FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 40642

FusionGeneSummary for UBXN2A_TPO

check button Fusion gene summary
Fusion gene informationFusion gene name: UBXN2A_TPO
Fusion gene ID: 40642
HgeneTgene
Gene symbol

UBXN2A

TPO

Gene ID

165324

7173

Gene nameUBX domain protein 2Athyroid peroxidase
SynonymsUBXD4MSA|TDH2A|TPX
Cytomap

2p23.3

2p25.3

Type of geneprotein-codingprotein-coding
DescriptionUBX domain-containing protein 2AUBX domain containing 4UBX domain-containing protein 4thyroid peroxidasethyroid microsomal antigenthyroperoxidase
Modification date2018052320180523
UniProtAcc

P68543

P07202

Ensembl transtripts involved in fusion geneENST00000446425, ENST00000404924, 
ENST00000309033, ENST00000535786, 
ENST00000497517, ENST00000539820, 
ENST00000382269, ENST00000349624, 
ENST00000345913, ENST00000346956, 
ENST00000337415, ENST00000329066, 
ENST00000382201, ENST00000382198, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 4=100
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBXN2A [Title/Abstract] AND TPO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTPO

GO:0035162

embryonic hemopoiesis

21149635


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-WY-A859-01AUBXN2Achr2

24181225

+TPOchr2

1497574

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000446425ENST00000497517UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000539820UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000382269UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000349624UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000345913UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000346956UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000337415UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000329066UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000382201UBXN2Achr2

24181225

+TPOchr2

1497574

+
3UTR-intronENST00000446425ENST00000382198UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-3UTRENST00000404924ENST00000497517UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000539820UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000382269UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000349624UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000345913UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000346956UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000337415UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000329066UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000382201UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000404924ENST00000382198UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-3UTRENST00000309033ENST00000497517UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000539820UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000382269UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000349624UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000345913UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000346956UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000337415UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000329066UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000382201UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000309033ENST00000382198UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-3UTRENST00000535786ENST00000497517UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000539820UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000382269UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000349624UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000345913UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000346956UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000337415UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000329066UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000382201UBXN2Achr2

24181225

+TPOchr2

1497574

+
5CDS-intronENST00000535786ENST00000382198UBXN2Achr2

24181225

+TPOchr2

1497574

+

Top

FusionProtFeatures for UBXN2A_TPO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBXN2A

P68543

TPO

P07202


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for UBXN2A_TPO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for UBXN2A_TPO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBXN2AVCPIP1, VCP, PHAX, DBI, UBXN6, MYH11, PPP1CB, LIMA1, PPP1R7, HSPA9, ASPSCR1, PPP1R11, LACTB, MYLPF, NSFL1C, PPP1CA, UBXN10, TRIM25TPO


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UBXN2A_TPO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTPOP07202DB00763MethimazoleThyroid peroxidase {ECO:0000305}small moleculeapproved
TgeneTPOP07202DB11085ResorcinolThyroid peroxidase {ECO:0000305}small moleculeapproved
TgeneTPOP07202DB00389CarbimazoleThyroid peroxidase {ECO:0000305}small moleculeapproved|investigational
TgeneTPOP07202DB00509DextrothyroxineThyroid peroxidase {ECO:0000305}small moleculeapproved|investigational
TgeneTPOP07202DB00550PropylthiouracilThyroid peroxidase {ECO:0000305}small moleculeapproved|investigational
TgeneTPOP07202DB08604TriclosanThyroid peroxidase {ECO:0000305}small moleculeapproved|investigational

Top

RelatedDiseases for UBXN2A_TPO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPOC1291299Deficiency of iodide peroxidase (disorder)15CTD_human;UNIPROT
TgeneTPOC0010308Congenital Hypothyroidism4CTD_human
TgeneTPOC0018021Goiter3CTD_human;HPO
TgeneTPOC0005586Bipolar Disorder1PSYGENET