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Fusion gene ID: 40643 |
FusionGeneSummary for UBXN2B_PHF3 |
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Fusion gene information | Fusion gene name: UBXN2B_PHF3 | Fusion gene ID: 40643 | Hgene | Tgene | Gene symbol | UBXN2B | PHF3 | Gene ID | 137886 | 23469 |
Gene name | UBX domain protein 2B | PHD finger protein 3 | |
Synonyms | p37 | - | |
Cytomap | 8q12.1 | 6q12 | |
Type of gene | protein-coding | protein-coding | |
Description | UBX domain-containing protein 2BNSFL1 cofactor p37p97 cofactor p37 | PHD finger protein 3 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q14CS0 | Q92576 | |
Ensembl transtripts involved in fusion gene | ENST00000399598, ENST00000522978, | ENST00000262043, ENST00000509330, ENST00000393387, ENST00000420043, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 3=48 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: UBXN2B [Title/Abstract] AND PHF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-FX-A2QS-01A | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000399598 | ENST00000262043 | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
Frame-shift | ENST00000399598 | ENST00000509330 | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
Frame-shift | ENST00000399598 | ENST00000393387 | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
5CDS-intron | ENST00000399598 | ENST00000420043 | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
intron-3CDS | ENST00000522978 | ENST00000262043 | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
intron-3CDS | ENST00000522978 | ENST00000509330 | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
intron-3CDS | ENST00000522978 | ENST00000393387 | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
intron-intron | ENST00000522978 | ENST00000420043 | UBXN2B | chr8 | 59352329 | + | PHF3 | chr6 | 64389901 | + |
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FusionProtFeatures for UBXN2B_PHF3 |
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Hgene | Tgene |
UBXN2B | PHF3 |
Adapter protein required for Golgi and endoplasmicreticulum biogenesis (PubMed:17141156). Involved in Golgi andendoplasmic reticulum maintenance during interphase and in theirreassembly at the end of mitosis (PubMed:17141156). The complexformed with VCP has membrane fusion activity; membrane fusionactivity requires USO1-GOLGA2 tethering and BET1L(PubMed:17141156). VCPIP1 is also required, but not itsdeubiquitinating activity (PubMed:17141156). Together withNSFL1C/p47, regulates the centrosomal levels of kinaseAURKA/Aurora A during mitotic progression by promoting AURKAremoval from centrosomes in prophase (PubMed:23649807). Also,regulates spindle orientation during mitosis (PubMed:23649807).{ECO:0000269|PubMed:17141156, ECO:0000269|PubMed:23649807}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBXN2B_PHF3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBXN2B_PHF3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UBXN2B | VCPIP1, VCP, CRX, MEOX1, NGLY1, VAT1L, INCA1, CDC42BPB, NIF3L1, PPP1R7, PPP1R11, ASPSCR1, ACTR6, FAM104A, FANK1, LACTB, PPP1CA, PPP1CB, SEC24A, GSK3B, HSPBP1, KLHL36, PPP1CC, TRAF2, UBR2, FAF1, FAM89A | PHF3 | SIRT7, MAPK3, HECW2, BMI1, CLK1, ORC1, SUPT5H, YWHAZ, USP37, TMA16, ID2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBXN2B_PHF3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBXN2B_PHF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PHF3 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |