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Fusion gene ID: 40640 |
FusionGeneSummary for UBXN1_WDR74 |
Fusion gene summary |
Fusion gene information | Fusion gene name: UBXN1_WDR74 | Fusion gene ID: 40640 | Hgene | Tgene | Gene symbol | UBXN1 | WDR74 | Gene ID | 51035 | 54663 |
Gene name | UBX domain protein 1 | WD repeat domain 74 | |
Synonyms | 2B28|SAKS1|UBXD10 | - | |
Cytomap | 11q12.3 | 11q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | UBX domain-containing protein 1SAPK substrate protein 1UBA/UBX 33.3 kDa protein | WD repeat-containing protein 74NOP seven-associated protein 1 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q04323 | Q6RFH5 | |
Ensembl transtripts involved in fusion gene | ENST00000294119, ENST00000301935, ENST00000533000, ENST00000529640, ENST00000524762, | ENST00000311713, ENST00000278856, ENST00000529106, ENST00000525239, ENST00000525752, ENST00000540620, | |
Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 5 X 4 X 6=120 |
# samples | 3 | 8 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UBXN1 [Title/Abstract] AND WDR74 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | UBXN1 | GO:0031397 | negative regulation of protein ubiquitination | 20351172 |
Hgene | UBXN1 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 20351172 |
Hgene | UBXN1 | GO:1903094 | negative regulation of protein K48-linked deubiquitination | 21135095 |
Hgene | UBXN1 | GO:2000157 | negative regulation of ubiquitin-specific protease activity | 21135095 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCS | TCGA-N5-A4RD-01A | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000294119 | ENST00000311713 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000294119 | ENST00000278856 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000294119 | ENST00000529106 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-5UTR | ENST00000294119 | ENST00000525239 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-5UTR | ENST00000294119 | ENST00000525752 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000294119 | ENST00000540620 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000301935 | ENST00000311713 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000301935 | ENST00000278856 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000301935 | ENST00000529106 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-5UTR | ENST00000301935 | ENST00000525239 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-5UTR | ENST00000301935 | ENST00000525752 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000301935 | ENST00000540620 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000533000 | ENST00000311713 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000533000 | ENST00000278856 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000533000 | ENST00000529106 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-5UTR | ENST00000533000 | ENST00000525239 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-5UTR | ENST00000533000 | ENST00000525752 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000533000 | ENST00000540620 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000529640 | ENST00000311713 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000529640 | ENST00000278856 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000529640 | ENST00000529106 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-5UTR | ENST00000529640 | ENST00000525239 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-5UTR | ENST00000529640 | ENST00000525752 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5CDS-intron | ENST00000529640 | ENST00000540620 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5UTR-intron | ENST00000524762 | ENST00000311713 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5UTR-intron | ENST00000524762 | ENST00000278856 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5UTR-intron | ENST00000524762 | ENST00000529106 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5UTR-5UTR | ENST00000524762 | ENST00000525239 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5UTR-5UTR | ENST00000524762 | ENST00000525752 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
5UTR-intron | ENST00000524762 | ENST00000540620 | UBXN1 | chr11 | 62444990 | - | WDR74 | chr11 | 62607339 | - |
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FusionProtFeatures for UBXN1_WDR74 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
UBXN1 | WDR74 |
Ubiquitin-binding protein that plays a role in themodulation of innate immune response. Blocks both the RIG-I-likereceptors (RLR) and NF-kappa-B pathways. Following viralinfection, UBXN1 is induced and recruited to the RLR componentMAVS. In turn, interferes with MAVS oligomerization, and disruptsthe MAVS/TRAF3/TRAF6 signalosome. This function probably serves asa brake to prevent excessive RLR signaling (PubMed:23545497).Interferes with the TNFalpha-triggered NF-kappa-B pathway byinteracting with cellular inhibitors of apoptosis proteins (cIAPs)and thereby inhibiting their recruitment to TNFR1(PubMed:25681446). Prevents also the activation of NF-kappa-B byassociating with CUL1 and thus inhibiting NF-kappa-B inhibitoralpha/NFKBIA degradation that remains bound to NF-kappa-B(PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer andregulates its activity. Specifically binds 'Lys-6'-linkedpolyubiquitin chains. Interaction with autoubiquitinated BRCA1leads to the inhibition of the E3 ubiquitin-protein ligaseactivity of the BRCA1-BARD1 heterodimer (PubMed:20351172).Component of a complex required to couple deglycosylation andproteasome-mediated degradation of misfolded proteins in theendoplasmic reticulum that are retrotranslocated in the cytosol.{ECO:0000269|PubMed:20351172, ECO:0000269|PubMed:23545497,ECO:0000269|PubMed:25681446, ECO:0000269|PubMed:28152074}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBXN1_WDR74 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBXN1_WDR74 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UBXN1 | ASF1B, CDK4, USP32, BABAM1, WDR20, VCP, NPLOC4, UFD1L, CUL1, CUL2, CUL3, UBR1, HIF1A, ALPP, VCPIP1, KLHL12, KLHL22, KBTBD7, BTBD2, DDB1, AMFR, UBR2, UBR4, PJA2, BIRC3, RLIM, UBR5, UBE3A, HUWE1, UBE4B, BRCA1, BARD1, UBC, HOMER2, SPRTN, RPA1, UBE2V2, USP9X, SSSCA1, ZFYVE19, UNC45A, UBQLN4, UFC1, VPS4B, KIAA1598, CLNS1A, UNK, TWF1, USP34, TTC1, ZPR1, ATP6V1A, SEC22B, PIPSL, NPTN, RPA3, IGBP1, VTA1, SULT1A1, CSE1L, UBQLN1, TXNDC5, S100A16, AHCYL1, UFM1, DNAJB11, VAMP2, RPA2, UBE2C, UBE2L3, CD81, BASP1, CTPS1, HMGB3, MCTS1, NSFL1C, PAFAH1B1, PROSC, TUBB2A, TUFM, TXNRD1, CAPN2, DENR, HK1, HSPA5, STK26, PLAA, TRNT1, TWF2, YWHAE, MAVS, PLA2G4A, UBE2I, FAM189A2, UBXN1, TRIM39, NXF1, PSMD4, USP47, BTBD9, MARCH7, FAM115A, KCTD10, TNFAIP1, MID2, SHKBP1, BTBD1, PSMC3, ACAT2, PRPF19, SPDL1, TAGLN3, UBE2A, BIRC2, MCM2, BAG6, PPP1R7, PRPS2, PRPSAP2, GET4, PSMA1, UBL4A, FAF1, FAF2, MAGED1, MYO6, PPP1CB, SQSTM1, UBXN7, DSC1, DSG1, GAR1, HDAC8, JUP, TRA, DUSP6, EMILIN1, YAF2, CCDC102B, AARSD1, A1BG, KLHL10, KLRG2, CDK5R1 | WDR74 | RGS2, NUDT3, DDX39B, USP7, UBE3C, PUS7, WBSCR22, PPIP5K2, NSUN2, VAT1, HDAC11, RCHY1, CARD8, CCNJL, DDX47, DHX37, GNL2, RRS1, SSB, ZC3H15, IFI16, XPO1, PDGFRA, PKN2, THOC5, NOP56, IBTK, C17orf85, BOP1, MAK16, RPF1, RBM3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBXN1_WDR74 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBXN1_WDR74 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | UBXN1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | WDR74 | C0025202 | melanoma | 1 | CTD_human |