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Fusion gene ID: 40656 |
FusionGeneSummary for UCHL3_KLF5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UCHL3_KLF5 | Fusion gene ID: 40656 | Hgene | Tgene | Gene symbol | UCHL3 | KLF5 | Gene ID | 7347 | 688 |
| Gene name | ubiquitin C-terminal hydrolase L3 | Kruppel like factor 5 | |
| Synonyms | UCH-L3 | BTEB2|CKLF|IKLF | |
| Cytomap | 13q22.2 | 13q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase isozyme L3testicular tissue protein Li 221ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)ubiquitin thioesterase L3ubiquitin thiolesterase | Krueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorintes | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P15374 | Q13887 | |
| Ensembl transtripts involved in fusion gene | ENST00000377595, ENST00000606347, | ENST00000477333, ENST00000539231, ENST00000377687, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 2 X 3=24 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UCHL3 [Title/Abstract] AND KLF5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UCHL3 | GO:0016579 | protein deubiquitination | 9521656 |
| Hgene | UCHL3 | GO:0030163 | protein catabolic process | 21762696 |
| Tgene | KLF5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16595680 |
| Tgene | KLF5 | GO:0099156 | cell-cell signaling via exosome | 28408180 |
| Tgene | KLF5 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 28408180 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-V5-A7RB-01A | UCHL3 | chr13 | 76135017 | + | KLF5 | chr13 | 73636247 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000377595 | ENST00000477333 | UCHL3 | chr13 | 76135017 | + | KLF5 | chr13 | 73636247 | + |
| 5CDS-3UTR | ENST00000377595 | ENST00000539231 | UCHL3 | chr13 | 76135017 | + | KLF5 | chr13 | 73636247 | + |
| 5CDS-3UTR | ENST00000377595 | ENST00000377687 | UCHL3 | chr13 | 76135017 | + | KLF5 | chr13 | 73636247 | + |
| intron-3UTR | ENST00000606347 | ENST00000477333 | UCHL3 | chr13 | 76135017 | + | KLF5 | chr13 | 73636247 | + |
| intron-3UTR | ENST00000606347 | ENST00000539231 | UCHL3 | chr13 | 76135017 | + | KLF5 | chr13 | 73636247 | + |
| intron-3UTR | ENST00000606347 | ENST00000377687 | UCHL3 | chr13 | 76135017 | + | KLF5 | chr13 | 73636247 | + |
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FusionProtFeatures for UCHL3_KLF5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UCHL3 | KLF5 |
| Deubiquitinating enzyme (DUB) that controls levels ofcellular ubiquitin through processing of ubiquitin precursors andubiquitinated proteins. Thiol protease that recognizes andhydrolyzes a peptide bond at the C-terminal glycine of eitherubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys atposition P3", and exhibits a preference towards 'Lys-48'-linkedubiquitin chains. Deubiquitinates ENAC in apical compartments,thereby regulating apical membrane recycling. Indirectly increasesthe phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. Maybe involved in working memory. Can hydrolyze UBB(+1), a mutatedform of ubiquitin which is not effectively degraded by theproteasome and is associated with neurogenerative disorders.{ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696,ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630,ECO:0000269|PubMed:9790970}. | Transcription factor that binds to GC box promoterelements. Activates the transcription of these genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UCHL3_KLF5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UCHL3_KLF5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UCHL3 | NEDD8, COPS5, COPS6, USP20, CLPB, SMAD1, HMP19, POGK, UBC, UBE2S, UCHL3, ATXN7L3, PJA1, TRIM63, TRIM55, TRIM54, USP21, USP15, USP28, TSN, ZFYVE19, AHCYL1, UBA6, ZNF593, USP48, USP9X, SSSCA1, USP34, USP5, UBE2V1, UBQLN1, CSE1L, UBE2A, XIAP, UBXN7, UBR1, UNK, ZYX, SNRPD1, UBE2L3, ZRANB2, ATP6V1F, PCMT1, TTC9C, SULT1A1, YAP1, UBE4B, TTC1, VPS33B, PBX1, NT5DC1, UBL7, LONRF1, TRIM27, BAG3, CDH1, PLA2G2A, ZMYM6, ACAA2, ARHGDIA, GDI1, GPX4, HINT1, IMPDH2, MAPRE1, PEBP1, PGD, STIP1, DLD, ENO1, ENO2, EZR, HSD17B10, ISYNA1, MSN, NUP93, P4HB, PPIB, RDX, SMS, SOD2, SUMO3, TAGLN, TAGLN2, TPD52, TPD52L1, UBA1, RAD51, ATM, ZEB1 | KLF5 | SET, EP300, NFKB1, PRKCA, CREBBP, GTF2B, TBP, WWP1, ESR1, HDAC1, FBXW7, GSK3B, HDAC2, RARA, TRIM25, ESR2, SMURF2, WWTR1, ELAVL1, YAP1, SMAD2, RRBP1, SMAD4, SMAD3, ZBTB17, CTNNB1, SREBF1, SUMO1, UBE2I, NCOR2, NCOR1, PPARG, ANP32B, PARP1, TP53, GTF2E2, GTF2F2, ATXN3L, XPO1, ACTR5, RXRA, CEBPB, CEBPG, CSRP3, CEBPA, JUN, BAP1, HCFC1, OGT, ACTA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UCHL3_KLF5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UCHL3_KLF5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | UCHL3 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | KLF5 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | KLF5 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | KLF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | KLF5 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | KLF5 | C2936380 | Neointima | 1 | CTD_human |
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