FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 40715

FusionGeneSummary for UGP2_CSE1L

check button Fusion gene summary
Fusion gene informationFusion gene name: UGP2_CSE1L
Fusion gene ID: 40715
HgeneTgene
Gene symbol

UGP2

CSE1L

Gene ID

7360

1434

Gene nameUDP-glucose pyrophosphorylase 2chromosome segregation 1 like
SynonymsUDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379CAS|CSE1|XPO2
Cytomap

2p15

20q13.13

Type of geneprotein-codingprotein-coding
DescriptionUTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testiexportin-2CSE1 chromosome segregation 1-likecellular apoptosis susceptibility proteinchromosome segregation 1-like proteinexp2importin-alpha re-exporter
Modification date2018052320180523
UniProtAcc

Q16851

P55060

Ensembl transtripts involved in fusion geneENST00000394417, ENST00000467648, 
ENST00000487469, ENST00000337130, 
ENST00000445915, 
ENST00000262982, 
ENST00000542325, ENST00000396192, 
ENST00000469700, 
Fusion gene scores* DoF score5 X 4 X 3=608 X 9 X 5=360
# samples 69
** MAII scorelog2(6/60*10)=0log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UGP2 [Title/Abstract] AND CSE1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP430745UGP2chr2

64114644

+CSE1Lchr20

47706108

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000394417ENST00000262982UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000394417ENST00000542325UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000394417ENST00000396192UGP2chr2

64114644

+CSE1Lchr20

47706108

+
5CDS-intronENST00000394417ENST00000469700UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000467648ENST00000262982UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000467648ENST00000542325UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000467648ENST00000396192UGP2chr2

64114644

+CSE1Lchr20

47706108

+
5CDS-intronENST00000467648ENST00000469700UGP2chr2

64114644

+CSE1Lchr20

47706108

+
intron-3CDSENST00000487469ENST00000262982UGP2chr2

64114644

+CSE1Lchr20

47706108

+
intron-3CDSENST00000487469ENST00000542325UGP2chr2

64114644

+CSE1Lchr20

47706108

+
intron-3CDSENST00000487469ENST00000396192UGP2chr2

64114644

+CSE1Lchr20

47706108

+
intron-intronENST00000487469ENST00000469700UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000337130ENST00000262982UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000337130ENST00000542325UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000337130ENST00000396192UGP2chr2

64114644

+CSE1Lchr20

47706108

+
5CDS-intronENST00000337130ENST00000469700UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000445915ENST00000262982UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000445915ENST00000542325UGP2chr2

64114644

+CSE1Lchr20

47706108

+
Frame-shiftENST00000445915ENST00000396192UGP2chr2

64114644

+CSE1Lchr20

47706108

+
5CDS-intronENST00000445915ENST00000469700UGP2chr2

64114644

+CSE1Lchr20

47706108

+

Top

FusionProtFeatures for UGP2_CSE1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UGP2

Q16851

CSE1L

P55060

Plays a central role as a glucosyl donor in cellularmetabolic pathways.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for UGP2_CSE1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for UGP2_CSE1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UGP2_CSE1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for UGP2_CSE1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource