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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40659

FusionGeneSummary for UCHL5_TARS2

check button Fusion gene summary
Fusion gene informationFusion gene name: UCHL5_TARS2
Fusion gene ID: 40659
HgeneTgene
Gene symbol

UCHL5

TARS2

Gene ID

51377

80222

Gene nameubiquitin C-terminal hydrolase L5threonyl-tRNA synthetase 2, mitochondrial
SynonymsCGI-70|INO80R|UCH-L5|UCH37COXPD21|TARSL1|thrRS
Cytomap

1q31.2

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase isozyme L5INO80 complex subunit Rubiquitin C-terminal hydrolase UCH37ubiquitin carboxyl-terminal esterase L5ubiquitin carboxyl-terminal hydrolase L5ubiquitin thioesterase L5threonine--tRNA ligase, mitochondrialthreonyl-tRNA synthetase 2, mitochondrial (putative)threonyl-tRNA synthetase-like 1
Modification date2018052720180523
UniProtAcc

Q9Y5K5

Q9BW92

Ensembl transtripts involved in fusion geneENST00000367455, ENST00000367454, 
ENST00000367451, ENST00000367448, 
ENST00000367449, ENST00000367452, 
ENST00000530098, ENST00000483156, 
ENST00000438568, ENST00000369054, 
ENST00000369064, ENST00000606933, 
ENST00000463555, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 3 X 4=60
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UCHL5 [Title/Abstract] AND TARS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUCHL5

GO:0016579

protein deubiquitination

18922472


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EB-A42Z-01AUCHL5chr1

192990227

-TARS2chr1

150468958

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000367455ENST00000438568UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367455ENST00000369054UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367455ENST00000369064UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367455ENST00000606933UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367455ENST00000463555UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-3UTRENST00000367454ENST00000438568UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367454ENST00000369054UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367454ENST00000369064UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367454ENST00000606933UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367454ENST00000463555UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-3UTRENST00000367451ENST00000438568UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367451ENST00000369054UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367451ENST00000369064UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367451ENST00000606933UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367451ENST00000463555UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-3UTRENST00000367448ENST00000438568UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367448ENST00000369054UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367448ENST00000369064UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367448ENST00000606933UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367448ENST00000463555UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-3UTRENST00000367449ENST00000438568UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367449ENST00000369054UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367449ENST00000369064UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367449ENST00000606933UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367449ENST00000463555UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-3UTRENST00000367452ENST00000438568UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367452ENST00000369054UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367452ENST00000369064UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367452ENST00000606933UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000367452ENST00000463555UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-3UTRENST00000530098ENST00000438568UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000530098ENST00000369054UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000530098ENST00000369064UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000530098ENST00000606933UCHL5chr1

192990227

-TARS2chr1

150468958

+
5CDS-intronENST00000530098ENST00000463555UCHL5chr1

192990227

-TARS2chr1

150468958

+
intron-3UTRENST00000483156ENST00000438568UCHL5chr1

192990227

-TARS2chr1

150468958

+
intron-intronENST00000483156ENST00000369054UCHL5chr1

192990227

-TARS2chr1

150468958

+
intron-intronENST00000483156ENST00000369064UCHL5chr1

192990227

-TARS2chr1

150468958

+
intron-intronENST00000483156ENST00000606933UCHL5chr1

192990227

-TARS2chr1

150468958

+
intron-intronENST00000483156ENST00000463555UCHL5chr1

192990227

-TARS2chr1

150468958

+

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FusionProtFeatures for UCHL5_TARS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UCHL5

Q9Y5K5

TARS2

Q9BW92

Protease that specifically cleaves 'Lys-48'-linkedpolyubiquitin chains. Deubiquitinating enzyme associated with the19S regulatory subunit of the 26S proteasome. Putative regulatorycomponent of the INO80 complex; however is inactive in the INO80complex and is activated by a transient interaction of the INO80complex with the proteasome via ADRM1.{ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}. Catalyzes the attachment of threonine to tRNA(Thr) in atwo-step reaction: threonine is first activated by ATP to formThr-AMP and then transferred to the acceptor end of tRNA(Thr).Also edits incorrectly charged tRNA(Thr) via its editing domain.{ECO:0000269|PubMed:26811336}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UCHL5_TARS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UCHL5_TARS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UCHL5PSMD8, HAUS7, NFRKB, PSMB3, PSMB5, PSMB6, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD1, PSMD2, PSMD3, PSMD4, PSMD7, PSMD10, PSMD11, PSMD12, PSMD13, PTPN2, RAD23B, USP14, TXNL1, PSMD6, PSMD14, ADRM1, TFPT, USP12, PAAF1, INO80E, RUVBL2, SMAD2, SMAD3, SMAD7, INO80, UBC, YY1, RUVBL1, ACTR5, ACTR8, INO80D, MCRS1, HSPA5, ARG1, CASP14, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4J, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST4H4, HIST2H4B, SET, DSC1, ASPRV1, KRT80, POF1B, ACTN4, PNP, CSTA, IGHG1, ANXA1, KRT73, KRT78, HSPB1, ANXA8L1, ANXA8, PKM, DSP, FLG, GSTM3, SERPINB3, S100A7, YWHAZ, KRT28, KRT26, KRT12, KRT19, SERPINB5, EPPK1, TUBA4A, PRDX1, TGM3, PKP1, DSC3, ANP32B, PRDX6, CDSN, S100A16, EEF2, IDE, HBA1, HBA2, HBB, SERPINB12, DUSP14, ANXA7, CFL1, RAB7A, TPI1, EIF4A1, CAP1, NACA, TXN2, CTSD, CAPZA1, LMNA, IVL, ANP32E, ANXA4, S100A14, EEF1G, TXN, ACTB, ACTG1, POTEF, KRT1, KRT9, KRT6B, PFN1, POTEKP, POTEE, ACTC1, APOA1, APOB, PRDX3, ECHS1, PRDX2, SRXN1, FTL, FTH1, CYB5A, CYB5B, KRT10, NOS2, CALM1, RAD23A, PSMA2, ACTL6A, UCHL5, INO80B, INO80C, PSMA1, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB4, PSMB7, RFFL, PJA1, TRIM63, TRIM55, TRIM54, USP28, APP, WDR61, XPO5, PLRG1, SNRPA1, UNC45A, TRIM27, RBCK1, TRIM46, CBX7, PRPF19, KDM1A, KIAA0368, KCMF1, PPP1R2P4, RPS21, SHFM1, HUWE1, PLA2G2A, ZBED1, UBE3A, MAP3K1, CCDC74B, FHOD1, FDFT1, RGPD5, RGPD8, HERC2, CCDC92, PSMB9, CCNDBP1, C6orf211, PLCG1, PSMB8, RNF20, TIPRL, CIAPIN1, COMMD4, XPNPEP1, NTRK1, SNW1, CDC5L, E2F1, E2F2, E2F3, UBLCP1, KDELR1, SLC17A2, BRCA1TARS2ICT1, CUL3, AHSA1, CDC37, CHORDC1, FKBPL, EGFR, NTRK1, COQ9, CISD3, C2orf47, PTPN18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UCHL5_TARS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UCHL5_TARS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTARS2C4014668COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 211ORPHANET;UNIPROT