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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40714

FusionGeneSummary for UGP2_CECR2

check button Fusion gene summary
Fusion gene informationFusion gene name: UGP2_CECR2
Fusion gene ID: 40714
HgeneTgene
Gene symbol

UGP2

CECR2

Gene ID

7360

27443

Gene nameUDP-glucose pyrophosphorylase 2CECR2, histone acetyl-lysine reader
SynonymsUDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379-
Cytomap

2p15

22q11.1-q11.21

Type of geneprotein-codingprotein-coding
DescriptionUTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testicat eye syndrome critical region protein 2cat eye syndrome chromosome region, candidate 2
Modification date2018052320180519
UniProtAcc

Q16851

Q9BXF3

Ensembl transtripts involved in fusion geneENST00000394417, ENST00000467648, 
ENST00000487469, ENST00000337130, 
ENST00000445915, 
ENST00000342247, 
ENST00000400585, ENST00000497534, 
ENST00000400573, ENST00000262608, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 3=27
# samples 64
** MAII scorelog2(6/60*10)=0log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UGP2 [Title/Abstract] AND CECR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCECR2

GO:0043044

ATP-dependent chromatin remodeling

15640247

TgeneCECR2

GO:0097194

execution phase of apoptosis

12762840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI026848UGP2chr2

64087013

+CECR2chr22

17896181

-
ChiTaRS3.1BI026849UGP2chr2

64087013

+CECR2chr22

17896181

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000394417ENST00000342247UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000394417ENST00000400585UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000394417ENST00000497534UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000394417ENST00000400573UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000394417ENST00000262608UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000467648ENST00000342247UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000467648ENST00000400585UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000467648ENST00000497534UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000467648ENST00000400573UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000467648ENST00000262608UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000487469ENST00000342247UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000487469ENST00000400585UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000487469ENST00000497534UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000487469ENST00000400573UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000487469ENST00000262608UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000337130ENST00000342247UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000337130ENST00000400585UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000337130ENST00000497534UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000337130ENST00000400573UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000337130ENST00000262608UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000445915ENST00000342247UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000445915ENST00000400585UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000445915ENST00000497534UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000445915ENST00000400573UGP2chr2

64087013

+CECR2chr22

17896181

-
intron-intronENST00000445915ENST00000262608UGP2chr2

64087013

+CECR2chr22

17896181

-

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FusionProtFeatures for UGP2_CECR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UGP2

Q16851

CECR2

Q9BXF3

Plays a central role as a glucosyl donor in cellularmetabolic pathways. Chromatin reader component of histone-modifyingcomplexes, such as the CERF (CECR2-containing-remodeling factor)complex and ISWI-type complex (PubMed:15640247, PubMed:26365797,PubMed:22464331). It thereby plays a role in various processesduring development: required during embryogenesis for neural tubeclosure and inner ear development. In adults, required forspermatogenesis, via the formation of ISWI-type chromatincomplexes (By similarity). In histone-modifying complexes, CECR2recognizes and binds acylated histones: binds histones that areacetylated and/or butyrylated (PubMed:26365797, PubMed:22464331).May also be involved through its interaction with LRPPRC in theintegration of cytoskeletal network with vesicular trafficking,nucleocytosolic shuttling, transcription, chromosome remodelingand cytokinesis (PubMed:11827465). {ECO:0000250|UniProtKB:E9Q2Z1,ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:15640247,ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UGP2_CECR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UGP2_CECR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UGP2_CECR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UGP2_CECR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCECR2C0027794Neural Tube Defects1CTD_human