![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 40693 |
FusionGeneSummary for UFSP2_CCDC110 |
![]() |
Fusion gene information | Fusion gene name: UFSP2_CCDC110 | Fusion gene ID: 40693 | Hgene | Tgene | Gene symbol | UFSP2 | CCDC110 | Gene ID | 55325 | 256309 |
Gene name | UFM1 specific peptidase 2 | coiled-coil domain containing 110 | |
Synonyms | BHD|C4orf20|SEMDDR | CT52|KM-HN-1|KMHN1 | |
Cytomap | 4q35.1 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ufm1-specific protease 2 | coiled-coil domain-containing protein 110cancer/testis antigen 52cancer/testis antigen KM-HN-1 | |
Modification date | 20180526 | 20180519 | |
UniProtAcc | Q9NUQ7 | Q8TBZ0 | |
Ensembl transtripts involved in fusion gene | ENST00000264689, ENST00000502282, | ENST00000393540, ENST00000307588, ENST00000510617, ENST00000507501, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 4 X 3=36 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: UFSP2 [Title/Abstract] AND CCDC110 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-DD-AAVP-01A | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000264689 | ENST00000393540 | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
Frame-shift | ENST00000264689 | ENST00000307588 | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
5CDS-intron | ENST00000264689 | ENST00000510617 | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
5CDS-intron | ENST00000264689 | ENST00000507501 | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
intron-3CDS | ENST00000502282 | ENST00000393540 | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
intron-3CDS | ENST00000502282 | ENST00000307588 | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
intron-intron | ENST00000502282 | ENST00000510617 | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
intron-intron | ENST00000502282 | ENST00000507501 | UFSP2 | chr4 | 186334880 | - | CCDC110 | chr4 | 186366696 | - |
Top |
FusionProtFeatures for UFSP2_CCDC110 |
![]() |
Hgene | Tgene |
UFSP2 | CCDC110 |
Thiol protease which recognizes and hydrolyzes thepeptide bond at the C-terminal Gly of UFM1, a ubiquitin-likemodifier protein bound to a number of target proteins. Does nothydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4deufmylation may regulate intracellular nuclear receptorstransactivation and thereby regulate cell proliferation anddifferentiation. {ECO:0000269|PubMed:25219498}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CCDC110 | chr4:186334880 | chr4:186366696 | ENST00000307588 | - | 5 | 7 | 431_778 | 820 | 834 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CCDC110 | chr4:186334880 | chr4:186366696 | ENST00000393540 | - | 4 | 6 | 431_778 | 783 | 797 | Coiled coil | Ontology_term=ECO:0000255 |
Top |
FusionGeneSequence for UFSP2_CCDC110 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for UFSP2_CCDC110 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UFSP2 | LIG4, ASCC1, FAS, HLA-C, CD244, SLAMF1, FAM177A1, SORT1, SYNCRIP, CDHR5, ASIC1, ARFGAP1, AMIGO3, CD79A, KCNJ6, ASIC4, CPD, NAPG, VAT1L, PLXDC2, PCDHA4, KIR3DL2, SIGLEC12, VASN, TMX1, SLC16A11, SIGLEC5, C1orf27 | CCDC110 | CUL3, CAND1, DEPTOR, XDH |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for UFSP2_CCDC110 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for UFSP2_CCDC110 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | UFSP2 | C1840572 | HIP DYSPLASIA, BEUKES TYPE | 1 | ORPHANET;UNIPROT |