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Fusion gene ID: 4063 |
FusionGeneSummary for BCL9_GOLPH3L |
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Fusion gene information | Fusion gene name: BCL9_GOLPH3L | Fusion gene ID: 4063 | Hgene | Tgene | Gene symbol | BCL9 | GOLPH3L | Gene ID | 607 | 55204 |
Gene name | B cell CLL/lymphoma 9 | golgi phosphoprotein 3 like | |
Synonyms | LGS | GPP34R | |
Cytomap | 1q21.2 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | B-cell CLL/lymphoma 9 proteinB-cell lymphoma 9 proteinbcl-9protein legless homolog | Golgi phosphoprotein 3-likeGPP34-related protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O00512 | Q9H4A5 | |
Ensembl transtripts involved in fusion gene | ENST00000234739, ENST00000473292, | ENST00000271732, ENST00000540514, ENST00000479757, | |
Fusion gene scores | * DoF score | 6 X 3 X 3=54 | 8 X 4 X 7=224 |
# samples | 5 | 8 | |
** MAII score | log2(5/54*10)=-0.111031312388744 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BCL9 [Title/Abstract] AND GOLPH3L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-VS-A8QC-01A | BCL9 | chr1 | 147013444 | + | GOLPH3L | chr1 | 150636239 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000234739 | ENST00000271732 | BCL9 | chr1 | 147013444 | + | GOLPH3L | chr1 | 150636239 | - |
5UTR-intron | ENST00000234739 | ENST00000540514 | BCL9 | chr1 | 147013444 | + | GOLPH3L | chr1 | 150636239 | - |
5UTR-intron | ENST00000234739 | ENST00000479757 | BCL9 | chr1 | 147013444 | + | GOLPH3L | chr1 | 150636239 | - |
intron-3CDS | ENST00000473292 | ENST00000271732 | BCL9 | chr1 | 147013444 | + | GOLPH3L | chr1 | 150636239 | - |
intron-intron | ENST00000473292 | ENST00000540514 | BCL9 | chr1 | 147013444 | + | GOLPH3L | chr1 | 150636239 | - |
intron-intron | ENST00000473292 | ENST00000479757 | BCL9 | chr1 | 147013444 | + | GOLPH3L | chr1 | 150636239 | - |
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FusionProtFeatures for BCL9_GOLPH3L |
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Hgene | Tgene |
BCL9 | GOLPH3L |
Involved in signal transduction through the Wnt pathway.Promotes beta-catenin's transcriptional activity (By similarity).{ECO:0000250, ECO:0000269|PubMed:11955446}. | Phosphatidylinositol-4-phosphate-binding protein thatmay antagonize the action of GOLPH3 which is required for theprocess of vesicle budding at the Golgi and anterograde transportto the plasma membrane. {ECO:0000269|PubMed:23345592}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BCL9_GOLPH3L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BCL9_GOLPH3L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BCL9 | PYGO1, ELAVL1, PYGO2, WWOX, CTNNB1, EWSR1, TRIM25 | GOLPH3L | ELAVL1, VCP, HTT, LNX1, SHMT2, MOV10, ZDHHC17, RWDD2B, PNKD, C3orf58, ARL6IP1, GPRC5C, P2RX1, CHST6, C5AR2, S1PR1, TNFRSF8, GLB1L2, SLC39A5, ENTPD7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BCL9_GOLPH3L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BCL9_GOLPH3L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BCL9 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | BCL9 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | BCL9 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | BCL9 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | BCL9 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | BCL9 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |