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGAACCCCAGAGGGAGAGTTTGTG
TCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTTCCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGG
AAGTTTGTTGAAGGTCTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTGACAGAAGAAAAAGAAAGTGCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_UGP2_ENST00000394417_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_1741nt
CTGTCGGTCCGTGCGGCAGGGACATTTCCGCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCT
GTGGGTGTCGGGAGCCGGCTGACGGGTGGACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGT
GAGGGAAGAGAGAGAGAGAGAAGGGCGCCTCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTC
CCAGCTGCTAAAGGAAGAGGAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGTCTGAACCAAT
CAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGCTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCC
TATAATTCTTGTGCTGTTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGTGCCCTTCCCCTCCT
GAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGACCTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGG
CATGGAGAGAAAAGATTTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCCAAGAAGTCAGTTAA
GGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCTTCCAAGTCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTT
GACTCGTTTGGATCACAACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAATGTCATTATCTGGGG
AAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTGAAATTGCAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGA
TGACAGCTGGCTCAAGGGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTATCCAGTGCCATGTC
TGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGAACCCCAGAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGG
CAACTCCTATGGTGTTCCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTTGAAGGTCTCCCTAT
TAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTGACAGAAGAAAAAGAAAGTGCTTTTGAATTTCTTTCCTCTGCCTG
ACTAGACAATGATGTTACTAAATGCTTCAAAGCTGAAGAATCTAAATGTCGTCTTTGACTCAAGTACCAAATAATAATAATGCTATACTT
AAATTACTTGTGAAAAACAACACATTTTAAAGATTACGTGCTTCTTGGTACAGGTTTGTGAATGACAGTTTATCGTCATGCTGTTAGTGT

>In-frame_UGP2_ENST00000467648_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_1773nt
GCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCTGTGGGTGTCGGGAGCCGGCTGACGGGTGG
ACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGTGAGGGAAGAGAGAGAGAGAGAAGGGCGCC
TCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTCCCAGCTGCTAAAGGAAGAGGAAGGTACCT
GTGCGTGCACGCAGACGGGAAGGGCTGGGGAAGCGGGAGGACTGAGAAAAGCCGGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCT
CAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTT
GAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATC
CAGAGACCCCCTGAAGATTCGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGCTGTACAGTATT
GGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTGTTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTA
ATGGAACTGCAAGACTGTGCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGACCTGGATGTGGCC
ATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGATTTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCA
GCCTTAGATAAATACGCCAAGAAGTCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCTTCCAAGTCAGCT
CCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCACAACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACT
GCTAATGATGTAAAGAATGTCATTATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTGAAATTGCAAGGA
AAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAGGGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTC
ATCAAGGCTCGAAAACTATCCAGTGCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGAACCCCAGAGGGA
GAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTTCCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAAT
AAGACCTGGAAGTTTGTTGAAGGTCTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTGACAGAAGAAAAA
GAAAGTGCTTTTGAATTTCTTTCCTCTGCCTGACTAGACAATGATGTTACTAAATGCTTCAAAGCTGAAGAATCTAAATGTCGTCTTTGA
CTCAAGTACCAAATAATAATAATGCTATACTTAAATTACTTGTGAAAAACAACACATTTTAAAGATTACGTGCTTCTTGGTACAGGTTTG

>In-frame_UGP2_ENST00000337130_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_1943nt
GGTTTTCGGGGGAGGCGTTTGGGGCCTGGACGGCGGCGCGGGGAGGGGGCAGCTAGGGGCGCGGCCTGCCAGTGCCTCCTGCAGTACAGC
CCTGGAGGGCGTGGGGACTTGGGGGCGGTGAAATAGCCGCTGTAGGTCCGCCTCTTTCATTGAAGAAATTTAAGTTCGTGTGGTTTTACC
TTTTCCGGGAGTCTCCAGCTGGCCCTCATTTGTGTCCGGAGCTCAGGAGTTCCCAAACCGACTCAGTCGCACCAAGTTTCCGTCTTTTGG
AATTGGGGAAGGAGTTTCTTTCTTTCTTTTCTTTTTTCTTGAGCCAGTTTTAATCGCTTTGAATAAATACTCCCTTAAGTAGTTAAATAT
AGGAGGAGAAAGAATACATCGGTTGTTAAAGCAGGAGAGGAAGAGAGACCTGCCCTGTAGCGTGACTCCTCTAGAAAAAAAAAAAAAAAG
CCGGAGTATTTTACTAAGCCCCTAAAATGTCGAGATTTGTACAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAG
AAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCA
AAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCC
CTGAAGATTCGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGCTGTACAGTATTGGAAATGGAT
CTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTGTTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGC
AAGACTGTGCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGACCTGGATGTGGCCATTCTTGTGG
GCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGATTTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATA
AATACGCCAAGAAGTCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCTTCCAAGTCAGCTCCATCCATCC
CCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCACAACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATG
TAAAGAATGTCATTATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTGAAATTGCAAGGAAAGGAAGTTG
GTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAGGGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTC
GAAAACTATCCAGTGCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGAACCCCAGAGGGAGAGTTTGTGT
CCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTTCCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGA
AGTTTGTTGAAGGTCTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTGACAGAAGAAAAAGAAAGTGCTT
TTGAATTTCTTTCCTCTGCCTGACTAGACAATGATGTTACTAAATGCTTCAAAGCTGAAGAATCTAAATGTCGTCTTTGACTCAAGTACC
AAATAATAATAATGCTATACTTAAATTACTTGTGAAAAACAACACATTTTAAAGATTACGTGCTTCTTGGTACAGGTTTGTGAATGACAG

