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Fusion gene ID: 40625 |
FusionGeneSummary for UBTD2_STK10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBTD2_STK10 | Fusion gene ID: 40625 | Hgene | Tgene | Gene symbol | UBTD2 | STK10 | Gene ID | 92181 | 6793 |
| Gene name | ubiquitin domain containing 2 | serine/threonine kinase 10 | |
| Synonyms | DCUBP | LOK|PRO2729 | |
| Cytomap | 5q35.1 | 5q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin domain-containing protein 2ubiquitin-like protein SB72 | serine/threonine-protein kinase 10lymphocyte-oriented kinase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8WUN7 | O94804 | |
| Ensembl transtripts involved in fusion gene | ENST00000393792, | ENST00000176763, ENST00000517775, | |
| Fusion gene scores | * DoF score | 7 X 4 X 6=168 | 10 X 10 X 4=400 |
| # samples | 8 | 10 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBTD2 [Title/Abstract] AND STK10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STK10 | GO:0046777 | protein autophosphorylation | 12639966|18239682 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-CC-A3MB-01A | UBTD2 | chr5 | 171710600 | - | STK10 | chr5 | 171554425 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393792 | ENST00000176763 | UBTD2 | chr5 | 171710600 | - | STK10 | chr5 | 171554425 | - |
| 5CDS-intron | ENST00000393792 | ENST00000517775 | UBTD2 | chr5 | 171710600 | - | STK10 | chr5 | 171554425 | - |
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FusionProtFeatures for UBTD2_STK10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBTD2 | STK10 |
| Serine/threonine-protein kinase involved in regulationof lymphocyte migration. Phosphorylates MSN, and possibly PLK1.Involved in regulation of lymphocyte migration by mediatingphosphorylation of ERM proteins such as MSN. Acts as a negativeregulator of MAP3K1/MEKK1. May also act as a cell cycle regulatorby acting as a polo kinase kinase: mediates phosphorylation ofPLK1 in vitro; however such data require additional evidences invivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966,ECO:0000269|PubMed:19255442}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >STK10 | chr5:171710600 | chr5:171554425 | ENST00000176763 | - | 1 | 19 | 573_947 | 107 | 969 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >STK10 | chr5:171710600 | chr5:171554425 | ENST00000176763 | - | 1 | 19 | 750_884 | 107 | 969 | Compositional bias | Note=Gln-rich |
| Tgene | >STK10 | chr5:171710600 | chr5:171554425 | ENST00000176763 | - | 1 | 19 | 175_224 | 107 | 969 | Region | Note=Activation segment |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UBTD2 | chr5:171710600 | chr5:171554425 | ENST00000393792 | - | 1 | 3 | 152_227 | 23 | 235 | Domain | Ubiquitin-like |
| Tgene | STK10 | chr5:171710600 | chr5:171554425 | ENST00000176763 | - | 1 | 19 | 36_294 | 107 | 969 | Domain | Protein kinase |
| Tgene | STK10 | chr5:171710600 | chr5:171554425 | ENST00000176763 | - | 1 | 19 | 42_50 | 107 | 969 | Nucleotide binding | ATP |
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FusionGeneSequence for UBTD2_STK10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBTD2_ENST00000393792_chr5_171710600_-_STK10_ENST00000176763_chr5_171554425_-_885aa MGGCVGAQHDSSGSLNENSEGTGDHDXVLSRGSRGRHHAGAGQRPHGAPDTGGLPPDARSPQLPAQQEDHPPRSESWQRADDPRGRHQAG XLWCVCQESEDSTETRFLHRHALLDGPRGGHVXDHERHALRLQSRHLVPGHHADXDGPDRAATPRAQPHAGPAKDRQVGPSHAAHALXVV CRVPXLPEDSPGXEPRNPTQCRAAAGASLRQQHHQXQGSAGAGGXGQGRGDGRDRRRPGXGGRGGRRGCRLHPGEPYSELLXGESAKPQC XQASRGVTFHPAGTQPVSGQCEXALQPALWGQIPPNHQSPSRGPWKXERPGSACAPAEVPTRVNGCQNSGSPGEASCXAGWGPQPSSQQI SKGQPEPAQQQRPGDLGWGEAGQWQPGATCPGSSRAFQEGLGLQQPLHLXEHGLWYQSLHXPVAEQRDGLSVHQGPETVQKNPQADTQIC GGWCGGEHHHLQDHQRRXEEGXGDEISQAPGTPRASAAPERRASEPDPAEXQAXAAAGANAXTFXTGNQRQEEVLXHGIREPGASAKAAS GEDGARPCRAPPGGGQADPPGAGSGLHQVPRAAQTDEERGEERGGEAPPTAAEGKHEAEDGGAHAEKAASXPGLCSQAEGGPGAGHEEAH HRQQAGDLXQGARVPHEEAGAPSRPGSSPVGDGRAPAAGEAPAGEAAAQRPVLPPAARAAAQAXEGAGADAALQPAHDRAAEGAAATGKG AAAQDPEEXGQDAHGHVQEEPPHQRRGQRSXAAXEDQAVLPAGGEEAEVGAAAATAETREPDAGHAGAVXEQHERAAAAAEXKVPPPGRA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBTD2_ENST00000393792_chr5_171710600_-_STK10_ENST00000176763_chr5_171554425_-_2656nt ATGGGCGGGTGTGTGGGCGCCCAGCACGACTCCTCGGGCAGCCTCAACGAGAACTCGGAGGGCACCGGAGATCATGATTGAGTTCTGTCC AGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGC CCTCAACTTCCTGCACAGCAAGAGGATCATCCACCGAGATCTGAAAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGC TGACTTTGGTGTGTCTGCCAAGAATCTGAAGACTCTACAGAAACGAGATTCCTTCATCGGCACGCCTTACTGGATGGCCCCCGAGGTGGT CATGTGTGAGACCATGAAAGACACGCCCTACGACTACAAAGCCGACATCTGGTCCCTGGGCATCACGCTGATTGAGATGGCCCAGATCGA GCCGCCACACCACGAGCTCAACCCCATGCGGGTCCTGCTAAAGATCGCCAAGTCGGACCCTCCCACGCTGCTCACGCCCTCTAAGTGGTC TGTAGAGTTCCGTGACTTCCTGAAGATAGCCCTGGATAAGAACCCAGAAACCCGACCCAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGT CAGCAGCATCACCAGTAACAAGGCTCTGCGGGAGCTGGTGGCTGAGGCCAAGGCCGAGGTGATGGAAGAGATCGAAGACGGCCGGGATGA GGGGGAAGAGGAGGACGCCGTGGATGCCGCCTCCACCCTGGAGAACCATACTCAGAACTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGC TGACAAGCCTCTCGAGGAGTCACCTTCCACCCCGCTGGCACCCAGCCAGTCTCAGGACAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGG GGACAGATCCCTCCAAACCACCAGTCCCCCAGTCGTGGCCCCTGGAAATGAGAACGGCCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCG ACCCGTGTCAATGGATGCCAGAATTCAGGTAGCCCAGGAGAAGCAAGTTGCTGAGCAGGGTGGGGACCTCAGCCCAGCAGCCAACAGATC TCAAAAGGCCAGCCAGAGCCGGCCCAACAGCAGCGCCCTGGAGACCTTGGGTGGGGAGAAGCTGGCCAATGGCAGCCTGGAGCCACCTGC