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Fusion gene ID: 40699 |
FusionGeneSummary for UGDH-AS1_GSS |
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Fusion gene information | Fusion gene name: UGDH-AS1_GSS | Fusion gene ID: 40699 | Hgene | Tgene | Gene symbol | UGDH-AS1 | GSS | Gene ID | 100885776 | 5621 |
Gene name | UGDH antisense RNA 1 | prion protein | |
Synonyms | - | ASCR|AltPrP|CD230|CJD|GSS|KURU|PRIP|PrP|PrP27-30|PrP33-35C|PrPc|p27-30 | |
Cytomap | 4p14 | 20p13 | |
Type of gene | ncRNA | protein-coding | |
Description | UGDH antisense RNA 1 (non-protein coding) | major prion proteinalternative prion proteinCD230 antigenprion-related protein | |
Modification date | 20180329 | 20180522 | |
UniProtAcc | P48637 | ||
Ensembl transtripts involved in fusion gene | ENST00000504032, | ENST00000216951, ENST00000541098, ENST00000451957, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 7 X 7 X 3=147 |
# samples | 3 | 8 | |
** MAII score | log2(3/4*10)=2.90689059560852 | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UGDH-AS1 [Title/Abstract] AND GSS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GSS | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 22820466 |
Tgene | GSS | GO:0071280 | cellular response to copper ion | 16254249 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA389075 | UGDH-AS1 | chr4 | 39587469 | - | GSS | chr20 | 33543599 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000504032 | ENST00000216951 | UGDH-AS1 | chr4 | 39587469 | - | GSS | chr20 | 33543599 | - |
intron-intron | ENST00000504032 | ENST00000541098 | UGDH-AS1 | chr4 | 39587469 | - | GSS | chr20 | 33543599 | - |
intron-intron | ENST00000504032 | ENST00000451957 | UGDH-AS1 | chr4 | 39587469 | - | GSS | chr20 | 33543599 | - |
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FusionProtFeatures for UGDH-AS1_GSS |
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Hgene | Tgene |
UGDH-AS1 | GSS |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UGDH-AS1_GSS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UGDH-AS1_GSS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UGDH-AS1_GSS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | GSS | P48637 | DB06151 | Acetylcysteine | Glutathione synthetase | small molecule | approved|investigational |
Tgene | GSS | P48637 | DB00143 | Glutathione | Glutathione synthetase | small molecule | approved|investigational|nutraceutical |
Tgene | GSS | P48637 | DB00145 | Glycine | Glutathione synthetase | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for UGDH-AS1_GSS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GSS | C0011616 | Contact Dermatitis | 1 | CTD_human |
Tgene | GSS | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | GSS | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | GSS | C0026636 | Mouth Diseases | 1 | CTD_human |
Tgene | GSS | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | GSS | C0398746 | Gluthathione synthetase deficiency | 1 | CTD_human;HPO;ORPHANET;UNIPROT |