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Fusion gene ID: 40603

FusionGeneSummary for UBR4_NRP1

Fusion gene summary

Fusion gene information	Fusion gene name: UBR4_NRP1
	Fusion gene ID: 40603
		Hgene	Tgene
	Gene symbol	UBR4	NRP1
	Gene ID	23352	8829
	Gene name	ubiquitin protein ligase E3 component n-recognin 4	neuropilin 1
	Synonyms	RBAF600\|ZUBR1\|p600	BDCA4\|CD304\|NP1\|NRP\|VEGF165R
	Cytomap	1p36.13	10p11.22
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase UBR4N-recognin-4RING-type E3 ubiquitin transferase UBR4retinoblastoma-associated factor 600-like proteinretinoblastoma-associated factor of 600 kDazinc finger UBR1-type protein 1	neuropilin-1transmembrane receptorvascular endothelial cell growth factor 165 receptor
	Modification date	20180523	20180519
	UniProtAcc	Q5T4S7	O14786
	Ensembl transtripts involved in fusion gene	ENST00000375217, ENST00000375226, ENST00000375267, ENST00000375254, ENST00000375225, ENST00000429347, ENST00000375224, ENST00000543981, ENST00000467272, ENST00000375218,	ENST00000374875, ENST00000265371, ENST00000374867, ENST00000395995, ENST00000374821, ENST00000374822, ENST00000374823, ENST00000374816, ENST00000432372,
Fusion gene scores	* DoF score	10 X 10 X 5=500	5 X 5 X 2=50
	# samples	10	6
	** MAII score	log2(10/500*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: UBR4 [Title/Abstract] AND NRP1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBR4	GO:0006511	ubiquitin-dependent protein catabolic process	23932781
Tgene	NRP1	GO:0051894	positive regulation of focal adhesion assembly	24863063

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF839271	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000375217	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375217	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375217	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375217	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375217	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375217	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375217	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375217	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375217	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375226	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375267	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375254	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375225	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000429347	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375224	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000543981	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000467272	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000374875	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000265371	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000374867	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000395995	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000374821	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000374822	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000374823	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000374816	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-
intron-intron	ENST00000375218	ENST00000432372	UBR4	chr1	19456298	+	NRP1	chr10	33480390	-

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FusionProtFeatures for UBR4_NRP1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UBR4 Q5T4S7	NRP1 O14786

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for UBR4_NRP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBR4_NRP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for UBR4_NRP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	NRP1	O14786	DB00039	Palifermin	Neuropilin-1	biotech	approved
Tgene	NRP1	O14786	DB04895	Pegaptanib	Neuropilin-1	biotech	approved\|investigational

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RelatedDiseases for UBR4_NRP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NRP1	C0014175	Endometriosis	1	CTD_human
Tgene	NRP1	C0023895	Liver diseases	1	CTD_human
Tgene	NRP1	C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene	NRP1	C0033578	Prostatic Neoplasms	1	CTD_human

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Fusion gene ID: 40603

FusionGeneSummary for UBR4_NRP1

FusionProtFeatures for UBR4_NRP1

FusionGeneSequence for UBR4_NRP1

FusionGenePPI for UBR4_NRP1

RelatedDrugs for UBR4_NRP1

RelatedDiseases for UBR4_NRP1