CCAGGCAGCTCCAGGGCCTTCCAAGAGGGACTCGGACTGCAGCAGCCTCTGCACCTCTGAGAGCATGGACTATGGTACCAATCTCTCCAC TGACCTGTCGCTGAACAAAGAGATGGGCTCTCTGTCCATCAAGGACCCGAAACTGTACAAAAAAACCCTCAAGCGGACACGCAAATTTGT GGTGGATGGTGTGGAGGTGAGCATCACCACCTCCAAGATCATCAGCGAAGATGAGAAGAAGGATGAGGAGATGAGATTTCTCAGGCGCCA GGAACTCCGAGAGCTTCGGCTGCTCCAGAAAGAAGAGCATCGGAACCAGACCCAGCTGAGTAACAAGCATGAGCTGCAGCTGGAGCAAAT GCATAAACGTTTTGAACAGGAAATCAACGCCAAGAAGAAGTTCTTTGACACGGAATTAGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGT GGAGAAGATGGAGCAAGACCATGCCGTGCGCCGCCGGGAGGAGGCCAGGCGGATCCGCCTGGAGCAGGATCGGGACTACACCAGGTTCCA AGAGCAGCTCAAACTGATGAAGAAAGAGGTGAAGAACGAGGTGGAGAAGCTCCCCCGACAGCAGCGGAAGGAAAGCATGAAGCAGAAGAT GGAGGAGCACACGCAGAAAAAGCAGCTTCTTGACCGGGACTTTGTAGCCAAGCAGAAGGAGGACCTGGAGCTGGCCATGAAGAGGCTCAC CACCGACAACAGGCGGGAGATCTGTGACAAGGAGCGCGAGTGCCTCATGAAGAAGCAGGAGCTCCTTCGAGACCGGGAAGCAGCCCTGTG GGAGATGGAAGAGCACCAGCTGCAGGAGAGGCACCAGCTGGTGAAGCAGCAGCTCAAAGACCAGTACTTCCTCCAGCGGCACGAGCTGCT GCGCAAGCATGAGAAGGAGCGGGAGCAGATGCAGCGCTACAACCAGCGCATGATAGAGCAGCTGAAGGTGCGGCAGCAACAGGAAAAGGC GCGGCTGCCCAAGATCCAGAGGAGTGAGGGCAAGACGCGCATGGCCATGTACAAGAAGAGCCTCCACATCAACGGCGGGGGCAGCGCAGC TGAGCAGCGTGAGAAGATCAAGCAGTTCTCCCAGCAGGAGGAGAAGAGGCAGAAGTCGGAGCGGCTGCAGCAACAGCAGAAACACGAGAA CCAGATGCGGGACATGCTGGCGCAGTGTGAGAGCAACATGAGCGAGCTGCAGCAGCTGCAGAATGAAAAGTGCCACCTCCTGGTAGAGCA CGAAACCCAGAAACTGAAGGCCCTGGATGAGAGCCATAACCAGAACCTGAAGGAATGGCGGGACAAGCTTCGGCCGCGCAAGAAGGCTCT GGAAGAGGATCTGAACCAGAAGAAGCGGGAGCAGGAGATGTTCTTCAAGCTGAGCGAGGAGGCGGAGTGCCCAAACCCCTCCACCCCAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBTD2_ENST00000393792_chr5_171710600_-_STK10_ENST00000176763_chr5_171554425_-_5871nt GGCGCCGCGGGCCGGGGGCCGATGGGTCCTGGCGGACGCGAGGCGCCGGCGCGGGGCTCGCCTGGACTCGGGTGTGCGGGGCTGTGAGGG GGCGAGGCGGGCGCTGCGGCCCGCCCGGGATGGGCCAGCCCTGGCCTGGCGGGGCTGAGCCGAAGGCGAGGGCGGCGCGCGGGCCAGGCC TGCCGGGCGGGCGGCCCGGGGGTTGAGGTAGAAGTGGGCGCGGAGGAAGGGGCCGAGCCAAGGCGGTGGGTGGAGCGGCGAGGGGGGCGG AGGCTGGGCCGCGGCGGGCGAGCGGAGCGGCGCGCCTGTCCGGAGCTCGGCGGTGGCGCCGGAGGAGGCTGCAGCGGCGGCGGCGGCGGG CCCGGACGAGCGTCCGGAGGTGGCGGACGAGGCGCCGGGGGCCCCCATGGGCGGGTGTGTGGGCGCCCAGCACGACTCCTCGGGCAGCCT CAACGAGAACTCGGAGGGCACCGGAGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGGACAGAGGCC TCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGCAAGAGGATCATCCACCGAGATCTGA AAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCCAAGAATCTGAAGACTCTACAGAAAC GAGATTCCTTCATCGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAAGACACGCCCTACGACTACAAAGCCG ACATCTGGTCCCTGGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTCAACCCCATGCGGGTCCTGCTAAAGA TCGCCAAGTCGGACCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTCCTGAAGATAGCCCTGGATAAGAACC CAGAAACCCGACCCAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAACAAGGCTCTGCGGGAGCTGGTGGCTG AGGCCAAGGCCGAGGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCCGTGGATGCCGCCTCCACCCTGGAGA ACCATACTCAGAACTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAGTCACCTTCCACCCCGCTGGCACCCA GCCAGTCTCAGGACAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACCACCAGTCCCCCAGTCGTGGCCCCTG GAAATGAGAACGGCCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCCAGAATTCAGGTAGCCCAGGAGAAGC AAGTTGCTGAGCAGGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGCCGGCCCAACAGCAGCGCCCTGGAGA CCTTGGGTGGGGAGAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCTTCCAAGAGGGACTCGGACTGCAGCA GCCTCTGCACCTCTGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAAGAGATGGGCTCTCTGTCCATCAAGG ACCCGAAACTGTACAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTGAGCATCACCACCTCCAAGATCATCA GCGAAGATGAGAAGAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGGCTGCTCCAGAAAGAAGAGCATCGGA ACCAGACCCAGCTGAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAGGAAATCAACGCCAAGAAGAAGTTCT TTGACACGGAATTAGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGACCATGCCGTGCGCCGCCGGGAGGAGG CCAGGCGGATCCGCCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATGAAGAAAGAGGTGAAGAACGAGGTGG AGAAGCTCCCCCGACAGCAGCGGAAGGAAAGCATGAAGCAGAAGATGGAGGAGCACACGCAGAAAAAGCAGCTTCTTGACCGGGACTTTG TAGCCAAGCAGAAGGAGGACCTGGAGCTGGCCATGAAGAGGCTCACCACCGACAACAGGCGGGAGATCTGTGACAAGGAGCGCGAGTGCC TCATGAAGAAGCAGGAGCTCCTTCGAGACCGGGAAGCAGCCCTGTGGGAGATGGAAGAGCACCAGCTGCAGGAGAGGCACCAGCTGGTGA AGCAGCAGCTCAAAGACCAGTACTTCCTCCAGCGGCACGAGCTGCTGCGCAAGCATGAGAAGGAGCGGGAGCAGATGCAGCGCTACAACC AGCGCATGATAGAGCAGCTGAAGGTGCGGCAGCAACAGGAAAAGGCGCGGCTGCCCAAGATCCAGAGGAGTGAGGGCAAGACGCGCATGG CCATGTACAAGAAGAGCCTCCACATCAACGGCGGGGGCAGCGCAGCTGAGCAGCGTGAGAAGATCAAGCAGTTCTCCCAGCAGGAGGAGA AGAGGCAGAAGTCGGAGCGGCTGCAGCAACAGCAGAAACACGAGAACCAGATGCGGGACATGCTGGCGCAGTGTGAGAGCAACATGAGCG AGCTGCAGCAGCTGCAGAATGAAAAGTGCCACCTCCTGGTAGAGCACGAAACCCAGAAACTGAAGGCCCTGGATGAGAGCCATAACCAGA ACCTGAAGGAATGGCGGGACAAGCTTCGGCCGCGCAAGAAGGCTCTGGAAGAGGATCTGAACCAGAAGAAGCGGGAGCAGGAGATGTTCT TCAAGCTGAGCGAGGAGGCGGAGTGCCCAAACCCCTCCACCCCAAGCAAGGCCGCCAAGTTCTTCCCCTACAGTTCTGCGGATGCTTCTT AACAACCGCCCGGGGCTGTGGCTGGCAGCTTGGTGGGCCCCAGGGCCTTCTCCTTCATTCTCTGTGAACATGTAACTCAGGACCCCTTTT CCCTCTTGCGTCTGTGCCAGCTCAAATCCAGCCCCTCGCCCTGTGCCACCCCAACTGTGCCTGATAGACCTGCCCCAGCGTTCCTGACTT CTTGCTGGCCTGTGGAGGGTGAGGTGTAATTATTTGTCACCTGAACCTAATGTATATTCTCCTTGAGCCCCAGATCCCTTCAAGCTGGAA GGGATGGGGCTGTTGGTGGGGTCAGGGTCCAAGAGGAATGGGTGTTCTGTGGCCTCGAGTCCTCTCCTGTTTGCGAAAATACCAGTTTTG CTCTCTGTGGGACAAAGCACTGCTGATGAAGTCCCCGTGGGCTCATCCGGGCTGGAATTCTTGGTTTTTCAGCCATTCCCTGCAGAGTCA CTCAATCATCAAGTCCCTCACAGCCATTTCTGTTCCCAGAGGAGCCAGGCCTGCAGCTGGCTGCTCAGGAGATGGCCTCATTCCTCCTGT TCTCCCAGTTTGCTTTCCACTTAAGACAAAGCCTTGTCTATGTGGGGGGCGGGGACCGGGGAAAGAGGGAGGCTGAAATGTTTATTCTGC TTCTCCCGTGTTTCATGCCATCTCGCGTCCCCCTTCCTGCACATGGGTGTGAATGCACACACATACGCGTACACACAGGACTTGGTCTGC