>In-frame_UGP2_ENST00000445915_chr2_64085070_+_MDH1_ENST00000233114_chr2_63821622_+_1561nt
CTTTTCGTTGAATTGTCATCTGAGCTGCCTTGAGCTGCTGGGTTGACGTTCCAGACGCGTATAATTTATGCTCCTGTACCCTGCTGGGTT
TAGTTTTGCCTCCCTGAAATCAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGTCTGAACCAAT
CAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGCTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCC
TATAATTCTTGTGCTGTTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGTGCCCTTCCCCTCCT
GAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGACCTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGG
CATGGAGAGAAAAGATTTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCCAAGAAGTCAGTTAA
GGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCTTCCAAGTCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTT
GACTCGTTTGGATCACAACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAATGTCATTATCTGGGG
AAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTGAAATTGCAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGA
TGACAGCTGGCTCAAGGGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTATCCAGTGCCATGTC
TGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGAACCCCAGAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGG
CAACTCCTATGGTGTTCCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTTGAAGGTCTCCCTAT
TAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTGACAGAAGAAAAAGAAAGTGCTTTTGAATTTCTTTCCTCTGCCTG
ACTAGACAATGATGTTACTAAATGCTTCAAAGCTGAAGAATCTAAATGTCGTCTTTGACTCAAGTACCAAATAATAATAATGCTATACTT
AAATTACTTGTGAAAAACAACACATTTTAAAGATTACGTGCTTCTTGGTACAGGTTTGTGAATGACAGTTTATCGTCATGCTGTTAGTGT


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FusionGenePPI for UGP2_MDH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UGP2ARIH2, UGP2, PUF60, ABCA1, CDK2, PCBP1, DNPEP, ISG15, MROH2B, LYN, CBS, CUL1, FARSB, GART, HIRIP3, HSPH1, ILK, NUDC, NUSAP1, PACSIN2, PAPOLA, PARVA, PLOD2, PPM1G, PPP2R5C, RANBP3, SET, TARS, TROVE2, BUB1B, CARM1, CC2D1B, CSDE1, FAF1, PTPN12, USP15, VASN, ZYX, GLRX3, HDAC7, SNX24, DCAF15, GPSM1, UNK, ALDH16A1, GK2, HSPE1, KHK, GCK, PAICS, NTRK1, MCM2, SUN2, GTF2E2MDH1MPP3, EGFR, TP53, TERF1, TERF2IP, AKT1, LDHA, SDHA, PRDX6, SLC9A3R1, PRDX5, ESD, PGM1, HSP90AA1, HSP90AB1, IQCB1, PARK2, FUS, GLRX, GOT1, HIBADH, LDHAL6A, LDHAL6B, LDHB, LDHC, OXCT1, SOD2, SPR, UQCRFS1, PDXK, PGM2, SCCPDH, NTRK1, HSPB2, MED20, HSD17B10, TRIM25, BRCA1, SERPINB5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UGP2_MDH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMDH1P40925DB11638ArtenimolMalate dehydrogenase, cytoplasmicsmall moleculeapproved|investigational

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RelatedDiseases for UGP2_MDH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMDH1C0020538Hypertensive disease1CTD_human
TgeneMDH1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMDH1C0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneMDH1C0036341Schizophrenia1PSYGENET
TgeneMDH1C4277682Chemical and Drug Induced Liver Injury1CTD_human