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Fusion gene ID: 40714 |
FusionGeneSummary for UGP2_CECR2 |
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Fusion gene information | Fusion gene name: UGP2_CECR2 | Fusion gene ID: 40714 | Hgene | Tgene | Gene symbol | UGP2 | CECR2 | Gene ID | 7360 | 27443 |
Gene name | UDP-glucose pyrophosphorylase 2 | CECR2, histone acetyl-lysine reader | |
Synonyms | UDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379 | - | |
Cytomap | 2p15 | 22q11.1-q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | UTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testi | cat eye syndrome critical region protein 2cat eye syndrome chromosome region, candidate 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q16851 | Q9BXF3 | |
Ensembl transtripts involved in fusion gene | ENST00000394417, ENST00000467648, ENST00000487469, ENST00000337130, ENST00000445915, | ENST00000342247, ENST00000400585, ENST00000497534, ENST00000400573, ENST00000262608, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 3 X 3 X 3=27 |
# samples | 6 | 4 | |
** MAII score | log2(6/60*10)=0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: UGP2 [Title/Abstract] AND CECR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CECR2 | GO:0043044 | ATP-dependent chromatin remodeling | 15640247 |
Tgene | CECR2 | GO:0097194 | execution phase of apoptosis | 12762840 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI026848 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - | ||
ChiTaRS3.1 | BI026849 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000394417 | ENST00000342247 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000394417 | ENST00000400585 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000394417 | ENST00000497534 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000394417 | ENST00000400573 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000394417 | ENST00000262608 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000467648 | ENST00000342247 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000467648 | ENST00000400585 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000467648 | ENST00000497534 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000467648 | ENST00000400573 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000467648 | ENST00000262608 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000487469 | ENST00000342247 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000487469 | ENST00000400585 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000487469 | ENST00000497534 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000487469 | ENST00000400573 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000487469 | ENST00000262608 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000337130 | ENST00000342247 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000337130 | ENST00000400585 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000337130 | ENST00000497534 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000337130 | ENST00000400573 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000337130 | ENST00000262608 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000445915 | ENST00000342247 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000445915 | ENST00000400585 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000445915 | ENST00000497534 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000445915 | ENST00000400573 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
intron-intron | ENST00000445915 | ENST00000262608 | UGP2 | chr2 | 64087013 | + | CECR2 | chr22 | 17896181 | - |
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FusionProtFeatures for UGP2_CECR2 |
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Hgene | Tgene |
UGP2 | CECR2 |
Plays a central role as a glucosyl donor in cellularmetabolic pathways. | Chromatin reader component of histone-modifyingcomplexes, such as the CERF (CECR2-containing-remodeling factor)complex and ISWI-type complex (PubMed:15640247, PubMed:26365797,PubMed:22464331). It thereby plays a role in various processesduring development: required during embryogenesis for neural tubeclosure and inner ear development. In adults, required forspermatogenesis, via the formation of ISWI-type chromatincomplexes (By similarity). In histone-modifying complexes, CECR2recognizes and binds acylated histones: binds histones that areacetylated and/or butyrylated (PubMed:26365797, PubMed:22464331).May also be involved through its interaction with LRPPRC in theintegration of cytoskeletal network with vesicular trafficking,nucleocytosolic shuttling, transcription, chromosome remodelingand cytokinesis (PubMed:11827465). {ECO:0000250|UniProtKB:E9Q2Z1,ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:15640247,ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UGP2_CECR2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UGP2_CECR2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UGP2_CECR2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UGP2_CECR2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CECR2 | C0027794 | Neural Tube Defects | 1 | CTD_human |