TGGCCTGGCCTCTTCTGCCCAGGTGGGTTGGAACACGTTTGCTGCCTGAGCCTGTGCCACTGAGCATGTTAGGTGGAGCAGTTGGTGTGG CACGTGCGGGGTGTTGGCACCGGAGGCATGGAAAAGCACAGGCTGTACTGCCAGGCTGCGATGCGTGCTGGCCCCCGCACAGGCTCCTGT GTGCAGGGACTGATTCCTCAGCACACGAGGCTTCCACAACCCAGTCTGCTCCATAGCACTCTGGCCCACCCTGTCTGCAGGTGAAACAGG AGGGCTGTTTGCCTCTGCCCCATCCCCCCGACTGTGTTCAGGAGTCCCACCTTGCATTTCAGACCTGGGCTGGCAGTCTGTTGGACTTCT CTTCAGGAAGAAAAAGCATCAGGGGGAAATGGAATGCCCCTGCCCCAGGAACATGGCAGAAGCACAGGTTCTGTACCTCAGATGGACTCC TGCTGGGCCTTCGGGGTCTCAGTTGGCTTCCCCCAGATTCTGATTCTACAGCTGCAGAATGTATATAACGCAATAAAAGCAAATGTTTGA ACCAGTATGCGGGTTTACTTACAAGGAAACCTTTTTTCACCCTGATTTCTAATTATTTTATTGAAACAACTATAAAATGTATGGTTTCTC CAGGAAGATATCTGCTTTTTAAAACAACAAACAAGAACAACAACACAAAACTGGTAATGATTTGGAGTAATCATGCGGGCATATTGAGTC TGGGTAGTGTTTCGCTGGTGGTAGAGTGGTTGAGACTTCCTGGGAGGACTTTTTCCGCCTTCACTCCTACAGATTTAAGATTCTTTATTT TTAGGCCGGGCATGGTGACTCACCTGAGGTGAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAGTACAAA AATTAGCCAGGCGTGGTGGTGCATGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTT GCAGTAAGCCAAGGTCACACCACTGCACTCCAGCCTAGGTGACAGGGCGAGACTCTGTCTCTCAAAAAAAAAAAAAAAAAAAATTCTTTG AGACAGGGTCTCTAATATGTTGCCCAAGCTGATCTCAAACTCGTGGCTCAACTGATTCTCCCGCTTCAACCTTGAGTAGCTGGGACGACA GATACATGCTACTGCACCCAGCTAGGTTAAGGTTCTGTATACTCTGTCTTTCTAAAGCAATTCCCTGGAAATTTTCTCAACATTGGTTAT AACTGAATGCTTGGGAAGGGAGGGGCAGCCCTTCAACAGGAAAAGGGGACTGCCCAAATCTTAAATGCACAGTCAAGATTCTCTTGGAGC TAGCAATGGTTCTCAGGTTAGTGAGCATTTAGCTTGCCTGCTGCAGAATTTGACCCAGATGGGGGTGTTTTTTAGGTCTCTCACAAATGA GACAAGCGAAACAATTGTCTCCTTTTATTCTCTTTGGTGCATTGGTGCTGGGGAAACATGAACTAGCGGCAGTGTAACTGCAGAACATAG ACCCAGTTCTACCAGGCCAGGCCAGCGTTGGGAACCACCAGACAGGGCTGCTTTGGGCTTTGCTTACAGTATTTCCATGTGTAGCCTGGC GTGTGAGAAAGTATTAGGTGAAATGCCAGTTTCATGGTTCAGGTGAAAGTCTGTGATCATTCCCCTCGTGGCTCGTCCTTCACATCACTT TTGCCCTTCAAGGAGTTGCCGCGTCCCCGCTCAGTGCCGCCTGAGCCCTCAGAGCTCCCCTGTGCTTTTCTGGATGGGGACTGGCGGGGT CACCTAGCCTCACCGTGGAGCCACCGTGCAATGCCCATCTCTGAGAGGCCCACGCGGTATTCCTCGTGCCCTGTGTTAGTGCTTTCTGTA TAAGGGACAGACAGAACTGGGTTTTTTTCCTCTGTCTGGTTTTAGAGTAAATGTAACTAACTTTTATTTTCCCTTTATGAAAGATAGAAA TTATTTTTATGTAGTTTCCAGACTTTATACAAAATTTTTGTAAAATGTTCTCTGGAAAGTTAACTACAAGAATGTAAATATGCTTCTAAT |
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FusionGenePPI for UBTD2_STK10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBTD2 | UBC, UBA1, USP5, TRIM39, GALT, CST1, CST4, SMR3B, DUSP22, TMEM185A, PCDHGC3, GJB7, HOXB5 | STK10 | CD81, ENO1, SHMT2, MOV10, NXF1, KIFC1, XPO1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBTD2_STK10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBTD2_STK10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | STK10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | STK10 | C1336708 | Testicular Germ Cell Tumor | 1 | UNIPROT |
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